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ACETOPHENETIDIN SENSITIVITY

MedGen UID:
395437
•Concept ID:
C1860214
•
Finding
OMIM®: 200300

Clinical features

From HPO
Hemolytic anemia
MedGen UID:
1916
•Concept ID:
C0002878
•
Disease or Syndrome
A type of anemia caused by premature destruction of red blood cells (hemolysis).
See: Feature record | Search on this feature
Methemoglobinemia
MedGen UID:
6339
•Concept ID:
C0025637
•
Disease or Syndrome
Abnormally increased levels of methemoglobin in the blood. In this form of hemoglobin, there is an oxidized ferric iron (Fe +3) rather than the reduced ferrous form (Fe 2+) that is normally found in hemoglobin. Methemoglobin has a reduced affinity for oxygen, resulting in a reduced ability to release oxygen to tissues.
See: Feature record | Search on this feature
Abnormality of blood and blood-forming tissues
MedGen UID:
163092
•Concept ID:
C0850715
•
Finding
An abnormality of the hematopoietic system.
See: Feature record | Search on this feature

Professional guidelines

PubMed

Tests of renal function in patients with quiescent colitis: effects of drug treatment.
Riley SA, Lloyd DR, Mani V
Gut 1992 Oct;33(10):1348-52. doi: 10.1136/gut.33.10.1348. PMID: 1446858Free PMC Article

Recent clinical studies

Etiology

Effects of Avitinib on CYP450 Enzyme Activity in vitro and in vivo in Rats.
Shi Y, Meng D, Wang S, Geng P, Xu T, Zhou Q, Zhou Y, Li W, Chen X
Drug Des Devel Ther 2021;15:3661-3673. Epub 2021 Aug 21 doi: 10.2147/DDDT.S323186. PMID: 34456561Free PMC Article
Simultaneous LC-MS-MS Determination of Lopinavir and Rifabutin in Human Plasma.
Jaiswal S, Sharma A, Shukla M, Lal J
J Chromatogr Sci 2017 Jul 1;55(6):617-624. doi: 10.1093/chromsci/bmx016. PMID: 28334925
Profiling cocaine by ATR-FTIR.
Marcelo MC, Mariotti KC, Ferrão MF, Ortiz RS
Forensic Sci Int 2015 Jan;246:65-71. Epub 2014 Nov 22 doi: 10.1016/j.forsciint.2014.11.011. PMID: 25460107
Neonatal mouse model: review of methods and results.
McClain RM, Keller D, Casciano D, Fu P, MacDonald J, Popp J, Sagartz J
Toxicol Pathol 2001;29 Suppl:128-37. doi: 10.1080/019262301753178537. PMID: 11695548
What makes P450s work? Searches for answers with known and new P450s.
Guengerich FP, Parikh A, Yun CH, Kim D, Nakamura K, Notley LM, Gillam EM
Drug Metab Rev 2000 Aug-Nov;32(3-4):267-81. doi: 10.1081/dmr-100102334. PMID: 11139129

Diagnosis

Profiling cocaine by ATR-FTIR.
Marcelo MC, Mariotti KC, Ferrão MF, Ortiz RS
Forensic Sci Int 2015 Jan;246:65-71. Epub 2014 Nov 22 doi: 10.1016/j.forsciint.2014.11.011. PMID: 25460107
Analgesic nephropathy: is it caused by multi-analgesic abuse or single substance use?
Elseviers MM, De Broe ME
Drug Saf 1999 Jan;20(1):15-24. doi: 10.2165/00002018-199920010-00003. PMID: 9935274
Analgesic nephropathy in rodents.
Schnellmann RG
J Toxicol Environ Health B Crit Rev 1998 Jan-Mar;1(1):81-90. doi: 10.1080/10937409809524544. PMID: 9487094
Drugs causing fixed eruptions.
Pasricha JS
Br J Dermatol 1979 Feb;100(2):183-5. doi: 10.1111/j.1365-2133.1979.tb05559.x. PMID: 154920
Acetophenetidin sensitivity.
Shahidi NT
Am J Dis Child 1967 Jan;113(1):81-2. doi: 10.1001/archpedi.1967.02090160131017. PMID: 6015912

