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Leriche syndrome

MedGen UID:
44114
•Concept ID:
C0023370
•
Disease or Syndrome
Synonyms: Leriche Syndrome; Leriche's Syndrome; Leriches Syndrome; Syndrome, Leriche; Syndrome, Leriche's
SNOMED CT: Leriche syndrome (307816004); Aortic bifurcation syndrome (233972005); Saddle embolus (233972005); Aortoiliac obstruction (233972005); Saddle embolus of abdominal aorta (233972005); Aortic bifurcation embolus (233972005); Leriche's syndrome (307816004); Saddle embolus (37778000)
 
Monarch Initiative: MONDO:0043683

Definition

An atherosclerotic disorder of the peripheral vascular system affecting mostly males in their later decades. It is caused by thrombotic occlusion of the abdominal aorta just above the level of the bifurcation. Clinical signs include impotence, intermittent claudication, diminished femoral pulses and cold, pallid lower extremities. Prognosis is favorable with surgical or endovascular intervention. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLeriche syndrome

Professional guidelines

PubMed

Endovascular management of aorto-iliac occlusive disease (Leriche syndrome).
Liang HL, Li MF, Hsiao CC, Wu CJ, Wu TH
J Formos Med Assoc 2021 Jul;120(7):1485-1492. Epub 2020 Nov 12 doi: 10.1016/j.jfma.2020.10.033. PMID: 33189506
THE LERICHE SYNDROME-PRESENT CONCEPTS OF DIAGNOSIS AND TREATMENT.
SPENCER FC
Med Rec Ann 1964 Aug;57:443-6. PMID: 14179813
VASOSPASTIC REACTION TO METHYSERGIDE MALEATE SIMULATING LERICHE SYNDROME: INEFFECTIVE TREATMENT WITH ADRENERGIC BLOCKADE.
DANIELL HW
Ann Intern Med 1964 May;60:881-5. doi: 10.7326/0003-4819-60-5-881. PMID: 14156613

Recent clinical studies

Etiology

Pre and Postoperative Sexual Dysfunction in Patients with Leriche Syndrome-A Prospective Pilot Study.
Tkocz M, Brzęk A, Marcinek M, Skrzypulec-Plinta V, Ziaja D
Int J Environ Res Public Health 2022 Mar 6;19(5) doi: 10.3390/ijerph19053091. PMID: 35270783Free PMC Article
Endovascular Reconstruction for Total Aorto-Iliac Occlusion.
Piffaretti G, Fargion AT, Dorigo W, Pulli R, Ferri M, Antonello M, Bellosta R, Veraldi G, Benedetto F, Gargiulo M, Pratesi C; ILIACS Registry Group
J Endovasc Ther 2022 Aug;29(4):565-575. Epub 2021 Dec 1 doi: 10.1177/15266028211059908. PMID: 35112596
Endovascular management of aorto-iliac occlusive disease (Leriche syndrome).
Liang HL, Li MF, Hsiao CC, Wu CJ, Wu TH
J Formos Med Assoc 2021 Jul;120(7):1485-1492. Epub 2020 Nov 12 doi: 10.1016/j.jfma.2020.10.033. PMID: 33189506
A 56-year-old man with co-prevalence of Leriche syndrome and dilated cardiomyopathy: case report and review.
Keller K, Beule J, Oliver Balzer J, Coldewey M, Munzel T, Dippold W, Wild P
Wien Klin Wochenschr 2014 Mar;126(5-6):163-8. Epub 2013 Dec 17 doi: 10.1007/s00508-013-0476-2. PMID: 24343041
Surgical and endovascular treatment of occlusive aortic syndromes.
Verma H, Baliga K, George RK, Tripathi RK
J Cardiovasc Surg (Torino) 2013 Feb;54(1 Suppl 1):55-69. PMID: 23443590

Diagnosis

Leriche syndrome.
Matsuura H, Honda H
Cleve Clin J Med 2021 Sep 1;88(9):482-483. doi: 10.3949/ccjm.88a.20179. PMID: 34470750
Anatomical significance in aortoiliac occlusive disease.
Wooten C, Hayat M, du Plessis M, Cesmebasi A, Koesterer M, Daly KP, Matusz P, Tubbs RS, Loukas M
Clin Anat 2014 Nov;27(8):1264-74. Epub 2014 Jul 25 doi: 10.1002/ca.22444. PMID: 25065617
Leriche syndrome.
Liao SL, Luthra M, Rogers KM
J Am Coll Cardiol 2009 Nov 3;54(19):e11. doi: 10.1016/j.jacc.2009.06.037. PMID: 19874987
Vascular echinococcosis.
Kaynak K, Köksal C, Kazimoğlu K, Ozbek C
Asian Cardiovasc Thorac Ann 2002 Sep;10(3):259-61. doi: 10.1177/021849230201000317. PMID: 12213754
Leriche's syndrome.
Julsrud ME
J Am Podiatr Med Assoc 1992 Apr;82(4):196-201. doi: 10.7547/87507315-82-4-196. PMID: 1597828

