U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Infection of bone

MedGen UID:
412197
•Concept ID:
C2242472
•
Disease or Syndrome
Synonyms: Bone infection; Bone Infection
SNOMED CT: Infection of bone (111253001); Bone infection (111253001)

Definition

An acute or chronic infectious process affecting the bones. [from NCI]

Professional guidelines

PubMed

Hydrogel-Based Strategies for the Management of Osteomyelitis.
Kuo CY, Lin TY, Yeh YC
ACS Biomater Sci Eng 2023 Apr 10;9(4):1843-1861. Epub 2023 Mar 30 doi: 10.1021/acsbiomaterials.2c01057. PMID: 36995966
Implantable drug delivery systems for the treatment of osteomyelitis.
Smith M, Roberts M, Al-Kassas R
Drug Dev Ind Pharm 2022 Oct;48(10):511-527. Epub 2022 Oct 24 doi: 10.1080/03639045.2022.2135729. PMID: 36222433
Progress in diagnosis and treatment of post-traumatic osteomyelitis.
Tang B, Zhu W
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2021 Nov 28;46(11):1290-1297. doi: 10.11817/j.issn.1672-7347.2021.200621. PMID: 34911865Free PMC Article

Recent clinical studies

Etiology

A comprehensive review of bacterial osteomyelitis with emphasis on Staphylococcus aureus.
Nasser A, Azimi T, Ostadmohammadi S, Ostadmohammadi S
Microb Pathog 2020 Nov;148:104431. Epub 2020 Aug 12 doi: 10.1016/j.micpath.2020.104431. PMID: 32801004
Interactions of staphylococci with osteoblasts and phagocytes in the pathogenesis of implant-associated osteomyelitis.
Arciola CR, Hänsch GM, Visai L, Testoni F, Maurer S, Campoccia D, Selan L, Montanaro L
Int J Artif Organs 2012 Oct;35(10):713-26. doi: 10.5301/ijao.5000158. PMID: 23080215
Helicobacter pylori and gastric cancer.
Pritchard DM, Crabtree JE
Curr Opin Gastroenterol 2006 Nov;22(6):620-5. doi: 10.1097/01.mog.0000245539.50765.f6. PMID: 17053439
Hematopoietic stem cell deficiency resulting from cytomegalovirus infection of bone marrow stroma.
Reddehase MJ, Dreher-Stumpp L, Angele P, Balthesen M, Susa M
Ann Hematol 1992 Jun;64 Suppl:A125-7. doi: 10.1007/BF01715364. PMID: 1322181
Risk factors for osteomyelitis.
Wald ER
Am J Med 1985 Jun 28;78(6B):206-12. doi: 10.1016/0002-9343(85)90386-9. PMID: 3893117

Diagnosis

Microstructural analysis of bony alterations in a historic case of actinomycosis.
Schamall D, Nebot Valenzuela E, Pietschmann P, Tangl S, Edelmayer M, Dobsak T, Teschler-Nicola M
Int J Paleopathol 2020 Sep;30:1-9. Epub 2020 Feb 25 doi: 10.1016/j.ijpp.2019.12.009. PMID: 32109842
Nuclear medicine imaging of bone infections.
Prandini N, Lazzeri E, Rossi B, Erba P, Parisella MG, Signore A
Nucl Med Commun 2006 Aug;27(8):633-44. doi: 10.1097/00006231-200608000-00006. PMID: 16829764
The Mycobacterium avium complex.
Inderlied CB, Kemper CA, Bermudez LE
Clin Microbiol Rev 1993 Jul;6(3):266-310. doi: 10.1128/CMR.6.3.266. PMID: 8358707Free PMC Article
Subacute osteomyelitis.
Hayes CS, Heinrich SD, Craver R, MacEwen GD
Orthopedics 1990 Mar;13(3):363-6. doi: 10.3928/0147-7447-19900301-18. PMID: 2179915
Risk factors for osteomyelitis.
Wald ER
Am J Med 1985 Jun 28;78(6B):206-12. doi: 10.1016/0002-9343(85)90386-9. PMID: 3893117

