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Neovascularization

MedGen UID:
45041
Concept ID:
C0027686
Pathologic Function
Synonyms: Angiogenesis, Pathologic; Angiogenesis, Pathological; Neovascularization, Pathologic; Neovascularization, Pathological; Pathologic Angiogenesis; Pathologic Neovascularization; Pathological Angiogenesis; Pathological Neovascularization
SNOMED CT: Neovascularization (13018008); Neovascularity (13018008); Vascularization (13018008)

Definition

The formation of new or recent blood vessels. The vasculature network is critical to the development of neoplasms. As the tumor burden grows, vascular endothelial cells are recruited to form new blood vessels as an increased demand for blood and nourishment is required. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeovascularization

Professional guidelines

PubMed

Moncla LM, Briend M, Bossé Y, Mathieu P
Nat Rev Cardiol 2023 Aug;20(8):546-559. Epub 2023 Feb 24 doi: 10.1038/s41569-023-00845-7. PMID: 36829083
Flores R, Carneiro Â, Vieira M, Tenreiro S, Seabra MC
Ophthalmologica 2021;244(6):495-511. Epub 2021 Jun 15 doi: 10.1159/000517520. PMID: 34130290
Knapik JJ, Pope R
J Spec Oper Med 2020 Spring;20(1):125-140. doi: 10.55460/QXTX-A72P. PMID: 32203618

Recent clinical studies

Etiology

Boswell-Patterson CA, Hétu MF, Pang SC, Herr JE, Zhou J, Jain S, Bambokian A, Johri AM
Atherosclerosis 2023 Jun;374:1-10. Epub 2023 May 2 doi: 10.1016/j.atherosclerosis.2023.04.008. PMID: 37149970
Ebrahimiadib N, Maleki A, Fadakar K, Manhapra A, Ghassemi F, Foster CS
Surv Ophthalmol 2021 Jul-Aug;66(4):653-667. Epub 2021 Jan 5 doi: 10.1016/j.survophthal.2020.12.006. PMID: 33412171
Liu S, Romano V, Steger B, Kaye SB, Hamill KJ, Willoughby CE
Surv Ophthalmol 2018 Mar-Apr;63(2):193-213. Epub 2017 Nov 15 doi: 10.1016/j.survophthal.2017.10.006. PMID: 29080632
Jensen LD, Gyllenhaal C, Block K
Biomol Concepts 2014 Jun;5(3):245-56. doi: 10.1515/bmc-2014-0009. PMID: 25372756
Thuruthumaly C, Yee DC, Rao PK
Curr Opin Ophthalmol 2014 Nov;25(6):508-12. doi: 10.1097/ICU.0000000000000100. PMID: 25237930

Diagnosis

Deindl E, Quax PHA
Int J Mol Sci 2021 Dec 9;22(24) doi: 10.3390/ijms222413244. PMID: 34948041Free PMC Article
Nicholas MP, Mysore N
Exp Eye Res 2021 Jan;202:108363. Epub 2020 Nov 19 doi: 10.1016/j.exer.2020.108363. PMID: 33221371
Summerhill V, Orekhov A
Adv Exp Med Biol 2019;1147:279-297. doi: 10.1007/978-3-030-16908-4_13. PMID: 31147883
James JJ, Tennant SL
Clin Radiol 2018 Aug;73(8):715-723. Epub 2018 Jun 21 doi: 10.1016/j.crad.2018.05.005. PMID: 29937340
Spaide RF
Retina 2017 Apr;37(4):609-610. doi: 10.1097/IAE.0000000000001575. PMID: 28207610

Therapy

Hayreh SS
Prog Retin Eye Res 2021 Nov;85:100964. Epub 2021 Mar 11 doi: 10.1016/j.preteyeres.2021.100964. PMID: 33713810
Garcia J, Hurwitz HI, Sandler AB, Miles D, Coleman RL, Deurloo R, Chinot OL
Cancer Treat Rev 2020 Jun;86:102017. Epub 2020 Mar 26 doi: 10.1016/j.ctrv.2020.102017. PMID: 32335505
Tien J
Compr Physiol 2019 Jun 12;9(3):1155-1212. doi: 10.1002/cphy.c180037. PMID: 31187896Free PMC Article
Todorova D, Simoncini S, Lacroix R, Sabatier F, Dignat-George F
Circ Res 2017 May 12;120(10):1658-1673. doi: 10.1161/CIRCRESAHA.117.309681. PMID: 28495996Free PMC Article
Petty AJ, Yang Y
Immunotherapy 2017 Mar;9(3):289-302. doi: 10.2217/imt-2016-0135. PMID: 28231720Free PMC Article

