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Fluoxetine response

MedGen UID:
450456
•Concept ID:
CN077984
•
Sign or Symptom
Synonym: Prozac response
Drug:
Fluoxetine
MedGen UID:
42053
•Concept ID:
C0016365
•
Pharmacologic Substance
A diphenhydramine derivative and selective serotonin reuptake inhibitor with antidepressant, anti-anxiety, antiobsessional and antibulimic activity and with potential immunomodulating activity. Upon administration, fluoxetine binds to the presynaptic serotonin (5-HT) receptor resulting in negative allosteric modulation of the receptor complex, thereby blocking recycling of serotonin by the presynaptic receptor. Inhibition of serotonin reuptake by fluoxetine enhances serotonergic function through serotonin accumulation in the synaptic space, resulting in long-term desensitization and downregulation of 5-HT receptors, preventing 5-HT-mediated signaling and leading to antidepressant, anti-anxiety, antiobsessional and antibulimic effects. In addition, fluoxetine may inhibit the expression of pro-inflammatory cytokines, including interleukin-6 (IL-6). This may prevent IL-6-mediated inflammation and cytokine storm. [from NCI]
Fluoxetine

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Professional guidelines

PubMed

Augmentation strategies for treatment resistant major depression: A systematic review and network meta-analysis.
Nuñez NA, Joseph B, Pahwa M, Kumar R, Resendez MG, Prokop LJ, Veldic M, Seshadri A, Biernacka JM, Frye MA, Wang Z, Singh B
J Affect Disord 2022 Apr 1;302:385-400. Epub 2022 Jan 2 doi: 10.1016/j.jad.2021.12.134. PMID: 34986373Free PMC Article
Clinical picture and treatment of bipolar affective disorder in children and adolescents.
Cichoń L, Janas-Kozik M, Siwiec A, Rybakowski JK
Psychiatr Pol 2020 Mar 29;54(1):35-50. doi: 10.12740/PP/OnlineFirst/92740. PMID: 32447355
Update of EULAR recommendations for the treatment of systemic sclerosis.
Kowal-Bielecka O, Fransen J, Avouac J, Becker M, Kulak A, Allanore Y, Distler O, Clements P, Cutolo M, Czirjak L, Damjanov N, Del Galdo F, Denton CP, Distler JHW, Foeldvari I, Figelstone K, Frerix M, Furst DE, Guiducci S, Hunzelmann N, Khanna D, Matucci-Cerinic M, Herrick AL, van den Hoogen F, van Laar JM, Riemekasten G, Silver R, Smith V, Sulli A, Tarner I, Tyndall A, Welling J, Wigley F, Valentini G, Walker UA, Zulian F, Müller-Ladner U; EUSTAR Coauthors
Ann Rheum Dis 2017 Aug;76(8):1327-1339. Epub 2016 Nov 9 doi: 10.1136/annrheumdis-2016-209909. PMID: 27941129

Curated

DailyMed Drug Label, FLUOXETINE capsule HUMAN PRESCRIPTION DRUG LABEL, 2019

DailyMed Drug Label, fluoxetine, 2018

Recent clinical studies

Etiology

Fluoxetine response in impulsive-aggressive behavior and serotonin transporter polymorphism in personality disorder.
Silva H, Iturra P, Solari A, Villarroel J, Jerez S, Jiménez M, Galleguillos F, Bustamante ML
Psychiatr Genet 2010 Feb;20(1):25-30. doi: 10.1097/YPG.0b013e328335125d. PMID: 20010449
Fluoxetine response in children with autistic spectrum disorders: correlation with familial major affective disorder and intellectual achievement.
DeLong GR, Ritch CR, Burch S
Dev Med Child Neurol 2002 Oct;44(10):652-9. doi: 10.1017/s0012162201002717. PMID: 12418789
The functional neuroanatomy of the placebo effect.
Mayberg HS, Silva JA, Brannan SK, Tekell JL, Mahurin RK, McGinnis S, Jerabek PA
Am J Psychiatry 2002 May;159(5):728-37. doi: 10.1176/appi.ajp.159.5.728. PMID: 11986125
Estrogen replacement and response to fluoxetine in a multicenter geriatric depression trial. Fluoxetine Collaborative Study Group.
Schneider LS, Small GW, Hamilton SH, Bystritsky A, Nemeroff CB, Meyers BS
Am J Geriatr Psychiatry 1997 Spring;5(2):97-106. PMID: 9106373
Mood, major depression, and fluoxetine response in cigarette smokers.
Dalack GW, Glassman AH, Rivelli S, Covey L, Stetner F
Am J Psychiatry 1995 Mar;152(3):398-403. doi: 10.1176/ajp.152.3.398. PMID: 7864266

