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Anorectal Infection

MedGen UID:
397844
•Concept ID:
C2700620
•
Disease or Syndrome

Definition

An infectious process affecting the anal area and the rectum. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnorectal Infection

Professional guidelines

PubMed

Prevalence of anorectal Chlamydia trachomatis infection and its genotype distribution among men who have sex with men in Shenzhen, China.
Li JH, Cai YM, Yin YP, Hong FC, Shi MQ, Feng TJ, Peng RR, Wang BX, Chen XS
Jpn J Infect Dis 2011;64(2):143-6. PMID: 21519129
Management and outcomes of anorectal infection in the cancer patient.
Badgwell BD, Chang GJ, Rodriguez-Bigas MA, Smith K, Lupo PJ, Frankowski RF, Delclos G, Du XL, Cormier J
Ann Surg Oncol 2009 Oct;16(10):2752-8. Epub 2009 Aug 1 doi: 10.1245/s10434-009-0626-y. PMID: 19649556
Fournier's gangrene: risk assessment and enzymatic debridement with lyophilized collagenase application.
Aşci R, Sarikaya S, Büyükalpelli R, Yilmaz AF, Yildiz S
Eur Urol 1998;34(5):411-8. doi: 10.1159/000019775. PMID: 9803004

Recent clinical studies

Etiology

Doxycycline versus azithromycin for the treatment of anorectal Chlamydia trachomatis infection in women concurrent with vaginal infection (CHLAZIDOXY study): a multicentre, open-label, randomised, controlled, superiority trial.
Peuchant O, Lhomme E, Martinet P, Grob A, Baïta D, Bernier C, Gibaud SA, Le Hen I, Le Naour E, Trignol-Viguier N, Lanotte P, Lefebvre P, Vachée A, Girard T, Loubinoux J, Bébéar C, Ghezzoul B, Roussillon C, Kret M, de Barbeyrac B; CHLAZIDOXY Study Group
Lancet Infect Dis 2022 Aug;22(8):1221-1230. Epub 2022 May 9 doi: 10.1016/S1473-3099(22)00148-7. PMID: 35550262
Increased risk of subsequent chlamydia infection among women not tested at the anorectal anatomical location.
Visser M, Dvorakova M, van Aar F, Heijne JCM
Sex Transm Infect 2022 Aug;98(5):317-322. Epub 2021 Jul 16 doi: 10.1136/sextrans-2021-054991. PMID: 34272331
Comparison of the patterns of chlamydia and gonorrhoea at the oropharynx, anorectum and urethra among men who have sex with men.
Tabesh M, Fairley CK, Hocking JS, Williamson DA, Zhang L, Xu X, Bradshaw CS, Chen MY, Chow EP
Sex Transm Infect 2022 Feb;98(1):11-16. Epub 2021 Jan 12 doi: 10.1136/sextrans-2020-054632. PMID: 33436503
A longitudinal study to investigate previous Chlamydia trachomatis infection as a risk factor for subsequent anorectal infection in men who have sex with men (MSM) and women visiting STI clinics in the Netherlands.
Leenen J, van Liere GAFS, Hoebe CJPA, Hogewoning AA, de Vries HJC, Dukers-Muijrers NHTM
Epidemiol Infect 2019 Jan;147:e214. doi: 10.1017/S0950268819001018. PMID: 31364548Free PMC Article
Management and outcomes of anorectal infection in the cancer patient.
Badgwell BD, Chang GJ, Rodriguez-Bigas MA, Smith K, Lupo PJ, Frankowski RF, Delclos G, Du XL, Cormier J
Ann Surg Oncol 2009 Oct;16(10):2752-8. Epub 2009 Aug 1 doi: 10.1245/s10434-009-0626-y. PMID: 19649556

