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Vascular Regression

MedGen UID:
414947
•Concept ID:
C2826596
•
Finding

Definition

A finding indicating shrinkage of the tissue volume of the vascular structures. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVascular Regression

Professional guidelines

PubMed

VEGF signaling in cancer treatment.
Sia D, Alsinet C, Newell P, Villanueva A
Curr Pharm Des 2014;20(17):2834-42. doi: 10.2174/13816128113199990590. PMID: 23944367
AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer.
Wedge SR, Kendrew J, Hennequin LF, Valentine PJ, Barry ST, Brave SR, Smith NR, James NH, Dukes M, Curwen JO, Chester R, Jackson JA, Boffey SJ, Kilburn LL, Barnett S, Richmond GH, Wadsworth PF, Walker M, Bigley AL, Taylor ST, Cooper L, Beck S, Jürgensmeier JM, Ogilvie DJ
Cancer Res 2005 May 15;65(10):4389-400. doi: 10.1158/0008-5472.CAN-04-4409. PMID: 15899831
Expression of vascular endothelial growth factor, apoptosis inhibitors (survivin and p16) and CCL27 in alopecia areata before and after diphencyprone treatment: an immunohistochemical study.
Simonetti O, Lucarini G, Bernardini ML, Simoncini C, Biagini G, Offidani A
Br J Dermatol 2004 May;150(5):940-8. doi: 10.1111/j.1365-2133.2004.05881.x. PMID: 15149507

Recent clinical studies

Etiology

Rolipram optimizes therapeutic effect of bevacizumab by enhancing proapoptotic, antiproliferative signals in a glioblastoma heterotopic model.
Ramezani S, Vousooghi N, Ramezani Kapourchali F, Yousefzadeh-Chabok S, Reihanian Z, Alizadeh AM, Khodayari S, Khodayari H
Life Sci 2019 Dec 15;239:116880. Epub 2019 Oct 31 doi: 10.1016/j.lfs.2019.116880. PMID: 31678282
Vascular Regression After Pinguecula Excision and Conjunctival Autograft Using Fibrin Glue.
Jung S, Kwon JW, Hwang HS, Chuck RS
Eye Contact Lens 2017 May;43(3):199-202. doi: 10.1097/ICL.0000000000000250. PMID: 27058827
Engineering the microcirculation.
Lokmic Z, Mitchell GM
Tissue Eng Part B Rev 2008 Mar;14(1):87-103. doi: 10.1089/teb.2007.0299. PMID: 18454636
Blood vessels are regulators of growth, diagnostic markers and therapeutic targets in prostate cancer.
Lissbrant IF, Lissbrant E, Damber JE, Bergh A
Scand J Urol Nephrol 2001 Dec;35(6):437-52. doi: 10.1080/003655901753367532. PMID: 11848422
Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody.
Yuan F, Chen Y, Dellian M, Safabakhsh N, Ferrara N, Jain RK
Proc Natl Acad Sci U S A 1996 Dec 10;93(25):14765-70. doi: 10.1073/pnas.93.25.14765. PMID: 8962129Free PMC Article

Diagnosis

Modeling early pathophysiological phenotypes of diabetic retinopathy in a human inner blood-retinal barrier-on-a-chip.
Maurissen TL, Spielmann AJ, Schellenberg G, Bickle M, Vieira JR, Lai SY, Pavlou G, Fauser S, Westenskow PD, Kamm RD, Ragelle H
Nat Commun 2024 Feb 14;15(1):1372. doi: 10.1038/s41467-024-45456-z. PMID: 38355716Free PMC Article
Mammary Microvessels are Sensitive to Menstrual Cycle Sex Hormones.
Moccia C, Cherubini M, Fortea M, Akinbote A, Padmanaban P, Beltran-Sastre V, Haase K
Adv Sci (Weinh) 2023 Dec;10(35):e2302561. Epub 2023 Oct 28 doi: 10.1002/advs.202302561. PMID: 37897317Free PMC Article
Primary cilia sensitize endothelial cells to BMP and prevent excessive vascular regression.
Vion AC, Alt S, Klaus-Bergmann A, Szymborska A, Zheng T, Perovic T, Hammoutene A, Oliveira MB, Bartels-Klein E, Hollfinger I, Rautou PE, Bernabeu MO, Gerhardt H
J Cell Biol 2018 May 7;217(5):1651-1665. Epub 2018 Mar 2 doi: 10.1083/jcb.201706151. PMID: 29500191Free PMC Article
Extravasating uterine pseudoaneurysm: A rare cause of postpartum haemorrhage.
Yi SW
J Obstet Gynaecol 2017 May;37(4):416-420. Epub 2017 Feb 25 doi: 10.1080/01443615.2016.1274292. PMID: 28421908
Persistent hyperplastic primary vitreous: congenital malformation of the eye.
Shastry BS
Clin Exp Ophthalmol 2009 Dec;37(9):884-90. doi: 10.1111/j.1442-9071.2009.02150.x. PMID: 20092598

