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Liver Neoplasms, Experimental

MedGen UID:
44184
•Concept ID:
C0023904
•
Experimental Model of Disease; Neoplastic Process
Synonyms: Experimental Liver Neoplasm; Experimental Liver Neoplasms; Liver Neoplasm, Experimental; Neoplasms, Experimental Liver

Definition

Experimentally induced tumors of the LIVER. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLiver Neoplasms, Experimental

Professional guidelines

PubMed

New concepts in the treatment of hepatocellular carcinoma.
Sidali S, Trépo E, Sutter O, Nault JC
United European Gastroenterol J 2022 Sep;10(7):765-774. Epub 2022 Aug 16 doi: 10.1002/ueg2.12286. PMID: 35975347Free PMC Article
Cholangiocarcinoma 2020: the next horizon in mechanisms and management.
Banales JM, Marin JJG, Lamarca A, Rodrigues PM, Khan SA, Roberts LR, Cardinale V, Carpino G, Andersen JB, Braconi C, Calvisi DF, Perugorria MJ, Fabris L, Boulter L, Macias RIR, Gaudio E, Alvaro D, Gradilone SA, Strazzabosco M, Marzioni M, Coulouarn C, Fouassier L, Raggi C, Invernizzi P, Mertens JC, Moncsek A, Rizvi S, Heimbach J, Koerkamp BG, Bruix J, Forner A, Bridgewater J, Valle JW, Gores GJ
Nat Rev Gastroenterol Hepatol 2020 Sep;17(9):557-588. Epub 2020 Jun 30 doi: 10.1038/s41575-020-0310-z. PMID: 32606456Free PMC Article
EAA clinical practice guidelines-gynecomastia evaluation and management.
Kanakis GA, Nordkap L, Bang AK, Calogero AE, Bártfai G, Corona G, Forti G, Toppari J, Goulis DG, Jørgensen N
Andrology 2019 Nov;7(6):778-793. Epub 2019 May 16 doi: 10.1111/andr.12636. PMID: 31099174

Recent clinical studies

Etiology

Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination.
Yu J, Green MD, Li S, Sun Y, Journey SN, Choi JE, Rizvi SM, Qin A, Waninger JJ, Lang X, Chopra Z, El Naqa I, Zhou J, Bian Y, Jiang L, Tezel A, Skvarce J, Achar RK, Sitto M, Rosen BS, Su F, Narayanan SP, Cao X, Wei S, Szeliga W, Vatan L, Mayo C, Morgan MA, Schonewolf CA, Cuneo K, Kryczek I, Ma VT, Lao CD, Lawrence TS, Ramnath N, Wen F, Chinnaiyan AM, Cieslik M, Alva A, Zou W
Nat Med 2021 Jan;27(1):152-164. Epub 2021 Jan 4 doi: 10.1038/s41591-020-1131-x. PMID: 33398162Free PMC Article
Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma.
Li X, Yao W, Yuan Y, Chen P, Li B, Li J, Chu R, Song H, Xie D, Jiang X, Wang H
Gut 2017 Jan;66(1):157-167. Epub 2015 Oct 9 doi: 10.1136/gutjnl-2015-310514. PMID: 26452628
Proteoglycans in liver cancer.
Baghy K, Tátrai P, Regős E, Kovalszky I
World J Gastroenterol 2016 Jan 7;22(1):379-93. doi: 10.3748/wjg.v22.i1.379. PMID: 26755884Free PMC Article
The tamoxifen dilemma.
White IN
Carcinogenesis 1999 Jul;20(7):1153-60. doi: 10.1093/carcin/20.7.1153. PMID: 10383884
Hepatitis B virus immunopathogenesis.
Chisari FV, Ferrari C
Annu Rev Immunol 1995;13:29-60. doi: 10.1146/annurev.iy.13.040195.000333. PMID: 7612225

Diagnosis

Multi-Modal Imaging Probe for Glypican-3 Overexpressed in Orthotopic Hepatocellular Carcinoma.
Feng S, Meng X, Li Z, Chang TS, Wu X, Zhou J, Joshi B, Choi EY, Zhao L, Zhu J, Wang TD
J Med Chem 2021 Nov 11;64(21):15639-15650. Epub 2021 Sep 30 doi: 10.1021/acs.jmedchem.1c00697. PMID: 34590489Free PMC Article
Glucose deprivation-induced aberrant FUT1-mediated fucosylation drives cancer stemness in hepatocellular carcinoma.
Loong JH, Wong TL, Tong M, Sharma R, Zhou L, Ng KY, Yu HJ, Li CH, Man K, Lo CM, Guan XY, Lee TK, Yun JP, Ma SK
J Clin Invest 2021 Jun 1;131(11) doi: 10.1172/JCI143377. PMID: 33878034Free PMC Article
Stem cell origins and animal models of hepatocellular carcinoma.
Aravalli RN, Steer CJ, Sahin MB, Cressman EN
Dig Dis Sci 2010 May;55(5):1241-50. Epub 2009 Jun 10 doi: 10.1007/s10620-009-0861-x. PMID: 19513833
Modeling liver cancer using zebrafish: a comparative oncogenomics approach.
Lam SH, Gong Z
Cell Cycle 2006 Mar;5(6):573-7. Epub 2006 Mar 15 doi: 10.4161/cc.5.6.2550. PMID: 16582610
Mechanism of action of ochratoxin A.
Dirheimer G, Creppy EE
IARC Sci Publ 1991;(115):171-86. PMID: 1820332

