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Dyspepsia

MedGen UID:
41681
•Concept ID:
C0013395
•
Sign or Symptom
Synonyms: Dyspepsias; Indigestion; Indigestions
SNOMED CT: Indigestion (162031009); Dyspepsia (162031009)
 
HPO: HP:0410281
Monarch Initiative: MONDO:0002268

Definition

A heterogeneous group of symptoms that are localized in the epigastric region. Typical dyspeptic symptoms include postprandial fullness, early satiation, epigastric pain and epigastric burning, but other upper gastrointestinal symptoms such as nausea, belching or abdominal bloating often occur. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDyspepsia

Professional guidelines

PubMed

Diagnosis and Treatment of Peptic Ulcer Disease.
Kavitt RT, Lipowska AM, Anyane-Yeboa A, Gralnek IM
Am J Med 2019 Apr;132(4):447-456. Epub 2019 Jan 3 doi: 10.1016/j.amjmed.2018.12.009. PMID: 30611829
ACG and CAG Clinical Guideline: Management of Dyspepsia.
Moayyedi P, Lacy BE, Andrews CN, Enns RA, Howden CW, Vakil N
Am J Gastroenterol 2017 Jul;112(7):988-1013. Epub 2017 Jun 20 doi: 10.1038/ajg.2017.154. PMID: 28631728
ACG Clinical Guideline: Treatment of Helicobacter pylori Infection.
Chey WD, Leontiadis GI, Howden CW, Moss SF
Am J Gastroenterol 2017 Feb;112(2):212-239. Epub 2017 Jan 10 doi: 10.1038/ajg.2016.563. PMID: 28071659

Curated

UK NICE Clinical Guideline CG184, Gastro-oesophageal reflux disease and dyspepsia in adults: investigation and management, 2019

UK NICE Guideline NG1, Gastro-oesophageal reflux disease in children and young people: diagnosis and management, 2019

Recent clinical studies

Etiology

Functional dyspepsia.
Ford AC, Mahadeva S, Carbone MF, Lacy BE, Talley NJ
Lancet 2020 Nov 21;396(10263):1689-1702. Epub 2020 Oct 10 doi: 10.1016/S0140-6736(20)30469-4. PMID: 33049222
ACG and CAG Clinical Guideline: Management of Dyspepsia.
Moayyedi P, Lacy BE, Andrews CN, Enns RA, Howden CW, Vakil N
Am J Gastroenterol 2017 Jul;112(7):988-1013. Epub 2017 Jun 20 doi: 10.1038/ajg.2017.154. PMID: 28631728
Functional dyspepsia.
Holtmann G, Talley NJ
Curr Opin Gastroenterol 2015 Nov;31(6):492-8. doi: 10.1097/MOG.0000000000000219. PMID: 26444826
Global prevalence of, and risk factors for, uninvestigated dyspepsia: a meta-analysis.
Ford AC, Marwaha A, Sood R, Moayyedi P
Gut 2015 Jul;64(7):1049-57. Epub 2014 Aug 21 doi: 10.1136/gutjnl-2014-307843. PMID: 25147201
Managing dyspepsia.
Ford AC, Moayyedi P
Curr Gastroenterol Rep 2009 Aug;11(4):288-94. doi: 10.1007/s11894-009-0042-2. PMID: 19615304

Diagnosis

MODERN APPROACH TO DYSPEPSIA.
Medić B, Babić Ž, Banić M, Ljubičić L
Acta Clin Croat 2021 Dec;60(4):731-738. doi: 10.20471/acc.2021.60.04.21. PMID: 35734496Free PMC Article
Functional dyspepsia.
Ford AC, Mahadeva S, Carbone MF, Lacy BE, Talley NJ
Lancet 2020 Nov 21;396(10263):1689-1702. Epub 2020 Oct 10 doi: 10.1016/S0140-6736(20)30469-4. PMID: 33049222
Functional Dyspepsia: Diagnostic and Therapeutic Approaches.
Sayuk GS, Gyawali CP
Drugs 2020 Sep;80(13):1319-1336. doi: 10.1007/s40265-020-01362-4. PMID: 32691294
Functional dyspepsia.
Enck P, Azpiroz F, Boeckxstaens G, Elsenbruch S, Feinle-Bisset C, Holtmann G, Lackner JM, Ronkainen J, Schemann M, Stengel A, Tack J, Zipfel S, Talley NJ
Nat Rev Dis Primers 2017 Nov 3;3:17081. doi: 10.1038/nrdp.2017.81. PMID: 29099093
Dyspepsia: organic versus functional.
Oustamanolakis P, Tack J
J Clin Gastroenterol 2012 Mar;46(3):175-90. doi: 10.1097/MCG.0b013e318241b335. PMID: 22327302

Therapy

Microbiota in the stomach and application of probiotics to gastroduodenal diseases.
Koga Y
World J Gastroenterol 2022 Dec 21;28(47):6702-6715. doi: 10.3748/wjg.v28.i47.6702. PMID: 36620346Free PMC Article
Dyspepsia: organic versus functional.
Oustamanolakis P, Tack J
J Clin Gastroenterol 2012 Mar;46(3):175-90. doi: 10.1097/MCG.0b013e318241b335. PMID: 22327302
Tadalafil.
Curran M, Keating G
Drugs 2003;63(20):2203-12; discussion 2213-4. doi: 10.2165/00003495-200363200-00004. PMID: 14498756
Vardenafil.
Ormrod D, Easthope SE, Figgitt DP
Drugs Aging 2002;19(3):217-27; discussion 228-9. doi: 10.2165/00002512-200219030-00005. PMID: 12027779
Colesevelam.
Melian EB, Plosker GL
Am J Cardiovasc Drugs 2001;1(2):141-6; discussion 147-8. doi: 10.2165/00129784-200101020-00007. PMID: 14728043

