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Malignant Ovarian Steroid Cell Tumor

MedGen UID:
412169
•Concept ID:
C2212011
•
Neoplastic Process

Definition

A steroid tumor of the ovary which has an aggressive clinical course and metastasizes to other anatomic sites. It is usually of large size and is characterized by nuclear atypia, increased mitotic activity, hemorrhage, and necrosis. Sometimes, patients have abdominal metastases at presentation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Ovarian Steroid Cell Tumor

Professional guidelines

PubMed

Menopause hormone treatment after cancer.
Gompel A
Climacteric 2023 Jun;26(3):240-247. Epub 2023 Apr 3 doi: 10.1080/13697137.2023.2176216. PMID: 37011657
Clinical Case Seminar: Postmenopausal androgen excess-challenges in diagnostic work-up and management of ovarian thecosis.
Mamoojee Y, Ganguri M, Taylor N, Quinton R
Clin Endocrinol (Oxf) 2018 Jan;88(1):13-20. Epub 2017 Nov 7 doi: 10.1111/cen.13492. PMID: 28980338
The physiology and clinical utility of anti-Mullerian hormone in women.
Dewailly D, Andersen CY, Balen A, Broekmans F, Dilaver N, Fanchin R, Griesinger G, Kelsey TW, La Marca A, Lambalk C, Mason H, Nelson SM, Visser JA, Wallace WH, Anderson RA
Hum Reprod Update 2014 May-Jun;20(3):370-85. Epub 2014 Jan 14 doi: 10.1093/humupd/dmt062. PMID: 24430863

Recent clinical studies

Etiology

Polycystic ovarian syndrome: Correlation between hyperandrogenism, insulin resistance and obesity.
Zeng X, Xie YJ, Liu YT, Long SL, Mo ZC
Clin Chim Acta 2020 Mar;502:214-221. Epub 2019 Nov 13 doi: 10.1016/j.cca.2019.11.003. PMID: 31733195
Hormone Replacement Therapy in Cancer Survivors - Review of the Literature.
Deli T, Orosz M, Jakab A
Pathol Oncol Res 2020 Jan;26(1):63-78. Epub 2019 Jan 8 doi: 10.1007/s12253-018-00569-x. PMID: 30617760Free PMC Article
Gut microbiota-bile acid-interleukin-22 axis orchestrates polycystic ovary syndrome.
Qi X, Yun C, Sun L, Xia J, Wu Q, Wang Y, Wang L, Zhang Y, Liang X, Wang L, Gonzalez FJ, Patterson AD, Liu H, Mu L, Zhou Z, Zhao Y, Li R, Liu P, Zhong C, Pang Y, Jiang C, Qiao J
Nat Med 2019 Aug;25(8):1225-1233. Epub 2019 Jul 22 doi: 10.1038/s41591-019-0509-0. PMID: 31332392Free PMC Article
Vitamin D: And its role in breast cancer.
de La Puente-Yagüe M, Cuadrado-Cenzual MA, Ciudad-Cabañas MJ, Hernández-Cabria M, Collado-Yurrita L
Kaohsiung J Med Sci 2018 Aug;34(8):423-427. Epub 2018 Apr 5 doi: 10.1016/j.kjms.2018.03.004. PMID: 30041759
Ovarian sex cord-stromal tumours and their mimics.
Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723

Diagnosis

Single-Cell RNA-Seq Identifies Pathways and Genes Contributing to the Hyperandrogenemia Associated with Polycystic Ovary Syndrome.
Harris RA, McAllister JM, Strauss JF 3rd
Int J Mol Sci 2023 Jun 25;24(13) doi: 10.3390/ijms241310611. PMID: 37445796Free PMC Article
Polycystic ovarian syndrome: Correlation between hyperandrogenism, insulin resistance and obesity.
Zeng X, Xie YJ, Liu YT, Long SL, Mo ZC
Clin Chim Acta 2020 Mar;502:214-221. Epub 2019 Nov 13 doi: 10.1016/j.cca.2019.11.003. PMID: 31733195
Androgen-Secreting Ovarian Tumors.
Macut D, Ilić D, Mitrović Jovanović A, Bjekić-Macut J
Front Horm Res 2019;53:100-107. Epub 2019 Sep 9 doi: 10.1159/000494906. PMID: 31499493
Ovarian sex cord-stromal tumours and their mimics.
Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723
Role of vitamin D in ovarian physiology and its implication in reproduction: a systematic review.
Irani M, Merhi Z
Fertil Steril 2014 Aug;102(2):460-468.e3. Epub 2014 Jun 3 doi: 10.1016/j.fertnstert.2014.04.046. PMID: 24933120

