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Abnormal pregnancy

MedGen UID:
452377
•Concept ID:
C0278056
•
Pathologic Function
Synonym: Abnormal Pregnancy
SNOMED CT: Abnormal pregnancy (11082009)

Definition

A pregnancy that is complicated and affected by an abnormal finding or disease condition in either the fetus and/or the mother. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal pregnancy

Professional guidelines

PubMed

Considerations for treatment of lipid disorders during pregnancy and breastfeeding.
Kaur G, Gulati M
Prog Cardiovasc Dis 2022 Nov-Dec;75:33-39. Epub 2022 Nov 16 doi: 10.1016/j.pcad.2022.11.001. PMID: 36400231
Fetal umbilical artery thrombosis: prenatal diagnosis, treatment and follow-up.
Wu X, Wei C, Chen R, Yang L, Huang W, Huang L, Yan X, Deng X, Gou Z
Orphanet J Rare Dis 2022 Nov 12;17(1):414. doi: 10.1186/s13023-022-02563-8. PMID: 36371215Free PMC Article
Pregnancy of unknown location: Evaluation and management.
Carusi D
Semin Perinatol 2019 Mar;43(2):95-100. Epub 2018 Dec 20 doi: 10.1053/j.semperi.2018.12.006. PMID: 30606496

Recent clinical studies

Etiology

On the reproductive capabilities of aneuploid human preimplantation embryos.
Capalbo A, Poli M, Jalas C, Forman EJ, Treff NR
Am J Hum Genet 2022 Sep 1;109(9):1572-1581. doi: 10.1016/j.ajhg.2022.07.009. PMID: 36055209Free PMC Article
Complementary tool in diagnosis of hydatidiform mole: Review.
Laviola GM, Fortini AS, Salles D, da Silva Lourenço C, Ribeiro DA, Sun SY, Ishigai MM, Iwamura ESM, Alves MTS, Malinverni ACM
Pathol Res Pract 2022 Sep;237:154041. Epub 2022 Jul 28 doi: 10.1016/j.prp.2022.154041. PMID: 35961058
Pregnancy of unknown location: Evaluation and management.
Carusi D
Semin Perinatol 2019 Mar;43(2):95-100. Epub 2018 Dec 20 doi: 10.1053/j.semperi.2018.12.006. PMID: 30606496
Suspected ectopic pregnancy.
Seeber BE, Barnhart KT
Obstet Gynecol 2006 Feb;107(2 Pt 1):399-413. doi: 10.1097/01.AOG.0000198632.15229.be. PMID: 16449130
Postmolar contraception.
Pandiyan N, Jequier AM
Obstet Gynecol Surv 1988 May;43(5):258-62. PMID: 3287245

Diagnosis

On the reproductive capabilities of aneuploid human preimplantation embryos.
Capalbo A, Poli M, Jalas C, Forman EJ, Treff NR
Am J Hum Genet 2022 Sep 1;109(9):1572-1581. doi: 10.1016/j.ajhg.2022.07.009. PMID: 36055209Free PMC Article
Complementary tool in diagnosis of hydatidiform mole: Review.
Laviola GM, Fortini AS, Salles D, da Silva Lourenço C, Ribeiro DA, Sun SY, Ishigai MM, Iwamura ESM, Alves MTS, Malinverni ACM
Pathol Res Pract 2022 Sep;237:154041. Epub 2022 Jul 28 doi: 10.1016/j.prp.2022.154041. PMID: 35961058
Pregnancy of unknown location: Evaluation and management.
Carusi D
Semin Perinatol 2019 Mar;43(2):95-100. Epub 2018 Dec 20 doi: 10.1053/j.semperi.2018.12.006. PMID: 30606496
Computer modeling tools to understand the causes of preterm birth.
Westervelt AR, Myers KM
Semin Perinatol 2017 Dec;41(8):485-492. Epub 2017 Sep 27 doi: 10.1053/j.semperi.2017.08.007. PMID: 28958628Free PMC Article
Postmolar contraception.
Pandiyan N, Jequier AM
Obstet Gynecol Surv 1988 May;43(5):258-62. PMID: 3287245

Therapy

ACE2: a key modulator of the renin-angiotensin system and pregnancy.
Tamanna S, Lumbers ER, Morosin SK, Delforce SJ, Pringle KG
Am J Physiol Regul Integr Comp Physiol 2021 Dec 1;321(6):R833-R843. Epub 2021 Oct 20 doi: 10.1152/ajpregu.00211.2021. PMID: 34668428Free PMC Article
Abnormal pregnancy outcome associated with high-dose maternal tranylcypromine therapy: Case report and literature review.
Kennedy D, Webster WS, Hill M, Ritchie HE
Reprod Toxicol 2017 Apr;69:146-149. Epub 2017 Feb 22 doi: 10.1016/j.reprotox.2017.02.012. PMID: 28237611
Imaging Unusual Pregnancy Implantations: Rare Ectopic Pregnancies and More.
Dibble EH, Lourenco AP
AJR Am J Roentgenol 2016 Dec;207(6):1380-1392. Epub 2016 Aug 30 doi: 10.2214/AJR.15.15290. PMID: 27574902
Pregnancy and alcohol: occasional, light drinking may be safe.
Prescrire Int 2012 Feb;21(124):44-50. PMID: 22413723
Suspected ectopic pregnancy.
Seeber BE, Barnhart KT
Obstet Gynecol 2006 Feb;107(2 Pt 1):399-413. doi: 10.1097/01.AOG.0000198632.15229.be. PMID: 16449130

