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Chronic hepatic failure

MedGen UID:
423539
•Concept ID:
C2936476
•
Disease or Syndrome
Synonym: Chronic liver failure
SNOMED CT: Chronic hepatic failure (235886005)
 
HPO: HP:0100626
Monarch Initiative: MONDO:0100193

Definition

Liver failure that develops slowly and gradually for some time, possibly for years, often as the result of cirrhosis, or malnutrition. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic hepatic failure

Professional guidelines

PubMed

Mechanism and efficacy of mobilization of granulocyte colony-stimulating factor in the treatment of chronic hepatic failure.
Xing TJ, Xu HT, Xian JC, Shen ML, Li H, Ye J, Zhang LX
Hepatogastroenterology 2013 Jan-Feb;60(121):170-5. doi: 10.5754/hge12590. PMID: 22945339
Pro-inflammatory interleukin-18 and Caspase-1 serum levels in liver failure are unaffected by MARS treatment.
Roth GA, Faybik P, Hetz H, Hacker S, Ankersmit HJ, Bacher A, Thalhammer T, Krenn CG
Dig Liver Dis 2009 Jun;41(6):417-23. Epub 2008 Nov 18 doi: 10.1016/j.dld.2008.09.021. PMID: 19019743
Treatment of hepatic venoocclusive disease with recombinant human tissue plasminogen activator or orthotopic liver transplantation after allogeneic bone marrow transplantation.
Hágglund H, Ringdén O, Ericzon BG, Duraj F, Ljungman P, Lönnqvist B, Winiarski J, Tydén G
Transplantation 1996 Oct 27;62(8):1076-80. doi: 10.1097/00007890-199610270-00009. PMID: 8900305

Recent clinical studies

Etiology

Factors improving mortality in critically ill patients with liver failure - A systematic review.
Kovács E, Maimeri N, Orlando F, Morselli F, Pallanch O, Fedrizzi M, Gál J, Székely A
Physiol Int 2023 Sep 5;110(3):211-226. Epub 2023 Aug 28 doi: 10.1556/2060.2023.00211. PMID: 37639341
Anesthesia for the Patient with Concomitant Hepatic and Renal Impairment.
Brentjens TE, Chadha R
Anesthesiol Clin 2016 Dec;34(4):645-658. doi: 10.1016/j.anclin.2016.06.002. PMID: 27816125
Liver transplantation reverses hypergammaglobulinemia in patients with chronic hepatic failure.
Lebherz-Eichinger D, Schwarzer R, Motal MC, Klaus DA, Mangold A, Ankersmit HJ, Berlakovich GA, Krenn CG, Roth GA
Biochem Med (Zagreb) 2015;25(2):252-61. Epub 2015 Jun 5 doi: 10.11613/BM.2015.026. PMID: 26110038Free PMC Article
Nucleosome serum levels in acute hepatic failure and MARS treatment.
Roth GA, Lubsczyk BA, Pilz J, Faybik P, Hetz H, Krenn CG
Transplant Proc 2009 Dec;41(10):4207-10. doi: 10.1016/j.transproceed.2009.08.073. PMID: 20005370
Liver transplantation. Living donor, hepatocyte, and xenotransplantation.
Sterling RK, Fisher RA
Clin Liver Dis 2001 May;5(2):431-60, vii. doi: 10.1016/s1089-3261(05)70173-2. PMID: 11385971

Diagnosis

Elevated lactate/albumin ratio as a novel predictor of in-hospital mortality in hospitalized cirrhotics.
Krispin I, Mahamid M, Goldin E, Fteiha B
Ann Hepatol 2023 May-Jun;28(3):100897. Epub 2023 Jan 9 doi: 10.1016/j.aohep.2023.100897. PMID: 36632976
Combining K-72 Hepatic Failure with 15 Individual T-Codes to Identify Patients with Idiosyncratic Drug-Induced Liver Injury in the Electronic Medical Record.
Louissaint J, Kassab I, Yeboah-Korang A, Fontana RJ
Dig Dis Sci 2022 Aug;67(8):4243-4249. Epub 2021 Aug 24 doi: 10.1007/s10620-021-07223-8. PMID: 34427818Free PMC Article
Raised intracranial pressure in hepatic encephalopathy.
Mukherjee KK, Chhabra R, Khosla VK
Indian J Gastroenterol 2003 Dec;22 Suppl 2:S62-5. PMID: 15025259
Aetiology and prognostic factors in hepatic failure in central India.
Jaiswal SB, Chitnis DS, Asolkar MV, Naik G, Artwani KK
Trop Gastroenterol 1996 Oct-Dec;17(4):217-20. PMID: 9094861
Chronic acquired hepatic failure: MR imaging of the brain at 1.5 T.
Brunberg JA, Kanal E, Hirsch W, Van Thiel DH
AJNR Am J Neuroradiol 1991 Sep-Oct;12(5):909-14. PMID: 1950920Free PMC Article

