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Synovial chondromatosis

MedGen UID:
40275
•Concept ID:
C0008476
•
Neoplastic Process
Synonyms: Chondromatoses, Synovial; Chondromatosis, Synovial; Chondrometaplasia, Synovial; Chondrometaplasias, Synovial; Henderson Jones Syndrome; Henderson-Jones Syndrome; Reichel Syndrome; Reichel's Syndrome; Reichels Syndrome; Syndrome, Henderson-Jones; Syndrome, Reichel's; Synovial Chondromatoses; Synovial Chondromatosis; Synovial Chondrometaplasia; Synovial Chondrometaplasias
SNOMED CT: Synovial chondromatosis (240207006)
 
Monarch Initiative: MONDO:0006438

Definition

An uncommon, benign cartilaginous neoplasm usually occurring in adults. The nodular tumor arises from the synovial membranes of joints. It is characterized by the presence of chondrocytes, nuclear pleomorphism, and hyaline cartilage differentiation. Clinical presentation may include joint pain, swelling, and limited range of motion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSynovial chondromatosis

Professional guidelines

PubMed

Assessment and Management of Loose Bodies in the Knee Joint and Related Disease: A Narrative Review.
Zmerly H, Moscato M, Akkawi I
Curr Rheumatol Rev 2022;18(1):12-19. doi: 10.2174/1573397117666211021165807. PMID: 34674623
Arthroscopic management of elbow synovial chondromatosis.
Zhu W, Wang W, Mao X, Chen Y
Medicine (Baltimore) 2018 Oct;97(40):e12402. doi: 10.1097/MD.0000000000012402. PMID: 30290596Free PMC Article
Arthroscopic management of primary synovial chondromatosis of the hip.
Zini R, Longo UG, de Benedetto M, Loppini M, Carraro A, Maffulli N, Denaro V
Arthroscopy 2013 Mar;29(3):420-6. Epub 2013 Jan 20 doi: 10.1016/j.arthro.2012.10.014. PMID: 23343712

Recent clinical studies

Etiology

Intra-Articular Tumors.
Sbaraglia M, Gambarotti M, Businello G, Righi A, Fassan M, Dei Tos AP
Surg Pathol Clin 2021 Dec;14(4):665-677. Epub 2021 Oct 7 doi: 10.1016/j.path.2021.06.008. PMID: 34742486
Efficacy of image-guided synovial biopsy.
McKee TC, Belair JA, Sobol K, Brown SA, Abraham J, Morrison W
Skeletal Radiol 2020 Jun;49(6):921-928. Epub 2020 Jan 7 doi: 10.1007/s00256-019-03370-2. PMID: 31912178
Synovial chondromatosis of the upper extremity.
Ho YY, Choueka J
J Hand Surg Am 2013 Apr;38(4):804-10. Epub 2013 Mar 6 doi: 10.1016/j.jhsa.2013.01.041. PMID: 23474166
Synovial neoformations and tumours.
Szendrói M, Deodhar A
Baillieres Best Pract Res Clin Rheumatol 2000 Jun;14(2):363-83. doi: 10.1053/berh.1999.0070. PMID: 10925750
Extraskeletal chondromas.
Marcial-Seoane RA, Marcial-Seoane MA, Ramos E, Marcial-Rojas RA
Bol Asoc Med P R 1990 Sep;82(9):394-402. PMID: 2076144

Diagnosis

Soft Tissue Pathology.
Shane AM, Reeves CL, Nguyen GB, Ferrise TD, Calaj PM
Clin Podiatr Med Surg 2023 Jul;40(3):381-395. Epub 2023 Apr 28 doi: 10.1016/j.cpm.2023.02.003. PMID: 37236677
Synovial Chondromatosis.
Neumann JA, Garrigues GE, Brigman BE, Eward WC
JBJS Rev 2016 May 10;4(5) doi: 10.2106/JBJS.RVW.O.00054. PMID: 27490219
Temporomandibular Joint Disorders and Orofacial Pain.
Ahmad M, Schiffman EL
Dent Clin North Am 2016 Jan;60(1):105-24. Epub 2015 Oct 21 doi: 10.1016/j.cden.2015.08.004. PMID: 26614951Free PMC Article
Benign synovial disorders.
Adelani MA, Wupperman RM, Holt GE
J Am Acad Orthop Surg 2008 May;16(5):268-75. doi: 10.5435/00124635-200805000-00005. PMID: 18460687
Synovial chondromatosis.
Christensen JH, Poulsen JO
Acta Orthop Scand 1975 Dec;46(6):919-25. doi: 10.3109/17453677508989279. PMID: 1211128

Therapy

Potential utility of anti-TNF drugs in synovial chondromatosis associated with ankylosing spondylitis.
Yu S, Wu M, Zhou G, Ishikawa T, Liang J, Nallapothula D, Singh RR, Wang Q, Wang M
Int J Rheum Dis 2019 Nov;22(11):2073-2079. Epub 2019 Oct 24 doi: 10.1111/1756-185X.13734. PMID: 31647182
Synovial osteochondromatosis.
Langguth DM, Klestov A, Denaro C
Intern Med J 2002 Aug;32(8):419-20. doi: 10.1046/j.1445-5994.2002.00260.x. PMID: 12162400
Pathology of the synovium.
O'Connell JX
Am J Clin Pathol 2000 Nov;114(5):773-84. doi: 10.1309/LWW3-5XK0-FKG9-HDRK. PMID: 11068553
Operative hip arthroscopy.
Kim SJ, Choi NH, Kim HJ
Clin Orthop Relat Res 1998 Aug;(353):156-65. doi: 10.1097/00003086-199808000-00018. PMID: 9728170
Craniomandibular disorders in the geriatric patient.
Iacopino AM, Wathen WF
J Orofac Pain 1993 Winter;7(1):38-53. PMID: 8467296

