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Inflammatory bowel disease 25(IBD25)

MedGen UID:
393403
•Concept ID:
C2675508
•
Disease or Syndrome
Synonyms: Inflammatory bowel disease 25, autosomal recessive; Inflammatory bowel disease 25, early onset, autosomal recessive
 
Gene (location): IL10RB (21q22.11)
 
Monarch Initiative: MONDO:0012941
OMIM®: 612567

Definition

Any inflammatory bowel disease in which the cause of the disease is a mutation in the IL10RB gene. [from MONDO]

Clinical features

From HPO
Enterocolitis
MedGen UID:
4966
•Concept ID:
C0014356
•
Disease or Syndrome
An inflammation of the colon and small intestine. However, most conditions are either categorized as Enteritis (inflammation of the small intestine) or Colitis (inflammation of the large intestine).
See: Feature record | Search on this feature
Perianal abscess
MedGen UID:
14677
•Concept ID:
C0031019
•
Disease or Syndrome
The presence of an abscess located around the anus.
See: Feature record | Search on this feature
Rectovaginal fistula
MedGen UID:
11152
•Concept ID:
C0034895
•
Finding
The presence of a fistula between the vagina and the rectum.
See: Feature record | Search on this feature
Enterocutaneous fistula
MedGen UID:
137955
•Concept ID:
C0341318
•
Anatomical Abnormality
An abnormal connection (fistula) between the intra-abdominal intestinal tract and the skin.
See: Feature record | Search on this feature
Pancolitis
MedGen UID:
1720692
•Concept ID:
C0868908
•
Disease or Syndrome
Inflammation of the entire colon.
See: Feature record | Search on this feature
Recurrent bronchitis
MedGen UID:
148159
•Concept ID:
C0741796
•
Disease or Syndrome
An increased susceptibility to bronchitis as manifested by a history of recurrent bronchitis.
See: Feature record | Search on this feature
Folliculitis
MedGen UID:
4752
•Concept ID:
C0016436
•
Disease or Syndrome
Inflammatory cells within the wall and ostia of the hair follicle, creating a follicular-based pustule.
See: Feature record | Search on this feature
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Professional guidelines

PubMed

Management of Perianal Crohn's Disease.
Parian AM, Obi M, Fleshner P, Schwartz DA
Am J Gastroenterol 2023 Aug 1;118(8):1323-1331. Epub 2023 Jun 19 doi: 10.14309/ajg.0000000000002326. PMID: 37207318
Mild Crohn's Disease: Definition and Management.
Claytor J, Kumar P, Ananthakrishnan AN, Colombel JF, Agrawal M, Ungaro RC
Curr Gastroenterol Rep 2023 Mar;25(3):45-51. Epub 2023 Feb 8 doi: 10.1007/s11894-023-00863-y. PMID: 36753033
Inflammatory bowel diseases and spondyloarthropathies: From pathogenesis to treatment.
Fragoulis GE, Liava C, Daoussis D, Akriviadis E, Garyfallos A, Dimitroulas T
World J Gastroenterol 2019 May 14;25(18):2162-2176. doi: 10.3748/wjg.v25.i18.2162. PMID: 31143068Free PMC Article

Recent clinical studies

Etiology

Therapeutic targets for inflammatory bowel disease: proteome-wide Mendelian randomization and colocalization analyses.
Chen J, Xu F, Ruan X, Sun J, Zhang Y, Zhang H, Zhao J, Zheng J, Larsson SC, Wang X, Li X, Yuan S
EBioMedicine 2023 Mar;89:104494. Epub 2023 Feb 27 doi: 10.1016/j.ebiom.2023.104494. PMID: 36857861Free PMC Article
Systematic review with network meta-analysis: Risk of Herpes zoster with biological therapies and small molecules in inflammatory bowel disease.
Din S, Selinger CP, Black CJ, Ford AC
Aliment Pharmacol Ther 2023 Mar;57(6):666-675. Epub 2022 Dec 31 doi: 10.1111/apt.17379. PMID: 36585944
Causal Association Between Inflammatory Bowel Disease and Psoriasis: A Two-Sample Bidirectional Mendelian Randomization Study.
Li Y, Guo J, Cao Z, Wu J
Front Immunol 2022;13:916645. Epub 2022 Jun 10 doi: 10.3389/fimmu.2022.916645. PMID: 35757704Free PMC Article
Dual Biologic or Small Molecule Therapy for Treatment of Inflammatory Bowel Disease: A Systematic Review and Meta-analysis.
Ahmed W, Galati J, Kumar A, Christos PJ, Longman R, Lukin DJ, Scherl E, Battat R
Clin Gastroenterol Hepatol 2022 Mar;20(3):e361-e379. Epub 2021 Mar 31 doi: 10.1016/j.cgh.2021.03.034. PMID: 33798711
Neurology of inflammatory bowel disease.
Ferro JM, Oliveira Santos M
J Neurol Sci 2021 May 15;424:117426. Epub 2021 Mar 27 doi: 10.1016/j.jns.2021.117426. PMID: 33810878