Therapy

Serum 25-Hydroxyvitamin D and Cancer Risk: A Systematic Review of Mendelian Randomization Studies.
Lawler T, Warren Andersen S
Nutrients 2023 Jan 13;15(2) doi: 10.3390/nu15020422. PMID: 36678292Free PMC Article
Targeting ARID1A mutations in cancer.
Mullen J, Kato S, Sicklick JK, Kurzrock R
Cancer Treat Rev 2021 Nov;100:102287. Epub 2021 Sep 6 doi: 10.1016/j.ctrv.2021.102287. PMID: 34619527
Polycystic ovarian syndrome: Correlation between hyperandrogenism, insulin resistance and obesity.
Zeng X, Xie YJ, Liu YT, Long SL, Mo ZC
Clin Chim Acta 2020 Mar;502:214-221. Epub 2019 Nov 13 doi: 10.1016/j.cca.2019.11.003. PMID: 31733195
Hormone Replacement Therapy in Cancer Survivors - Review of the Literature.
Deli T, Orosz M, Jakab A
Pathol Oncol Res 2020 Jan;26(1):63-78. Epub 2019 Jan 8 doi: 10.1007/s12253-018-00569-x. PMID: 30617760Free PMC Article
Role of vitamin D in ovarian physiology and its implication in reproduction: a systematic review.
Irani M, Merhi Z
Fertil Steril 2014 Aug;102(2):460-468.e3. Epub 2014 Jun 3 doi: 10.1016/j.fertnstert.2014.04.046. PMID: 24933120

Prognosis

Serum 25-Hydroxyvitamin D and Cancer Risk: A Systematic Review of Mendelian Randomization Studies.
Lawler T, Warren Andersen S
Nutrients 2023 Jan 13;15(2) doi: 10.3390/nu15020422. PMID: 36678292Free PMC Article
Qi Gong Wan ameliorates adipocyte hypertrophy and inflammation in adipose tissue in a PCOS mouse model through the Nrf2/HO-1/Cyp1b1 pathway: Integrating network pharmacology and experimental validation in vivo.
Zheng R, Shen H, Li J, Zhao J, Lu L, Hu M, Lin Z, Ma H, Tan H, Hu M, Li J
J Ethnopharmacol 2023 Jan 30;301:115824. Epub 2022 Oct 20 doi: 10.1016/j.jep.2022.115824. PMID: 36273747
Glial fibrillary acidic protein immunoglobulin G as biomarker of autoimmune astrocytopathy: Analysis of 102 patients.
Flanagan EP, Hinson SR, Lennon VA, Fang B, Aksamit AJ, Morris PP, Basal E, Honorat JA, Alfugham NB, Linnoila JJ, Weinshenker BG, Pittock SJ, McKeon A
Ann Neurol 2017 Feb;81(2):298-309. doi: 10.1002/ana.24881. PMID: 28120349
Swyer syndrome.
King TF, Conway GS
Curr Opin Endocrinol Diabetes Obes 2014 Dec;21(6):504-10. doi: 10.1097/MED.0000000000000113. PMID: 25314337
The physiology and clinical utility of anti-Mullerian hormone in women.
Dewailly D, Andersen CY, Balen A, Broekmans F, Dilaver N, Fanchin R, Griesinger G, Kelsey TW, La Marca A, Lambalk C, Mason H, Nelson SM, Visser JA, Wallace WH, Anderson RA
Hum Reprod Update 2014 May-Jun;20(3):370-85. Epub 2014 Jan 14 doi: 10.1093/humupd/dmt062. PMID: 24430863

