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Early Favorable Hodgkin Lymphoma

MedGen UID:
418026
•Concept ID:
C2348369
•
Neoplastic Process

Definition

An early Hodgkin lymphoma with favorable prognosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEarly Favorable Hodgkin Lymphoma

Professional guidelines

PubMed

Management of marginal zone lymphomas.
Merli M, Arcaini L
Hematology Am Soc Hematol Educ Program 2022 Dec 9;2022(1):676-687. doi: 10.1182/hematology.2022000362. PMID: 36485086Free PMC Article
Early Progression of Follicular Lymphoma: Biology and Treatment.
Lipof JJ, Barr PM
Hematol Oncol Clin North Am 2020 Aug;34(4):757-769. Epub 2020 May 5 doi: 10.1016/j.hoc.2020.02.009. PMID: 32586579
Risk-Adapted Treatment of Advanced Hodgkin Lymphoma With PET-CT.
Lynch RC, Advani RH
Am Soc Clin Oncol Educ Book 2016;35:e376-85. doi: 10.1200/EDBK_159036. PMID: 27249744

Recent clinical studies

Etiology

Nivolumab and Doxorubicin, Vinblastine, and Dacarbazine in Early-Stage Unfavorable Hodgkin Lymphoma: Final Analysis of the Randomized German Hodgkin Study Group Phase II NIVAHL Trial.
Bröckelmann PJ, Bühnen I, Meissner J, Trautmann-Grill K, Herhaus P, Halbsguth TV, Schaub V, Kerkhoff A, Mathas S, Bormann M, Dickhut A, Kaul H, Fuchs M, Kobe C, Baues C, Borchmann P, Engert A, von Tresckow B
J Clin Oncol 2023 Feb 20;41(6):1193-1199. Epub 2022 Dec 12 doi: 10.1200/JCO.22.02355. PMID: 36508302
Positron Emission Tomography-Guided Treatment in Early-Stage Favorable Hodgkin Lymphoma: Final Results of the International, Randomized Phase III HD16 Trial by the German Hodgkin Study Group.
Fuchs M, Goergen H, Kobe C, Kuhnert G, Lohri A, Greil R, Sasse S, Topp MS, Schäfer E, Hertenstein B, Soekler M, Vogelhuber M, Zijlstra JM, Keller UB, Krause SW, Wilhelm M, Maschmeyer G, Thiemer J, Dührsen U, Meissner J, Viardot A, Eich H, Baues C, Diehl V, Rosenwald A, von Tresckow B, Dietlein M, Borchmann P, Engert A
J Clin Oncol 2019 Nov 1;37(31):2835-2845. Epub 2019 Sep 10 doi: 10.1200/JCO.19.00964. PMID: 31498753
Balancing risk and benefit in early-stage classical Hodgkin lymphoma.
Bröckelmann PJ, Sasse S, Engert A
Blood 2018 Apr 12;131(15):1666-1678. Epub 2018 Mar 2 doi: 10.1182/blood-2017-10-772665. PMID: 29500174
Early Positron Emission Tomography Response-Adapted Treatment in Stage I and II Hodgkin Lymphoma: Final Results of the Randomized EORTC/LYSA/FIL H10 Trial.
André MPE, Girinsky T, Federico M, Reman O, Fortpied C, Gotti M, Casasnovas O, Brice P, van der Maazen R, Re A, Edeline V, Fermé C, van Imhoff G, Merli F, Bouabdallah R, Sebban C, Specht L, Stamatoullas A, Delarue R, Fiaccadori V, Bellei M, Raveloarivahy T, Versari A, Hutchings M, Meignan M, Raemaekers J
J Clin Oncol 2017 Jun 1;35(16):1786-1794. Epub 2017 Mar 14 doi: 10.1200/JCO.2016.68.6394. PMID: 28291393
Hodgkin lymphoma.
Gobbi PG, Ferreri AJ, Ponzoni M, Levis A
Crit Rev Oncol Hematol 2013 Feb;85(2):216-37. Epub 2012 Aug 4 doi: 10.1016/j.critrevonc.2012.07.002. PMID: 22867814

