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Airway Remodeling

MedGen UID:
404634
•Concept ID:
C2717792
•
Pathologic Function
Synonyms: Airway Remodelings; Airway Remodelling; Airway Remodellings; Airway Wall Remodelling; Airway Wall Remodellings; Remodeling, Airway; Remodelings, Airway; Remodelling, Airway; Remodelling, Airway Wall; Remodellings, Airway; Remodellings, Airway Wall; Wall Remodelling, Airway; Wall Remodellings, Airway

Definition

The structural changes in the number, mass, size and/or composition of the airway tissues. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAirway Remodeling

Professional guidelines

PubMed

T-helper cells and their cytokines in pathogenesis and treatment of asthma.
Ji T, Li H
Front Immunol 2023;14:1149203. Epub 2023 Jun 12 doi: 10.3389/fimmu.2023.1149203. PMID: 37377958Free PMC Article
Diagnosis and Management of T2-High Asthma.
Coverstone AM, Seibold MA, Peters MC
J Allergy Clin Immunol Pract 2020 Feb;8(2):442-450. doi: 10.1016/j.jaip.2019.11.020. PMID: 32037108
An expert consensus framework for asthma remission as a treatment goal.
Menzies-Gow A, Bafadhel M, Busse WW, Casale TB, Kocks JWH, Pavord ID, Szefler SJ, Woodruff PG, de Giorgio-Miller A, Trudo F, Fageras M, Ambrose CS
J Allergy Clin Immunol 2020 Mar;145(3):757-765. Epub 2019 Dec 19 doi: 10.1016/j.jaci.2019.12.006. PMID: 31866436

Recent clinical studies

Etiology

Genetics and Epigenetics in Asthma.
Ntontsi P, Photiades A, Zervas E, Xanthou G, Samitas K
Int J Mol Sci 2021 Feb 27;22(5) doi: 10.3390/ijms22052412. PMID: 33673725Free PMC Article
Japanese guidelines for adult asthma 2020.
Nakamura Y, Tamaoki J, Nagase H, Yamaguchi M, Horiguchi T, Hozawa S, Ichinose M, Iwanaga T, Kondo R, Nagata M, Yokoyama A, Tohda Y; Japanese Society of Allergology
Allergol Int 2020 Oct;69(4):519-548. Epub 2020 Sep 4 doi: 10.1016/j.alit.2020.08.001. PMID: 32893125
Mucins, Mucus, and Goblet Cells.
Ma J, Rubin BK, Voynow JA
Chest 2018 Jul;154(1):169-176. Epub 2017 Nov 21 doi: 10.1016/j.chest.2017.11.008. PMID: 29170036
Novel aspects of pathogenesis and regeneration mechanisms in COPD.
Bagdonas E, Raudoniute J, Bruzauskaite I, Aldonyte R
Int J Chron Obstruct Pulmon Dis 2015;10:995-1013. Epub 2015 Jun 2 doi: 10.2147/COPD.S82518. PMID: 26082624Free PMC Article
The allergic asthma phenotype.
Schatz M, Rosenwasser L
J Allergy Clin Immunol Pract 2014 Nov-Dec;2(6):645-8; quiz 649. Epub 2014 Nov 6 doi: 10.1016/j.jaip.2014.09.004. PMID: 25439351

