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Papillary cystadenoma

MedGen UID:
41386
•Concept ID:
C0010636
•
Neoplastic Process
Synonyms: Cystadenoma, Papillary; Cystadenomas, Papillary; Papillary Cystadenoma; Papillary Cystadenomas
SNOMED CT: Papillary cystadenoma (32140001)
 
Monarch Initiative: MONDO:0021091

Definition

A serous or mucinous benign or low malignant potential cystic epithelial neoplasm. It is characterized by the presence of glandular epithelial cells forming papillary structures. [from NCI]

Professional guidelines

PubMed

Papillary cystadenoma lymphomatosum (Warthin's tumor) with a clinical note on the management of parotid tumors in general.
ABBISS JW, PIERSON JC
Del State Med J 1954 Oct;26(10):257-60. PMID: 13210035

Recent clinical studies

Etiology

Warthin Tumor of the Parotid Gland: The History of an Eponym.
Ide F, Sakamoto S, Miyazaki Y, Nishimura M, Ito Y, Muramatsu T, Kikuchi K
Head Neck Pathol 2023 Sep;17(3):775-781. Epub 2023 May 25 doi: 10.1007/s12105-023-01559-5. PMID: 37227678Free PMC Article
Oncocytic papillary cystadenoma of the larynx: comparative study of ten cases and review of the literature.
Svejdova A, Kalfert D, Skoloudik L, Satankova J, Laco J, Celakovsky P, Chrobok V
Eur Arch Otorhinolaryngol 2021 Sep;278(9):3381-3386. Epub 2021 Apr 28 doi: 10.1007/s00405-021-06841-2. PMID: 33909144
Uncommon hereditary gynaecological tumour syndromes: pathological features in tumours that may predict risk for a germline mutation.
Garg K, Karnezis AN, Rabban JT
Pathology 2018 Feb;50(2):238-256. Epub 2018 Jan 17 doi: 10.1016/j.pathol.2017.10.009. PMID: 29373116
P63 expression in papillary cystadenoma and mucoepidermoid carcinoma of minor salivary glands.
Fonseca FP, de Andrade BA, Lopes MA, Pontes HA, Vargas PA, de Almeida OP
Oral Surg Oral Med Oral Pathol Oral Radiol 2013 Jan;115(1):79-86. doi: 10.1016/j.oooo.2012.09.005. PMID: 23217538
Cysts and epithelial proliferations of the testicular collecting system (including rete testis).
Jones EC, Murray SK, Young RH
Semin Diagn Pathol 2000 Nov;17(4):270-93. PMID: 11202545

Diagnosis

Oncocytic papillary cystadenoma of the larynx: comparative study of ten cases and review of the literature.
Svejdova A, Kalfert D, Skoloudik L, Satankova J, Laco J, Celakovsky P, Chrobok V
Eur Arch Otorhinolaryngol 2021 Sep;278(9):3381-3386. Epub 2021 Apr 28 doi: 10.1007/s00405-021-06841-2. PMID: 33909144
Papillary cystadenoma of the epididymis and broad ligament: morphologic and immunohistochemical overlap with clear cell papillary renal cell carcinoma.
Cox R, Vang R, Epstein JI
Am J Surg Pathol 2014 May;38(5):713-8. doi: 10.1097/PAS.0000000000000152. PMID: 24441657
Pancreatic cystic neoplasm.
Roggin KK, Chennat J, Oto A, Noffsinger A, Briggs A, Matthews JB
Curr Probl Surg 2010 Jun;47(6):459-510. doi: 10.1067/j.cpsurg.2010.02.002. PMID: 20451023
Papillary cystadenoma of the epididymis.
Odrzywolski KJ, Mukhopadhyay S
Arch Pathol Lab Med 2010 Apr;134(4):630-3. doi: 10.5858/134.4.630. PMID: 20367315
Extraparotid Warthin's tumor.
Snyderman C, Johnson JT, Barnes EL
Otolaryngol Head Neck Surg 1986 Feb;94(2):169-75. doi: 10.1177/019459988609400207. PMID: 3083330

