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Pelvic organ prolapse, susceptibility to(PVOP1)

MedGen UID:
442887
•Concept ID:
C2752090
•
Finding
Synonyms: PROLAPSE OF VAGINA AND RECTUM; VAGINAL PROLAPSE
 
Monarch Initiative: MONDO:0008313
OMIM®: 176780

Definition

Female pelvic floor disorders, including pelvic organ prolapse (POP), urinary incontinence, and stress urinary incontinence, affect over one-third of adult women (Bump and Norton, 1998). These disorders are characterized by weakening of the tissues supporting and anchoring the pelvic organs, which can affect both structure and function of the vagina, uterus, bladder, anus, and intestines. [from OMIM]

Clinical features

From HPO
Bowel incontinence
MedGen UID:
41977
•Concept ID:
C0015732
•
Disease or Syndrome
Involuntary fecal soiling in adults and children who have usually already been toilet trained.
See: Feature record | Search on this feature
Rectal prolapse
MedGen UID:
11151
•Concept ID:
C0034888
•
Disease or Syndrome
Protrusion of the rectal mucous membrane through the anus.
See: Feature record | Search on this feature
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Professional guidelines

PubMed

Assessment of Metalloproteinase Matrix 9 (MMP9) Gene Polymorphisms Risk Factors for Pelvic Organ Prolapse in the Brazilian Population.
Ghersel FR, Souto RP, Gonzales EWP, Paulo DS, Fernandes CE, Oliveira E
Rev Bras Ginecol Obstet 2019 Mar;41(3):164-169. Epub 2019 Apr 2 doi: 10.1055/s-0039-1681112. PMID: 30939607Free PMC Article
Evaluation of demographic, clinical characteristics, and genetic polymorphism as risk factors for pelvic organ prolapse in Brazilian women.
Martins Kde F, de Jármy-DiBella ZI, da Fonseca AM, Castro RA, da Silva ID, Girão MJ, Sartori MG
Neurourol Urodyn 2011 Sep;30(7):1325-8. Epub 2011 May 23 doi: 10.1002/nau.21066. PMID: 21608022

Curated

UK NICE Guideline NG210, Pelvic floor dysfunction: prevention and non-surgical management, 2021

Recent clinical studies

Etiology

Pregnancy, labour and delivery as risk factors for pelvic organ prolapse: a systematic review.
Cattani L, Decoene J, Page AS, Weeg N, Deprest J, Dietz HP
Int Urogynecol J 2021 Jul;32(7):1623-1631. Epub 2021 Mar 11 doi: 10.1007/s00192-021-04724-y. PMID: 33704536
The vaginal microcirculation after prolapse surgery.
Kastelein AW, Diedrich CM, de Waal L, Ince C, Roovers JWR
Neurourol Urodyn 2020 Jan;39(1):331-338. Epub 2019 Nov 5 doi: 10.1002/nau.24203. PMID: 31691336Free PMC Article
Identification of pelvic organ prolapse risk susceptibility gene SNP locus in Xinjiang women.
Abulaizi A, Abula A, Ababaikeli G, Wan X, Du R, Zhakeer A
Int Urogynecol J 2020 Jan;31(1):123-130. Epub 2019 Jul 2 doi: 10.1007/s00192-019-04039-z. PMID: 31270553
The aetiology of prolapse.
Dietz HP
Int Urogynecol J Pelvic Floor Dysfunct 2008 Oct;19(10):1323-9. Epub 2008 Aug 2 doi: 10.1007/s00192-008-0695-7. PMID: 18677434
Pelvic organ prolapse.
Weber AM, Richter HE
Obstet Gynecol 2005 Sep;106(3):615-34. doi: 10.1097/01.AOG.0000175832.13266.bb. PMID: 16135597

