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Fatty liver

MedGen UID:
41974
Concept ID:
C0015695
Disease or Syndrome
Synonyms: Fatty Liver; Liver, Fatty
SNOMED CT: Fatty liver (197321007); Hepatic lipidosis (197321007)

Definition

Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS. [from MeSH]

Professional guidelines

PubMed

Tapper EB, Parikh ND
JAMA 2023 May 9;329(18):1589-1602. doi: 10.1001/jama.2023.5997. PMID: 37159031Free PMC Article
Pouwels S, Sakran N, Graham Y, Leal A, Pintar T, Yang W, Kassir R, Singhal R, Mahawar K, Ramnarain D
BMC Endocr Disord 2022 Mar 14;22(1):63. doi: 10.1186/s12902-022-00980-1. PMID: 35287643Free PMC Article
Smith JD, Fu E, Kobayashi MA
Annu Rev Clin Psychol 2020 May 7;16:351-378. Epub 2020 Feb 25 doi: 10.1146/annurev-clinpsy-100219-060201. PMID: 32097572Free PMC Article

Recent clinical studies

Etiology

Gofton C, Upendran Y, Zheng MH, George J
Clin Mol Hepatol 2023 Feb;29(Suppl):S17-S31. Epub 2022 Nov 29 doi: 10.3350/cmh.2022.0367. PMID: 36443926Free PMC Article
Cotter TG, Rinella M
Gastroenterology 2020 May;158(7):1851-1864. Epub 2020 Feb 13 doi: 10.1053/j.gastro.2020.01.052. PMID: 32061595
Wang XJ, Malhi H
Ann Intern Med 2018 Nov 6;169(9):ITC65-ITC80. doi: 10.7326/AITC201811060. PMID: 30398639
Friedman SL, Neuschwander-Tetri BA, Rinella M, Sanyal AJ
Nat Med 2018 Jul;24(7):908-922. Epub 2018 Jul 2 doi: 10.1038/s41591-018-0104-9. PMID: 29967350Free PMC Article
Byrne CD, Targher G
J Hepatol 2015 Apr;62(1 Suppl):S47-64. doi: 10.1016/j.jhep.2014.12.012. PMID: 25920090

Diagnosis

Gofton C, Upendran Y, Zheng MH, George J
Clin Mol Hepatol 2023 Feb;29(Suppl):S17-S31. Epub 2022 Nov 29 doi: 10.3350/cmh.2022.0367. PMID: 36443926Free PMC Article
Saiman Y, Duarte-Rojo A, Rinella ME
Annu Rev Med 2022 Jan 27;73:529-544. Epub 2021 Nov 22 doi: 10.1146/annurev-med-042220-020407. PMID: 34809436Free PMC Article
Wang XJ, Malhi H
Ann Intern Med 2018 Nov 6;169(9):ITC65-ITC80. doi: 10.7326/AITC201811060. PMID: 30398639
Byrne CD, Targher G
J Hepatol 2015 Apr;62(1 Suppl):S47-64. doi: 10.1016/j.jhep.2014.12.012. PMID: 25920090
Dietrich P, Hellerbrand C
Best Pract Res Clin Gastroenterol 2014 Aug;28(4):637-53. Epub 2014 Jul 11 doi: 10.1016/j.bpg.2014.07.008. PMID: 25194181

Therapy

Tapper EB, Parikh ND
JAMA 2023 May 9;329(18):1589-1602. doi: 10.1001/jama.2023.5997. PMID: 37159031Free PMC Article
Patikorn C, Roubal K, Veettil SK, Chandran V, Pham T, Lee YY, Giovannucci EL, Varady KA, Chaiyakunapruk N
JAMA Netw Open 2021 Dec 1;4(12):e2139558. doi: 10.1001/jamanetworkopen.2021.39558. PMID: 34919135Free PMC Article
Vuppalanchi R, Noureddin M, Alkhouri N, Sanyal AJ
Nat Rev Gastroenterol Hepatol 2021 Jun;18(6):373-392. Epub 2021 Feb 10 doi: 10.1038/s41575-020-00408-y. PMID: 33568794
Abenavoli L, Izzo AA, Milić N, Cicala C, Santini A, Capasso R
Phytother Res 2018 Nov;32(11):2202-2213. Epub 2018 Aug 6 doi: 10.1002/ptr.6171. PMID: 30080294
Friedman SL, Neuschwander-Tetri BA, Rinella M, Sanyal AJ
Nat Med 2018 Jul;24(7):908-922. Epub 2018 Jul 2 doi: 10.1038/s41591-018-0104-9. PMID: 29967350Free PMC Article