Therapy

Evaluating patients with mildly elevated transaminase levels.
Burns KA, Kurian S, Burke CC
Clin J Oncol Nurs 2007 Aug;11(4):499-502. doi: 10.1188/07.CJON.499-502. PMID: 17723962
Concomitant salivary duct carcinoma of a minor buccal salivary gland and papillary cystadenoma lymphomatosum of a cervical lymph node: report of a case and review of the literature.
Yoshimura Y, Tawara K, Yoshigi J, Nagaoka S
J Oral Maxillofac Surg 1995 Apr;53(4):448-53. doi: 10.1016/0278-2391(95)90722-x. PMID: 7699501
Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: an investigation of tumour cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patients.
Sessa F, Solcia E, Capella C, Bonato M, Scarpa A, Zamboni G, Pellegata NS, Ranzani GN, Rickaert F, Klöppel G
Virchows Arch 1994;425(4):357-67. doi: 10.1007/BF00189573. PMID: 7820300
Extraglandular Warthin's tumors.
Fantozzi RD, Bone RC, Fox R
Laryngoscope 1985 Jun;95(6):682-8. doi: 10.1288/00005537-198506000-00010. PMID: 3873593
Papillary cystadenoma within the testis.
Herschman BR, Ross MM
Am J Clin Pathol 1974 May;61(5):724-9. doi: 10.1093/ajcp/61.5.724. PMID: 4827055

Prognosis

Uncommon hereditary gynaecological tumour syndromes: pathological features in tumours that may predict risk for a germline mutation.
Garg K, Karnezis AN, Rabban JT
Pathology 2018 Feb;50(2):238-256. Epub 2018 Jan 17 doi: 10.1016/j.pathol.2017.10.009. PMID: 29373116
Papillary Cystadenoma of Minor Salivary Glands: Report of 11 Cases and Review of the English Literature.
Tjioe KC, de Lima HG, Thompson LD, Lara VS, Damante JH, de Oliveira-Santos C
Head Neck Pathol 2015 Sep;9(3):354-9. Epub 2014 Dec 30 doi: 10.1007/s12105-014-0602-0. PMID: 25547059Free PMC Article
Papillary cystadenoma of the epididymis.
Odrzywolski KJ, Mukhopadhyay S
Arch Pathol Lab Med 2010 Apr;134(4):630-3. doi: 10.5858/134.4.630. PMID: 20367315
Synchronous extra-parotid Warthin's tumour.
Nishikawa H, Kirkham N, Hogbin BM
J Laryngol Otol 1989 Aug;103(8):792-3. doi: 10.1017/s0022215100110102. PMID: 2769053
Tumors of the epididymis.
Elsässer E
Recent Results Cancer Res 1977;(60):163-75. doi: 10.1007/978-3-642-81095-4_18. PMID: 866788

Clinical prediction guides

Papillary cystadenoma of the major salivary gland: A case report and review of literature.
Malik V, Dixit M, Sharma S, Jain A, Dhankad A, Mohanty SK
Pathol Res Pract 2023 Nov;251:154884. Epub 2023 Oct 11 doi: 10.1016/j.prp.2023.154884. PMID: 37913638
Clinical and morphological features of the ovarian brenner tumour: current state of the problem.
Myroshnychenko MS, Dyadyk OO, Urzhumov VD, Kapustnyk NV, Borzenkova IV, Selivanova LI, Torianyk II, Fedulenkova YY, Kalashnyk IM, Tkachenko PV, Hryhorenko VR, Molodan DV, Myroshnychenko SS
Wiad Lek 2020;73(7):1420-1426. PMID: 32759431
Expression of Membrane-Bound Mucins and p63 in Distinguishing Mucoepidermoid Carcinoma from Papillary Cystadenoma.
Lanzel EA, Pourian A, Sousa Melo SL, Brogden KA, Hellstein JW
Head Neck Pathol 2016 Dec;10(4):521-526. Epub 2016 Jun 9 doi: 10.1007/s12105-016-0735-4. PMID: 27278378Free PMC Article
P63 expression in papillary cystadenoma and mucoepidermoid carcinoma of minor salivary glands.
Fonseca FP, de Andrade BA, Lopes MA, Pontes HA, Vargas PA, de Almeida OP
Oral Surg Oral Med Oral Pathol Oral Radiol 2013 Jan;115(1):79-86. doi: 10.1016/j.oooo.2012.09.005. PMID: 23217538
Cystic neoplasms of the pancreas.
Fernández-del Castillo C, Warshaw AL
Pancreatology 2001;1(6):641-7. doi: 10.1159/000055875. PMID: 12120248

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