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Large Cell Dysplasia

MedGen UID:
417476
•Concept ID:
C2826559
•
Finding
Synonym: Hepatocellular Large Cell Change

Definition

A premalignant neoplastic lesion of the liver. It is characterized by the presence of hepatocytes with enlarged nuclei and cytoplasm, nuclear pleomorphism, multinucleation, and hyperchromasia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLarge Cell Dysplasia

Recent clinical studies

Etiology

Hürthle cell-predominant thyroid fine needle aspiration cytology: A four risk-factor model highly accurate in excluding malignancy and predicting neoplasm.
Yuan L, Nasr C, Bena JF, Elsheikh TM
Diagn Cytopathol 2022 Sep;50(9):424-435. Epub 2022 Jun 8 doi: 10.1002/dc.25000. PMID: 35674254Free PMC Article
Fine-needle aspiration cytology of Hürthle cell carcinoma of the thyroid.
Wu HH, Clouse J, Ren R
Diagn Cytopathol 2008 Mar;36(3):149-54. doi: 10.1002/dc.20750. PMID: 18232004
Preneoplastic lesions in human hepatocarcinogenesis.
Libbrecht L, Desmet V, Roskams T
Liver Int 2005 Feb;25(1):16-27. doi: 10.1111/j.1478-3231.2005.01016.x. PMID: 15698394
DNA ploidy and liver cell dysplasia in liver biopsies from patients with liver cirrhosis.
El-Sayed SS, El-Sadany M, Tabll AA, Soltan A, El-Dosoky I, Attallah AM
Can J Gastroenterol 2004 Feb;18(2):87-91. doi: 10.1155/2004/638136. PMID: 14997216
Hepatocellular proliferation and development of hepatocellular carcinoma: a case-control study in chronic hepatitis C.
Dutta U, Kench J, Byth K, Khan MH, Lin R, Liddle C, Farrell GC
Hum Pathol 1998 Nov;29(11):1279-84. doi: 10.1016/s0046-8177(98)90257-x. PMID: 9824107

Diagnosis

Preoperative diagnostic categories of fine needle aspiration cytology for histologically proven thyroid follicular adenoma and carcinoma, and Hurthle cell adenoma and carcinoma: Analysis of cause of under- or misdiagnoses.
Na HY, Moon JH, Choi JY, Yu HW, Jeong WJ, Kim YK, Choe JY, Park SY
PLoS One 2020;15(11):e0241597. Epub 2020 Nov 4 doi: 10.1371/journal.pone.0241597. PMID: 33147258Free PMC Article
Preoperative Diagnosis of Neoplastic or Malignant Hürthle Cell Lesions: A Chimera?
Díaz Del Arco C, Fernández Aceñero MJ
Acta Cytol 2018;62(3):193-203. Epub 2018 May 3 doi: 10.1159/000488441. PMID: 29723867
Fine-needle aspiration cytology of Hürthle cell carcinoma of the thyroid.
Wu HH, Clouse J, Ren R
Diagn Cytopathol 2008 Mar;36(3):149-54. doi: 10.1002/dc.20750. PMID: 18232004
DNA ploidy and liver cell dysplasia in liver biopsies from patients with liver cirrhosis.
El-Sayed SS, El-Sadany M, Tabll AA, Soltan A, El-Dosoky I, Attallah AM
Can J Gastroenterol 2004 Feb;18(2):87-91. doi: 10.1155/2004/638136. PMID: 14997216
Premalignant lesions of hepatocellular carcinoma: pathologic viewpoint.
Kojiro M
J Hepatobiliary Pancreat Surg 2000;7(6):535-41. doi: 10.1007/s005340070001. PMID: 11180884

Therapy

Hepatocellular carcinoma without cirrhosis in the West: epidemiological factors and histopathology of the non-tumorous liver. Groupe d'Etude et de Traitement du Carcinome Hépatocellulaire.
Grando-Lemaire V, Guettier C, Chevret S, Beaugrand M, Trinchet JC
J Hepatol 1999 Sep;31(3):508-13. doi: 10.1016/s0168-8278(99)80044-0. PMID: 10488711
Predictive score for the development of hepatocellular carcinoma and additional value of liver large cell dysplasia in Western patients with cirrhosis.
Ganne-Carrié N, Chastang C, Chapel F, Munz C, Pateron D, Sibony M, Dény P, Trinchet JC, Callard P, Guettier C, Beaugrand M
Hepatology 1996 May;23(5):1112-8. doi: 10.1002/hep.510230527. PMID: 8621142

Prognosis

Hürthle cell-predominant thyroid fine needle aspiration cytology: A four risk-factor model highly accurate in excluding malignancy and predicting neoplasm.
Yuan L, Nasr C, Bena JF, Elsheikh TM
Diagn Cytopathol 2022 Sep;50(9):424-435. Epub 2022 Jun 8 doi: 10.1002/dc.25000. PMID: 35674254Free PMC Article
Preoperative Diagnosis of Neoplastic or Malignant Hürthle Cell Lesions: A Chimera?
Díaz Del Arco C, Fernández Aceñero MJ
Acta Cytol 2018;62(3):193-203. Epub 2018 May 3 doi: 10.1159/000488441. PMID: 29723867
Preneoplastic lesions in human hepatocarcinogenesis.
Libbrecht L, Desmet V, Roskams T
Liver Int 2005 Feb;25(1):16-27. doi: 10.1111/j.1478-3231.2005.01016.x. PMID: 15698394
Cytohistologic correlation of cirrhosis and hepatocellular carcinoma. Pitfall in diagnosis?
Hill KA, Nayar R, DeFrias DV
Acta Cytol 2004 Mar-Apr;48(2):127-32. doi: 10.1159/000326304. PMID: 15085741
Liver transplantation for alcoholic liver disease with or without hepatitis C.
Goldar-Najafi A, Gordon FD, Lewis WD, Pomfret E, Pomposelli JJ, Jenkins RL, Khettry U
Int J Surg Pathol 2002 Apr;10(2):115-22. doi: 10.1177/106689690201000204. PMID: 12075404

Clinical prediction guides

Hürthle cell-predominant thyroid fine needle aspiration cytology: A four risk-factor model highly accurate in excluding malignancy and predicting neoplasm.
Yuan L, Nasr C, Bena JF, Elsheikh TM
Diagn Cytopathol 2022 Sep;50(9):424-435. Epub 2022 Jun 8 doi: 10.1002/dc.25000. PMID: 35674254Free PMC Article
Preoperative Diagnosis of Neoplastic or Malignant Hürthle Cell Lesions: A Chimera?
Díaz Del Arco C, Fernández Aceñero MJ
Acta Cytol 2018;62(3):193-203. Epub 2018 May 3 doi: 10.1159/000488441. PMID: 29723867
Fine-needle aspiration cytology of Hürthle cell carcinoma of the thyroid.
Wu HH, Clouse J, Ren R
Diagn Cytopathol 2008 Mar;36(3):149-54. doi: 10.1002/dc.20750. PMID: 18232004
Preneoplastic lesions in human hepatocarcinogenesis.
Libbrecht L, Desmet V, Roskams T
Liver Int 2005 Feb;25(1):16-27. doi: 10.1111/j.1478-3231.2005.01016.x. PMID: 15698394
Hepatocellular proliferation and development of hepatocellular carcinoma: a case-control study in chronic hepatitis C.
Dutta U, Kench J, Byth K, Khan MH, Lin R, Liddle C, Farrell GC
Hum Pathol 1998 Nov;29(11):1279-84. doi: 10.1016/s0046-8177(98)90257-x. PMID: 9824107

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