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Cleft vertebral arch

MedGen UID:
395267
•Concept ID:
C1859458
•
Congenital Abnormality; Finding
Synonym: Cleft vertebral arches
 
HPO: HP:0004616

Definition

A discontinuity of the vertebral arch, i.e., of the posterior part of a vertebra. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCleft vertebral arch

Conditions with this feature

Osteodysplastic primordial dwarfism, type 1
MedGen UID:
347149
•Concept ID:
C1859452
•
Congenital Abnormality
Microcephalic osteodysplastic primordial dwarfism type I (MOPD1) is a severe autosomal recessive skeletal dysplasia characterized by dwarfism, microcephaly, and neurologic abnormalities, including mental retardation, brain malformations, and ocular/auditory sensory deficits. Patients often die in early childhood (summary by Pierce and Morse, 2012).
See: Condition Record
Osteodysplastic primordial dwarfism, type 1

Professional guidelines

PubMed

A novel bone cement screw system combined with vertebroplasty for the treatment of Kummell disease with bone deficiency at the vertebral anterior border: A minimum 3-year follow-up study.
Wang B, Wang Y, Zhang H, Yan L, Kong L, He S, Hao D
Clin Neurol Neurosurg 2021 Feb;201:106434. Epub 2020 Dec 17 doi: 10.1016/j.clineuro.2020.106434. PMID: 33370625
Risk factors for conservative treatment failure in acute osteoporotic vertebral compression fractures (OVCFs).
Zhang J, He X, Fan Y, Du J, Hao D
Arch Osteoporos 2019 Feb 26;14(1):24. doi: 10.1007/s11657-019-0563-8. PMID: 30806831
Percutaneous Kyphoplasty for the Treatment of Osteoporotic Vertebral Fractures With Intravertebral Fluid or Air: A Comparative Study.
Niu J, Song D, Zhou H, Meng Q, Meng B, Yang H
Clin Spine Surg 2017 Oct;30(8):367-373. doi: 10.1097/BSD.0000000000000262. PMID: 28937459

Recent clinical studies

Etiology

Development and validation of a machine learning model to predict imminent new vertebral fractures after vertebral augmentation.
Jiang Y, Cai J, Zeng Y, Ye H, Yang T, Liu Z, Liu Q
BMC Musculoskelet Disord 2023 Jun 9;24(1):472. doi: 10.1186/s12891-023-06557-w. PMID: 37296426Free PMC Article
Does the Relationship Between Bone Cement and the Intravertebral Cleft of Kummell Disease Affect the Efficacy of PKP?
Lv NN, Hou MZ, Zhou ZZ, Feng XX, Liu HJ, Shan FR, Li EH, Guan BY, He SJ, Liu MM
World Neurosurg 2022 Apr;160:e430-e435. Epub 2022 Jan 18 doi: 10.1016/j.wneu.2022.01.050. PMID: 35051635
Evaluation of the cervical vertebral anomalies in patients with cleft lip and palate in Aegean region of Turkey.
Dogan E, Ergican GO, Dogan S
J Pak Med Assoc 2021 Jan;71(1(B)):215-218. doi: 10.47391/JPMA.213. PMID: 35157652
Morphological changes of vertebral compression fracture with intra-vertebral cleft treated with percutaneous vertebroplasty.
Park SM, Park JW, Kim H, Kim HJ, Yeom JS, Lee CK, Chang BS
J Orthop Sci 2018 Mar;23(2):237-247. Epub 2017 Nov 23 doi: 10.1016/j.jos.2017.11.006. PMID: 29174421
Cervical vertebral anomalies in cleft lip and palate.
Sandham A
Cleft Palate J 1986 Jul;23(3):206-14. PMID: 3524906

