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Stigmata of Chronic Liver Disease

MedGen UID:
414953
•Concept ID:
C2826616
•
Finding

Definition

Signs of chronic liver disease which include jaundice, ascites, palmar erythema, spider hemangiomas, gynecomastia, and encephalopathy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVStigmata of Chronic Liver Disease

Professional guidelines

PubMed

Rapid improvement of psychiatric stigmata after IFN-free treatment in HCV patients with and without cryoglobulinemic vasculitis.
Gragnani L, Lorini S, Martini L, Stasi C, Visentini M, Petraccia L, Marello N, Monti M, Marri S, Madia F, Ricca V, Zignego AL
Clin Rheumatol 2022 Jan;41(1):147-157. Epub 2021 Aug 19 doi: 10.1007/s10067-021-05877-3. PMID: 34409558Free PMC Article
Indications, results, and clinical impact of endoscopic ultrasound (EUS)-guided sampling in gastroenterology: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline - Updated January 2017.
Dumonceau JM, Deprez PH, Jenssen C, Iglesias-Garcia J, Larghi A, Vanbiervliet G, Aithal GP, Arcidiacono PG, Bastos P, Carrara S, Czakó L, Fernández-Esparrach G, Fockens P, Ginès À, Havre RF, Hassan C, Vilmann P, van Hooft JE, Polkowski M
Endoscopy 2017 Jul;49(7):695-714. Epub 2017 May 16 doi: 10.1055/s-0043-109021. PMID: 28511234
Management of upper gastrointestinal bleeding in cirrhotic patients with documented esophageal varices evaluated at the Puerto Rico Medical Center.
González EJ, Rivera-Acosta JE, Sánchez JM, Romero C, Meléndez M, Pérez C, Torres EA
Bol Asoc Med P R 2011 Jan-Mar;103(1):5-8. PMID: 21696096

Recent clinical studies

Etiology

Rapid improvement of psychiatric stigmata after IFN-free treatment in HCV patients with and without cryoglobulinemic vasculitis.
Gragnani L, Lorini S, Martini L, Stasi C, Visentini M, Petraccia L, Marello N, Monti M, Marri S, Madia F, Ricca V, Zignego AL
Clin Rheumatol 2022 Jan;41(1):147-157. Epub 2021 Aug 19 doi: 10.1007/s10067-021-05877-3. PMID: 34409558Free PMC Article
Prevalence of minimal hepatic encephalopathy among patients with chronic liver disease in Ilorin, Nigeria.
Bamidele OF, Olokoba AB, Bojuwoye MO, Akintayo RO, Bamidele O
Ghana Med J 2019 Dec;53(4):299-303. doi: 10.4314/gmj.v53i4.8. PMID: 32116342Free PMC Article
The expanding spectrum of HCV-related cryoglobulinemic vasculitis: a narrative review.
Dammacco F, Racanelli V, Russi S, Sansonno D
Clin Exp Med 2016 Aug;16(3):233-42. Epub 2016 Mar 2 doi: 10.1007/s10238-016-0410-9. PMID: 26935415
Cutaneous manifestations of alcohol abuse.
Smith KE, Fenske NA
J Am Acad Dermatol 2000 Jul;43(1 Pt 1):1-16; quiz 16-8. doi: 10.1067/mjd.2000.104512. PMID: 10863217
Alcohol and the skin.
Higgins EM, du Vivier AW
Alcohol Alcohol 1992 Nov;27(6):595-602. PMID: 1292432

Diagnosis

An essential accessory.
Prince D, Popuri R, Majumdar A
BMJ Open Gastroenterol 2021 Sep;8(1) doi: 10.1136/bmjgast-2021-000770. PMID: 34588177Free PMC Article
Prevalence of minimal hepatic encephalopathy among patients with chronic liver disease in Ilorin, Nigeria.
Bamidele OF, Olokoba AB, Bojuwoye MO, Akintayo RO, Bamidele O
Ghana Med J 2019 Dec;53(4):299-303. doi: 10.4314/gmj.v53i4.8. PMID: 32116342Free PMC Article
Cutaneous manifestations of alcohol abuse.
Smith KE, Fenske NA
J Am Acad Dermatol 2000 Jul;43(1 Pt 1):1-16; quiz 16-8. doi: 10.1067/mjd.2000.104512. PMID: 10863217
Peripheral edema.
Powell AA, Armstrong MA
Am Fam Physician 1997 Apr;55(5):1721-6. PMID: 9105200
Alcohol and the skin.
Higgins EM, du Vivier AW
Alcohol Alcohol 1992 Nov;27(6):595-602. PMID: 1292432