Prognosis

Effect of Acupuncture for Postprandial Distress Syndrome: A Randomized Clinical Trial.
Yang JW, Wang LQ, Zou X, Yan SY, Wang Y, Zhao JJ, Tu JF, Wang J, Shi GX, Hu H, Zhou W, Du Y, Liu CZ
Ann Intern Med 2020 Jun 16;172(12):777-785. Epub 2020 May 12 doi: 10.7326/M19-2880. PMID: 32422066
Functional Dyspepsia and Irritable Bowel Syndrome: Beyond Rome IV.
Stanghellini V
Dig Dis 2017;35 Suppl 1:14-17. Epub 2018 Feb 8 doi: 10.1159/000485408. PMID: 29421792
Managing dyspepsia.
Ford AC, Moayyedi P
Curr Gastroenterol Rep 2009 Aug;11(4):288-94. doi: 10.1007/s11894-009-0042-2. PMID: 19615304
Dyspepsia.
Quigley EM, Keohane J
Curr Opin Gastroenterol 2008 Nov;24(6):692-7. doi: 10.1097/MOG.0b013e328313b983. PMID: 19122517
Dyspepsia and Helicobacter pylori.
Selgrad M, Kandulski A, Malfertheiner P
Dig Dis 2008;26(3):210-4. Epub 2008 May 6 doi: 10.1159/000121348. PMID: 18463437

Clinical prediction guides

Curcumin and proton pump inhibitors for functional dyspepsia: a randomised, double blind controlled trial.
Kongkam P, Khongkha W, Lopimpisuth C, Chumsri C, Kosarussawadee P, Phutrakool P, Khamsai S, Sawanyawisuth K, Sura T, Phisalprapa P, Buamahakul T, Siwamogsatham S, Angsusing J, Poonniam P, Wanaratna K, Teerachaisakul M, Pongpirul K
BMJ Evid Based Med 2023 Nov 22;28(6):399-406. doi: 10.1136/bmjebm-2022-112231. PMID: 37696679
Clinical and Psychological Factors Predict Outcome in Patients With Functional Dyspepsia: A Prospective Study.
Singh P, Ballou S, Rangan V, Katon J, Hassan R, Iturrino J, Lembo A, Nee J
Clin Gastroenterol Hepatol 2022 Jun;20(6):1251-1258.e1. Epub 2021 Jul 31 doi: 10.1016/j.cgh.2021.07.043. PMID: 34339874
Functional dyspepsia: new insights into pathogenesis and therapy.
Talley NJ
Korean J Intern Med 2016 May;31(3):444-56. Epub 2016 Apr 6 doi: 10.3904/kjim.2016.091. PMID: 27048251Free PMC Article
The use of SmartPill for gastric monitoring.
Hasler WL
Expert Rev Gastroenterol Hepatol 2014 Aug;8(6):587-600. Epub 2014 May 31 doi: 10.1586/17474124.2014.922869. PMID: 24881810
Gastroparesis Cardinal Symptom Index (GCSI): development and validation of a patient reported assessment of severity of gastroparesis symptoms.
Revicki DA, Rentz AM, Dubois D, Kahrilas P, Stanghellini V, Talley NJ, Tack J
Qual Life Res 2004 May;13(4):833-44. doi: 10.1023/B:QURE.0000021689.86296.e4. PMID: 15129893

Recent systematic reviews

Effect of glucagon-like peptide-1 receptor agonists on body weight in adults with obesity without diabetes mellitus-a systematic review and meta-analysis of randomized control trials.
Iqbal J, Wu HX, Hu N, Zhou YH, Li L, Xiao F, Wang T, Jiang HL, Xu SN, Huang BL, Zhou HD
Obes Rev 2022 Jun;23(6):e13435. Epub 2022 Feb 22 doi: 10.1111/obr.13435. PMID: 35194917
Ultraprocessed food and chronic noncommunicable diseases: A systematic review and meta-analysis of 43 observational studies.
Lane MM, Davis JA, Beattie S, Gómez-Donoso C, Loughman A, O'Neil A, Jacka F, Berk M, Page R, Marx W, Rocks T
Obes Rev 2021 Mar;22(3):e13146. Epub 2020 Nov 9 doi: 10.1111/obr.13146. PMID: 33167080
Systematic review and network meta-analysis: efficacy of drugs for functional dyspepsia.
Ford AC, Moayyedi P, Black CJ, Yuan Y, Veettil SK, Mahadeva S, Kengkla K, Chaiyakunapruk N, Lee YY
Aliment Pharmacol Ther 2021 Jan;53(1):8-21. Epub 2020 Sep 16 doi: 10.1111/apt.16072. PMID: 32936964
Gastroesophageal Reflux Disease and Probiotics: A Systematic Review.
Cheng J, Ouwehand AC
Nutrients 2020 Jan 2;12(1) doi: 10.3390/nu12010132. PMID: 31906573Free PMC Article
Helicobacter pylori eradication therapy for functional dyspepsia: Systematic review and meta-analysis.
Du LJ, Chen BR, Kim JJ, Kim S, Shen JH, Dai N
World J Gastroenterol 2016 Mar 28;22(12):3486-95. doi: 10.3748/wjg.v22.i12.3486. PMID: 27022230Free PMC Article

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    Clinical resources

    Practice guidelines

    • PubMed
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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2019
      UK NICE Clinical Guideline CG184, Gastro-oesophageal reflux disease and dyspepsia in adults: investigation and management, 2019
    • NICE, 2019
      UK NICE Guideline NG1, Gastro-oesophageal reflux disease in children and young people: diagnosis and management, 2019

    Consumer resources

    Reviews

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