Diagnosis

Development and internal validation of a clinical prediction model for acute adjacent vertebral fracture after vertebral augmentation : the AVA score.
Hijikata Y, Kamitani T, Nakahara M, Kumamoto S, Sakai T, Itaya T, Yamazaki H, Ogawa Y, Kusumegi A, Inoue T, Yoshida T, Furue N, Fukuhara SI, Yamamoto Y; AVA Score Research Group
Bone Joint J 2022 Jan;104-B(1):97-102. doi: 10.1302/0301-620X.104B1.BJJ-2021-0151.R3. PMID: 34969274
Multi-level sagittally cleft vertebrae: a case report and review of the literature.
Zeoli T, Iwanaga J, Dumont AS, Tubbs RS
Surg Radiol Anat 2021 Jan;43(1):127-130. Epub 2020 Jun 14 doi: 10.1007/s00276-020-02517-4. PMID: 32537674
Cervical pedicle agenesis: case report and bibliographic review.
Sarotto AJ, Rosado Pardo J, Fossa Riglos S, Besse M
Surg Radiol Anat 2020 Feb;42(2):121-125. Epub 2019 Oct 29 doi: 10.1007/s00276-019-02333-5. PMID: 31664469
Refracture of osteoporotic vertebral body after treatment by balloon kyphoplasty: Three cases report.
Li X, Lu Y, Lin X
Medicine (Baltimore) 2017 Dec;96(49):e8961. doi: 10.1097/MD.0000000000008961. PMID: 29245267Free PMC Article
Pseudoarthrosis of vertebral fracture: radiographic and characteristic clinical features and natural history.
Hashidate H, Kamimura M, Nakagawa H, Takahara K, Uchiyama S
J Orthop Sci 2006 Jan;11(1):28-33. doi: 10.1007/s00776-005-0967-8. PMID: 16437345

Therapy

Development and validation of a machine learning model to predict imminent new vertebral fractures after vertebral augmentation.
Jiang Y, Cai J, Zeng Y, Ye H, Yang T, Liu Z, Liu Q
BMC Musculoskelet Disord 2023 Jun 9;24(1):472. doi: 10.1186/s12891-023-06557-w. PMID: 37296426Free PMC Article
Relationship between sarcopenia/paravertebral muscles and the incidence of vertebral refractures following percutaneous kyphoplasty: a retrospective study.
Chen Q, Lei C, Zhao T, Dai Z, Zhang J, Jin Y, Xia C
BMC Musculoskelet Disord 2022 Sep 22;23(1):879. doi: 10.1186/s12891-022-05832-6. PMID: 36138369Free PMC Article
CT-Guided Percutaneous Vertebroplasty for Vertebral Non-union Following Posterior Fixation: A Preliminary Retrospective Study.
Pavan LJ, Dalili D, Ranc C, Torre F, Clerk-Lamalice O, Burns R, Andreani O, Ranc PA, Bronsard N, Prestat A, Amoretti N
Cardiovasc Intervent Radiol 2022 May;45(5):687-695. Epub 2022 Jan 22 doi: 10.1007/s00270-021-03037-3. PMID: 35064285
Does the Relationship Between Bone Cement and the Intravertebral Cleft of Kummell Disease Affect the Efficacy of PKP?
Lv NN, Hou MZ, Zhou ZZ, Feng XX, Liu HJ, Shan FR, Li EH, Guan BY, He SJ, Liu MM
World Neurosurg 2022 Apr;160:e430-e435. Epub 2022 Jan 18 doi: 10.1016/j.wneu.2022.01.050. PMID: 35051635
Percutaneous kyphoplasty: Risk Factors for Recollapse of Cemented Vertebrae.
Wang C, Zhang X, Liu J, Shan Z, Li S, Zhao F
World Neurosurg 2019 Oct;130:e307-e315. Epub 2019 Jun 19 doi: 10.1016/j.wneu.2019.06.071. PMID: 31226459