Diagnosis

Early prediction of fluoxetine response for Han Chinese inpatients with major depressive disorder.
Lin CH, Lane HY, Chen CC, Juo SH, Yen CF
J Clin Psychopharmacol 2011 Apr;31(2):187-93. doi: 10.1097/JCP.0b013e318210856f. PMID: 21346612
The role of clinical variables, neuropsychological performance and SLC6A4 and COMT gene polymorphisms on the prediction of early response to fluoxetine in major depressive disorder.
Gudayol-Ferré E, Herrera-Guzmán I, Camarena B, Cortés-Penagos C, Herrera-Abarca JE, Martínez-Medina P, Cruz D, Hernández S, Genis A, Carrillo-Guerrero MY, Avilés Reyes R, Guàrdia-Olmos J
J Affect Disord 2010 Dec;127(1-3):343-51. Epub 2010 Jul 2 doi: 10.1016/j.jad.2010.06.002. PMID: 20584552
Fluoxetine response in children with autistic spectrum disorders: correlation with familial major affective disorder and intellectual achievement.
DeLong GR, Ritch CR, Burch S
Dev Med Child Neurol 2002 Oct;44(10):652-9. doi: 10.1017/s0012162201002717. PMID: 12418789
Clinical response predictors in a double-blind, placebo-controlled trial of fluoxetine for geriatric major depression. Fluoxetine Collaborative Study Group.
Small GW, Hamilton SH, Bystritsky A, Meyers BS, Nemeroff CB
Int Psychogeriatr 1995;7 Suppl:41-53. doi: 10.1017/s1041610295002341. PMID: 8580391
Mood, major depression, and fluoxetine response in cigarette smokers.
Dalack GW, Glassman AH, Rivelli S, Covey L, Stetner F
Am J Psychiatry 1995 Mar;152(3):398-403. doi: 10.1176/ajp.152.3.398. PMID: 7864266

Therapy

Association Study Between Serotonin Transporter Gene and Fluoxetine Response in Mexican Patients With Major Depressive Disorder.
Camarena B, Álvarez-Icaza D, Hernández S, Aguilar A, Münch L, Martínez C, Becerra-Palars C
Clin Neuropharmacol 2019 Jan/Feb;42(1):9-13. doi: 10.1097/WNF.0000000000000315. PMID: 30520759
Evaluation of interleukin-6 and serotonin as biomarkers to predict response to fluoxetine.
Manoharan A, Rajkumar RP, Shewade DG, Sundaram R, Muthuramalingam A, Paul A
Hum Psychopharmacol 2016 May;31(3):178-84. Epub 2016 Mar 27 doi: 10.1002/hup.2525. PMID: 27018372
Fluoxetine pharmacogenetics in child and adult populations.
Blazquez A, Mas S, Plana MT, Lafuente A, Lázaro L
Eur Child Adolesc Psychiatry 2012 Nov;21(11):599-610. Epub 2012 Jul 12 doi: 10.1007/s00787-012-0305-6. PMID: 22791347
Fluoxetine response in impulsive-aggressive behavior and serotonin transporter polymorphism in personality disorder.
Silva H, Iturra P, Solari A, Villarroel J, Jerez S, Jiménez M, Galleguillos F, Bustamante ML
Psychiatr Genet 2010 Feb;20(1):25-30. doi: 10.1097/YPG.0b013e328335125d. PMID: 20010449
Estrogen replacement and response to fluoxetine in a multicenter geriatric depression trial. Fluoxetine Collaborative Study Group.
Schneider LS, Small GW, Hamilton SH, Bystritsky A, Nemeroff CB, Meyers BS
Am J Geriatr Psychiatry 1997 Spring;5(2):97-106. PMID: 9106373