Diagnosis

Genome-Wide Association Study of Pelvic Organ Prolapse Using the Michigan Genomics Initiative.
Cox CK, Pandit A, Zawistowski M, Dutta D, Narla G, Swenson CW
Female Pelvic Med Reconstr Surg 2021 Aug 1;27(8):502-506. doi: 10.1097/SPV.0000000000001075. PMID: 34027909Free PMC Article
Oxidative Stress: A Possible Trigger for Pelvic Organ Prolapse.
Marcu RD, Mischianu DLD, Iorga L, Diaconu CC, Surcel M, Munteanu AN, Constantin C, Isvoranu G, Bratu OG
J Immunol Res 2020;2020:3791934. Epub 2020 Sep 1 doi: 10.1155/2020/3791934. PMID: 32953891Free PMC Article
Identification of pelvic organ prolapse risk susceptibility gene SNP locus in Xinjiang women.
Abulaizi A, Abula A, Ababaikeli G, Wan X, Du R, Zhakeer A
Int Urogynecol J 2020 Jan;31(1):123-130. Epub 2019 Jul 2 doi: 10.1007/s00192-019-04039-z. PMID: 31270553
The aetiology of prolapse.
Dietz HP
Int Urogynecol J Pelvic Floor Dysfunct 2008 Oct;19(10):1323-9. Epub 2008 Aug 2 doi: 10.1007/s00192-008-0695-7. PMID: 18677434
Pelvic organ prolapse.
Weber AM, Richter HE
Obstet Gynecol 2005 Sep;106(3):615-34. doi: 10.1097/01.AOG.0000175832.13266.bb. PMID: 16135597

Therapy

Pregnancy, labour and delivery as risk factors for pelvic organ prolapse: a systematic review.
Cattani L, Decoene J, Page AS, Weeg N, Deprest J, Dietz HP
Int Urogynecol J 2021 Jul;32(7):1623-1631. Epub 2021 Mar 11 doi: 10.1007/s00192-021-04724-y. PMID: 33704536
Prevalence and antimicrobial susceptibility of asymptomatic bacteriuria among women with pelvic organ prolapse in Abakaliki, South-East Nigeria.
Ekwedigwe KC, Sunday-Adeoye I, Eliboh MO, Isikhuemen ME, Uro-Chukwu H, Ezeonu P, Daniyan ABC, Yakubu EN
BMC Womens Health 2018 Mar 27;18(1):53. doi: 10.1186/s12905-018-0545-9. PMID: 29587739Free PMC Article
A review of the impact of pregnancy and childbirth on pelvic floor function as assessed by objective measurement techniques.
Van Geelen H, Ostergard D, Sand P
Int Urogynecol J 2018 Mar;29(3):327-338. Epub 2018 Jan 13 doi: 10.1007/s00192-017-3540-z. PMID: 29332252
Open retropubic colposuspension for urinary incontinence in women.
Lapitan MCM, Cody JD, Mashayekhi A
Cochrane Database Syst Rev 2017 Jul 25;7(7):CD002912. doi: 10.1002/14651858.CD002912.pub7. PMID: 28741303Free PMC Article
The aetiology of prolapse.
Dietz HP
Int Urogynecol J Pelvic Floor Dysfunct 2008 Oct;19(10):1323-9. Epub 2008 Aug 2 doi: 10.1007/s00192-008-0695-7. PMID: 18677434

Prognosis

The rs2018736 fibulin-5 polymorphism as a determinant for pelvic organ prolapse: a case-control study.
Teixeira JB, Bortolini MAT, Silva RSP, Batista NC, Costa E Silva CL, Allen-Brady K, Castro RA
Climacteric 2024 Jun;27(3):321-325. Epub 2024 Mar 27 doi: 10.1080/13697137.2024.2327988. PMID: 38533754
Pelvic Organ Prolapse in a Fighter Pilot with Alpha-1 Antitrypsin Deficiency.
Buckley K, Gann J, Barbier H, Greer J
Aerosp Med Hum Perform 2018 Jan 1;89(1):66-69. doi: 10.3357/AMHP.4964.2018. PMID: 29233247
Retropubic Midurethral Sling Colonization With Staphylococcus lugdunensis.
Stone DE, Swarer KM, Barenberg BJ, OʼLeary DE
Female Pelvic Med Reconstr Surg 2016 May-Jun;22(3):e22-3. doi: 10.1097/SPV.0000000000000281. PMID: 27054795
The aetiology of prolapse.
Dietz HP
Int Urogynecol J Pelvic Floor Dysfunct 2008 Oct;19(10):1323-9. Epub 2008 Aug 2 doi: 10.1007/s00192-008-0695-7. PMID: 18677434
True incidence of vaginal vault prolapse. Thirteen years of experience.
Marchionni M, Bracco GL, Checcucci V, Carabaneanu A, Coccia EM, Mecacci F, Scarselli G
J Reprod Med 1999 Aug;44(8):679-84. PMID: 10483537