Prognosis

On the reproductive capabilities of aneuploid human preimplantation embryos.
Capalbo A, Poli M, Jalas C, Forman EJ, Treff NR
Am J Hum Genet 2022 Sep 1;109(9):1572-1581. doi: 10.1016/j.ajhg.2022.07.009. PMID: 36055209Free PMC Article
Factors affecting clinical manifestation of chromosomal imbalance in carriers of segmental autosomal mosaicism: differential impact of gender.
Kovaleva NV, Cotter PD
J Appl Genet 2022 May;63(2):281-291. Epub 2022 Jan 1 doi: 10.1007/s13353-021-00673-w. PMID: 34973130Free PMC Article
Computational modeling of the interactions between the maternal and fetal circulations in human pregnancy.
Clark AR, Lee TC, James JL
WIREs Mech Dis 2021 Jan;13(1):e1502. Epub 2020 Aug 3 doi: 10.1002/wsbm.1502. PMID: 32744412
Computer modeling tools to understand the causes of preterm birth.
Westervelt AR, Myers KM
Semin Perinatol 2017 Dec;41(8):485-492. Epub 2017 Sep 27 doi: 10.1053/j.semperi.2017.08.007. PMID: 28958628Free PMC Article
Postmolar contraception.
Pandiyan N, Jequier AM
Obstet Gynecol Surv 1988 May;43(5):258-62. PMID: 3287245

Clinical prediction guides

On the reproductive capabilities of aneuploid human preimplantation embryos.
Capalbo A, Poli M, Jalas C, Forman EJ, Treff NR
Am J Hum Genet 2022 Sep 1;109(9):1572-1581. doi: 10.1016/j.ajhg.2022.07.009. PMID: 36055209Free PMC Article
Adaptations of the human placenta to hypoxia: opportunities for interventions in fetal growth restriction.
Colson A, Sonveaux P, Debiève F, Sferruzzi-Perri AN
Hum Reprod Update 2021 Apr 21;27(3):531-569. doi: 10.1093/humupd/dmaa053. PMID: 33377492
Computational modeling of the interactions between the maternal and fetal circulations in human pregnancy.
Clark AR, Lee TC, James JL
WIREs Mech Dis 2021 Jan;13(1):e1502. Epub 2020 Aug 3 doi: 10.1002/wsbm.1502. PMID: 32744412
Computer modeling tools to understand the causes of preterm birth.
Westervelt AR, Myers KM
Semin Perinatol 2017 Dec;41(8):485-492. Epub 2017 Sep 27 doi: 10.1053/j.semperi.2017.08.007. PMID: 28958628Free PMC Article
Autoantibodies in normal and abnormal pregnancy.
Gleicher N
Am J Reprod Immunol 1992 Oct-Dec;28(3-4):269-73. doi: 10.1111/j.1600-0897.1992.tb00812.x. PMID: 1285899

Recent systematic reviews

Prevalence of perinatal anxiety and its determinants in mainland China: A systematic review and meta-analysis.
Yang L, Sun J, Nan Y, Waqas A, Nisar A, Wang D, Rahman A, Li X
J Affect Disord 2023 Feb 15;323:193-203. Epub 2022 Nov 25 doi: 10.1016/j.jad.2022.11.075. PMID: 36442655
Routine ultrasound for fetal assessment before 24 weeks' gestation.
Kaelin Agten A, Xia J, Servante JA, Thornton JG, Jones NW
Cochrane Database Syst Rev 2021 Aug 26;8(8):CD014698. doi: 10.1002/14651858.CD014698. PMID: 34438475Free PMC Article
Vitamin D and assisted reproductive treatment outcome: a systematic review and meta-analysis.
Chu J, Gallos I, Tobias A, Tan B, Eapen A, Coomarasamy A
Hum Reprod 2018 Jan 1;33(1):65-80. doi: 10.1093/humrep/dex326. PMID: 29149263
Efficacy and safety of prophylactic vaccines against cervical HPV infection and diseases among women: a systematic review & meta-analysis.
Lu B, Kumar A, Castellsagué X, Giuliano AR
BMC Infect Dis 2011 Jan 12;11:13. doi: 10.1186/1471-2334-11-13. PMID: 21226933Free PMC Article
Is elevated maternal serum alpha-fetoprotein in the second trimester of pregnancy associated with increased preterm birth risk? A systematic review and meta-analysis.
Yuan W, Chen L, Bernal AL
Eur J Obstet Gynecol Reprod Biol 2009 Jul;145(1):57-64. Epub 2009 May 19 doi: 10.1016/j.ejogrb.2009.04.017. PMID: 19457604

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