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Enlarged uterus

MedGen UID:
452126
•Concept ID:
C0151994
•
Finding
Synonyms: Enlarged Uterus; Large uterus; Uterine enlargement
SNOMED CT: Enlarged uterus (198319004); Uterine enlargement (198319004); Large uterus (198319004)
 
HPO: HP:0100878

Definition

An increase in the overall dimensions or volume of the uterus compared to normal. [from NCI]

Professional guidelines

PubMed

An innovative surgical approach: suture fixation of the levonorgestrel-releasing intrauterine system in the treatment of adenomyosis.
Zhang H, Cao B, Tong J, Guo J, Zheng J, Zhu L, Niu Z, Chen L
BMC Womens Health 2022 Nov 16;22(1):451. doi: 10.1186/s12905-022-01932-6. PMID: 36384588Free PMC Article
Diagnosis and initial management of dysmenorrhea.
Osayande AS, Mehulic S
Am Fam Physician 2014 Mar 1;89(5):341-6. PMID: 24695505
Diagnosis, treatment and need for hysterectomy in management of postcaesarean section vesicouterine fistula.
Ali-El-Dein B, El-Tabey N, El-Hefnawy A, Osman Y, Soliman S, Shaaban AA
Scand J Urol 2014 Oct;48(5):460-5. Epub 2014 Apr 3 doi: 10.3109/21681805.2014.903511. PMID: 24694181

Recent clinical studies

Etiology

Efficacy and safety of robotic-assisted surgery in challenging hysterectomies - a single institutional experience.
Perutelli A, Domenici L, Garibaldi S, Albanesi G, Baroni C, Salvati L, Salvati N, Cecchi E, Bottone P, Salerno MG
Eur Rev Med Pharmacol Sci 2022 Feb;26(4):1235-1240. doi: 10.26355/eurrev_202202_28115. PMID: 35253179
Characteristics of ovarian endometrioma during pregnancy.
Takami M, Kajiyama R, Miyagi E, Aoki S
J Obstet Gynaecol Res 2021 Sep;47(9):3250-3256. Epub 2021 Jun 21 doi: 10.1111/jog.14862. PMID: 34155737
The analysis of vaginal hysterectomy results depending on the uterine size.
Pogoda KA, Malinowski A, Majchrzak-Baczmanska D, Wosiak A
Ginekol Pol 2021;92(5):339-343. Epub 2021 Apr 12 doi: 10.5603/GP.a2021.0021. PMID: 33844245
Laparoscopically-assisted vaginal hysterectomy for enlarged uterus: operative outcomes and the learning curve.
Dolanbay M, Kutuk MS, Ozgun MT, Uludag S, Sahin Y
Ginekol Pol 2016;87(5):333-7. doi: 10.5603/GP.2016.0003. PMID: 27304647
Reproductive outcomes after hydatiform mole and gestational trophoblastic neoplasia.
Gadducci A, Lanfredini N, Cosio S
Gynecol Endocrinol 2015;31(9):673-8. Epub 2015 Aug 18 doi: 10.3109/09513590.2015.1054803. PMID: 26288335

Diagnosis

Clinical practice. Uterine fibroids.
Stewart EA
N Engl J Med 2015 Apr 23;372(17):1646-55. doi: 10.1056/NEJMcp1411029. PMID: 25901428
Challenges in magnetic resonance imaging for suspected acute appendicitis in pregnant patients.
Ditkofsky NG, Singh A
Curr Probl Diagn Radiol 2015 Jul-Aug;44(4):297-302. Epub 2015 Jan 14 doi: 10.1067/j.cpradiol.2015.01.001. PMID: 25754942
Diagnosis and initial management of dysmenorrhea.
Osayande AS, Mehulic S
Am Fam Physician 2014 Mar 1;89(5):341-6. PMID: 24695505
The sonographic diagnosis of adenomyosis.
Andreotti RF, Fleischer AC
Ultrasound Q 2005 Sep;21(3):167-70. doi: 10.1097/01.ruq.0000174751.34633.9a. PMID: 16096612
Adenomyosis.
Siegler AM, Camilien L
J Reprod Med 1994 Nov;39(11):841-53. PMID: 7853271

