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Acute Myeloid Leukemia with Gene Mutations

MedGen UID:
443160
Concept ID:
C2826176
Neoplastic Process
Synonym: AML with Gene Mutations

Definition

A term referring to acute myeloid leukemias associated with gene mutations most often of the FLT3, NPM1, and CEBPA genes. These leukemias may have normal karyotypes or additional chromosomal aberrations. [from NCI]

Recent clinical studies

Etiology

Weinberg OK, Porwit A, Orazi A, Hasserjian RP, Foucar K, Duncavage EJ, Arber DA
Virchows Arch 2023 Jan;482(1):27-37. Epub 2022 Oct 20 doi: 10.1007/s00428-022-03430-4. PMID: 36264379
Falini B, Brunetti L, Sportoletti P, Martelli MP
Blood 2020 Oct 8;136(15):1707-1721. doi: 10.1182/blood.2019004226. PMID: 32609823
Prada-Arismendy J, Arroyave JC, Röthlisberger S
Blood Rev 2017 Jan;31(1):63-76. Epub 2016 Sep 2 doi: 10.1016/j.blre.2016.08.005. PMID: 27639498
Papaemmanuil E, Gerstung M, Bullinger L, Gaidzik VI, Paschka P, Roberts ND, Potter NE, Heuser M, Thol F, Bolli N, Gundem G, Van Loo P, Martincorena I, Ganly P, Mudie L, McLaren S, O'Meara S, Raine K, Jones DR, Teague JW, Butler AP, Greaves MF, Ganser A, Döhner K, Schlenk RF, Döhner H, Campbell PJ
N Engl J Med 2016 Jun 9;374(23):2209-2221. doi: 10.1056/NEJMoa1516192. PMID: 27276561Free PMC Article
Cancer Genome Atlas Research Network, Ley TJ, Miller C, Ding L, Raphael BJ, Mungall AJ, Robertson A, Hoadley K, Triche TJ Jr, Laird PW, Baty JD, Fulton LL, Fulton R, Heath SE, Kalicki-Veizer J, Kandoth C, Klco JM, Koboldt DC, Kanchi KL, Kulkarni S, Lamprecht TL, Larson DE, Lin L, Lu C, McLellan MD, McMichael JF, Payton J, Schmidt H, Spencer DH, Tomasson MH, Wallis JW, Wartman LD, Watson MA, Welch J, Wendl MC, Ally A, Balasundaram M, Birol I, Butterfield Y, Chiu R, Chu A, Chuah E, Chun HJ, Corbett R, Dhalla N, Guin R, He A, Hirst C, Hirst M, Holt RA, Jones S, Karsan A, Lee D, Li HI, Marra MA, Mayo M, Moore RA, Mungall K, Parker J, Pleasance E, Plettner P, Schein J, Stoll D, Swanson L, Tam A, Thiessen N, Varhol R, Wye N, Zhao Y, Gabriel S, Getz G, Sougnez C, Zou L, Leiserson MD, Vandin F, Wu HT, Applebaum F, Baylin SB, Akbani R, Broom BM, Chen K, Motter TC, Nguyen K, Weinstein JN, Zhang N, Ferguson ML, Adams C, Black A, Bowen J, Gastier-Foster J, Grossman T, Lichtenberg T, Wise L, Davidsen T, Demchok JA, Shaw KR, Sheth M, Sofia HJ, Yang L, Downing JR, Eley G
N Engl J Med 2013 May 30;368(22):2059-74. Epub 2013 May 1 doi: 10.1056/NEJMoa1301689. PMID: 23634996Free PMC Article

