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Cerebellar neoplasm

MedGen UID:
40187
•Concept ID:
C0007762
•
Neoplastic Process
Synonyms: Cerebellar Neoplasm; Cerebellar Neoplasms; Cerebellar Tumor; Cerebellar Tumors; Neoplasm, Cerebellar; Neoplasms, Cerebellar; Tumor, Cerebellar
SNOMED CT: Neoplasm of cerebellum (126960003)
 
Monarch Initiative: MONDO:0002913

Definition

A benign or malignant (primary or metastatic) tumor involving the cerebellum. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCerebellar neoplasm

Professional guidelines

PubMed

Genotype-phenotype correlates in Joubert syndrome: A review.
Gana S, Serpieri V, Valente EM
Am J Med Genet C Semin Med Genet 2022 Mar;190(1):72-88. Epub 2022 Mar 3 doi: 10.1002/ajmg.c.31963. PMID: 35238134Free PMC Article
Molecular stratifications, biomarker candidates and new therapeutic options in current medulloblastoma treatment approaches.
Menyhárt O, Győrffy B
Cancer Metastasis Rev 2020 Mar;39(1):211-233. doi: 10.1007/s10555-020-09854-1. PMID: 31970590Free PMC Article
EANO-EURACAN clinical practice guideline for diagnosis, treatment, and follow-up of post-pubertal and adult patients with medulloblastoma.
Franceschi E, Hofer S, Brandes AA, Frappaz D, Kortmann RD, Bromberg J, Dangouloff-Ros V, Boddaert N, Hattingen E, Wiestler B, Clifford SC, Figarella-Branger D, Giangaspero F, Haberler C, Pietsch T, Pajtler KW, Pfister SM, Guzman R, Stummer W, Combs SE, Seidel C, Beier D, McCabe MG, Grotzer M, Laigle-Donadey F, Stücklin ASG, Idbaih A, Preusser M, van den Bent M, Weller M, Hau P
Lancet Oncol 2019 Dec;20(12):e715-e728. doi: 10.1016/S1470-2045(19)30669-2. PMID: 31797797

Recent clinical studies

Etiology

Findings on preoperative brain MRI predict histopathology in children with cerebellar neoplasms.
Forbes JA, Reig AS, Smith JG, Jermakowicz W, Tomycz L, Shay SD, Sun DA, Wushensky CA, Pearson MM
Pediatr Neurosurg 2011;47(1):51-9. Epub 2011 Aug 22 doi: 10.1159/000329627. PMID: 21921669Free PMC Article
Lhermitte-Duclos disease and Cowden's syndrome. Report of two cases.
Peltier J, Lok C, Fichten A, Bruniau A, Lefranc M, Toussaint P, Desenclos C, Le Gars D
Neurochirurgie 2006 Nov;52(5):407-14. doi: 10.1016/s0028-3770(06)71239-5. PMID: 17185946
Cerebellar primitive neuroectodermal tumor with multipotent differentiation in a family with von Hippel-Lindau disease. Case report.
Becker R, Bauer BL, Mennel HD, Plate KH
Clin Neuropathol 1993 Mar-Apr;12(2):107-11. PMID: 8386599

Diagnosis

Cerebellar liponeurocytoma in an elderly patient: DNA methylation profiling as a helpful diagnostic tool.
Alzoubi H, Gianno F, Abuelhaija Y, Najadat AA, Mustafa A, Al-Arman AY, Al-Arman LY, Banihani D, Mustafa A, Abualdahab N, Broggi G, Gaggero G, Piol N, Fiaschi P, Miele E, Giangaspero F
Clin Neuropathol 2022 Jan-Feb;41(1):12-17. doi: 10.5414/NP301415. PMID: 34672257
Metachronic Breast and Cerebellar Neoplasm in a Young Patient.
Nascimento JO, Haro LCA, Sá RDS, Storch RE
Rev Bras Ginecol Obstet 2020 Feb;42(2):114-119. Epub 2020 Mar 30 doi: 10.1055/s-0040-1701456. PMID: 32227327Free PMC Article
Non-granulomatous cerebellar infection by Acanthamoeba spp. in an immunocompetent host.
Modica S, Miracco C, Cusi MG, Tordini G, Muzii VF, Iacoangeli F, Nocentini C, Ali IKM, Roy S, Cerase A, Zanelli G, De Luca A, Montagnani F
Infection 2018 Dec;46(6):885-889. Epub 2018 Oct 4 doi: 10.1007/s15010-018-1231-4. PMID: 30288678
Apparent diffusion coefficients for differentiation of cerebellar tumors in children.
Rumboldt Z, Camacho DL, Lake D, Welsh CT, Castillo M
AJNR Am J Neuroradiol 2006 Jun-Jul;27(6):1362-9. PMID: 16775298Free PMC Article
Medullocytoma (lipidized medulloblastoma). A cerebellar neoplasm of adults with favorable prognosis.
Giangaspero F, Cenacchi G, Roncaroli F, Rigobello L, Manetto V, Gambacorta M, Allegranza A
Am J Surg Pathol 1996 Jun;20(6):656-64. doi: 10.1097/00000478-199606000-00002. PMID: 8651344