Diagnosis

Doxycycline versus azithromycin for the treatment of anorectal Chlamydia trachomatis infection in women concurrent with vaginal infection (CHLAZIDOXY study): a multicentre, open-label, randomised, controlled, superiority trial.
Peuchant O, Lhomme E, Martinet P, Grob A, Baïta D, Bernier C, Gibaud SA, Le Hen I, Le Naour E, Trignol-Viguier N, Lanotte P, Lefebvre P, Vachée A, Girard T, Loubinoux J, Bébéar C, Ghezzoul B, Roussillon C, Kret M, de Barbeyrac B; CHLAZIDOXY Study Group
Lancet Infect Dis 2022 Aug;22(8):1221-1230. Epub 2022 May 9 doi: 10.1016/S1473-3099(22)00148-7. PMID: 35550262
Increased risk of subsequent chlamydia infection among women not tested at the anorectal anatomical location.
Visser M, Dvorakova M, van Aar F, Heijne JCM
Sex Transm Infect 2022 Aug;98(5):317-322. Epub 2021 Jul 16 doi: 10.1136/sextrans-2021-054991. PMID: 34272331
Classical Cryptoglandular Theory for Anorectal Infection: Reconsidered.
Gottesman L
Dis Colon Rectum 2021 Mar 1;64(3):259-261. doi: 10.1097/DCR.0000000000001911. PMID: 33399409
Management and outcomes of anorectal infection in the cancer patient.
Badgwell BD, Chang GJ, Rodriguez-Bigas MA, Smith K, Lupo PJ, Frankowski RF, Delclos G, Du XL, Cormier J
Ann Surg Oncol 2009 Oct;16(10):2752-8. Epub 2009 Aug 1 doi: 10.1245/s10434-009-0626-y. PMID: 19649556
Anorectal gonococcal infection.
Klein EJ, Fisher LS, Chow AW, Guze LB
Ann Intern Med 1977 Mar;86(3):340-6. doi: 10.7326/0003-4819-86-3-340. PMID: 402879

Therapy

Doxycycline versus azithromycin for the treatment of anorectal Chlamydia trachomatis infection in women concurrent with vaginal infection (CHLAZIDOXY study): a multicentre, open-label, randomised, controlled, superiority trial.
Peuchant O, Lhomme E, Martinet P, Grob A, Baïta D, Bernier C, Gibaud SA, Le Hen I, Le Naour E, Trignol-Viguier N, Lanotte P, Lefebvre P, Vachée A, Girard T, Loubinoux J, Bébéar C, Ghezzoul B, Roussillon C, Kret M, de Barbeyrac B; CHLAZIDOXY Study Group
Lancet Infect Dis 2022 Aug;22(8):1221-1230. Epub 2022 May 9 doi: 10.1016/S1473-3099(22)00148-7. PMID: 35550262
Randomized, open-label, multicenter study of azithromycin compared with doxycycline for treating anorectal Chlamydia trachomatis infection concomitant to a vaginal infection (CHLAZIDOXY study).
Peuchant O, Lhomme E, Krêt M, Ghezzoul B, Roussillon C, Bébéar C, Perry F, de Barbeyrac B; and the Chlazidoxy study group
Medicine (Baltimore) 2019 Feb;98(7):e14572. doi: 10.1097/MD.0000000000014572. PMID: 30762806Free PMC Article
Mycoplasma genitalium: high prevalence of resistance to macrolides and frequent anorectal infection in men who have sex with men in western Sydney.
Couldwell DL, Jalocon D, Power M, Jeoffreys NJ, Chen SC, Lewis DA
Sex Transm Infect 2018 Sep;94(6):406-410. Epub 2018 Mar 22 doi: 10.1136/sextrans-2017-053480. PMID: 29567802
Management and outcomes of anorectal infection in the cancer patient.
Badgwell BD, Chang GJ, Rodriguez-Bigas MA, Smith K, Lupo PJ, Frankowski RF, Delclos G, Du XL, Cormier J
Ann Surg Oncol 2009 Oct;16(10):2752-8. Epub 2009 Aug 1 doi: 10.1245/s10434-009-0626-y. PMID: 19649556
Anorectal gonococcal infection.
Klein EJ, Fisher LS, Chow AW, Guze LB
Ann Intern Med 1977 Mar;86(3):340-6. doi: 10.7326/0003-4819-86-3-340. PMID: 402879