Diagnosis

The genetically predicted causal relationship of inflammatory bowel disease with bone mineral density and osteoporosis: evidence from two-sample Mendelian randomization.
Xu D, Chen Y, Gao X, Xie W, Wang Y, Shen J, Yang G, Xie B
Front Immunol 2023;14:1148107. Epub 2023 May 18 doi: 10.3389/fimmu.2023.1148107. PMID: 37275908Free PMC Article
Intestinal Barrier Healing Is Superior to Endoscopic and Histologic Remission for Predicting Major Adverse Outcomes in Inflammatory Bowel Disease: The Prospective ERIca Trial.
Rath T, Atreya R, Bodenschatz J, Uter W, Geppert CE, Vitali F, Fischer S, Waldner MJ, Colombel JF, Hartmann A, Neurath MF
Gastroenterology 2023 Feb;164(2):241-255. Epub 2022 Oct 21 doi: 10.1053/j.gastro.2022.10.014. PMID: 36279923
Causal Association Between Inflammatory Bowel Disease and Psoriasis: A Two-Sample Bidirectional Mendelian Randomization Study.
Li Y, Guo J, Cao Z, Wu J
Front Immunol 2022;13:916645. Epub 2022 Jun 10 doi: 10.3389/fimmu.2022.916645. PMID: 35757704Free PMC Article
Pediatric Inflammatory Bowel Disease.
Kapoor A, Bhatia V, Sibal A
Indian Pediatr 2016 Nov 15;53(11):993-1002. doi: 10.1007/s13312-016-0975-0. PMID: 27889728
The global burden of IBD: from 2015 to 2025.
Kaplan GG
Nat Rev Gastroenterol Hepatol 2015 Dec;12(12):720-7. Epub 2015 Sep 1 doi: 10.1038/nrgastro.2015.150. PMID: 26323879

Therapy

Therapeutic targets for inflammatory bowel disease: proteome-wide Mendelian randomization and colocalization analyses.
Chen J, Xu F, Ruan X, Sun J, Zhang Y, Zhang H, Zhao J, Zheng J, Larsson SC, Wang X, Li X, Yuan S
EBioMedicine 2023 Mar;89:104494. Epub 2023 Feb 27 doi: 10.1016/j.ebiom.2023.104494. PMID: 36857861Free PMC Article
Causal Association Between Inflammatory Bowel Disease and Psoriasis: A Two-Sample Bidirectional Mendelian Randomization Study.
Li Y, Guo J, Cao Z, Wu J
Front Immunol 2022;13:916645. Epub 2022 Jun 10 doi: 10.3389/fimmu.2022.916645. PMID: 35757704Free PMC Article
Dual Biologic or Small Molecule Therapy for Treatment of Inflammatory Bowel Disease: A Systematic Review and Meta-analysis.
Ahmed W, Galati J, Kumar A, Christos PJ, Longman R, Lukin DJ, Scherl E, Battat R
Clin Gastroenterol Hepatol 2022 Mar;20(3):e361-e379. Epub 2021 Mar 31 doi: 10.1016/j.cgh.2021.03.034. PMID: 33798711
Inflammatory bowel diseases and spondyloarthropathies: From pathogenesis to treatment.
Fragoulis GE, Liava C, Daoussis D, Akriviadis E, Garyfallos A, Dimitroulas T
World J Gastroenterol 2019 May 14;25(18):2162-2176. doi: 10.3748/wjg.v25.i18.2162. PMID: 31143068Free PMC Article
The Role of Early Biologic Therapy in Inflammatory Bowel Disease.
Berg DR, Colombel JF, Ungaro R
Inflamm Bowel Dis 2019 Nov 14;25(12):1896-1905. doi: 10.1093/ibd/izz059. PMID: 30934053Free PMC Article

Prognosis

Temporal trends in the prevalence of autoimmune diseases from 1990 to 2019.
Cao F, Liu YC, Ni QY, Chen Y, Wan CH, Liu SY, Tao LM, Jiang ZX, Ni J, Pan HF
Autoimmun Rev 2023 Aug;22(8):103359. Epub 2023 May 16 doi: 10.1016/j.autrev.2023.103359. PMID: 37201621
Therapeutic targets for inflammatory bowel disease: proteome-wide Mendelian randomization and colocalization analyses.
Chen J, Xu F, Ruan X, Sun J, Zhang Y, Zhang H, Zhao J, Zheng J, Larsson SC, Wang X, Li X, Yuan S
EBioMedicine 2023 Mar;89:104494. Epub 2023 Feb 27 doi: 10.1016/j.ebiom.2023.104494. PMID: 36857861Free PMC Article
Intestinal Barrier Healing Is Superior to Endoscopic and Histologic Remission for Predicting Major Adverse Outcomes in Inflammatory Bowel Disease: The Prospective ERIca Trial.
Rath T, Atreya R, Bodenschatz J, Uter W, Geppert CE, Vitali F, Fischer S, Waldner MJ, Colombel JF, Hartmann A, Neurath MF
Gastroenterology 2023 Feb;164(2):241-255. Epub 2022 Oct 21 doi: 10.1053/j.gastro.2022.10.014. PMID: 36279923
Bidirectional brain-gut axis effects influence mood and prognosis in IBD: a systematic review and meta-analysis.
Fairbrass KM, Lovatt J, Barberio B, Yuan Y, Gracie DJ, Ford AC
Gut 2022 Sep;71(9):1773-1780. Epub 2021 Nov 1 doi: 10.1136/gutjnl-2021-325985. PMID: 34725197
The Role of Early Biologic Therapy in Inflammatory Bowel Disease.
Berg DR, Colombel JF, Ungaro R
Inflamm Bowel Dis 2019 Nov 14;25(12):1896-1905. doi: 10.1093/ibd/izz059. PMID: 30934053Free PMC Article