Prognosis

Temporomandibular joint synovial chondromatosis: An analysis of 7 cases and literature review.
Song Z, Yuan S, Liu J, Bakker AD, Klein-Nulend J, Pathak JL, Zhang Q
Sci Prog 2022 Jul-Sep;105(3):368504221115232. doi: 10.1177/00368504221115232. PMID: 35850569Free PMC Article
A systematic literature review of synovial chondromatosis and pigmented villonodular synovitis of the hip.
Startzman A, Collins D, Carreira D
Phys Sportsmed 2016 Nov;44(4):425-431. Epub 2016 Aug 2 doi: 10.1080/00913847.2016.1216238. PMID: 27462929
Chondro-Osseous Lesions of Soft Tissue.
Cho SJ, Horvai A
Surg Pathol Clin 2015 Sep;8(3):419-44. doi: 10.1016/j.path.2015.05.004. PMID: 26297064
Synovial chondromatosis of the upper extremity.
Ho YY, Choueka J
J Hand Surg Am 2013 Apr;38(4):804-10. Epub 2013 Mar 6 doi: 10.1016/j.jhsa.2013.01.041. PMID: 23474166
Extra-articular synovial chondromatosis.
Sim FH, Dahlin DC, Ivins JC
J Bone Joint Surg Am 1977 Jun;59(4):492-5. PMID: 863944

Clinical prediction guides

Clinical Outcomes after Arthroscopic Treatment of Synovial Chondromatosis in the Hip.
Zhang X, Gao G, Wang J, Xu Y
Cartilage 2021 Dec;13(1_suppl):1324S-1330S. Epub 2020 Mar 20 doi: 10.1177/1947603520912316. PMID: 32192367Free PMC Article
Clinical Results of Surgical Resection and Histopathological Evaluation of Synovial Chondromatosis in the Shoulder: A Retrospective Study and Literature Review.
Utashima D, Matsumura N, Suzuki T, Iwamoto T, Ogawa K
Clin Orthop Surg 2020 Mar;12(1):68-75. Epub 2020 Feb 13 doi: 10.4055/cios.2020.12.1.68. PMID: 32117541Free PMC Article
Synovial chondromatosis and soft tissue chondroma: extraosseous cartilaginous tumor defined by FN1 gene rearrangement.
Amary F, Perez-Casanova L, Ye H, Cottone L, Strobl AC, Cool P, Miranda E, Berisha F, Aston W, Rocha M, O'Donnell P, Pillay N, Tirabosco R, Baumhoer D, Hookway ES, Flanagan AM
Mod Pathol 2019 Dec;32(12):1762-1771. Epub 2019 Jul 4 doi: 10.1038/s41379-019-0315-8. PMID: 31273315Free PMC Article
Pseudotumors and tumors of the temporomandibular joint. A review.
Poveda-Roda R, Bagán JV, Sanchis JM, Margaix M
Med Oral Patol Oral Cir Bucal 2013 May 1;18(3):e392-402. doi: 10.4317/medoral.18799. PMID: 23385515Free PMC Article
Metachondromatosis.
Hunter AG, Kozlowski K, Hochberger O
Can Assoc Radiol J 1995 Jun;46(3):202-8. PMID: 7538882

Recent systematic reviews

Arthroscopic Management of Synovial Chondromatosis of the Ankle Joint: A Systematic Review of the Literature.
Al Farii H, Doyle-Kelly C, Marwan Y, Volesky M, Turcotte R
JBJS Rev 2020 Sep;8(9):e2000045. doi: 10.2106/JBJS.RVW.20.00045. PMID: 33151646
A systematic literature review of synovial chondromatosis and pigmented villonodular synovitis of the hip.
Startzman A, Collins D, Carreira D
Phys Sportsmed 2016 Nov;44(4):425-431. Epub 2016 Aug 2 doi: 10.1080/00913847.2016.1216238. PMID: 27462929
Humeral Head Reconstruction With Osteochondral Allograft Transplantation.
Saltzman BM, Riboh JC, Cole BJ, Yanke AB
Arthroscopy 2015 Sep;31(9):1827-34. Epub 2015 May 13 doi: 10.1016/j.arthro.2015.03.021. PMID: 25979686
Arthroscopic surgery for synovial chondromatosis of the hip: a systematic review of rates and predisposing factors for recurrence.
de Sa D, Horner NS, MacDonald A, Simunovic N, Ghert MA, Philippon MJ, Ayeni OR
Arthroscopy 2014 Nov;30(11):1499-1504.e2. Epub 2014 Jul 23 doi: 10.1016/j.arthro.2014.05.033. PMID: 25064754
Synovial chondromatosis of the temporomandibular joint: a case description with systematic literature review.
Guarda-Nardini L, Piccotti F, Ferronato G, Manfredini D
Int J Oral Maxillofac Surg 2010 Aug;39(8):745-55. doi: 10.1016/j.ijom.2010.03.028. PMID: 20434884

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