Therapy

Non-granulomatous cerebellar infection by Acanthamoeba spp. in an immunocompetent host.
Modica S, Miracco C, Cusi MG, Tordini G, Muzii VF, Iacoangeli F, Nocentini C, Ali IKM, Roy S, Cerase A, Zanelli G, De Luca A, Montagnani F
Infection 2018 Dec;46(6):885-889. Epub 2018 Oct 4 doi: 10.1007/s15010-018-1231-4. PMID: 30288678
Tumor devascularization by intratumoral ethanol injection during surgery. Technical note.
Lonser RR, Heiss JD, Oldfield EH
J Neurosurg 1998 May;88(5):923-4. doi: 10.3171/jns.1998.88.5.0923. PMID: 9576266

Prognosis

Non-granulomatous cerebellar infection by Acanthamoeba spp. in an immunocompetent host.
Modica S, Miracco C, Cusi MG, Tordini G, Muzii VF, Iacoangeli F, Nocentini C, Ali IKM, Roy S, Cerase A, Zanelli G, De Luca A, Montagnani F
Infection 2018 Dec;46(6):885-889. Epub 2018 Oct 4 doi: 10.1007/s15010-018-1231-4. PMID: 30288678
Findings on preoperative brain MRI predict histopathology in children with cerebellar neoplasms.
Forbes JA, Reig AS, Smith JG, Jermakowicz W, Tomycz L, Shay SD, Sun DA, Wushensky CA, Pearson MM
Pediatr Neurosurg 2011;47(1):51-9. Epub 2011 Aug 22 doi: 10.1159/000329627. PMID: 21921669Free PMC Article
Trilateral retinoblastoma variant indicative of the relevance of the retinoblastoma tumor-suppressor pathway to medulloblastomas in humans.
Elias WJ, Lopes MB, Golden WL, Jane JA Sr, Gonzalez-Fernandez F
J Neurosurg 2001 Nov;95(5):871-8. doi: 10.3171/jns.2001.95.5.0871. PMID: 11702879
Medullocytoma (lipidized medulloblastoma). A cerebellar neoplasm of adults with favorable prognosis.
Giangaspero F, Cenacchi G, Roncaroli F, Rigobello L, Manetto V, Gambacorta M, Allegranza A
Am J Surg Pathol 1996 Jun;20(6):656-64. doi: 10.1097/00000478-199606000-00002. PMID: 8651344
Cerebellar primitive neuroectodermal tumor with multipotent differentiation in a family with von Hippel-Lindau disease. Case report.
Becker R, Bauer BL, Mennel HD, Plate KH
Clin Neuropathol 1993 Mar-Apr;12(2):107-11. PMID: 8386599

Clinical prediction guides

Cerebellar liponeurocytoma in an elderly patient: DNA methylation profiling as a helpful diagnostic tool.
Alzoubi H, Gianno F, Abuelhaija Y, Najadat AA, Mustafa A, Al-Arman AY, Al-Arman LY, Banihani D, Mustafa A, Abualdahab N, Broggi G, Gaggero G, Piol N, Fiaschi P, Miele E, Giangaspero F
Clin Neuropathol 2022 Jan-Feb;41(1):12-17. doi: 10.5414/NP301415. PMID: 34672257
Findings on preoperative brain MRI predict histopathology in children with cerebellar neoplasms.
Forbes JA, Reig AS, Smith JG, Jermakowicz W, Tomycz L, Shay SD, Sun DA, Wushensky CA, Pearson MM
Pediatr Neurosurg 2011;47(1):51-9. Epub 2011 Aug 22 doi: 10.1159/000329627. PMID: 21921669Free PMC Article
Apparent diffusion coefficients for differentiation of cerebellar tumors in children.
Rumboldt Z, Camacho DL, Lake D, Welsh CT, Castillo M
AJNR Am J Neuroradiol 2006 Jun-Jul;27(6):1362-9. PMID: 16775298Free PMC Article
Medullocytoma (lipidized medulloblastoma). A cerebellar neoplasm of adults with favorable prognosis.
Giangaspero F, Cenacchi G, Roncaroli F, Rigobello L, Manetto V, Gambacorta M, Allegranza A
Am J Surg Pathol 1996 Jun;20(6):656-64. doi: 10.1097/00000478-199606000-00002. PMID: 8651344

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