Therapy

Factors improving mortality in critically ill patients with liver failure - A systematic review.
Kovács E, Maimeri N, Orlando F, Morselli F, Pallanch O, Fedrizzi M, Gál J, Székely A
Physiol Int 2023 Sep 5;110(3):211-226. Epub 2023 Aug 28 doi: 10.1556/2060.2023.00211. PMID: 37639341
Liver transplantation reverses hypergammaglobulinemia in patients with chronic hepatic failure.
Lebherz-Eichinger D, Schwarzer R, Motal MC, Klaus DA, Mangold A, Ankersmit HJ, Berlakovich GA, Krenn CG, Roth GA
Biochem Med (Zagreb) 2015;25(2):252-61. Epub 2015 Jun 5 doi: 10.11613/BM.2015.026. PMID: 26110038Free PMC Article
Mechanism and efficacy of mobilization of granulocyte colony-stimulating factor in the treatment of chronic hepatic failure.
Xing TJ, Xu HT, Xian JC, Shen ML, Li H, Ye J, Zhang LX
Hepatogastroenterology 2013 Jan-Feb;60(121):170-5. doi: 10.5754/hge12590. PMID: 22945339
Extracorporeal detoxification using the molecular adsorbent recirculating system for critically ill patients with liver failure.
Mitzner SR, Stange J, Klammt S, Peszynski P, Schmidt R, Nöldge-Schomburg G
J Am Soc Nephrol 2001 Feb;12 Suppl 17:S75-82. PMID: 11251037
Fat elimination in chronic hepatic failure: long-chain vs medium-chain triglycerides.
Druml W, Fischer M, Pidlich J, Lenz K
Am J Clin Nutr 1995 Apr;61(4):812-7. doi: 10.1093/ajcn/61.4.812. PMID: 7702024

Prognosis

Elevated lactate/albumin ratio as a novel predictor of in-hospital mortality in hospitalized cirrhotics.
Krispin I, Mahamid M, Goldin E, Fteiha B
Ann Hepatol 2023 May-Jun;28(3):100897. Epub 2023 Jan 9 doi: 10.1016/j.aohep.2023.100897. PMID: 36632976
Combining K-72 Hepatic Failure with 15 Individual T-Codes to Identify Patients with Idiosyncratic Drug-Induced Liver Injury in the Electronic Medical Record.
Louissaint J, Kassab I, Yeboah-Korang A, Fontana RJ
Dig Dis Sci 2022 Aug;67(8):4243-4249. Epub 2021 Aug 24 doi: 10.1007/s10620-021-07223-8. PMID: 34427818Free PMC Article
Liver transplantation reverses hypergammaglobulinemia in patients with chronic hepatic failure.
Lebherz-Eichinger D, Schwarzer R, Motal MC, Klaus DA, Mangold A, Ankersmit HJ, Berlakovich GA, Krenn CG, Roth GA
Biochem Med (Zagreb) 2015;25(2):252-61. Epub 2015 Jun 5 doi: 10.11613/BM.2015.026. PMID: 26110038Free PMC Article
Nucleosome serum levels in acute hepatic failure and MARS treatment.
Roth GA, Lubsczyk BA, Pilz J, Faybik P, Hetz H, Krenn CG
Transplant Proc 2009 Dec;41(10):4207-10. doi: 10.1016/j.transproceed.2009.08.073. PMID: 20005370
Intestinal endotoxemia as a pathogenetic mechanism in liver failure.
Han DW
World J Gastroenterol 2002 Dec;8(6):961-5. doi: 10.3748/wjg.v8.i6.961. PMID: 12439906Free PMC Article

Clinical prediction guides

Elevated lactate/albumin ratio as a novel predictor of in-hospital mortality in hospitalized cirrhotics.
Krispin I, Mahamid M, Goldin E, Fteiha B
Ann Hepatol 2023 May-Jun;28(3):100897. Epub 2023 Jan 9 doi: 10.1016/j.aohep.2023.100897. PMID: 36632976
Combining K-72 Hepatic Failure with 15 Individual T-Codes to Identify Patients with Idiosyncratic Drug-Induced Liver Injury in the Electronic Medical Record.
Louissaint J, Kassab I, Yeboah-Korang A, Fontana RJ
Dig Dis Sci 2022 Aug;67(8):4243-4249. Epub 2021 Aug 24 doi: 10.1007/s10620-021-07223-8. PMID: 34427818Free PMC Article
Proliferation and survival of human amniotic epithelial cells during their hepatic differentiation.
Maymó JL, Riedel R, Pérez-Pérez A, Magatti M, Maskin B, Dueñas JL, Parolini O, Sánchez-Margalet V, Varone CL
PLoS One 2018;13(1):e0191489. Epub 2018 Jan 18 doi: 10.1371/journal.pone.0191489. PMID: 29346426Free PMC Article
Raised intracranial pressure in hepatic encephalopathy.
Mukherjee KK, Chhabra R, Khosla VK
Indian J Gastroenterol 2003 Dec;22 Suppl 2:S62-5. PMID: 15025259
Aetiology and prognostic factors in hepatic failure in central India.
Jaiswal SB, Chitnis DS, Asolkar MV, Naik G, Artwani KK
Trop Gastroenterol 1996 Oct-Dec;17(4):217-20. PMID: 9094861

Recent systematic reviews

Factors improving mortality in critically ill patients with liver failure - A systematic review.
Kovács E, Maimeri N, Orlando F, Morselli F, Pallanch O, Fedrizzi M, Gál J, Székely A
Physiol Int 2023 Sep 5;110(3):211-226. Epub 2023 Aug 28 doi: 10.1556/2060.2023.00211. PMID: 37639341

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