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Hemihypertrophy of upper limb

MedGen UID:
451054
•Concept ID:
C0431810
•
Congenital Abnormality
Synonyms: Overgrowth of one arm; Overgrowth of upper limb
SNOMED CT: Hemihypertrophy of upper limb (253920006); Overgrowth of upper limb (253920006)
 
HPO: HP:0100554

Definition

Overgrowth of only one arm. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHemihypertrophy of upper limb

Professional guidelines

PubMed

Vascular abnormalities of the extremities: clinical findings and management.
Rogalski R, Hensinger R, Loder R
J Pediatr Orthop 1993 Jan-Feb;13(1):9-14. doi: 10.1097/01241398-199301000-00003. PMID: 8416363

Recent clinical studies

Etiology

Axial and appendicular body proportions for evaluation of limb and trunk asymmetry.
Weinberg DS, Liu RW, Li SQ, Sanders JO, Cooperman DR
Acta Orthop 2017 Apr;88(2):185-191. Epub 2016 Dec 21 doi: 10.1080/17453674.2016.1265876. PMID: 27998211Free PMC Article
Idiopathic hemihypertrophy.
Mohanna MA, Sallam AK
Saudi Med J 2014 Apr;35(4):403-5. PMID: 24749139
Congenital hemihypertrophy with hemihypertrichosis.
Akarsu S, Coskun BK, Aydin AM, Tekatli M, Aygun AD
J Dermatol 2005 Jun;32(6):478-81. doi: 10.1111/j.1346-8138.2005.tb00784.x. PMID: 16043924
Twelve cases with hemihypertrophy: etiology and follow up.
Stoll C, Alembik Y, Steib JP, De Saint-Martin A
Genet Couns 1993;4(2):119-26. PMID: 8357562
Beckwith-Wiedemann syndrome: role of ultrasound in its management.
Shah KJ
Clin Radiol 1983 May;34(3):313-9. doi: 10.1016/s0009-9260(83)80346-8. PMID: 6301743

Diagnosis

Case for diagnosis. Vascular malformations, hemihypertrophy and macrodactyly: Proteus syndrome.
Barbosa BEDC, Alfredo MAC, Abbade LPF, Miot HA
An Bras Dermatol 2023 May-Jun;98(3):384-386. Epub 2023 Feb 6 doi: 10.1016/j.abd.2021.11.012. PMID: 36754650Free PMC Article
Idiopathic hemihypertrophy.
Mohanna MA, Sallam AK
Saudi Med J 2014 Apr;35(4):403-5. PMID: 24749139
Congenital hemihypertrophy with hemihypertrichosis.
Akarsu S, Coskun BK, Aydin AM, Tekatli M, Aygun AD
J Dermatol 2005 Jun;32(6):478-81. doi: 10.1111/j.1346-8138.2005.tb00784.x. PMID: 16043924
Hemihypertrophy. Concepts and controversies.
Ballock RT, Wiesner GL, Myers MT, Thompson GH
J Bone Joint Surg Am 1997 Nov;79(11):1731-8. doi: 10.2106/00004623-199711000-00016. PMID: 9384434
Proteus syndrome.
Samlaska CP, Levin SW, James WD, Benson PM, Walker JC, Perlik PC
Arch Dermatol 1989 Aug;125(8):1109-14. PMID: 2667470

Prognosis

Axial and appendicular body proportions for evaluation of limb and trunk asymmetry.
Weinberg DS, Liu RW, Li SQ, Sanders JO, Cooperman DR
Acta Orthop 2017 Apr;88(2):185-191. Epub 2016 Dec 21 doi: 10.1080/17453674.2016.1265876. PMID: 27998211Free PMC Article
Congenital hemihypertrophy with hemihypertrichosis.
Akarsu S, Coskun BK, Aydin AM, Tekatli M, Aygun AD
J Dermatol 2005 Jun;32(6):478-81. doi: 10.1111/j.1346-8138.2005.tb00784.x. PMID: 16043924
Vascular abnormalities of the extremities: clinical findings and management.
Rogalski R, Hensinger R, Loder R
J Pediatr Orthop 1993 Jan-Feb;13(1):9-14. doi: 10.1097/01241398-199301000-00003. PMID: 8416363
Twelve cases with hemihypertrophy: etiology and follow up.
Stoll C, Alembik Y, Steib JP, De Saint-Martin A
Genet Couns 1993;4(2):119-26. PMID: 8357562
Beckwith-Wiedemann syndrome: role of ultrasound in its management.
Shah KJ
Clin Radiol 1983 May;34(3):313-9. doi: 10.1016/s0009-9260(83)80346-8. PMID: 6301743

Clinical prediction guides

CHOROIDAL MELANOMA IN PHAKOMATOSIS PIGMENTOVASCULARIS WITH OVERLAPPING STURGE-WEBER SYNDROME AND KLIPPEL-TRENAUNAY SYNDROME.
Fry MV, Williams BK Jr, Kim HJ, Di Nicola M
Retin Cases Brief Rep 2023 Mar 1;17(2):130-133. doi: 10.1097/ICB.0000000000001154. PMID: 33907078
Axial and appendicular body proportions for evaluation of limb and trunk asymmetry.
Weinberg DS, Liu RW, Li SQ, Sanders JO, Cooperman DR
Acta Orthop 2017 Apr;88(2):185-191. Epub 2016 Dec 21 doi: 10.1080/17453674.2016.1265876. PMID: 27998211Free PMC Article
Vascular abnormalities of the extremities: clinical findings and management.
Rogalski R, Hensinger R, Loder R
J Pediatr Orthop 1993 Jan-Feb;13(1):9-14. doi: 10.1097/01241398-199301000-00003. PMID: 8416363
Macrodactyly in Proteus syndrome.
Miura H, Uchida Y, Ihara K, Sugioka Y
J Hand Surg Br 1993 Jun;18(3):308-9. doi: 10.1016/0266-7681(93)90047-j. PMID: 8345255
Limb overgrowth--clinical observations and nosological considerations.
Pearn J, Viljoen D, Beighton P
S Afr Med J 1983 Nov 26;64(23):905-8. PMID: 6314563

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