Therapy

Environmental eustress modulates β-ARs/CCL2 axis to induce anti-tumor immunity and sensitize immunotherapy against liver cancer in mice.
Liu C, Yang Y, Chen C, Li L, Li J, Wang X, Chu Q, Qiu L, Ba Q, Li X, Wang H
Nat Commun 2021 Sep 30;12(1):5725. doi: 10.1038/s41467-021-25967-9. PMID: 34593796Free PMC Article
Cancer-Associated Fibroblasts Provide a Stromal Niche for Liver Cancer Organoids That Confers Trophic Effects and Therapy Resistance.
Liu J, Li P, Wang L, Li M, Ge Z, Noordam L, Lieshout R, Verstegen MMA, Ma B, Su J, Yang Q, Zhang R, Zhou G, Carrascosa LC, Sprengers D, IJzermans JNM, Smits R, Kwekkeboom J, van der Laan LJW, Peppelenbosch MP, Pan Q, Cao W
Cell Mol Gastroenterol Hepatol 2021;11(2):407-431. Epub 2020 Sep 12 doi: 10.1016/j.jcmgh.2020.09.003. PMID: 32932015Free PMC Article
Antithrombin Insufficiency Promotes Susceptibility to Liver Tumorigenesis.
Iwako H, Tashiro H, Okimoto S, Yamaguchi M, Abe T, Kuroda S, Kobayashi T, Ohdan H
J Surg Res 2019 Apr;236:198-208. Epub 2018 Dec 20 doi: 10.1016/j.jss.2018.11.026. PMID: 30694755
Systemic therapy in hepatocellular carcinoma.
Wrzesinski SH, Taddei TH, Strazzabosco M
Clin Liver Dis 2011 May;15(2):423-41, vii-x. doi: 10.1016/j.cld.2011.03.002. PMID: 21689622Free PMC Article
PDGFRalpha: a new therapeutic target in the treatment of hepatocellular carcinoma?
Oseini AM, Roberts LR
Expert Opin Ther Targets 2009 Apr;13(4):443-54. doi: 10.1517/14728220902719233. PMID: 19335066

Prognosis

Combined inhibition of surface CD51 and γ-secretase-mediated CD51 cleavage improves therapeutic efficacy in experimental metastatic hepatocellular carcinoma.
Cai J, Wang J, Jiang C, Ye L, He X, Huang J, Sun X, Ren Z, Lai X, Qiu Y, Wang H, Lv G, Zheng J, Lu T, Chen H, Liu Y, Chen H, Guan Y, Wang Y, Wang T, Yao J, Sui X, Kang Y, Zhang Y, Li H, Wang J, Li W, Chen G, Yang Y, Xiang AP
J Hepatol 2023 Dec;79(6):1418-1434. Epub 2023 Aug 19 doi: 10.1016/j.jhep.2023.08.007. PMID: 37604269
Glucose deprivation-induced aberrant FUT1-mediated fucosylation drives cancer stemness in hepatocellular carcinoma.
Loong JH, Wong TL, Tong M, Sharma R, Zhou L, Ng KY, Yu HJ, Li CH, Man K, Lo CM, Guan XY, Lee TK, Yun JP, Ma SK
J Clin Invest 2021 Jun 1;131(11) doi: 10.1172/JCI143377. PMID: 33878034Free PMC Article
Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma.
Li X, Yao W, Yuan Y, Chen P, Li B, Li J, Chu R, Song H, Xie D, Jiang X, Wang H
Gut 2017 Jan;66(1):157-167. Epub 2015 Oct 9 doi: 10.1136/gutjnl-2015-310514. PMID: 26452628
The tamoxifen dilemma.
White IN
Carcinogenesis 1999 Jul;20(7):1153-60. doi: 10.1093/carcin/20.7.1153. PMID: 10383884
Hepatocarcinogenesis.
Lau JY, Lai CL
Trop Gastroenterol 1990 Jan-Mar;11(1):9-24. PMID: 2162576

Clinical prediction guides

ATXN7L3B promotes hepatocellular carcinoma stemness and is downregulated by metformin.
Chen B, Cha JH, Yan M, Cao N, Ye P, Yan X, Yang WH
Biochem Biophys Res Commun 2021 Oct 8;573:1-8. Epub 2021 Aug 6 doi: 10.1016/j.bbrc.2021.08.009. PMID: 34375763
Mode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARα) as a case study.
Corton JC, Cunningham ML, Hummer BT, Lau C, Meek B, Peters JM, Popp JA, Rhomberg L, Seed J, Klaunig JE
Crit Rev Toxicol 2014 Jan;44(1):1-49. Epub 2013 Nov 4 doi: 10.3109/10408444.2013.835784. PMID: 24180432
Promotion of hepatocarcinogenesis in humans and animal models.
Köhle C, Schwarz M, Bock KW
Arch Toxicol 2008 Sep;82(9):623-31. Epub 2008 Jan 16 doi: 10.1007/s00204-007-0273-7. PMID: 18204979
A decade's studies on metastasis of hepatocellular carcinoma.
Tang ZY, Ye SL, Liu YK, Qin LX, Sun HC, Ye QH, Wang L, Zhou J, Qiu SJ, Li Y, Ji XN, Liu H, Xia JL, Wu ZQ, Fan J, Ma ZC, Zhou XD, Lin ZY, Liu KD
J Cancer Res Clin Oncol 2004 Apr;130(4):187-96. Epub 2003 Dec 18 doi: 10.1007/s00432-003-0511-1. PMID: 14685850
Human and experimental hepatocarcinogenesis.
Schaff Z, Kovalszky I, Nagy P, Zalatnai A, Jeney A, Lapis K
Scand J Gastroenterol Suppl 1998;228:90-7. doi: 10.1080/003655298750026615. PMID: 9867118

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