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Pseudoangiomatous stromal hyperplasia

MedGen UID:
418966
•Concept ID:
C2931031
•
Disease or Syndrome
Synonyms: Mammary pseudoangiomatous stromal hyperplasia; Pseudoangiomatous stromal hyperplasia of the breast
SNOMED CT: Pseudoangiomatous stromal hyperplasia (705153001)

Definition

A benign proliferation of the stromal cells in the breast. It is classified as simple, when associated with the presence of slit-like spaces without erythrocytes and as fascicular/proliferative, when spindle cell proliferation without atypia is present. It is often seen in breast tissue specimens as small foci associated with benign epithelial lesions. Pseudoangiomatous stromal hyperplasia presenting as a well-circumscribed palpable mass is rare. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPseudoangiomatous stromal hyperplasia

Professional guidelines

PubMed

Management of Gynecomastia and Male Benign Diseases.
Karamchandani MM, De La Cruz Ku G, Sokol BL, Chatterjee A, Homsy C
Surg Clin North Am 2022 Dec;102(6):989-1005. doi: 10.1016/j.suc.2022.06.003. PMID: 36335933
Differential Diagnosis of Benign Spindle Cell Lesions.
Magro G
Surg Pathol Clin 2018 Mar;11(1):91-121. Epub 2017 Dec 9 doi: 10.1016/j.path.2017.09.005. PMID: 29413661
Diagnosis and management of benign, atypical, and indeterminate breast lesions detected on core needle biopsy.
Neal L, Sandhu NP, Hieken TJ, Glazebrook KN, Mac Bride MB, Dilaveri CA, Wahner-Roedler DL, Ghosh K, Visscher DW
Mayo Clin Proc 2014 Apr;89(4):536-47. doi: 10.1016/j.mayocp.2014.02.004. PMID: 24684875

Recent clinical studies

Etiology

Pseudoangiomatous stromal hyperplasia: A clinical perspective and a brief review.
Patel G, Bipte S, Narurkar S
J Cancer Res Ther 2023 Oct 1;19(7):1714-1720. Epub 2023 Jan 3 doi: 10.4103/jcrt.jcrt_127_22. PMID: 38376269
Pseudoangiomatous stromal hyperplasia of the breast: Clinical evaluation.
Esmer AC, Tazeoglu D, Dag A
Breast Dis 2023;42(1):115-119. doi: 10.3233/BD-220070. PMID: 37066901
MRI features of pseudoangiomatous stromal hyperplasia with histopathological correlation.
Nia ES, Adrada BE, Whitman GJ, Candelaria RP, Krishnamurthy S, Bassett RL, M Arribas E
Breast J 2021 Mar;27(3):242-247. Epub 2021 Jan 4 doi: 10.1111/tbj.14154. PMID: 33393706
Optimal treatment of pseudoangiomatous stromal hyperplasia of the breast.
Yoon KH, Koo B, Lee KB, Lee H, Lee J, Kim JY, Park HS, Park S, Kim SI, Cho YU, Park BW
Asian J Surg 2020 Jul;43(7):735-741. Epub 2019 Oct 26 doi: 10.1016/j.asjsur.2019.09.008. PMID: 31669037
Pseudoangiomatous stromal hyperplasia: an overview.
Virk RK, Khan A
Arch Pathol Lab Med 2010 Jul;134(7):1070-4. doi: 10.5858/2008-0686-RS.1. PMID: 20586640

Diagnosis

Management of Stromal Lesions.
Yu J, Kansal K
Surg Clin North Am 2022 Dec;102(6):1017-1030. doi: 10.1016/j.suc.2022.07.002. PMID: 36335922
Bilateral Diffuse Pseudoangiomatous Stromal Hyperplasia Necessitating Mastectomy.
Jones VM, Cairns A, Miller-Ocuin J, Steele T, Aguila-Seara G, Ghandili M, LeRoy Coldren D, Marks MW, Howard-McNatt M, Chiba A
Am Surg 2022 Aug;88(8):1919-1921. Epub 2022 Apr 17 doi: 10.1177/00031348221086811. PMID: 35435015
MRI features of pseudoangiomatous stromal hyperplasia with histopathological correlation.
Nia ES, Adrada BE, Whitman GJ, Candelaria RP, Krishnamurthy S, Bassett RL, M Arribas E
Breast J 2021 Mar;27(3):242-247. Epub 2021 Jan 4 doi: 10.1111/tbj.14154. PMID: 33393706
Mesenchymal breast lesions.
Schickman R, Leibman AJ, Handa P, Kornmehl A, Abadi M
Clin Radiol 2015 Jun;70(6):567-75. Epub 2015 Jan 29 doi: 10.1016/j.crad.2014.12.015. PMID: 25638601
Pseudoangiomatous stromal hyperplasia: an overview.
Virk RK, Khan A
Arch Pathol Lab Med 2010 Jul;134(7):1070-4. doi: 10.5858/2008-0686-RS.1. PMID: 20586640