Therapy

Mechanisms of Antibiotic Failure During Staphylococcus aureus Osteomyelitis.
Gimza BD, Cassat JE
Front Immunol 2021;12:638085. Epub 2021 Feb 12 doi: 10.3389/fimmu.2021.638085. PMID: 33643322Free PMC Article
Advances in the local and targeted delivery of anti-infective agents for management of osteomyelitis.
Ford CA, Cassat JE
Expert Rev Anti Infect Ther 2017 Sep;15(9):851-860. Epub 2017 Sep 1 doi: 10.1080/14787210.2017.1372192. PMID: 28837368Free PMC Article
Hepatitis C and neutropenia.
Sheehan VA, Weir A, Waters B
Curr Opin Hematol 2014 Jan;21(1):58-63. doi: 10.1097/MOH.0000000000000006. PMID: 24257097
Interactions of staphylococci with osteoblasts and phagocytes in the pathogenesis of implant-associated osteomyelitis.
Arciola CR, Hänsch GM, Visai L, Testoni F, Maurer S, Campoccia D, Selan L, Montanaro L
Int J Artif Organs 2012 Oct;35(10):713-26. doi: 10.5301/ijao.5000158. PMID: 23080215
HIV-1 infection of bone marrow hematopoietic progenitor cells and their role in trafficking and viral dissemination.
Alexaki A, Wigdahl B
PLoS Pathog 2008 Dec;4(12):e1000215. Epub 2008 Dec 26 doi: 10.1371/journal.ppat.1000215. PMID: 19112504Free PMC Article

Prognosis

Predicting the causative pathogen among children with osteomyelitis using Bayesian networks - improving antibiotic selection in clinical practice.
Wu Y, McLeod C, Blyth C, Bowen A, Martin A, Nicholson A, Mascaro S, Snelling T
Artif Intell Med 2020 Jul;107:101895. Epub 2020 Jun 3 doi: 10.1016/j.artmed.2020.101895. PMID: 32828444
Hepatitis C and neutropenia.
Sheehan VA, Weir A, Waters B
Curr Opin Hematol 2014 Jan;21(1):58-63. doi: 10.1097/MOH.0000000000000006. PMID: 24257097
HIV-1 infection of bone marrow hematopoietic progenitor cells and their role in trafficking and viral dissemination.
Alexaki A, Wigdahl B
PLoS Pathog 2008 Dec;4(12):e1000215. Epub 2008 Dec 26 doi: 10.1371/journal.ppat.1000215. PMID: 19112504Free PMC Article
Spread of human cytomegalovirus (HCMV) after infection of human hematopoietic progenitor cells: model of HCMV latency.
Zhuravskaya T, Maciejewski JP, Netski DM, Bruening E, Mackintosh FR, St Jeor S
Blood 1997 Sep 15;90(6):2482-91. PMID: 9310501
The Mycobacterium avium complex.
Inderlied CB, Kemper CA, Bermudez LE
Clin Microbiol Rev 1993 Jul;6(3):266-310. doi: 10.1128/CMR.6.3.266. PMID: 8358707Free PMC Article

Clinical prediction guides

Microstructural analysis of bony alterations in a historic case of actinomycosis.
Schamall D, Nebot Valenzuela E, Pietschmann P, Tangl S, Edelmayer M, Dobsak T, Teschler-Nicola M
Int J Paleopathol 2020 Sep;30:1-9. Epub 2020 Feb 25 doi: 10.1016/j.ijpp.2019.12.009. PMID: 32109842
Predictors of Outcome in Pediatric Osteomyelitis: Five Years Experience in a Single Tertiary Center.
Martin AC, Anderson D, Lucey J, Guttinger R, Jacoby PA, Mok TJ, Whitmore TJ, Whitewood CN, Burgner DP, Blyth CC
Pediatr Infect Dis J 2016 Apr;35(4):387-91. doi: 10.1097/INF.0000000000001031. PMID: 26669740
Parvovirus B19 infection of bone marrow in systemic sclerosis patients.
Ferri C, Zakrzewska K, Longombardo G, Giuggioli D, Storino FA, Pasero G, Azzi A
Clin Exp Rheumatol 1999 Nov-Dec;17(6):718-20. PMID: 10609071
Absence of paramyxovirus RNA in cultures of pagetic bone cells and in pagetic bone.
Birch MA, Taylor W, Fraser WD, Ralston SH, Hart CA, Gallagher JA
J Bone Miner Res 1994 Jan;9(1):11-6. doi: 10.1002/jbmr.5650090103. PMID: 8154304
In vitro suppression of bone marrow progenitor cell differentiation by human herpesvirus 6 infection.
Knox KK, Carrigan DR
J Infect Dis 1992 May;165(5):925-9. doi: 10.1093/infdis/165.5.925. PMID: 1314872

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...