Diagnosis

Japanese guidelines for adult asthma 2020.
Nakamura Y, Tamaoki J, Nagase H, Yamaguchi M, Horiguchi T, Hozawa S, Ichinose M, Iwanaga T, Kondo R, Nagata M, Yokoyama A, Tohda Y; Japanese Society of Allergology
Allergol Int 2020 Oct;69(4):519-548. Epub 2020 Sep 4 doi: 10.1016/j.alit.2020.08.001. PMID: 32893125
Pathophysiology of severe asthma: We've only just started.
King GG, James A, Harkness L, Wark PAB
Respirology 2018 Mar;23(3):262-271. Epub 2018 Jan 9 doi: 10.1111/resp.13251. PMID: 29316003
Pathogenesis of rhinitis.
Eifan AO, Durham SR
Clin Exp Allergy 2016 Sep;46(9):1139-51. doi: 10.1111/cea.12780. PMID: 27434218
The allergic asthma phenotype.
Schatz M, Rosenwasser L
J Allergy Clin Immunol Pract 2014 Nov-Dec;2(6):645-8; quiz 649. Epub 2014 Nov 6 doi: 10.1016/j.jaip.2014.09.004. PMID: 25439351
Chronic obstructive pulmonary disease.
Decramer M, Janssens W, Miravitlles M
Lancet 2012 Apr 7;379(9823):1341-51. Epub 2012 Feb 6 doi: 10.1016/S0140-6736(11)60968-9. PMID: 22314182Free PMC Article

Therapy

Biologics and airway remodeling in severe asthma.
Varricchi G, Ferri S, Pepys J, Poto R, Spadaro G, Nappi E, Paoletti G, Virchow JC, Heffler E, Canonica WG
Allergy 2022 Dec;77(12):3538-3552. Epub 2022 Aug 23 doi: 10.1111/all.15473. PMID: 35950646Free PMC Article
Necroptosis Signaling Promotes Inflammation, Airway Remodeling, and Emphysema in Chronic Obstructive Pulmonary Disease.
Lu Z, Van Eeckhoutte HP, Liu G, Nair PM, Jones B, Gillis CM, Nalkurthi BC, Verhamme F, Buyle-Huybrecht T, Vandenabeele P, Vanden Berghe T, Brusselle GG, Horvat JC, Murphy JM, Wark PA, Bracke KR, Fricker M, Hansbro PM
Am J Respir Crit Care Med 2021 Sep 15;204(6):667-681. doi: 10.1164/rccm.202009-3442OC. PMID: 34133911
An expert consensus framework for asthma remission as a treatment goal.
Menzies-Gow A, Bafadhel M, Busse WW, Casale TB, Kocks JWH, Pavord ID, Szefler SJ, Woodruff PG, de Giorgio-Miller A, Trudo F, Fageras M, Ambrose CS
J Allergy Clin Immunol 2020 Mar;145(3):757-765. Epub 2019 Dec 19 doi: 10.1016/j.jaci.2019.12.006. PMID: 31866436
Non-genomic Effects of Glucocorticoids: An Updated View.
Panettieri RA, Schaafsma D, Amrani Y, Koziol-White C, Ostrom R, Tliba O
Trends Pharmacol Sci 2019 Jan;40(1):38-49. Epub 2018 Nov 26 doi: 10.1016/j.tips.2018.11.002. PMID: 30497693Free PMC Article
Chronic obstructive pulmonary disease.
Decramer M, Janssens W, Miravitlles M
Lancet 2012 Apr 7;379(9823):1341-51. Epub 2012 Feb 6 doi: 10.1016/S0140-6736(11)60968-9. PMID: 22314182Free PMC Article

Prognosis

Genetics and Epigenetics in Asthma.
Ntontsi P, Photiades A, Zervas E, Xanthou G, Samitas K
Int J Mol Sci 2021 Feb 27;22(5) doi: 10.3390/ijms22052412. PMID: 33673725Free PMC Article
Tuberculosis and lung damage: from epidemiology to pathophysiology.
Ravimohan S, Kornfeld H, Weissman D, Bisson GP
Eur Respir Rev 2018 Mar 31;27(147) Epub 2018 Feb 28 doi: 10.1183/16000617.0077-2017. PMID: 29491034Free PMC Article
Novel aspects of pathogenesis and regeneration mechanisms in COPD.
Bagdonas E, Raudoniute J, Bruzauskaite I, Aldonyte R
Int J Chron Obstruct Pulmon Dis 2015;10:995-1013. Epub 2015 Jun 2 doi: 10.2147/COPD.S82518. PMID: 26082624Free PMC Article
The allergic asthma phenotype.
Schatz M, Rosenwasser L
J Allergy Clin Immunol Pract 2014 Nov-Dec;2(6):645-8; quiz 649. Epub 2014 Nov 6 doi: 10.1016/j.jaip.2014.09.004. PMID: 25439351
Chronic obstructive pulmonary disease.
Decramer M, Janssens W, Miravitlles M
Lancet 2012 Apr 7;379(9823):1341-51. Epub 2012 Feb 6 doi: 10.1016/S0140-6736(11)60968-9. PMID: 22314182Free PMC Article