Clinical prediction guides

The vaginal microcirculation after prolapse surgery.
Kastelein AW, Diedrich CM, de Waal L, Ince C, Roovers JWR
Neurourol Urodyn 2020 Jan;39(1):331-338. Epub 2019 Nov 5 doi: 10.1002/nau.24203. PMID: 31691336Free PMC Article
Relationship of advanced glycation end products and their receptor to pelvic organ prolapse.
Chen Y, Huang J, Hu C, Hua K
Int J Clin Exp Pathol 2015;8(3):2288-99. Epub 2015 Mar 1 PMID: 26045736Free PMC Article
Evidence for pelvic organ prolapse predisposition genes on chromosomes 10 and 17.
Allen-Brady K, Cannon-Albright LA, Farnham JM, Norton PA
Am J Obstet Gynecol 2015 Jun;212(6):771.e1-7. Epub 2014 Dec 31 doi: 10.1016/j.ajog.2014.12.037. PMID: 25557205Free PMC Article
Genetic epidemiology of pelvic organ prolapse: a systematic review.
Ward RM, Velez Edwards DR, Edwards T, Giri A, Jerome RN, Wu JM
Am J Obstet Gynecol 2014 Oct;211(4):326-35. Epub 2014 Apr 12 doi: 10.1016/j.ajog.2014.04.006. PMID: 24721264Free PMC Article
Pelvic floor disorders: linking genetic risk factors to biochemical changes.
Campeau L, Gorbachinsky I, Badlani GH, Andersson KE
BJU Int 2011 Oct;108(8):1240-7. Epub 2011 Aug 26 doi: 10.1111/j.1464-410X.2011.10385.x. PMID: 21883823

Recent systematic reviews

Pregnancy, labour and delivery as risk factors for pelvic organ prolapse: a systematic review.
Cattani L, Decoene J, Page AS, Weeg N, Deprest J, Dietz HP
Int Urogynecol J 2021 Jul;32(7):1623-1631. Epub 2021 Mar 11 doi: 10.1007/s00192-021-04724-y. PMID: 33704536
Expression changes in pelvic organ prolapse: a systematic review and in silico study.
Khadzhieva MB, Kolobkov DS, Kamoeva SV, Salnikova LE
Sci Rep 2017 Aug 9;7(1):7668. doi: 10.1038/s41598-017-08185-6. PMID: 28794464Free PMC Article
Open retropubic colposuspension for urinary incontinence in women.
Lapitan MCM, Cody JD, Mashayekhi A
Cochrane Database Syst Rev 2017 Jul 25;7(7):CD002912. doi: 10.1002/14651858.CD002912.pub7. PMID: 28741303Free PMC Article
Genetic epidemiology of pelvic organ prolapse: a systematic review.
Ward RM, Velez Edwards DR, Edwards T, Giri A, Jerome RN, Wu JM
Am J Obstet Gynecol 2014 Oct;211(4):326-35. Epub 2014 Apr 12 doi: 10.1016/j.ajog.2014.04.006. PMID: 24721264Free PMC Article
A systematic review of clinical studies on hereditary factors in pelvic organ prolapse.
Lince SL, van Kempen LC, Vierhout ME, Kluivers KB
Int Urogynecol J 2012 Oct;23(10):1327-36. Epub 2012 Mar 16 doi: 10.1007/s00192-012-1704-4. PMID: 22422218Free PMC Article

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    • PubMed
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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2021
      UK NICE Guideline NG210, Pelvic floor dysfunction: prevention and non-surgical management, 2021

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