Prognosis

Doxycycline versus azithromycin for the treatment of anorectal Chlamydia trachomatis infection in women concurrent with vaginal infection (CHLAZIDOXY study): a multicentre, open-label, randomised, controlled, superiority trial.
Peuchant O, Lhomme E, Martinet P, Grob A, Baïta D, Bernier C, Gibaud SA, Le Hen I, Le Naour E, Trignol-Viguier N, Lanotte P, Lefebvre P, Vachée A, Girard T, Loubinoux J, Bébéar C, Ghezzoul B, Roussillon C, Kret M, de Barbeyrac B; CHLAZIDOXY Study Group
Lancet Infect Dis 2022 Aug;22(8):1221-1230. Epub 2022 May 9 doi: 10.1016/S1473-3099(22)00148-7. PMID: 35550262
A Multidisciplinary Approach to Perianal and Intra-Abdominal Infections in the Neutropenic Cancer Patient.
Sullivan PS, Moreno C
Oncology (Williston Park) 2015 Aug;29(8):581-90. PMID: 26281844
Denial of risk behavior does not exclude asymptomatic anorectal sexually transmitted infection in HIV-infected men.
Cachay ER, Sitapati A, Caperna J, Freeborn K, Lonergan JT, Jocson E, Mathews WC; Owen Clinic Study Group
PLoS One 2009 Dec 30;4(12):e8504. doi: 10.1371/journal.pone.0008504. PMID: 20041143Free PMC Article
Management and outcomes of anorectal infection in the cancer patient.
Badgwell BD, Chang GJ, Rodriguez-Bigas MA, Smith K, Lupo PJ, Frankowski RF, Delclos G, Du XL, Cormier J
Ann Surg Oncol 2009 Oct;16(10):2752-8. Epub 2009 Aug 1 doi: 10.1245/s10434-009-0626-y. PMID: 19649556
Prognostic factors in Fournier gangrene.
Jeong HJ, Park SC, Seo IY, Rim JS
Int J Urol 2005 Dec;12(12):1041-4. doi: 10.1111/j.1442-2042.2005.01204.x. PMID: 16409607

Clinical prediction guides

Anorectal gonorrhoea and chlamydia among transgender women in Brazil: prevalence and assessment of performance and cost of anorectal infection detection and management approaches.
McCartney DJ, Luppi CG, Silva RJC, de Araújo S, Bassichetto KC, Mayaud P, Veras MA; TransOdara Research Group
Sex Transm Infect 2024 Jan 17;100(1):3-9. doi: 10.1136/sextrans-2023-055788. PMID: 38050133
Lymphogranuloma venereum: a retrospective analysis of an emerging sexually transmitted disease in a Lisbon Tertiary Center.
Neves JM, Ramos Pinheiro R, Côrte-Real R, Borrego MJ, Rodrigues A, Fernandes C
J Eur Acad Dermatol Venereol 2021 Aug;35(8):1712-1716. Epub 2021 May 13 doi: 10.1111/jdv.17302. PMID: 33896044
Observational study of anorectal Chlamydia trachomatis infections in France through the lymphogranuloma venereum surveillance network, 2010-2015.
de Barbeyrac B, Laurier-Nadalié C, Touati A, Le Roy C, Imounga L, Hénin N, Peuchant O, Bébéar C, La Ruche G, Ndeikoundam Ngangro N
Int J STD AIDS 2018 Oct;29(12):1215-1224. Epub 2018 Jul 4 doi: 10.1177/0956462418785266. PMID: 29973128
Asymptomatic anorectal Chlamydia trachomatis and Neisseria gonorrhoeae infections are associated with systemic CD8+ T-cell activation.
Vieira VA, Avelino-Silva VI, Cerqueira NB, Costa DA, Costa PR, Vasconcelos RP, Madruga VR, Moreira RI, Hoagland B, Veloso VG, Grinsztejn B, Kallás EG; PrEP Brasil Study Team
AIDS 2017 Sep 24;31(15):2069-2076. doi: 10.1097/QAD.0000000000001580. PMID: 28692536
Denial of risk behavior does not exclude asymptomatic anorectal sexually transmitted infection in HIV-infected men.
Cachay ER, Sitapati A, Caperna J, Freeborn K, Lonergan JT, Jocson E, Mathews WC; Owen Clinic Study Group
PLoS One 2009 Dec 30;4(12):e8504. doi: 10.1371/journal.pone.0008504. PMID: 20041143Free PMC Article

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