Diagnosis

Weinberg OK, Porwit A, Orazi A, Hasserjian RP, Foucar K, Duncavage EJ, Arber DA
Virchows Arch 2023 Jan;482(1):27-37. Epub 2022 Oct 20 doi: 10.1007/s00428-022-03430-4. PMID: 36264379
Falini B, Brunetti L, Sportoletti P, Martelli MP
Blood 2020 Oct 8;136(15):1707-1721. doi: 10.1182/blood.2019004226. PMID: 32609823
Kishtagari A, Levine RL, Viny AD
Curr Opin Hematol 2020 Mar;27(2):49-57. doi: 10.1097/MOH.0000000000000567. PMID: 31972687Free PMC Article
Prada-Arismendy J, Arroyave JC, Röthlisberger S
Blood Rev 2017 Jan;31(1):63-76. Epub 2016 Sep 2 doi: 10.1016/j.blre.2016.08.005. PMID: 27639498
Papaemmanuil E, Gerstung M, Bullinger L, Gaidzik VI, Paschka P, Roberts ND, Potter NE, Heuser M, Thol F, Bolli N, Gundem G, Van Loo P, Martincorena I, Ganly P, Mudie L, McLaren S, O'Meara S, Raine K, Jones DR, Teague JW, Butler AP, Greaves MF, Ganser A, Döhner K, Schlenk RF, Döhner H, Campbell PJ
N Engl J Med 2016 Jun 9;374(23):2209-2221. doi: 10.1056/NEJMoa1516192. PMID: 27276561Free PMC Article

Therapy

Daver N, Venugopal S, Ravandi F
Blood Cancer J 2021 May 27;11(5):104. doi: 10.1038/s41408-021-00495-3. PMID: 34045454Free PMC Article
Dunbar AJ, Rampal RK, Levine R
Blood 2020 Jul 2;136(1):61-70. doi: 10.1182/blood.2019000943. PMID: 32430500Free PMC Article
Daver N, Schlenk RF, Russell NH, Levis MJ
Leukemia 2019 Feb;33(2):299-312. Epub 2019 Jan 16 doi: 10.1038/s41375-018-0357-9. PMID: 30651634Free PMC Article
Estey EH
Am J Hematol 2018 Oct;93(10):1267-1291. doi: 10.1002/ajh.25214. PMID: 30328165
Papaemmanuil E, Gerstung M, Bullinger L, Gaidzik VI, Paschka P, Roberts ND, Potter NE, Heuser M, Thol F, Bolli N, Gundem G, Van Loo P, Martincorena I, Ganly P, Mudie L, McLaren S, O'Meara S, Raine K, Jones DR, Teague JW, Butler AP, Greaves MF, Ganser A, Döhner K, Schlenk RF, Döhner H, Campbell PJ
N Engl J Med 2016 Jun 9;374(23):2209-2221. doi: 10.1056/NEJMoa1516192. PMID: 27276561Free PMC Article

Prognosis

Falini B, Brunetti L, Sportoletti P, Martelli MP
Blood 2020 Oct 8;136(15):1707-1721. doi: 10.1182/blood.2019004226. PMID: 32609823
Kishtagari A, Levine RL, Viny AD
Curr Opin Hematol 2020 Mar;27(2):49-57. doi: 10.1097/MOH.0000000000000567. PMID: 31972687Free PMC Article
Narayanan D, Weinberg OK
Int J Lab Hematol 2020 Feb;42(1):3-15. Epub 2019 Dec 10 doi: 10.1111/ijlh.13135. PMID: 31820579
Prada-Arismendy J, Arroyave JC, Röthlisberger S
Blood Rev 2017 Jan;31(1):63-76. Epub 2016 Sep 2 doi: 10.1016/j.blre.2016.08.005. PMID: 27639498
Papaemmanuil E, Gerstung M, Bullinger L, Gaidzik VI, Paschka P, Roberts ND, Potter NE, Heuser M, Thol F, Bolli N, Gundem G, Van Loo P, Martincorena I, Ganly P, Mudie L, McLaren S, O'Meara S, Raine K, Jones DR, Teague JW, Butler AP, Greaves MF, Ganser A, Döhner K, Schlenk RF, Döhner H, Campbell PJ
N Engl J Med 2016 Jun 9;374(23):2209-2221. doi: 10.1056/NEJMoa1516192. PMID: 27276561Free PMC Article