Therapy

Efficacy and safety of robotic-assisted surgery in challenging hysterectomies - a single institutional experience.
Perutelli A, Domenici L, Garibaldi S, Albanesi G, Baroni C, Salvati L, Salvati N, Cecchi E, Bottone P, Salerno MG
Eur Rev Med Pharmacol Sci 2022 Feb;26(4):1235-1240. doi: 10.26355/eurrev_202202_28115. PMID: 35253179
Reproductive outcomes after hydatiform mole and gestational trophoblastic neoplasia.
Gadducci A, Lanfredini N, Cosio S
Gynecol Endocrinol 2015;31(9):673-8. Epub 2015 Aug 18 doi: 10.3109/09513590.2015.1054803. PMID: 26288335
Clinical practice. Uterine fibroids.
Stewart EA
N Engl J Med 2015 Apr 23;372(17):1646-55. doi: 10.1056/NEJMcp1411029. PMID: 25901428
Diagnosis and initial management of dysmenorrhea.
Osayande AS, Mehulic S
Am Fam Physician 2014 Mar 1;89(5):341-6. PMID: 24695505
Diffusely enlarged uterus: evaluation with MR imaging.
Kido A, Togashi K, Koyama T, Yamaoka T, Fujiwara T, Fujii S
Radiographics 2003 Nov-Dec;23(6):1423-39. doi: 10.1148/rg.236035033. PMID: 14615554

Prognosis

A Rare Case of Large Hydatidiform Mole Mimicking a Term Pregnancy.
Shrestha A , Bastakoti R , Pandey N , Poudel R , Ranjit S , Makaju R
Kathmandu Univ Med J (KUMJ) 2022 Apr-Jun;20(78):243-245. PMID: 37017175
Characteristics of ovarian endometrioma during pregnancy.
Takami M, Kajiyama R, Miyagi E, Aoki S
J Obstet Gynaecol Res 2021 Sep;47(9):3250-3256. Epub 2021 Jun 21 doi: 10.1111/jog.14862. PMID: 34155737
Reproductive outcomes after hydatiform mole and gestational trophoblastic neoplasia.
Gadducci A, Lanfredini N, Cosio S
Gynecol Endocrinol 2015;31(9):673-8. Epub 2015 Aug 18 doi: 10.3109/09513590.2015.1054803. PMID: 26288335
Diagnosis and initial management of dysmenorrhea.
Osayande AS, Mehulic S
Am Fam Physician 2014 Mar 1;89(5):341-6. PMID: 24695505
Impact of myomas on the results of transcervical resection of the endometrium.
Christoffersen C, Kahr HS, Sørensen SS
J Minim Invasive Gynecol 2014 Sep-Oct;21(5):811-7. Epub 2014 Mar 26 doi: 10.1016/j.jmig.2014.03.010. PMID: 24681167

Clinical prediction guides

Characteristics of ovarian endometrioma during pregnancy.
Takami M, Kajiyama R, Miyagi E, Aoki S
J Obstet Gynaecol Res 2021 Sep;47(9):3250-3256. Epub 2021 Jun 21 doi: 10.1111/jog.14862. PMID: 34155737
Laparoscopically-assisted vaginal hysterectomy for enlarged uterus: operative outcomes and the learning curve.
Dolanbay M, Kutuk MS, Ozgun MT, Uludag S, Sahin Y
Ginekol Pol 2016;87(5):333-7. doi: 10.5603/GP.2016.0003. PMID: 27304647
Impact of myomas on the results of transcervical resection of the endometrium.
Christoffersen C, Kahr HS, Sørensen SS
J Minim Invasive Gynecol 2014 Sep-Oct;21(5):811-7. Epub 2014 Mar 26 doi: 10.1016/j.jmig.2014.03.010. PMID: 24681167
Molar pregnancy in adolescents.
Braga A, Growdon WB, Bernstein M, Maestá I, Rudge MV, Goldstein DP, Berkowitz RS
J Reprod Med 2012 May-Jun;57(5-6):225-30. PMID: 22696817
History of adenomyosis.
Benagiano G, Brosens I
Best Pract Res Clin Obstet Gynaecol 2006 Aug;20(4):449-63. Epub 2006 Mar 2 doi: 10.1016/j.bpobgyn.2006.01.007. PMID: 16515887

Recent systematic reviews

A Case Series of Patients with Large Uterine Fibroids and Venous Thromboembolisms.
Cai E, Shao YH, Suarthana E, Bergeron A, Mansour FW, Krishnamurthy S
J Obstet Gynaecol Can 2021 Mar;43(3):352-360. Epub 2020 Nov 5 doi: 10.1016/j.jogc.2020.10.009. PMID: 33303409

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