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Grade 2 Follicular Lymphoma

MedGen UID:
42543
•Concept ID:
C0079758
•
Neoplastic Process
Synonyms: Follicular Lymphoma, Grade 2; Follicular Mixed Cell Lymphoma; Follicular Mixed-Cell Lymphoma; Follicular Mixed-Cell Lymphomas; Lymphoma, Follicular Mixed-Cell; Lymphoma, Follicular, Grade 2; Lymphoma, Follicular, Mixed Cell; Lymphoma, Follicular, Mixed Lymphocytic-Histiocytic; Lymphoma, Follicular, Mixed Small and Large Lymphoid; Lymphoma, Follicular, Small and Large Cleaved Cell; Lymphoma, Follicular, Small and Large Cleaved-Cell; Lymphoma, Mixed-Cell, Follicular; Lymphoma, Nodular, Mixed Lymphocytic Histiocytic; Lymphoma, Nodular, Mixed Lymphocytic-Histiocytic; Lymphoma, Nodular, Mixed Small and Large Cell; Lymphomas, Follicular Mixed-Cell; Mixed Cell Lymphoma, Follicular; Mixed-Cell Lymphoma, Follicular; Mixed-Cell Lymphomas, Follicular
SNOMED CT: Follicular non-Hodgkin's lymphoma, mixed small cleaved cell and large cell (clinical) (109971005); Follicular lymphoma, grade 2 (55020008); Follicular non-Hodgkin's lymphoma, mixed small cleaved cell and large cell (109971005); Follicular non-Hodgkin lymphoma, mixed small cleaved cell and large cell (109971005); Follicular non-Hodgkin mixed small cleaved and large cell lymphoma (188672005); Follicular non-Hodgkin's mixed small cleaved and large cell lymphoma (188672005); Follicular lymphoma grade 2 (109971005); Follicular malignant lymphoma - mixed cell type (277624003); Follicular malignant lymphoma - mixed small cleaved and large cell (277624003); Malignant lymphoma, mixed lymphocytic-histiocytic, nodular (307636001); Reticulolymphosarcoma, follicular (307636001); Reticulolymphosarcoma, nodular (307636001); Malignant lymphoma, mixed small cleaved and large cell, follicular (55020008); Malignant lymphoma, mixed lymphocytic-histiocytic, nodular (55020008); Malignant lymphoma, mixed cell type, follicular (55020008); Malignant lymphoma, mixed cell type, nodular (55020008)

Definition

A follicular lymphoma which contains 6-15 centroblasts per 40X high-power microscopic field. [from NCI]

Professional guidelines

PubMed

Follicular lymphoma: 2023 update on diagnosis and management.
Jacobsen E
Am J Hematol 2022 Dec;97(12):1638-1651. Epub 2022 Oct 18 doi: 10.1002/ajh.26737. PMID: 36255040
Management of adults and children receiving CAR T-cell therapy: 2021 best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) and the European Haematology Association (EHA).
Hayden PJ, Roddie C, Bader P, Basak GW, Bonig H, Bonini C, Chabannon C, Ciceri F, Corbacioglu S, Ellard R, Sanchez-Guijo F, Jäger U, Hildebrandt M, Hudecek M, Kersten MJ, Köhl U, Kuball J, Mielke S, Mohty M, Murray J, Nagler A, Rees J, Rioufol C, Saccardi R, Snowden JA, Styczynski J, Subklewe M, Thieblemont C, Topp M, Ispizua ÁU, Chen D, Vrhovac R, Gribben JG, Kröger N, Einsele H, Yakoub-Agha I
Ann Oncol 2022 Mar;33(3):259-275. Epub 2021 Dec 16 doi: 10.1016/j.annonc.2021.12.003. PMID: 34923107
Follicular lymphoma: 2020 update on diagnosis and management.
Freedman A, Jacobsen E
Am J Hematol 2020 Mar;95(3):316-327. Epub 2019 Dec 22 doi: 10.1002/ajh.25696. PMID: 31814159

Recent clinical studies

Etiology

Endoscopic ultrasound-guided fine-needle aspiration of lesions near the aortoiliac bifurcation via an upper gastrointestinal approach.
Doi S, Yasuda I, Nakashima M, Kawaguchi J, Yamauchi T, Iwashita T, Toda K, Adachi S, Shimizu M, Tsurumi H, Moriwaki H
J Gastroenterol Hepatol 2011 Dec;26(12):1717-20. doi: 10.1111/j.1440-1746.2011.06787.x. PMID: 21615791