Diagnosis

Management of marginal zone lymphomas.
Merli M, Arcaini L
Hematology Am Soc Hematol Educ Program 2022 Dec 9;2022(1):676-687. doi: 10.1182/hematology.2022000362. PMID: 36485086Free PMC Article
Positron Emission Tomography-Guided Treatment in Early-Stage Favorable Hodgkin Lymphoma: Final Results of the International, Randomized Phase III HD16 Trial by the German Hodgkin Study Group.
Fuchs M, Goergen H, Kobe C, Kuhnert G, Lohri A, Greil R, Sasse S, Topp MS, Schäfer E, Hertenstein B, Soekler M, Vogelhuber M, Zijlstra JM, Keller UB, Krause SW, Wilhelm M, Maschmeyer G, Thiemer J, Dührsen U, Meissner J, Viardot A, Eich H, Baues C, Diehl V, Rosenwald A, von Tresckow B, Dietlein M, Borchmann P, Engert A
J Clin Oncol 2019 Nov 1;37(31):2835-2845. Epub 2019 Sep 10 doi: 10.1200/JCO.19.00964. PMID: 31498753
How I treat early-relapsing follicular lymphoma.
Casulo C, Barr PM
Blood 2019 Apr 4;133(14):1540-1547. Epub 2019 Jan 30 doi: 10.1182/blood-2018-08-822148. PMID: 30700421
Hodgkin lymphoma in elderly patients.
Borchmann S, Engert A, Böll B
Curr Opin Oncol 2018 Sep;30(5):308-316. doi: 10.1097/CCO.0000000000000464. PMID: 29994901
Hodgkin lymphoma.
Gobbi PG, Ferreri AJ, Ponzoni M, Levis A
Crit Rev Oncol Hematol 2013 Feb;85(2):216-37. Epub 2012 Aug 4 doi: 10.1016/j.critrevonc.2012.07.002. PMID: 22867814

Therapy

Nivolumab and Doxorubicin, Vinblastine, and Dacarbazine in Early-Stage Unfavorable Hodgkin Lymphoma: Final Analysis of the Randomized German Hodgkin Study Group Phase II NIVAHL Trial.
Bröckelmann PJ, Bühnen I, Meissner J, Trautmann-Grill K, Herhaus P, Halbsguth TV, Schaub V, Kerkhoff A, Mathas S, Bormann M, Dickhut A, Kaul H, Fuchs M, Kobe C, Baues C, Borchmann P, Engert A, von Tresckow B
J Clin Oncol 2023 Feb 20;41(6):1193-1199. Epub 2022 Dec 12 doi: 10.1200/JCO.22.02355. PMID: 36508302
Cardiotoxicity of BTK inhibitors: ibrutinib and beyond.
Christensen BW, Zaha VG, Awan FT
Expert Rev Hematol 2022 Apr;15(4):321-331. Epub 2022 Apr 22 doi: 10.1080/17474086.2022.2067526. PMID: 35437106
Glofitamab, a Novel, Bivalent CD20-Targeting T-Cell-Engaging Bispecific Antibody, Induces Durable Complete Remissions in Relapsed or Refractory B-Cell Lymphoma: A Phase I Trial.
Hutchings M, Morschhauser F, Iacoboni G, Carlo-Stella C, Offner FC, Sureda A, Salles G, Martínez-Lopez J, Crump M, Thomas DN, Morcos PN, Ferlini C, Bröske AE, Belousov A, Bacac M, Dimier N, Carlile DJ, Lundberg L, Perez-Callejo D, Umaña P, Moore T, Weisser M, Dickinson MJ
J Clin Oncol 2021 Jun 20;39(18):1959-1970. Epub 2021 Mar 19 doi: 10.1200/JCO.20.03175. PMID: 33739857Free PMC Article
Positron Emission Tomography-Guided Treatment in Early-Stage Favorable Hodgkin Lymphoma: Final Results of the International, Randomized Phase III HD16 Trial by the German Hodgkin Study Group.
Fuchs M, Goergen H, Kobe C, Kuhnert G, Lohri A, Greil R, Sasse S, Topp MS, Schäfer E, Hertenstein B, Soekler M, Vogelhuber M, Zijlstra JM, Keller UB, Krause SW, Wilhelm M, Maschmeyer G, Thiemer J, Dührsen U, Meissner J, Viardot A, Eich H, Baues C, Diehl V, Rosenwald A, von Tresckow B, Dietlein M, Borchmann P, Engert A
J Clin Oncol 2019 Nov 1;37(31):2835-2845. Epub 2019 Sep 10 doi: 10.1200/JCO.19.00964. PMID: 31498753
Early Positron Emission Tomography Response-Adapted Treatment in Stage I and II Hodgkin Lymphoma: Final Results of the Randomized EORTC/LYSA/FIL H10 Trial.
André MPE, Girinsky T, Federico M, Reman O, Fortpied C, Gotti M, Casasnovas O, Brice P, van der Maazen R, Re A, Edeline V, Fermé C, van Imhoff G, Merli F, Bouabdallah R, Sebban C, Specht L, Stamatoullas A, Delarue R, Fiaccadori V, Bellei M, Raveloarivahy T, Versari A, Hutchings M, Meignan M, Raemaekers J
J Clin Oncol 2017 Jun 1;35(16):1786-1794. Epub 2017 Mar 14 doi: 10.1200/JCO.2016.68.6394. PMID: 28291393

