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Ischemic Myocardium

MedGen UID:
416260
•Concept ID:
C2919051
•
Finding

Definition

Myocardial tissue which exhibits characteristics of inadequate blood flow. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIschemic Myocardium

Professional guidelines

PubMed

Application of mesenchymal stem cell sheet to treatment of ischemic heart disease.
Chang D, Fan T, Gao S, Jin Y, Zhang M, Ono M
Stem Cell Res Ther 2021 Jul 7;12(1):384. doi: 10.1186/s13287-021-02451-1. PMID: 34233729Free PMC Article
Management of cardiogenic shock complicating myocardial infarction.
Mebazaa A, Combes A, van Diepen S, Hollinger A, Katz JN, Landoni G, Hajjar LA, Lassus J, Lebreton G, Montalescot G, Park JJ, Price S, Sionis A, Yannopolos D, Harjola VP, Levy B, Thiele H
Intensive Care Med 2018 Jun;44(6):760-773. Epub 2018 May 16 doi: 10.1007/s00134-018-5214-9. PMID: 29767322
Treatment of Myocardial Ischemia/Reperfusion Injury by Ischemic and Pharmacological Postconditioning.
Heusch G
Compr Physiol 2015 Jul 1;5(3):1123-45. doi: 10.1002/cphy.c140075. PMID: 26140711

Recent clinical studies

Etiology

The role and mechanisms of microvascular damage in the ischemic myocardium.
Zhao BH, Ruze A, Zhao L, Li QL, Tang J, Xiefukaiti N, Gai MT, Deng AX, Shan XF, Gao XM
Cell Mol Life Sci 2023 Oct 29;80(11):341. doi: 10.1007/s00018-023-04998-z. PMID: 37898977Free PMC Article
Sarcomere length affects Ca2+ sensitivity of contraction in ischemic but not non-ischemic myocardium.
Tanner BCW, Awinda PO, Agonias KB, Attili S, Blair CA, Thompson MS, Walker LA, Kampourakis T, Campbell KS
J Gen Physiol 2023 Mar 6;155(3) Epub 2023 Jan 12 doi: 10.1085/jgp.202213200. PMID: 36633584Free PMC Article
Coronary microvascular adaptations distal to epicardial artery stenosis.
Merkus D, Muller-Delp J, Heaps CL
Am J Physiol Heart Circ Physiol 2021 Jun 1;320(6):H2351-H2370. Epub 2021 May 7 doi: 10.1152/ajpheart.00992.2020. PMID: 33961506Free PMC Article
Management of cardiogenic shock complicating myocardial infarction.
Mebazaa A, Combes A, van Diepen S, Hollinger A, Katz JN, Landoni G, Hajjar LA, Lassus J, Lebreton G, Montalescot G, Park JJ, Price S, Sionis A, Yannopolos D, Harjola VP, Levy B, Thiele H
Intensive Care Med 2018 Jun;44(6):760-773. Epub 2018 May 16 doi: 10.1007/s00134-018-5214-9. PMID: 29767322
Angiogenesis in the infarcted myocardium.
Cochain C, Channon KM, Silvestre JS
Antioxid Redox Signal 2013 Mar 20;18(9):1100-13. Epub 2012 Sep 25 doi: 10.1089/ars.2012.4849. PMID: 22870932Free PMC Article