Therapy

Management of Stromal Lesions.
Yu J, Kansal K
Surg Clin North Am 2022 Dec;102(6):1017-1030. doi: 10.1016/j.suc.2022.07.002. PMID: 36335922
Breast hamartoma: reassessment of an under-recognised breast lesion.
Alran L, Chamming's F, Auriol-Leizagoyen S, Velasco V, Deleau F, Brouste V, Bonhomme B, Ben Rejeb H, Marty M, MacGrogan G
Histopathology 2022 Jan;80(2):304-313. Epub 2021 Sep 22 doi: 10.1111/his.14544. PMID: 34403159
Testosterone therapy and breast histopathological features in transgender individuals.
Baker GM, Guzman-Arocho YD, Bret-Mounet VC, Torous VF, Schnitt SJ, Tobias AM, Bartlett RA, Fein-Zachary VJ, Collins LC, Wulf GM, Heng YJ
Mod Pathol 2021 Jan;34(1):85-94. Epub 2020 Sep 16 doi: 10.1038/s41379-020-00675-9. PMID: 32939016Free PMC Article
Pseudoangiomatous stromal hyperplasia (PASH) presenting as axillary lump: case report and review of the literature.
Canu GL, Medas F, Ravarino A, Furcas S, Loi G, Cerrone G, Rossi C, Erdas E, Calò P G
G Chir 2018 Nov-Dec;39(6):378-382. PMID: 30563602
Pseudoangiomatous stromal hyperplasia of the breast.
AbdullGaffar B
Arch Pathol Lab Med 2009 Aug;133(8):1335-8. doi: 10.5858/133.8.1335. PMID: 19653734

Prognosis

Pseudoangiomatous stromal hyperplasia: A clinical perspective and a brief review.
Patel G, Bipte S, Narurkar S
J Cancer Res Ther 2023 Oct 1;19(7):1714-1720. Epub 2023 Jan 3 doi: 10.4103/jcrt.jcrt_127_22. PMID: 38376269
Tumoral pseudoangiomatous stromal hyperplasia (PASH) of the male breast: A systematic analysis.
Salati SA, Sulaiman Alsulaim L, Elmuttalut MA, Alfehaid M, Ahmad Alsuwaydani S
Pol Przegl Chir 2023 Sep 6;96(0):78-83. doi: 10.5604/01.3001.0053.8610. PMID: 38348993
Management of Stromal Lesions.
Yu J, Kansal K
Surg Clin North Am 2022 Dec;102(6):1017-1030. doi: 10.1016/j.suc.2022.07.002. PMID: 36335922
Myofibroblastic, fibroblastic and myoid lesions of the breast.
Krings G, McIntire P, Shin SJ
Semin Diagn Pathol 2017 Sep;34(5):427-437. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.010. PMID: 28751104
Pseudoangiomatous stromal hyperplasia: an overview.
Virk RK, Khan A
Arch Pathol Lab Med 2010 Jul;134(7):1070-4. doi: 10.5858/2008-0686-RS.1. PMID: 20586640

Clinical prediction guides

Pseudoangiomatous stromal hyperplasia: A clinical perspective and a brief review.
Patel G, Bipte S, Narurkar S
J Cancer Res Ther 2023 Oct 1;19(7):1714-1720. Epub 2023 Jan 3 doi: 10.4103/jcrt.jcrt_127_22. PMID: 38376269
Giant juvenile fibroadenomas with and without prominent pseudoangiomatous stromal hyperplasia (PASH)-like change: clinicopathological and molecular characteristics.
Jorns JM, Farooq A, Puzyrenko A, Jarzembowski J, Thike AA, Nasir NDM, Ng CCY, Liu W, Lee JY, Lim AH, Guan P, Teh BT, Tan PH
Histopathology 2023 Sep;83(3):357-365. Epub 2023 May 4 doi: 10.1111/his.14935. PMID: 37140543
Pseudoangiomatous stromal hyperplasia of the breast: Clinical evaluation.
Esmer AC, Tazeoglu D, Dag A
Breast Dis 2023;42(1):115-119. doi: 10.3233/BD-220070. PMID: 37066901
Management of Stromal Lesions.
Yu J, Kansal K
Surg Clin North Am 2022 Dec;102(6):1017-1030. doi: 10.1016/j.suc.2022.07.002. PMID: 36335922
Myofibroblastic, fibroblastic and myoid lesions of the breast.
Krings G, McIntire P, Shin SJ
Semin Diagn Pathol 2017 Sep;34(5):427-437. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.010. PMID: 28751104

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