Prognosis

Theranostics in Hematooncology.
Buck AK, Serfling SE, Kraus S, Samnick S, Dreher N, Higuchi T, Rasche L, Einsele H, Werner RA
J Nucl Med 2023 Jul;64(7):1009-1016. Epub 2023 Jun 8 doi: 10.2967/jnumed.122.265199. PMID: 37290799Free PMC Article
Glofitamab, a Novel, Bivalent CD20-Targeting T-Cell-Engaging Bispecific Antibody, Induces Durable Complete Remissions in Relapsed or Refractory B-Cell Lymphoma: A Phase I Trial.
Hutchings M, Morschhauser F, Iacoboni G, Carlo-Stella C, Offner FC, Sureda A, Salles G, Martínez-Lopez J, Crump M, Thomas DN, Morcos PN, Ferlini C, Bröske AE, Belousov A, Bacac M, Dimier N, Carlile DJ, Lundberg L, Perez-Callejo D, Umaña P, Moore T, Weisser M, Dickinson MJ
J Clin Oncol 2021 Jun 20;39(18):1959-1970. Epub 2021 Mar 19 doi: 10.1200/JCO.20.03175. PMID: 33739857Free PMC Article
Positron Emission Tomography-Guided Treatment in Early-Stage Favorable Hodgkin Lymphoma: Final Results of the International, Randomized Phase III HD16 Trial by the German Hodgkin Study Group.
Fuchs M, Goergen H, Kobe C, Kuhnert G, Lohri A, Greil R, Sasse S, Topp MS, Schäfer E, Hertenstein B, Soekler M, Vogelhuber M, Zijlstra JM, Keller UB, Krause SW, Wilhelm M, Maschmeyer G, Thiemer J, Dührsen U, Meissner J, Viardot A, Eich H, Baues C, Diehl V, Rosenwald A, von Tresckow B, Dietlein M, Borchmann P, Engert A
J Clin Oncol 2019 Nov 1;37(31):2835-2845. Epub 2019 Sep 10 doi: 10.1200/JCO.19.00964. PMID: 31498753
Early Positron Emission Tomography Response-Adapted Treatment in Stage I and II Hodgkin Lymphoma: Final Results of the Randomized EORTC/LYSA/FIL H10 Trial.
André MPE, Girinsky T, Federico M, Reman O, Fortpied C, Gotti M, Casasnovas O, Brice P, van der Maazen R, Re A, Edeline V, Fermé C, van Imhoff G, Merli F, Bouabdallah R, Sebban C, Specht L, Stamatoullas A, Delarue R, Fiaccadori V, Bellei M, Raveloarivahy T, Versari A, Hutchings M, Meignan M, Raemaekers J
J Clin Oncol 2017 Jun 1;35(16):1786-1794. Epub 2017 Mar 14 doi: 10.1200/JCO.2016.68.6394. PMID: 28291393
Hodgkin lymphoma.
Gobbi PG, Ferreri AJ, Ponzoni M, Levis A
Crit Rev Oncol Hematol 2013 Feb;85(2):216-37. Epub 2012 Aug 4 doi: 10.1016/j.critrevonc.2012.07.002. PMID: 22867814