Prognosis

Evaluation of interleukin-6 and serotonin as biomarkers to predict response to fluoxetine.
Manoharan A, Rajkumar RP, Shewade DG, Sundaram R, Muthuramalingam A, Paul A
Hum Psychopharmacol 2016 May;31(3):178-84. Epub 2016 Mar 27 doi: 10.1002/hup.2525. PMID: 27018372
Early prediction of fluoxetine response for Han Chinese inpatients with major depressive disorder.
Lin CH, Lane HY, Chen CC, Juo SH, Yen CF
J Clin Psychopharmacol 2011 Apr;31(2):187-93. doi: 10.1097/JCP.0b013e318210856f. PMID: 21346612
Fluoxetine response in impulsive-aggressive behavior and serotonin transporter polymorphism in personality disorder.
Silva H, Iturra P, Solari A, Villarroel J, Jerez S, Jiménez M, Galleguillos F, Bustamante ML
Psychiatr Genet 2010 Feb;20(1):25-30. doi: 10.1097/YPG.0b013e328335125d. PMID: 20010449
Fluoxetine response in children with autistic spectrum disorders: correlation with familial major affective disorder and intellectual achievement.
DeLong GR, Ritch CR, Burch S
Dev Med Child Neurol 2002 Oct;44(10):652-9. doi: 10.1017/s0012162201002717. PMID: 12418789
Side effects and time course of response in a placebo-controlled trial of fluoxetine for the treatment of geriatric depression.
Ackerman DL, Greenland S, Bystritsky A, Small GW
J Clin Psychopharmacol 2000 Dec;20(6):658-65. doi: 10.1097/00004714-200012000-00012. PMID: 11106138

Clinical prediction guides

Association Study Between Serotonin Transporter Gene and Fluoxetine Response in Mexican Patients With Major Depressive Disorder.
Camarena B, Álvarez-Icaza D, Hernández S, Aguilar A, Münch L, Martínez C, Becerra-Palars C
Clin Neuropharmacol 2019 Jan/Feb;42(1):9-13. doi: 10.1097/WNF.0000000000000315. PMID: 30520759
Evaluation of interleukin-6 and serotonin as biomarkers to predict response to fluoxetine.
Manoharan A, Rajkumar RP, Shewade DG, Sundaram R, Muthuramalingam A, Paul A
Hum Psychopharmacol 2016 May;31(3):178-84. Epub 2016 Mar 27 doi: 10.1002/hup.2525. PMID: 27018372
Early prediction of fluoxetine response for Han Chinese inpatients with major depressive disorder.
Lin CH, Lane HY, Chen CC, Juo SH, Yen CF
J Clin Psychopharmacol 2011 Apr;31(2):187-93. doi: 10.1097/JCP.0b013e318210856f. PMID: 21346612
Fluoxetine response in impulsive-aggressive behavior and serotonin transporter polymorphism in personality disorder.
Silva H, Iturra P, Solari A, Villarroel J, Jerez S, Jiménez M, Galleguillos F, Bustamante ML
Psychiatr Genet 2010 Feb;20(1):25-30. doi: 10.1097/YPG.0b013e328335125d. PMID: 20010449
Clinical predictors of early fluoxetine treatment response in obsessive-compulsive disorder.
Storch EA, Larson MJ, Shapira NA, Ward HE, Murphy TK, Geffken GR, Valerio H, Goodman WK
Depress Anxiety 2006;23(7):429-33. doi: 10.1002/da.20197. PMID: 16841343

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