Diagnosis

Neurolymphomatosis in follicular lymphoma: an autopsy case report.
Ando T, Kamoshita S, Riku Y, Ito A, Ozawa Y, Miyamura K, Fujino M, Ito M, Goto Y, Mano K, Akagi A, Miyahara H, Katsuno M, Yoshida M, Iwasaki Y
Neuropathology 2022 Aug;42(4):295-301. Epub 2022 May 23 doi: 10.1111/neup.12807. PMID: 35607714
Lymphoid proliferation in Eyelid: A Primary Follicular Lymphoma Case.
Cruzado-Sánchez D, Tellez WA, Serpa-Frias S, Maquera G
Gulf J Oncolog 2018 Jan;1(26):58-60. PMID: 29607824
Optimal specimen processing of fine needle aspirates of non-Hodgkin lymphoma.
Shetuni B, Lakey M, Kulesza P
Diagn Cytopathol 2012 Nov;40(11):984-6. Epub 2011 Oct 11 doi: 10.1002/dc.21780. PMID: 21987470
Endoscopic ultrasound-guided fine-needle aspiration of lesions near the aortoiliac bifurcation via an upper gastrointestinal approach.
Doi S, Yasuda I, Nakashima M, Kawaguchi J, Yamauchi T, Iwashita T, Toda K, Adachi S, Shimizu M, Tsurumi H, Moriwaki H
J Gastroenterol Hepatol 2011 Dec;26(12):1717-20. doi: 10.1111/j.1440-1746.2011.06787.x. PMID: 21615791
The prognostic significance of the intra-follicular tumor cell proliferative rate in follicular lymphoma.
Koster A, Tromp HA, Raemaekers JM, Borm GF, Hebeda K, Mackenzie MA, van Krieken JH
Haematologica 2007 Feb;92(2):184-90. doi: 10.3324/haematol.10384. PMID: 17296567

Therapy

Phase II study of CHOP-GR therapy for advanced-stage follicular lymphoma.
Tomita N, Kodama F, Oshima R, Hashimoto C, Koharazawa H, Takemura S, Yamazaki E, Fujimaki K, Sakai R, Fujita H, Fujisawa S, Kanamori H, Motomura S, Ishigatsubo Y
Leuk Lymphoma 2006 Jun;47(6):1041-7. doi: 10.1080/10428190500472784. PMID: 16840195

Prognosis

Lymphoid proliferation in Eyelid: A Primary Follicular Lymphoma Case.
Cruzado-Sánchez D, Tellez WA, Serpa-Frias S, Maquera G
Gulf J Oncolog 2018 Jan;1(26):58-60. PMID: 29607824
The prognostic significance of the intra-follicular tumor cell proliferative rate in follicular lymphoma.
Koster A, Tromp HA, Raemaekers JM, Borm GF, Hebeda K, Mackenzie MA, van Krieken JH
Haematologica 2007 Feb;92(2):184-90. doi: 10.3324/haematol.10384. PMID: 17296567
Phase II study of CHOP-GR therapy for advanced-stage follicular lymphoma.
Tomita N, Kodama F, Oshima R, Hashimoto C, Koharazawa H, Takemura S, Yamazaki E, Fujimaki K, Sakai R, Fujita H, Fujisawa S, Kanamori H, Motomura S, Ishigatsubo Y
Leuk Lymphoma 2006 Jun;47(6):1041-7. doi: 10.1080/10428190500472784. PMID: 16840195

Clinical prediction guides

Neurolymphomatosis in follicular lymphoma: an autopsy case report.
Ando T, Kamoshita S, Riku Y, Ito A, Ozawa Y, Miyamura K, Fujino M, Ito M, Goto Y, Mano K, Akagi A, Miyahara H, Katsuno M, Yoshida M, Iwasaki Y
Neuropathology 2022 Aug;42(4):295-301. Epub 2022 May 23 doi: 10.1111/neup.12807. PMID: 35607714
Endoscopic ultrasound-guided fine-needle aspiration of lesions near the aortoiliac bifurcation via an upper gastrointestinal approach.
Doi S, Yasuda I, Nakashima M, Kawaguchi J, Yamauchi T, Iwashita T, Toda K, Adachi S, Shimizu M, Tsurumi H, Moriwaki H
J Gastroenterol Hepatol 2011 Dec;26(12):1717-20. doi: 10.1111/j.1440-1746.2011.06787.x. PMID: 21615791
The prognostic significance of the intra-follicular tumor cell proliferative rate in follicular lymphoma.
Koster A, Tromp HA, Raemaekers JM, Borm GF, Hebeda K, Mackenzie MA, van Krieken JH
Haematologica 2007 Feb;92(2):184-90. doi: 10.3324/haematol.10384. PMID: 17296567
Phase II study of CHOP-GR therapy for advanced-stage follicular lymphoma.
Tomita N, Kodama F, Oshima R, Hashimoto C, Koharazawa H, Takemura S, Yamazaki E, Fujimaki K, Sakai R, Fujita H, Fujisawa S, Kanamori H, Motomura S, Ishigatsubo Y
Leuk Lymphoma 2006 Jun;47(6):1041-7. doi: 10.1080/10428190500472784. PMID: 16840195

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