Prognosis

Riazi K, Azhari H, Charette JH, Underwood FE, King JA, Afshar EE, Swain MG, Congly SE, Kaplan GG, Shaheen AA
Lancet Gastroenterol Hepatol 2022 Sep;7(9):851-861. Epub 2022 Jul 5 doi: 10.1016/S2468-1253(22)00165-0. PMID: 35798021
Asrani SK, Devarbhavi H, Eaton J, Kamath PS
J Hepatol 2019 Jan;70(1):151-171. Epub 2018 Sep 26 doi: 10.1016/j.jhep.2018.09.014. PMID: 30266282
Younossi Z, Tacke F, Arrese M, Chander Sharma B, Mostafa I, Bugianesi E, Wai-Sun Wong V, Yilmaz Y, George J, Fan J, Vos MB
Hepatology 2019 Jun;69(6):2672-2682. doi: 10.1002/hep.30251. PMID: 30179269
Chalasani N, Younossi Z, Lavine JE, Charlton M, Cusi K, Rinella M, Harrison SA, Brunt EM, Sanyal AJ
Hepatology 2018 Jan;67(1):328-357. Epub 2017 Sep 29 doi: 10.1002/hep.29367. PMID: 28714183
Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M
Hepatology 2016 Jul;64(1):73-84. Epub 2016 Feb 22 doi: 10.1002/hep.28431. PMID: 26707365

Clinical prediction guides

Newsome PN, Sasso M, Deeks JJ, Paredes A, Boursier J, Chan WK, Yilmaz Y, Czernichow S, Zheng MH, Wong VW, Allison M, Tsochatzis E, Anstee QM, Sheridan DA, Eddowes PJ, Guha IN, Cobbold JF, Paradis V, Bedossa P, Miette V, Fournier-Poizat C, Sandrin L, Harrison SA
Lancet Gastroenterol Hepatol 2020 Apr;5(4):362-373. Epub 2020 Feb 3 doi: 10.1016/S2468-1253(19)30383-8. PMID: 32027858Free PMC Article
Enomoto H, Bando Y, Nakamura H, Nishiguchi S, Koga M
World J Gastroenterol 2015 Jun 28;21(24):7427-35. doi: 10.3748/wjg.v21.i24.7427. PMID: 26139988Free PMC Article
Takahashi Y, Fukusato T
World J Gastroenterol 2014 Nov 14;20(42):15539-48. doi: 10.3748/wjg.v20.i42.15539. PMID: 25400438Free PMC Article
Bedogni G, Bellentani S, Miglioli L, Masutti F, Passalacqua M, Castiglione A, Tiribelli C
BMC Gastroenterol 2006 Nov 2;6:33. doi: 10.1186/1471-230X-6-33. PMID: 17081293Free PMC Article
Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, Ferrell LD, Liu YC, Torbenson MS, Unalp-Arida A, Yeh M, McCullough AJ, Sanyal AJ; Nonalcoholic Steatohepatitis Clinical Research Network
Hepatology 2005 Jun;41(6):1313-21. doi: 10.1002/hep.20701. PMID: 15915461

Recent systematic reviews

Shah ND, Barritt AS 4th
Clin Ther 2022 May;44(5):682-696. Epub 2022 May 25 doi: 10.1016/j.clinthera.2022.04.012. PMID: 35643886
Cariou B, Byrne CD, Loomba R, Sanyal AJ
Diabetes Obes Metab 2021 May;23(5):1069-1083. Epub 2021 Feb 10 doi: 10.1111/dom.14322. PMID: 33464677Free PMC Article
Younossi ZM, Golabi P, de Avila L, Paik JM, Srishord M, Fukui N, Qiu Y, Burns L, Afendy A, Nader F
J Hepatol 2019 Oct;71(4):793-801. Epub 2019 Jul 4 doi: 10.1016/j.jhep.2019.06.021. PMID: 31279902
Dulai PS, Singh S, Patel J, Soni M, Prokop LJ, Younossi Z, Sebastiani G, Ekstedt M, Hagstrom H, Nasr P, Stal P, Wong VW, Kechagias S, Hultcrantz R, Loomba R
Hepatology 2017 May;65(5):1557-1565. Epub 2017 Mar 31 doi: 10.1002/hep.29085. PMID: 28130788Free PMC Article
Rinella ME
JAMA 2015 Jun 9;313(22):2263-73. doi: 10.1001/jama.2015.5370. PMID: 26057287

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