Clinical prediction guides

George B, Kantarjian H, Baran N, Krocker JD, Rios A
Int J Mol Sci 2021 Oct 5;22(19) doi: 10.3390/ijms221910782. PMID: 34639121Free PMC Article
Daver N, Schlenk RF, Russell NH, Levis MJ
Leukemia 2019 Feb;33(2):299-312. Epub 2019 Jan 16 doi: 10.1038/s41375-018-0357-9. PMID: 30651634Free PMC Article
Prada-Arismendy J, Arroyave JC, Röthlisberger S
Blood Rev 2017 Jan;31(1):63-76. Epub 2016 Sep 2 doi: 10.1016/j.blre.2016.08.005. PMID: 27639498
Papaemmanuil E, Gerstung M, Bullinger L, Gaidzik VI, Paschka P, Roberts ND, Potter NE, Heuser M, Thol F, Bolli N, Gundem G, Van Loo P, Martincorena I, Ganly P, Mudie L, McLaren S, O'Meara S, Raine K, Jones DR, Teague JW, Butler AP, Greaves MF, Ganser A, Döhner K, Schlenk RF, Döhner H, Campbell PJ
N Engl J Med 2016 Jun 9;374(23):2209-2221. doi: 10.1056/NEJMoa1516192. PMID: 27276561Free PMC Article
Ley TJ, Ding L, Walter MJ, McLellan MD, Lamprecht T, Larson DE, Kandoth C, Payton JE, Baty J, Welch J, Harris CC, Lichti CF, Townsend RR, Fulton RS, Dooling DJ, Koboldt DC, Schmidt H, Zhang Q, Osborne JR, Lin L, O'Laughlin M, McMichael JF, Delehaunty KD, McGrath SD, Fulton LA, Magrini VJ, Vickery TL, Hundal J, Cook LL, Conyers JJ, Swift GW, Reed JP, Alldredge PA, Wylie T, Walker J, Kalicki J, Watson MA, Heath S, Shannon WD, Varghese N, Nagarajan R, Westervelt P, Tomasson MH, Link DC, Graubert TA, DiPersio JF, Mardis ER, Wilson RK
N Engl J Med 2010 Dec 16;363(25):2424-33. Epub 2010 Nov 10 doi: 10.1056/NEJMoa1005143. PMID: 21067377Free PMC Article

Recent systematic reviews

Qin Y, Shen K, Liu T, Ma H
BMC Cancer 2023 Jun 9;23(1):527. doi: 10.1186/s12885-023-11034-7. PMID: 37291515Free PMC Article
Sutandyo N, Mulyasari R, Kosasih A, Rinaldi I, Louisa M, Kevinsyah AP, Winston K
Asian Pac J Cancer Prev 2022 Apr 1;23(4):1107-1116. doi: 10.31557/APJCP.2022.23.4.1107. PMID: 35485665Free PMC Article
Zhou F, Chen B
Hematology 2018 Oct;23(9):608-612. Epub 2018 Jun 12 doi: 10.1080/10245332.2018.1482051. PMID: 29894279
Xu Q, Li Y, Lv N, Jing Y, Xu Y, Li Y, Li W, Yao Z, Chen X, Huang S, Wang L, Li Y, Yu L
Clin Cancer Res 2017 Aug 1;23(15):4511-4522. Epub 2017 Feb 28 doi: 10.1158/1078-0432.CCR-16-2628. PMID: 28246275
Port M, Böttcher M, Thol F, Ganser A, Schlenk R, Wasem J, Neumann A, Pouryamout L
Ann Hematol 2014 Aug;93(8):1279-86. Epub 2014 May 7 doi: 10.1007/s00277-014-2072-6. PMID: 24801015

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