Prognosis

Development and validation of a machine learning model to predict imminent new vertebral fractures after vertebral augmentation.
Jiang Y, Cai J, Zeng Y, Ye H, Yang T, Liu Z, Liu Q
BMC Musculoskelet Disord 2023 Jun 9;24(1):472. doi: 10.1186/s12891-023-06557-w. PMID: 37296426Free PMC Article
Relationship between sarcopenia/paravertebral muscles and the incidence of vertebral refractures following percutaneous kyphoplasty: a retrospective study.
Chen Q, Lei C, Zhao T, Dai Z, Zhang J, Jin Y, Xia C
BMC Musculoskelet Disord 2022 Sep 22;23(1):879. doi: 10.1186/s12891-022-05832-6. PMID: 36138369Free PMC Article
Development and internal validation of a clinical prediction model for acute adjacent vertebral fracture after vertebral augmentation : the AVA score.
Hijikata Y, Kamitani T, Nakahara M, Kumamoto S, Sakai T, Itaya T, Yamazaki H, Ogawa Y, Kusumegi A, Inoue T, Yoshida T, Furue N, Fukuhara SI, Yamamoto Y; AVA Score Research Group
Bone Joint J 2022 Jan;104-B(1):97-102. doi: 10.1302/0301-620X.104B1.BJJ-2021-0151.R3. PMID: 34969274
Morphological changes of vertebral compression fracture with intra-vertebral cleft treated with percutaneous vertebroplasty.
Park SM, Park JW, Kim H, Kim HJ, Yeom JS, Lee CK, Chang BS
J Orthop Sci 2018 Mar;23(2):237-247. Epub 2017 Nov 23 doi: 10.1016/j.jos.2017.11.006. PMID: 29174421
Intravertebral Vacuum Cleft and Its Varied Locations within Osteoporotic Vertebral Compression Fractures: Effect on Therapeutic Efficacy.
Yu W, Jiang X, Liang D, Yao Z, Qiu T, Ye L, Zhang S, Jin D
Pain Physician 2017 Sep;20(6):E979-E986. PMID: 28934802

Clinical prediction guides

Development and validation of a machine learning model to predict imminent new vertebral fractures after vertebral augmentation.
Jiang Y, Cai J, Zeng Y, Ye H, Yang T, Liu Z, Liu Q
BMC Musculoskelet Disord 2023 Jun 9;24(1):472. doi: 10.1186/s12891-023-06557-w. PMID: 37296426Free PMC Article
Does the Relationship Between Bone Cement and the Intravertebral Cleft of Kummell Disease Affect the Efficacy of PKP?
Lv NN, Hou MZ, Zhou ZZ, Feng XX, Liu HJ, Shan FR, Li EH, Guan BY, He SJ, Liu MM
World Neurosurg 2022 Apr;160:e430-e435. Epub 2022 Jan 18 doi: 10.1016/j.wneu.2022.01.050. PMID: 35051635
Development and internal validation of a clinical prediction model for acute adjacent vertebral fracture after vertebral augmentation : the AVA score.
Hijikata Y, Kamitani T, Nakahara M, Kumamoto S, Sakai T, Itaya T, Yamazaki H, Ogawa Y, Kusumegi A, Inoue T, Yoshida T, Furue N, Fukuhara SI, Yamamoto Y; AVA Score Research Group
Bone Joint J 2022 Jan;104-B(1):97-102. doi: 10.1302/0301-620X.104B1.BJJ-2021-0151.R3. PMID: 34969274
Morphological changes of vertebral compression fracture with intra-vertebral cleft treated with percutaneous vertebroplasty.
Park SM, Park JW, Kim H, Kim HJ, Yeom JS, Lee CK, Chang BS
J Orthop Sci 2018 Mar;23(2):237-247. Epub 2017 Nov 23 doi: 10.1016/j.jos.2017.11.006. PMID: 29174421
Intravertebral Vacuum Cleft and Its Varied Locations within Osteoporotic Vertebral Compression Fractures: Effect on Therapeutic Efficacy.
Yu W, Jiang X, Liang D, Yao Z, Qiu T, Ye L, Zhang S, Jin D
Pain Physician 2017 Sep;20(6):E979-E986. PMID: 28934802

Recent systematic reviews

Risk factors for secondary fractures to percutaneous vertebroplasty for osteoporotic vertebral compression fractures: a systematic review.
Mao W, Dong F, Huang G, He P, Chen H, Qin S, Li A
J Orthop Surg Res 2021 Oct 30;16(1):644. doi: 10.1186/s13018-021-02722-w. PMID: 34717682Free PMC Article

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