Clinical prediction guides

Airway smooth muscle pathophysiology in asthma.
Camoretti-Mercado B, Lockey RF
J Allergy Clin Immunol 2021 Jun;147(6):1983-1995. doi: 10.1016/j.jaci.2021.03.035. PMID: 34092351
Genetics and Epigenetics in Asthma.
Ntontsi P, Photiades A, Zervas E, Xanthou G, Samitas K
Int J Mol Sci 2021 Feb 27;22(5) doi: 10.3390/ijms22052412. PMID: 33673725Free PMC Article
Bidirectional interaction of airway epithelial remodeling and inflammation in asthma.
Banno A, Reddy AT, Lakshmi SP, Reddy RC
Clin Sci (Lond) 2020 May 15;134(9):1063-1079. doi: 10.1042/CS20191309. PMID: 32369100
Mucins, Mucus, and Goblet Cells.
Ma J, Rubin BK, Voynow JA
Chest 2018 Jul;154(1):169-176. Epub 2017 Nov 21 doi: 10.1016/j.chest.2017.11.008. PMID: 29170036
The allergic asthma phenotype.
Schatz M, Rosenwasser L
J Allergy Clin Immunol Pract 2014 Nov-Dec;2(6):645-8; quiz 649. Epub 2014 Nov 6 doi: 10.1016/j.jaip.2014.09.004. PMID: 25439351

Recent systematic reviews

The Role of Vitamin D Supplementation on Airway Remodeling in Asthma: A Systematic Review.
Salameh L, Mahmood W, Hamoudi R, Almazrouei K, Lochanan M, Seyhoglu S, Mahboub B
Nutrients 2023 May 26;15(11) doi: 10.3390/nu15112477. PMID: 37299440Free PMC Article
Long-term airway evolution after orthognathic surgery: Systematic Review.
Daluz ADJ, da Silva TVS, Tôrres BO, Costa DFN, Santos LAM
J Stomatol Oral Maxillofac Surg 2022 Apr;123(2):191-198. Epub 2021 Apr 18 doi: 10.1016/j.jormas.2021.04.006. PMID: 33882343
Exposure to Heated Tobacco Products and Adverse Health Effects, a Systematic Review.
Znyk M, Jurewicz J, Kaleta D
Int J Environ Res Public Health 2021 Jun 21;18(12) doi: 10.3390/ijerph18126651. PMID: 34205612Free PMC Article
Pharmacological mechanism of roflumilast in the treatment of asthma-COPD overlap.
Zhang X, Chen Y, Fan L, Ye J, Fan J, Xu X, You D, Liu S, Chen X, Luo P
Drug Des Devel Ther 2018;12:2371-2379. Epub 2018 Aug 1 doi: 10.2147/DDDT.S165161. PMID: 30122895Free PMC Article
The relationship between inflammation and remodeling in childhood asthma: A systematic review.
Castro-Rodriguez JA, Saglani S, Rodriguez-Martinez CE, Oyarzun MA, Fleming L, Bush A
Pediatr Pulmonol 2018 Jun;53(6):824-835. Epub 2018 Feb 22 doi: 10.1002/ppul.23968. PMID: 29469196

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