Therapy

Neonatal mouse model: review of methods and results.
McClain RM, Keller D, Casciano D, Fu P, MacDonald J, Popp J, Sagartz J
Toxicol Pathol 2001;29 Suppl:128-37. doi: 10.1080/019262301753178537. PMID: 11695548
Analgesic nephropathy: is it caused by multi-analgesic abuse or single substance use?
Elseviers MM, De Broe ME
Drug Saf 1999 Jan;20(1):15-24. doi: 10.2165/00002018-199920010-00003. PMID: 9935274
Analgesic nephropathy in rodents.
Schnellmann RG
J Toxicol Environ Health B Crit Rev 1998 Jan-Mar;1(1):81-90. doi: 10.1080/10937409809524544. PMID: 9487094
Drugs causing fixed eruptions.
Pasricha JS
Br J Dermatol 1979 Feb;100(2):183-5. doi: 10.1111/j.1365-2133.1979.tb05559.x. PMID: 154920
Acetophenetidin sensitivity.
Shahidi NT
Am J Dis Child 1967 Jan;113(1):81-2. doi: 10.1001/archpedi.1967.02090160131017. PMID: 6015912

Prognosis

Preoperative Phenacetin Metabolism Test in the Prediction of Postoperative Liver Dysfunction of Patients with Hepatocellular Carcinoma.
Pan X, Li X, Cui L, Wang Q
Med Sci Monit 2017 May 29;23:2607-2611. doi: 10.12659/msm.905228. PMID: 28553832Free PMC Article
Long-term culture and cryopreservation does not affect the stability and functionality of human embryonic stem cell-derived hepatocyte-like cells.
Mandal A, Raju S, Viswanathan C
In Vitro Cell Dev Biol Anim 2016 Feb;52(2):243-51. Epub 2015 Oct 20 doi: 10.1007/s11626-015-9956-1. PMID: 26487432
Profiling cocaine by ATR-FTIR.
Marcelo MC, Mariotti KC, Ferrão MF, Ortiz RS
Forensic Sci Int 2015 Jan;246:65-71. Epub 2014 Nov 22 doi: 10.1016/j.forsciint.2014.11.011. PMID: 25460107
Differences in cytochrome p450-mediated pharmacokinetics between chinese and caucasian populations predicted by mechanistic physiologically based pharmacokinetic modelling.
Barter ZE, Tucker GT, Rowland-Yeo K
Clin Pharmacokinet 2013 Dec;52(12):1085-100. doi: 10.1007/s40262-013-0089-y. PMID: 23818090
Evaluation of recombinant cytochrome P450 enzymes as an in vitro system for metabolic clearance predictions.
Stringer RA, Strain-Damerell C, Nicklin P, Houston JB
Drug Metab Dispos 2009 May;37(5):1025-34. Epub 2009 Feb 5 doi: 10.1124/dmd.108.024810. PMID: 19196847

Clinical prediction guides

Long-term culture and cryopreservation does not affect the stability and functionality of human embryonic stem cell-derived hepatocyte-like cells.
Mandal A, Raju S, Viswanathan C
In Vitro Cell Dev Biol Anim 2016 Feb;52(2):243-51. Epub 2015 Oct 20 doi: 10.1007/s11626-015-9956-1. PMID: 26487432
Profiling cocaine by ATR-FTIR.
Marcelo MC, Mariotti KC, Ferrão MF, Ortiz RS
Forensic Sci Int 2015 Jan;246:65-71. Epub 2014 Nov 22 doi: 10.1016/j.forsciint.2014.11.011. PMID: 25460107
Neonatal mouse model: review of methods and results.
McClain RM, Keller D, Casciano D, Fu P, MacDonald J, Popp J, Sagartz J
Toxicol Pathol 2001;29 Suppl:128-37. doi: 10.1080/019262301753178537. PMID: 11695548
What makes P450s work? Searches for answers with known and new P450s.
Guengerich FP, Parikh A, Yun CH, Kim D, Nakamura K, Notley LM, Gillam EM
Drug Metab Rev 2000 Aug-Nov;32(3-4):267-81. doi: 10.1081/dmr-100102334. PMID: 11139129
Analgesic nephropathy: is it caused by multi-analgesic abuse or single substance use?
Elseviers MM, De Broe ME
Drug Saf 1999 Jan;20(1):15-24. doi: 10.2165/00002018-199920010-00003. PMID: 9935274

Supplemental Content

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    Practice guidelines

    • PubMed
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    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • OMIM
      Related records in OMIM
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      Related literature resources in PubMed

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