Clinical prediction guides

Multi-omic insight into the molecular networks of mitochondrial dysfunction in the pathogenesis of inflammatory bowel disease.
Chen J, Ruan X, Sun Y, Lu S, Hu S, Yuan S, Li X
EBioMedicine 2024 Jan;99:104934. Epub 2023 Dec 16 doi: 10.1016/j.ebiom.2023.104934. PMID: 38103512Free PMC Article
Therapeutic targets for inflammatory bowel disease: proteome-wide Mendelian randomization and colocalization analyses.
Chen J, Xu F, Ruan X, Sun J, Zhang Y, Zhang H, Zhao J, Zheng J, Larsson SC, Wang X, Li X, Yuan S
EBioMedicine 2023 Mar;89:104494. Epub 2023 Feb 27 doi: 10.1016/j.ebiom.2023.104494. PMID: 36857861Free PMC Article
Causal Association Between Inflammatory Bowel Disease and Psoriasis: A Two-Sample Bidirectional Mendelian Randomization Study.
Li Y, Guo J, Cao Z, Wu J
Front Immunol 2022;13:916645. Epub 2022 Jun 10 doi: 10.3389/fimmu.2022.916645. PMID: 35757704Free PMC Article
Prevalence of symptoms of anxiety and depression in patients with inflammatory bowel disease: a systematic review and meta-analysis.
Barberio B, Zamani M, Black CJ, Savarino EV, Ford AC
Lancet Gastroenterol Hepatol 2021 May;6(5):359-370. Epub 2021 Mar 12 doi: 10.1016/S2468-1253(21)00014-5. PMID: 33721557
Effects of Low FODMAP Diet on Symptoms, Fecal Microbiome, and Markers of Inflammation in Patients With Quiescent Inflammatory Bowel Disease in a Randomized Trial.
Cox SR, Lindsay JO, Fromentin S, Stagg AJ, McCarthy NE, Galleron N, Ibraim SB, Roume H, Levenez F, Pons N, Maziers N, Lomer MC, Ehrlich SD, Irving PM, Whelan K
Gastroenterology 2020 Jan;158(1):176-188.e7. Epub 2019 Oct 2 doi: 10.1053/j.gastro.2019.09.024. PMID: 31586453

Recent systematic reviews

Systematic review with network meta-analysis: Risk of Herpes zoster with biological therapies and small molecules in inflammatory bowel disease.
Din S, Selinger CP, Black CJ, Ford AC
Aliment Pharmacol Ther 2023 Mar;57(6):666-675. Epub 2022 Dec 31 doi: 10.1111/apt.17379. PMID: 36585944
Efficacy of biological therapies and small molecules in induction and maintenance of remission in luminal Crohn's disease: systematic review and network meta-analysis.
Barberio B, Gracie DJ, Black CJ, Ford AC
Gut 2023 Feb;72(2):264-274. Epub 2022 Jul 30 doi: 10.1136/gutjnl-2022-328052. PMID: 35907636
Dual Biologic or Small Molecule Therapy for Treatment of Inflammatory Bowel Disease: A Systematic Review and Meta-analysis.
Ahmed W, Galati J, Kumar A, Christos PJ, Longman R, Lukin DJ, Scherl E, Battat R
Clin Gastroenterol Hepatol 2022 Mar;20(3):e361-e379. Epub 2021 Mar 31 doi: 10.1016/j.cgh.2021.03.034. PMID: 33798711
Comparative efficacy and safety of biologic therapies for moderate-to-severe Crohn's disease: a systematic review and network meta-analysis.
Singh S, Murad MH, Fumery M, Sedano R, Jairath V, Panaccione R, Sandborn WJ, Ma C
Lancet Gastroenterol Hepatol 2021 Dec;6(12):1002-1014. Epub 2021 Oct 22 doi: 10.1016/S2468-1253(21)00312-5. PMID: 34688373Free PMC Article
Prevalence of symptoms of anxiety and depression in patients with inflammatory bowel disease: a systematic review and meta-analysis.
Barberio B, Zamani M, Black CJ, Savarino EV, Ford AC
Lancet Gastroenterol Hepatol 2021 May;6(5):359-370. Epub 2021 Mar 12 doi: 10.1016/S2468-1253(21)00014-5. PMID: 33721557

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