Therapy

Infantile hemangioma: the common and enigmatic vascular tumor.
Holm A, Mulliken JB, Bischoff J
J Clin Invest 2024 Apr 15;134(8) doi: 10.1172/JCI172836. PMID: 38618963Free PMC Article
Primary cilia sensitize endothelial cells to BMP and prevent excessive vascular regression.
Vion AC, Alt S, Klaus-Bergmann A, Szymborska A, Zheng T, Perovic T, Hammoutene A, Oliveira MB, Bartels-Klein E, Hollfinger I, Rautou PE, Bernabeu MO, Gerhardt H
J Cell Biol 2018 May 7;217(5):1651-1665. Epub 2018 Mar 2 doi: 10.1083/jcb.201706151. PMID: 29500191Free PMC Article
VEGF signaling in cancer treatment.
Sia D, Alsinet C, Newell P, Villanueva A
Curr Pharm Des 2014;20(17):2834-42. doi: 10.2174/13816128113199990590. PMID: 23944367
Persistent vascular normalization as an alternative goal of anti-angiogenic cancer therapy.
Sato Y
Cancer Sci 2011 Jul;102(7):1253-6. Epub 2011 Apr 14 doi: 10.1111/j.1349-7006.2011.01929.x. PMID: 21401807
Tumor angiogenesis and accessibility: role of vascular endothelial growth factor.
Jain RK
Semin Oncol 2002 Dec;29(6 Suppl 16):3-9. doi: 10.1053/sonc.2002.37265. PMID: 12516032

Prognosis

Modeling early pathophysiological phenotypes of diabetic retinopathy in a human inner blood-retinal barrier-on-a-chip.
Maurissen TL, Spielmann AJ, Schellenberg G, Bickle M, Vieira JR, Lai SY, Pavlou G, Fauser S, Westenskow PD, Kamm RD, Ragelle H
Nat Commun 2024 Feb 14;15(1):1372. doi: 10.1038/s41467-024-45456-z. PMID: 38355716Free PMC Article
Vascular Regression After Pinguecula Excision and Conjunctival Autograft Using Fibrin Glue.
Jung S, Kwon JW, Hwang HS, Chuck RS
Eye Contact Lens 2017 May;43(3):199-202. doi: 10.1097/ICL.0000000000000250. PMID: 27058827
Angiopoietins in angiogenesis.
Fagiani E, Christofori G
Cancer Lett 2013 Jan 1;328(1):18-26. Epub 2012 Aug 23 doi: 10.1016/j.canlet.2012.08.018. PMID: 22922303
Degeneration and regeneration of the intervertebral disc: lessons from development.
Smith LJ, Nerurkar NL, Choi KS, Harfe BD, Elliott DM
Dis Model Mech 2011 Jan;4(1):31-41. Epub 2010 Dec 1 doi: 10.1242/dmm.006403. PMID: 21123625Free PMC Article
Regulated angiogenesis and vascular regression in mice overexpressing vascular endothelial growth factor in airways.
Baluk P, Lee CG, Link H, Ator E, Haskell A, Elias JA, McDonald DM
Am J Pathol 2004 Oct;165(4):1071-85. doi: 10.1016/S0002-9440(10)63369-X. PMID: 15466375Free PMC Article

Clinical prediction guides

Modeling early pathophysiological phenotypes of diabetic retinopathy in a human inner blood-retinal barrier-on-a-chip.
Maurissen TL, Spielmann AJ, Schellenberg G, Bickle M, Vieira JR, Lai SY, Pavlou G, Fauser S, Westenskow PD, Kamm RD, Ragelle H
Nat Commun 2024 Feb 14;15(1):1372. doi: 10.1038/s41467-024-45456-z. PMID: 38355716Free PMC Article
Mammary Microvessels are Sensitive to Menstrual Cycle Sex Hormones.
Moccia C, Cherubini M, Fortea M, Akinbote A, Padmanaban P, Beltran-Sastre V, Haase K
Adv Sci (Weinh) 2023 Dec;10(35):e2302561. Epub 2023 Oct 28 doi: 10.1002/advs.202302561. PMID: 37897317Free PMC Article
Yangxue Jiedu Fang Ameliorates Psoriasis by Regulating Vascular Regression via Survivin/PI3K/Akt Pathway.
Lv H, Liu X, Chen W, Xiao S, Ji Y, Han X, Li Y, Wang X, Zhang G, Li P
J Immunol Res 2021;2021:4678087. Epub 2021 Jan 8 doi: 10.1155/2021/4678087. PMID: 33532507Free PMC Article
The mammary gland vasculature revisited.
Andres AC, Djonov V
J Mammary Gland Biol Neoplasia 2010 Sep;15(3):319-28. Epub 2010 Aug 14 doi: 10.1007/s10911-010-9186-9. PMID: 20706777
Vascular regression and survival are differentially regulated by MT1-MMP and TIMPs in the aortic ring model of angiogenesis.
Aplin AC, Zhu WH, Fogel E, Nicosia RF
Am J Physiol Cell Physiol 2009 Aug;297(2):C471-80. Epub 2009 Jun 3 doi: 10.1152/ajpcell.00019.2009. PMID: 19494241Free PMC Article

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