Diagnosis

Heart Failure After Right Ventricular Myocardial Infarction.
Nägele MP, Flammer AJ
Curr Heart Fail Rep 2022 Dec;19(6):375-385. Epub 2022 Oct 5 doi: 10.1007/s11897-022-00577-8. PMID: 36197627Free PMC Article
Long Noncoding RNAs in Myocardial Ischemia-Reperfusion Injury.
Zhao Z, Sun W, Guo Z, Liu B, Yu H, Zhang J
Oxid Med Cell Longev 2021;2021:8889123. Epub 2021 Apr 5 doi: 10.1155/2021/8889123. PMID: 33884101Free PMC Article
HIF‑1α in myocardial ischemia‑reperfusion injury (Review).
Zheng J, Chen P, Zhong J, Cheng Y, Chen H, He Y, Chen C
Mol Med Rep 2021 May;23(5) Epub 2021 Mar 24 doi: 10.3892/mmr.2021.11991. PMID: 33760122Free PMC Article
Reperfusing the myocardium - a damocles Sword.
Shah VK, Shalia KK
Indian Heart J 2018 May-Jun;70(3):433-438. Epub 2017 Nov 8 doi: 10.1016/j.ihj.2017.11.009. PMID: 29961464Free PMC Article
Cardiac ischemia-insights from computational models.
Loewe A, Wülfers EM, Seemann G
Herzschrittmacherther Elektrophysiol 2018 Mar;29(1):48-56. Epub 2018 Jan 5 doi: 10.1007/s00399-017-0539-6. PMID: 29305703

Therapy

Restoring Cardiac Functions after Myocardial Infarction-Ischemia/Reperfusion via an Exosome Anchoring Conductive Hydrogel.
Zou Y, Li L, Li Y, Chen S, Xie X, Jin X, Wang X, Ma C, Fan G, Wang W
ACS Appl Mater Interfaces 2021 Dec 8;13(48):56892-56908. Epub 2021 Nov 25 doi: 10.1021/acsami.1c16481. PMID: 34823355
Cardioprotection of pharmacological postconditioning on myocardial ischemia/reperfusion injury.
Wu Y, Liu H, Wang X
Life Sci 2021 Jan 1;264:118628. Epub 2020 Oct 22 doi: 10.1016/j.lfs.2020.118628. PMID: 33131670
Engineered Exosomes With Ischemic Myocardium-Targeting Peptide for Targeted Therapy in Myocardial Infarction.
Wang X, Chen Y, Zhao Z, Meng Q, Yu Y, Sun J, Yang Z, Chen Y, Li J, Ma T, Liu H, Li Z, Yang J, Shen Z
J Am Heart Assoc 2018 Aug 7;7(15):e008737. doi: 10.1161/JAHA.118.008737. PMID: 30371236Free PMC Article
Ivabradine: Cardioprotection By and Beyond Heart Rate Reduction.
Heusch G, Kleinbongard P
Drugs 2016 May;76(7):733-40. doi: 10.1007/s40265-016-0567-2. PMID: 27041289
Myocardial protection.
Wechsler AS, Abd-Elfattah AS, Murphy CE, Salter DR, Brunsting LA, Goldstein JP
J Card Surg 1986 Sep;1(3):271-306. doi: 10.1111/j.1540-8191.1986.tb00715.x. PMID: 2979926

Prognosis

Cardioprotective Strategies After Ischemia-Reperfusion Injury.
Zhang H, Hu H, Zhai C, Jing L, Tian H
Am J Cardiovasc Drugs 2024 Jan;24(1):5-18. Epub 2023 Oct 10 doi: 10.1007/s40256-023-00614-4. PMID: 37815758Free PMC Article
The role and mechanisms of microvascular damage in the ischemic myocardium.
Zhao BH, Ruze A, Zhao L, Li QL, Tang J, Xiefukaiti N, Gai MT, Deng AX, Shan XF, Gao XM
Cell Mol Life Sci 2023 Oct 29;80(11):341. doi: 10.1007/s00018-023-04998-z. PMID: 37898977Free PMC Article
Heart Failure After Right Ventricular Myocardial Infarction.
Nägele MP, Flammer AJ
Curr Heart Fail Rep 2022 Dec;19(6):375-385. Epub 2022 Oct 5 doi: 10.1007/s11897-022-00577-8. PMID: 36197627Free PMC Article
Cytotoxic CD8(+) T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling.
Santos-Zas I, Lemarié J, Zlatanova I, Cachanado M, Seghezzi JC, Benamer H, Goube P, Vandestienne M, Cohen R, Ezzo M, Duval V, Zhang Y, Su JB, Bizé A, Sambin L, Bonnin P, Branchereau M, Heymes C, Tanchot C, Vilar J, Delacroix C, Hulot JS, Cochain C, Bruneval P, Danchin N, Tedgui A, Mallat Z, Simon T, Ghaleh B, Silvestre JS, Ait-Oufella H
Nat Commun 2021 Mar 5;12(1):1483. doi: 10.1038/s41467-021-21737-9. PMID: 33674611Free PMC Article
Coronary Microcirculation and the No-reflow Phenomenon.
Oikonomou E, Mourouzis K, Vogiatzi G, Siasos G, Deftereos S, Papaioannou S, Latsios G, Tsalamandris S, Tousoulis D
Curr Pharm Des 2018;24(25):2934-2942. doi: 10.2174/1381612824666180911122230. PMID: 30205793