Therapy

Rapid improvement of psychiatric stigmata after IFN-free treatment in HCV patients with and without cryoglobulinemic vasculitis.
Gragnani L, Lorini S, Martini L, Stasi C, Visentini M, Petraccia L, Marello N, Monti M, Marri S, Madia F, Ricca V, Zignego AL
Clin Rheumatol 2022 Jan;41(1):147-157. Epub 2021 Aug 19 doi: 10.1007/s10067-021-05877-3. PMID: 34409558Free PMC Article
Alcohol and skin disorders: with a focus on psoriasis.
Kazakevich N, Moody MN, Landau JM, Goldberg LH
Skin Therapy Lett 2011 Apr;16(4):5-6. PMID: 21611681
Chronic viral hepatitis in kidney transplantation.
Huskey J, Wiseman AC
Nat Rev Nephrol 2011 Mar;7(3):156-65. Epub 2011 Feb 1 doi: 10.1038/nrneph.2010.192. PMID: 21283138
Nonalcoholic steatohepatitis.
Reid AE
Gastroenterology 2001 Sep;121(3):710-23. doi: 10.1053/gast.2001.27126. PMID: 11522755
Alcohol and the skin.
Higgins EM, du Vivier AW
Alcohol Alcohol 1992 Nov;27(6):595-602. PMID: 1292432

Prognosis

Predictors of hepatocellular carcinoma in HCV cirrhotic patients treated with direct acting antivirals.
Lleo A, Aglitti A, Aghemo A, Maisonneuve P, Bruno S, Persico M; collaborators
Dig Liver Dis 2019 Feb;51(2):310-317. Epub 2018 Oct 31 doi: 10.1016/j.dld.2018.10.014. PMID: 30473220
Pharmacogenomics of drug-induced liver injury (DILI): Molecular biology to clinical applications.
Kaliyaperumal K, Grove JI, Delahay RM, Griffiths WJH, Duckworth A, Aithal GP
J Hepatol 2018 Oct;69(4):948-957. Epub 2018 May 21 doi: 10.1016/j.jhep.2018.05.013. PMID: 29792895
Liver involvement in multiple myeloma.
Bhandari MS, Mazumder A, Vesole DH
Clin Lymphoma Myeloma 2007 Sep;7(8):538-40. doi: 10.3816/clm.2007.n.039. PMID: 18021472
Non-alcoholic fatty liver disease--a common and benign finding in octogenarian patients.
Kagansky N, Levy S, Keter D, Rimon E, Taiba Z, Fridman Z, Berger D, Knobler H, Malnick S
Liver Int 2004 Dec;24(6):588-94. doi: 10.1111/j.1478-3231.2004.0969.x. PMID: 15566509
Fulminant hepatic failure.
Fingerote RJ, Bain VG
Am J Gastroenterol 1993 Jul;88(7):1000-10. PMID: 8317398

Clinical prediction guides

Rapid improvement of psychiatric stigmata after IFN-free treatment in HCV patients with and without cryoglobulinemic vasculitis.
Gragnani L, Lorini S, Martini L, Stasi C, Visentini M, Petraccia L, Marello N, Monti M, Marri S, Madia F, Ricca V, Zignego AL
Clin Rheumatol 2022 Jan;41(1):147-157. Epub 2021 Aug 19 doi: 10.1007/s10067-021-05877-3. PMID: 34409558Free PMC Article
Predictors of hepatocellular carcinoma in HCV cirrhotic patients treated with direct acting antivirals.
Lleo A, Aglitti A, Aghemo A, Maisonneuve P, Bruno S, Persico M; collaborators
Dig Liver Dis 2019 Feb;51(2):310-317. Epub 2018 Oct 31 doi: 10.1016/j.dld.2018.10.014. PMID: 30473220
DIAGNOSTIC SIGNIFICANCE OF SKIN "SIGNS" IN CHRONIC DIFFUSE LIVER DISFASES.
Pozdnyakova ON, Nemchaninova OB, Reshetnikova TB, Lykova SG, Khryanin AA
Eksp Klin Gastroenterol 2016;(9):38-41. PMID: 29889393
Natural history of chronic hepatitis B virus infection in children of different ethnic origins: a cohort study with up to 12 years' follow-up in northern Greece.
Zacharakis G, Koskinas J, Kotsiou S, Pouliou E, Papoutselis M, Tzara F, Vafeiadis N, Maltezos E, Archimandritis A, Papoutselis K
J Pediatr Gastroenterol Nutr 2007 Jan;44(1):84-91. doi: 10.1097/01.mpg.0000243438.47334.07. PMID: 17204959
Non-alcoholic fatty liver disease--a common and benign finding in octogenarian patients.
Kagansky N, Levy S, Keter D, Rimon E, Taiba Z, Fridman Z, Berger D, Knobler H, Malnick S
Liver Int 2004 Dec;24(6):588-94. doi: 10.1111/j.1478-3231.2004.0969.x. PMID: 15566509

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