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Sympathetic ophthalmia

MedGen UID:
45203
Concept ID:
C0029077
Disease or Syndrome
Synonyms: Ophthalmia, Sympathetic; Ophthalmias, Sympathetic; Sympathetic Ophthalmia; Sympathetic Ophthalmias; Sympathetic Uveitides; Sympathetic Uveitis; Uveitides, Sympathetic; Uveitis, Sympathetic
SNOMED CT: Sympathetic uveitis (75315001); Sympathetic ophthalmitis (75315001); Sympathetic ophthalmia (75315001)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0019198
Orphanet: ORPHA79098

Definition

Sympathetic ophthalmia (SO) is a bilateral granulomatous anterior uveitis usually occurring within the three months following trauma or a surgical procedure involving one eye. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSympathetic ophthalmia
Follow this link to review classifications for Sympathetic ophthalmia in Orphanet.

Professional guidelines

PubMed

Özdemir Yalçınsoy K, Özdamar Erol Y, Çakar Özdal P
Turk J Ophthalmol 2023 Feb 24;53(1):23-29. doi: 10.4274/tjo.galenos.2022.53383. PMID: 36847630Free PMC Article
Fromal OV, Swaminathan V, Soares RR, Ho AC
Curr Opin Ophthalmol 2021 Nov 1;32(6):555-560. doi: 10.1097/ICU.0000000000000803. PMID: 34494974
Standardization of Uveitis Nomenclature (SUN) Working Group
Am J Ophthalmol 2021 Aug;228:212-219. Epub 2021 May 11 doi: 10.1016/j.ajo.2021.03.048. PMID: 33845005Free PMC Article

Recent clinical studies

Etiology

Jordan DR, J Dutton J
Ophthalmic Plast Reconstr Surg 2022 Jul-Aug 01;38(4):315-324. Epub 2022 Sep 28 doi: 10.1097/IOP.0000000000002068. PMID: 34593714
He B, Tanya SM, Wang C, Kezouh A, Torun N, Ing E
Am J Ophthalmol 2022 Feb;234:117-125. Epub 2021 Jul 17 doi: 10.1016/j.ajo.2021.06.036. PMID: 34283983
Standardization of Uveitis Nomenclature (SUN) Working Group
Am J Ophthalmol 2021 Aug;228:212-219. Epub 2021 May 11 doi: 10.1016/j.ajo.2021.03.048. PMID: 33845005Free PMC Article
Zhong Z, Su G, Kijlstra A, Yang P
Prog Retin Eye Res 2021 Jan;80:100866. Epub 2020 May 16 doi: 10.1016/j.preteyeres.2020.100866. PMID: 32422390
Castiblanco CP, Adelman RA
Graefes Arch Clin Exp Ophthalmol 2009 Mar;247(3):289-302. Epub 2008 Sep 16 doi: 10.1007/s00417-008-0939-8. PMID: 18795315

Diagnosis

Parchand S, Agrawal D, Ayyadurai N, Agarwal A, Gangwe A, Behera S, Bhatia P, Mulkutkar S, Barwar G, Singh R, Sen A, Agarwal M
Indian J Ophthalmol 2022 Jun;70(6):1931-1944. doi: 10.4103/ijo.IJO_2363_21. PMID: 35647958Free PMC Article
Zhong Z, Su G, Kijlstra A, Yang P
Prog Retin Eye Res 2021 Jan;80:100866. Epub 2020 May 16 doi: 10.1016/j.preteyeres.2020.100866. PMID: 32422390
Cunningham ET Jr, Kilmartin D, Agarwal M, Zierhut M
Ocul Immunol Inflamm 2017 Apr;25(2):149-151. doi: 10.1080/09273948.2017.1305727. PMID: 28414613
Mahajan S, Invernizzi A, Agrawal R, Biswas J, Rao NA, Gupta V
Ocul Immunol Inflamm 2017 Apr;25(2):152-159. Epub 2016 Dec 14 doi: 10.1080/09273948.2016.1255339. PMID: 27960610
Chang GC, Young LH
Semin Ophthalmol 2011 Jul-Sep;26(4-5):316-20. doi: 10.3109/08820538.2011.588658. PMID: 21958181