Clinical prediction guides

Cytotoxic CD8(+) T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling.
Santos-Zas I, Lemarié J, Zlatanova I, Cachanado M, Seghezzi JC, Benamer H, Goube P, Vandestienne M, Cohen R, Ezzo M, Duval V, Zhang Y, Su JB, Bizé A, Sambin L, Bonnin P, Branchereau M, Heymes C, Tanchot C, Vilar J, Delacroix C, Hulot JS, Cochain C, Bruneval P, Danchin N, Tedgui A, Mallat Z, Simon T, Ghaleh B, Silvestre JS, Ait-Oufella H
Nat Commun 2021 Mar 5;12(1):1483. doi: 10.1038/s41467-021-21737-9. PMID: 33674611Free PMC Article
Engineered Exosomes With Ischemic Myocardium-Targeting Peptide for Targeted Therapy in Myocardial Infarction.
Wang X, Chen Y, Zhao Z, Meng Q, Yu Y, Sun J, Yang Z, Chen Y, Li J, Ma T, Liu H, Li Z, Yang J, Shen Z
J Am Heart Assoc 2018 Aug 7;7(15):e008737. doi: 10.1161/JAHA.118.008737. PMID: 30371236Free PMC Article
Cardiac ischemia-insights from computational models.
Loewe A, Wülfers EM, Seemann G
Herzschrittmacherther Elektrophysiol 2018 Mar;29(1):48-56. Epub 2018 Jan 5 doi: 10.1007/s00399-017-0539-6. PMID: 29305703
Ivabradine: Cardioprotection By and Beyond Heart Rate Reduction.
Heusch G, Kleinbongard P
Drugs 2016 May;76(7):733-40. doi: 10.1007/s40265-016-0567-2. PMID: 27041289
Myocardial protection.
Wechsler AS, Abd-Elfattah AS, Murphy CE, Salter DR, Brunsting LA, Goldstein JP
J Card Surg 1986 Sep;1(3):271-306. doi: 10.1111/j.1540-8191.1986.tb00715.x. PMID: 2979926

Recent systematic reviews

Ischemic functional mitral regurgitation: from pathophysiological concepts to current treatment options. A systemic review for optimal strategy.
Nappi F, Nenna A, Mihos C, Spadaccio C, Gentile F, Chello M, Matzui Y
Gen Thorac Cardiovasc Surg 2021 Feb;69(2):213-229. Epub 2021 Jan 5 doi: 10.1007/s11748-020-01562-5. PMID: 33400198
Prognostic value of the myocardial salvage index measured by T2-weighted and T1-weighted late gadolinium enhancement magnetic resonance imaging after ST-segment elevation myocardial infarction: A systematic review and meta-regression analysis.
Kendziora B, Dewey M
PLoS One 2020;15(2):e0228736. Epub 2020 Feb 13 doi: 10.1371/journal.pone.0228736. PMID: 32053651Free PMC Article
Role of adult bone marrow stem cells in the repair of ischemic myocardium: current state of the art.
Charwat S, Gyöngyösi M, Lang I, Graf S, Beran G, Hemetsberger R, Nyolczas N, Sochor H, Glogar D
Exp Hematol 2008 Jun;36(6):672-80. Epub 2008 Mar 20 doi: 10.1016/j.exphem.2008.01.005. PMID: 18358589

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