Prognosis

Iorga ER, Costin D
Rom J Ophthalmol 2020 Oct-Dec;64(4):323-332. doi: 10.22336/rjo.2020.54. PMID: 33367170Free PMC Article
Ikuno Y
Retina 2017 Dec;37(12):2347-2351. doi: 10.1097/IAE.0000000000001489. PMID: 28590964
Tsai ASH, Cheung N, Gan ATL, Jaffe GJ, Sivaprasad S, Wong TY, Cheung CMG
Surv Ophthalmol 2017 Jul-Aug;62(4):462-492. Epub 2017 Feb 9 doi: 10.1016/j.survophthal.2017.01.008. PMID: 28189495
Kaszubski P, Ben Ami T, Saade C, Smith RT
Ophthalmic Res 2016;55(4):185-93. Epub 2016 Feb 13 doi: 10.1159/000443209. PMID: 26871899Free PMC Article
Foster PJ, Jiang Y
Eye (Lond) 2014 Feb;28(2):202-8. Epub 2014 Jan 10 doi: 10.1038/eye.2013.280. PMID: 24406412Free PMC Article

Clinical prediction guides

Lin WP, Xing KL, Fu JC, Ling YH, Li SH, Yu WS, Zhang YF, Zhong C, Wang JH, Chen ZY, Lu LH, Wei W, Guo RP
JAMA Netw Open 2021 Sep 1;4(9):e2125055. doi: 10.1001/jamanetworkopen.2021.25055. PMID: 34515782Free PMC Article
Tsitsia V, Svolou P, Kapsalaki E, Theodorou K, Vassiou K, Valotassiou V, Georgoulias P, Fezoulidis I, Tsougos I
Hell J Nucl Med 2017 Jan-Apr;20(1):57-61. PMID: 28426840
McDermott S, Kilcoyne A
QJM 2016 May;109(5):295-9. Epub 2015 Aug 7 doi: 10.1093/qjmed/hcv141. PMID: 26253299Free PMC Article
Ohno-Matsui K, Kawasaki R, Jonas JB, Cheung CM, Saw SM, Verhoeven VJ, Klaver CC, Moriyama M, Shinohara K, Kawasaki Y, Yamazaki M, Meuer S, Ishibashi T, Yasuda M, Yamashita H, Sugano A, Wang JJ, Mitchell P, Wong TY; META-analysis for Pathologic Myopia (META-PM) Study Group
Am J Ophthalmol 2015 May;159(5):877-83.e7. Epub 2015 Jan 26 doi: 10.1016/j.ajo.2015.01.022. PMID: 25634530
Wykrzykowska JJ, Henry TD, Lesser JR, Schwartz RS
Nat Rev Cardiol 2009 Oct;6(10):648-58. Epub 2009 Sep 8 doi: 10.1038/nrcardio.2009.157. PMID: 19736553

Recent systematic reviews

Kirnaz S, Capadona C, Wong T, Goldberg JL, Medary B, Sommer F, McGrath LB Jr, Härtl R
World Neurosurg 2022 Jan;157:264-273. doi: 10.1016/j.wneu.2021.09.066. PMID: 34929784
De Wolde SD, Hulskes RH, Weenink RP, Hollmann MW, Van Hulst RA
Biomolecules 2021 Aug 14;11(8) doi: 10.3390/biom11081210. PMID: 34439876Free PMC Article
Gheorghe A, Mahdi L, Musat O
Rom J Ophthalmol 2015 Apr-Jun;59(2):74-7. PMID: 26978865Free PMC Article
Terelak-Borys B, Skonieczna K, Grabska-Liberek I
Med Sci Monit 2012 Aug;18(8):RA138-144. doi: 10.12659/msm.883260. PMID: 22847215Free PMC Article
Chen YB, LaCasce AS
Expert Opin Investig Drugs 2008 Jun;17(6):939-44. doi: 10.1517/13543784.17.6.939. PMID: 18491994

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