Clinical prediction guides

Nivolumab and Doxorubicin, Vinblastine, and Dacarbazine in Early-Stage Unfavorable Hodgkin Lymphoma: Final Analysis of the Randomized German Hodgkin Study Group Phase II NIVAHL Trial.
Bröckelmann PJ, Bühnen I, Meissner J, Trautmann-Grill K, Herhaus P, Halbsguth TV, Schaub V, Kerkhoff A, Mathas S, Bormann M, Dickhut A, Kaul H, Fuchs M, Kobe C, Baues C, Borchmann P, Engert A, von Tresckow B
J Clin Oncol 2023 Feb 20;41(6):1193-1199. Epub 2022 Dec 12 doi: 10.1200/JCO.22.02355. PMID: 36508302
Glofitamab, a Novel, Bivalent CD20-Targeting T-Cell-Engaging Bispecific Antibody, Induces Durable Complete Remissions in Relapsed or Refractory B-Cell Lymphoma: A Phase I Trial.
Hutchings M, Morschhauser F, Iacoboni G, Carlo-Stella C, Offner FC, Sureda A, Salles G, Martínez-Lopez J, Crump M, Thomas DN, Morcos PN, Ferlini C, Bröske AE, Belousov A, Bacac M, Dimier N, Carlile DJ, Lundberg L, Perez-Callejo D, Umaña P, Moore T, Weisser M, Dickinson MJ
J Clin Oncol 2021 Jun 20;39(18):1959-1970. Epub 2021 Mar 19 doi: 10.1200/JCO.20.03175. PMID: 33739857Free PMC Article
Bacterial infection and non-Hodgkin's lymphoma.
Melenotte C, Mezouar S, Mège JL, Gorvel JP, Kroemer G, Raoult D
Crit Rev Microbiol 2020 May;46(3):270-287. Epub 2020 May 15 doi: 10.1080/1040841X.2020.1760786. PMID: 32412856
Positron Emission Tomography-Guided Treatment in Early-Stage Favorable Hodgkin Lymphoma: Final Results of the International, Randomized Phase III HD16 Trial by the German Hodgkin Study Group.
Fuchs M, Goergen H, Kobe C, Kuhnert G, Lohri A, Greil R, Sasse S, Topp MS, Schäfer E, Hertenstein B, Soekler M, Vogelhuber M, Zijlstra JM, Keller UB, Krause SW, Wilhelm M, Maschmeyer G, Thiemer J, Dührsen U, Meissner J, Viardot A, Eich H, Baues C, Diehl V, Rosenwald A, von Tresckow B, Dietlein M, Borchmann P, Engert A
J Clin Oncol 2019 Nov 1;37(31):2835-2845. Epub 2019 Sep 10 doi: 10.1200/JCO.19.00964. PMID: 31498753
How I treat early-relapsing follicular lymphoma.
Casulo C, Barr PM
Blood 2019 Apr 4;133(14):1540-1547. Epub 2019 Jan 30 doi: 10.1182/blood-2018-08-822148. PMID: 30700421

Recent systematic reviews

Primary extranodal vaginal non-hodgkin lymphoma: Diagnostic pitfalls and therapeutic challenges.
Petrillo M, Fara AM, Fedeli MA, Fozza C, Cossu A, Gulotta A, Dessole F, Piana A, Capobianco G, Tanda F, Dessole S
Histol Histopathol 2019 Jul;34(7):723-730. Epub 2019 Jan 18 doi: 10.14670/HH-18-085. PMID: 30656635
Hodgkin Lymphoma in Adults.
Bröckelmann PJ, Eichenauer DA, Jakob T, Follmann M, Engert A, Skoetz N
Dtsch Arztebl Int 2018 Aug 6;115(31-32):535-540. doi: 10.3238/arztebl.2018.0535. PMID: 30149835Free PMC Article
Comparison of first-line chemotherapy including escalated BEACOPP versus chemotherapy including ABVD for people with early unfavourable or advanced stage Hodgkin lymphoma.
Skoetz N, Will A, Monsef I, Brillant C, Engert A, von Tresckow B
Cochrane Database Syst Rev 2017 May 25;5(5):CD007941. doi: 10.1002/14651858.CD007941.pub3. PMID: 28541603Free PMC Article
Positron emission tomography-adapted therapy for first-line treatment in individuals with Hodgkin lymphoma.
Sickinger MT, von Tresckow B, Kobe C, Engert A, Borchmann P, Skoetz N
Cochrane Database Syst Rev 2015 Jan 9;1(1):CD010533. doi: 10.1002/14651858.CD010533.pub2. PMID: 25572491Free PMC Article
Systematic review of efficacy of dose-dense versus non-dose-dense chemotherapy in breast cancer, non-Hodgkin lymphoma, and non-small cell lung cancer.
Lyman GH, Barron RL, Natoli JL, Miller RM
Crit Rev Oncol Hematol 2012 Mar;81(3):296-308. Epub 2011 Jun 1 doi: 10.1016/j.critrevonc.2011.04.010. PMID: 21636289

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