Therapy

Endovascular Reconstruction for Total Aorto-Iliac Occlusion.
Piffaretti G, Fargion AT, Dorigo W, Pulli R, Ferri M, Antonello M, Bellosta R, Veraldi G, Benedetto F, Gargiulo M, Pratesi C; ILIACS Registry Group
J Endovasc Ther 2022 Aug;29(4):565-575. Epub 2021 Dec 1 doi: 10.1177/15266028211059908. PMID: 35112596
Leriche syndrome in a patient with acute pulmonary embolism and acute myocardial infarction: a case report and review of literature.
An X, Fu R, Zhao Z, Ni X, Xiong C, Cheng X, Liu Z
BMC Cardiovasc Disord 2020 Jan 17;20(1):26. doi: 10.1186/s12872-019-01288-0. PMID: 31952498Free PMC Article
A 56-year-old man with co-prevalence of Leriche syndrome and dilated cardiomyopathy: case report and review.
Keller K, Beule J, Oliver Balzer J, Coldewey M, Munzel T, Dippold W, Wild P
Wien Klin Wochenschr 2014 Mar;126(5-6):163-8. Epub 2013 Dec 17 doi: 10.1007/s00508-013-0476-2. PMID: 24343041
Surgical and endovascular treatment of occlusive aortic syndromes.
Verma H, Baliga K, George RK, Tripathi RK
J Cardiovasc Surg (Torino) 2013 Feb;54(1 Suppl 1):55-69. PMID: 23443590
Transradial approach to lower extremity interventions.
Korabathina R, Yadav SS, Coppola JT, Staniloae CS
Vasc Health Risk Manag 2010 Aug 9;6:503-9. doi: 10.2147/vhrm.s11529. PMID: 20730066Free PMC Article

Prognosis

Transapical transcatheter aortic valve implantation in patients with aortic diseases.
Useini D, Beluli B, Christ H, Schlömicher M, Ewais E, Patsalis P, Haldenwang P, Naraghi H, Moustafine V, Bechtel M, Strauch J
Eur J Cardiothorac Surg 2021 Jun 14;59(6):1174-1181. doi: 10.1093/ejcts/ezab050. PMID: 33709139
Midterm outcomes of endovascular treatment with bare metal stents for Leriche syndrome patients.
Zhang B, Niu G, Yan Z, Zou Y, Tong X, Yang M
Interact Cardiovasc Thorac Surg 2021 Jan 1;32(1):83-88. doi: 10.1093/icvts/ivaa223. PMID: 33221834Free PMC Article
Acute Leriche Syndrome in Pancreatic Adenocarcinoma: A Case Report.
Mosa E, Manouvelou S, Tolia M, Tsoukalas N, Ardavanis A, Stasinopoulou M, Kyrgias G, Tavernaraki A
Curr Med Imaging 2020;16(5):622-624. doi: 10.2174/1573405615666190206161013. PMID: 32484097
Accelerated Atherogenicity in Tangier Disease.
Muratsu J, Koseki M, Masuda D, Yasuga Y, Tomoyama S, Ataka K, Yagi Y, Nakagawa A, Hamada H, Fujita S, Hattori H, Ohama T, Nishida M, Hiraoka H, Matsuzawa Y, Yamashita S
J Atheroscler Thromb 2018 Oct 1;25(10):1076-1085. Epub 2018 Mar 20 doi: 10.5551/jat.43257. PMID: 29563393Free PMC Article
Infrarenal aortic coarctation.
Alpagut U, Ugurlucan M, Sayin OA, Tireli E, Dayioglu E
Wien Med Wochenschr 2010 Jul;160(13-14):372-5. doi: 10.1007/s10354-010-0810-5. PMID: 20694768

Clinical prediction guides

Pre and Postoperative Sexual Dysfunction in Patients with Leriche Syndrome-A Prospective Pilot Study.
Tkocz M, Brzęk A, Marcinek M, Skrzypulec-Plinta V, Ziaja D
Int J Environ Res Public Health 2022 Mar 6;19(5) doi: 10.3390/ijerph19053091. PMID: 35270783Free PMC Article
Endovascular Reconstruction for Total Aorto-Iliac Occlusion.
Piffaretti G, Fargion AT, Dorigo W, Pulli R, Ferri M, Antonello M, Bellosta R, Veraldi G, Benedetto F, Gargiulo M, Pratesi C; ILIACS Registry Group
J Endovasc Ther 2022 Aug;29(4):565-575. Epub 2021 Dec 1 doi: 10.1177/15266028211059908. PMID: 35112596
Leriche Syndrome Misdiagnosed as Complex Regional Pain Syndrome in a Patient with Neuropathic Pain Caused by a Chip Fracture: A Case Report.
Lee BC, Oh DS, Lee HS, Kim SH, Park JH, Lee KH, Kim HJ, Yang JH, Lee SE
Medicina (Kaunas) 2021 May 12;57(5) doi: 10.3390/medicina57050486. PMID: 34066172Free PMC Article
Transapical transcatheter aortic valve implantation in patients with aortic diseases.
Useini D, Beluli B, Christ H, Schlömicher M, Ewais E, Patsalis P, Haldenwang P, Naraghi H, Moustafine V, Bechtel M, Strauch J
Eur J Cardiothorac Surg 2021 Jun 14;59(6):1174-1181. doi: 10.1093/ejcts/ezab050. PMID: 33709139
Accelerated Atherogenicity in Tangier Disease.
Muratsu J, Koseki M, Masuda D, Yasuga Y, Tomoyama S, Ataka K, Yagi Y, Nakagawa A, Hamada H, Fujita S, Hattori H, Ohama T, Nishida M, Hiraoka H, Matsuzawa Y, Yamashita S
J Atheroscler Thromb 2018 Oct 1;25(10):1076-1085. Epub 2018 Mar 20 doi: 10.5551/jat.43257. PMID: 29563393Free PMC Article

Recent systematic reviews

Update on covered endovascular reconstruction of the aortic bifurcation.
Reijnen MM
Vascular 2020 Jun;28(3):225-232. Epub 2020 Jan 2 doi: 10.1177/1708538119896197. PMID: 31896301
How to avoid and manage complications in aorto-iliac interventions.
Fourneau I
J Cardiovasc Surg (Torino) 2012 Jun;53(3):325-31. PMID: 22695265

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