Clinical prediction guides

Vitamins in Gynecologic Malignancies.
Wierzbowska N, Olszowski T, Chlubek D, Kozłowski M, Cymbaluk-Płoska A
Nutrients 2024 May 5;16(9) doi: 10.3390/nu16091392. PMID: 38732639Free PMC Article
Clinicopathologic Analysis and Molecular Profiling of Ovarian Steroid Cell Tumors.
Mendoza RP, Wang P, Smith HL, Fitzpatrick CA, Haridas R, Wanjari P, Briese R, Shahid A, McCluggage WG, Bennett JA
Am J Surg Pathol 2023 Dec 1;47(12):1398-1408. Epub 2023 Oct 5 doi: 10.1097/PAS.0000000000002124. PMID: 37796179
Serum 25-Hydroxyvitamin D and Cancer Risk: A Systematic Review of Mendelian Randomization Studies.
Lawler T, Warren Andersen S
Nutrients 2023 Jan 13;15(2) doi: 10.3390/nu15020422. PMID: 36678292Free PMC Article
Qi Gong Wan ameliorates adipocyte hypertrophy and inflammation in adipose tissue in a PCOS mouse model through the Nrf2/HO-1/Cyp1b1 pathway: Integrating network pharmacology and experimental validation in vivo.
Zheng R, Shen H, Li J, Zhao J, Lu L, Hu M, Lin Z, Ma H, Tan H, Hu M, Li J
J Ethnopharmacol 2023 Jan 30;301:115824. Epub 2022 Oct 20 doi: 10.1016/j.jep.2022.115824. PMID: 36273747
The physiology and clinical utility of anti-Mullerian hormone in women.
Dewailly D, Andersen CY, Balen A, Broekmans F, Dilaver N, Fanchin R, Griesinger G, Kelsey TW, La Marca A, Lambalk C, Mason H, Nelson SM, Visser JA, Wallace WH, Anderson RA
Hum Reprod Update 2014 May-Jun;20(3):370-85. Epub 2014 Jan 14 doi: 10.1093/humupd/dmt062. PMID: 24430863

Recent systematic reviews

Serum 25-Hydroxyvitamin D and Cancer Risk: A Systematic Review of Mendelian Randomization Studies.
Lawler T, Warren Andersen S
Nutrients 2023 Jan 13;15(2) doi: 10.3390/nu15020422. PMID: 36678292Free PMC Article
Antitumor effects of oleandrin in different types of cancers: Systematic review.
Francischini CRD, Mendonça CR, Barcelos KA, Silva MAM, Botelho AFM
Toxicon 2022 Sep;216:15-27. Epub 2022 Jun 27 doi: 10.1016/j.toxicon.2022.06.010. PMID: 35772506
Relationship between Advanced Glycation End Products and Steroidogenesis in PCOS.
Garg D, Merhi Z
Reprod Biol Endocrinol 2016 Oct 21;14(1):71. doi: 10.1186/s12958-016-0205-6. PMID: 27769286Free PMC Article
Role of vitamin D in ovarian physiology and its implication in reproduction: a systematic review.
Irani M, Merhi Z
Fertil Steril 2014 Aug;102(2):460-468.e3. Epub 2014 Jun 3 doi: 10.1016/j.fertnstert.2014.04.046. PMID: 24933120
The physiology and clinical utility of anti-Mullerian hormone in women.
Dewailly D, Andersen CY, Balen A, Broekmans F, Dilaver N, Fanchin R, Griesinger G, Kelsey TW, La Marca A, Lambalk C, Mason H, Nelson SM, Visser JA, Wallace WH, Anderson RA
Hum Reprod Update 2014 May-Jun;20(3):370-85. Epub 2014 Jan 14 doi: 10.1093/humupd/dmt062. PMID: 24430863

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