Therapy

Parchand S, Agrawal D, Ayyadurai N, Agarwal A, Gangwe A, Behera S, Bhatia P, Mulkutkar S, Barwar G, Singh R, Sen A, Agarwal M
Indian J Ophthalmol 2022 Jun;70(6):1931-1944. doi: 10.4103/ijo.IJO_2363_21. PMID: 35647958Free PMC Article
Mahajan S, Invernizzi A, Agrawal R, Biswas J, Rao NA, Gupta V
Ocul Immunol Inflamm 2017 Apr;25(2):152-159. Epub 2016 Dec 14 doi: 10.1080/09273948.2016.1255339. PMID: 27960610
Chang GC, Young LH
Semin Ophthalmol 2011 Jul-Sep;26(4-5):316-20. doi: 10.3109/08820538.2011.588658. PMID: 21958181
Castiblanco CP, Adelman RA
Graefes Arch Clin Exp Ophthalmol 2009 Mar;247(3):289-302. Epub 2008 Sep 16 doi: 10.1007/s00417-008-0939-8. PMID: 18795315
Damico FM, Kiss S, Young LH
Semin Ophthalmol 2005 Jul-Sep;20(3):191-7. doi: 10.1080/08820530500232100. PMID: 16282154

Prognosis

Agarwal M, Radosavljevic A, Tyagi M, Pichi F, Al Dhanhani AA, Agarwal A, Cunningham ET Jr
Ocul Immunol Inflamm 2023 May;31(4):793-809. Epub 2022 May 17 doi: 10.1080/09273948.2022.2058554. PMID: 35579612
Loporchio D, Mukkamala L, Gorukanti K, Zarbin M, Langer P, Bhagat N
Surv Ophthalmol 2016 Sep-Oct;61(5):582-96. Epub 2016 Mar 17 doi: 10.1016/j.survophthal.2016.03.005. PMID: 26994871
Castiblanco CP, Adelman RA
Graefes Arch Clin Exp Ophthalmol 2009 Mar;247(3):289-302. Epub 2008 Sep 16 doi: 10.1007/s00417-008-0939-8. PMID: 18795315
Damico FM, Kiss S, Young LH
Semin Ophthalmol 2005 Jul-Sep;20(3):191-7. doi: 10.1080/08820530500232100. PMID: 16282154
Dreyer WB Jr, Zegarra H, Zakov ZN, Gutman FA
Am J Ophthalmol 1981 Dec;92(6):816-23. doi: 10.1016/s0002-9394(14)75636-3. PMID: 7315933

Clinical prediction guides

Özdemir Yalçınsoy K, Özdamar Erol Y, Çakar Özdal P
Turk J Ophthalmol 2023 Feb 24;53(1):23-29. doi: 10.4274/tjo.galenos.2022.53383. PMID: 36847630Free PMC Article
Jordan DR, J Dutton J
Ophthalmic Plast Reconstr Surg 2022 Jul-Aug 01;38(4):315-324. Epub 2022 Sep 28 doi: 10.1097/IOP.0000000000002068. PMID: 34593714
Yang P, Liu S, Zhong Z, Du L, Ye Z, Zhou W, Kijlstra A
Ophthalmology 2019 Sep;126(9):1297-1305. Epub 2019 Apr 6 doi: 10.1016/j.ophtha.2019.03.049. PMID: 30959067
Yeung IY, Popp NA, Chan CC
Int Ophthalmol Clin 2015 Summer;55(3):111-31. doi: 10.1097/IIO.0000000000000072. PMID: 26035764Free PMC Article
Dreyer WB Jr, Zegarra H, Zakov ZN, Gutman FA
Am J Ophthalmol 1981 Dec;92(6):816-23. doi: 10.1016/s0002-9394(14)75636-3. PMID: 7315933

Recent systematic reviews

Patterson TJ, Kedzierski A, McKinney D, Ritson J, McLean C, Gu W, Colyer M, McClellan SF, Miller SC, Justin GA, Hoskin AK, Cavuoto K, Leong J, Rousselot Ascarza A, Woreta FA, Miller KE, Caldwell MC, Gensheimer WG, Williamson T, Dhawahir-Scala F, Shah P, Coombes A, Sundar G, Mazzoli RA, Woodcock M, Watson SL, Kuhn F, Halliday S, Gomes RSM, Agrawal R, Blanch RJ
Ophthalmology 2024 May;131(5):557-567. Epub 2023 Dec 10 doi: 10.1016/j.ophtha.2023.12.006. PMID: 38086434
He B, Tanya SM, Wang C, Kezouh A, Torun N, Ing E
Am J Ophthalmol 2022 Feb;234:117-125. Epub 2021 Jul 17 doi: 10.1016/j.ajo.2021.06.036. PMID: 34283983
Mehta S, Linton MM, Kempen JH
Am J Ophthalmol 2014 Oct;158(4):676-692.e7. Epub 2014 Jun 28 doi: 10.1016/j.ajo.2014.06.018. PMID: 24983790

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