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Paraphrenia

MedGen UID:
45322
•Concept ID:
C0030484
•
Mental or Behavioral Dysfunction
SNOMED CT: Paraphrenia (26472000)

Definition

A form of schizophrenia characterized by delusions (of persecution or grandeur or jealousy); symptoms may include anger and anxiety and aloofness and doubts about gender identity; unlike other types of schizophrenia the patients are usually presentable and (if delusions are not acted on) may function in an apparently normal manner. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVParaphrenia

Professional guidelines

PubMed

Wilhelm Mayer's follow-up study of Kraepelin's cases of paraphrenia: diagnostic validity in 1921.
Kendler KS
Mol Psychiatry 2023 Jan;28(1):236-241. Epub 2022 Sep 18 doi: 10.1038/s41380-022-01763-9. PMID: 36117212
Antipsychotic drug treatment for elderly people with late-onset schizophrenia.
Arunpongpaisal S, Ahmed I, Aqeel N, Suchat P
Cochrane Database Syst Rev 2003;(2):CD004162. doi: 10.1002/14651858.CD004162. PMID: 12804499
Fluphenazine enanthate in the outpatient treatment of late paraphrenia.
Raskind M, Alvarez C, Herlin S
J Am Geriatr Soc 1979 Oct;27(10):459-63. doi: 10.1111/j.1532-5415.1979.tb01727.x. PMID: 469146

Recent clinical studies

Etiology

The pathology of paraphrenia.
Casanova MF
Curr Psychiatry Rep 2010 Jun;12(3):196-201. doi: 10.1007/s11920-010-0108-8. PMID: 20425280
Epidemiology of schizophrenia.
Häfner H, an der Heiden W
Can J Psychiatry 1997 Mar;42(2):139-51. doi: 10.1177/070674379704200204. PMID: 9067063
Late-onset schizophrenia and late paraphrenia.
Riecher-Rössler A, Rössler W, Förstl H, Meise U
Schizophr Bull 1995;21(3):345-54; discussion 355-6. doi: 10.1093/schbul/21.3.345. PMID: 7481566
Paraphrenia revisited.
Naguib M
Br J Hosp Med 1991 Dec;46(6):371-5. PMID: 1760669
Delusional (paranoid) disorders.
Munro A
Can J Psychiatry 1988 Jun;33(5):399-404. doi: 10.1177/070674378803300516. PMID: 3044569

Diagnosis

The pathology of paraphrenia.
Casanova MF
Curr Psychiatry Rep 2010 Jun;12(3):196-201. doi: 10.1007/s11920-010-0108-8. PMID: 20425280
Paraphrenia redefined.
Ravindran AV, Yatham LN, Munro A
Can J Psychiatry 1999 Mar;44(2):133-7. doi: 10.1177/070674379904400202. PMID: 10097832
Epidemiology of schizophrenia.
Häfner H, an der Heiden W
Can J Psychiatry 1997 Mar;42(2):139-51. doi: 10.1177/070674379704200204. PMID: 9067063
Paraphrenia revisited.
Naguib M
Br J Hosp Med 1991 Dec;46(6):371-5. PMID: 1760669
Delusional (paranoid) disorders.
Munro A
Can J Psychiatry 1988 Jun;33(5):399-404. doi: 10.1177/070674378803300516. PMID: 3044569

Therapy

Hypoalgesia in schizophrenia is independent of antipsychotic drugs: a systematic quantitative review of experimental studies.
Potvin S, Marchand S
Pain 2008 Aug 15;138(1):70-78. Epub 2007 Dec 21 doi: 10.1016/j.pain.2007.11.007. PMID: 18160219
Antipsychotic drug treatment for elderly people with late-onset schizophrenia.
Arunpongpaisal S, Ahmed I, Aqeel N, Suchat P
Cochrane Database Syst Rev 2003;(2):CD004162. doi: 10.1002/14651858.CD004162. PMID: 12804499
Psychotic states arising in late life (late paraphrenia). The role of risk factors.
Almeida OP, Howard RJ, Levy R, David AS
Br J Psychiatry 1995 Feb;166(2):215-28. doi: 10.1192/bjp.166.2.215. PMID: 7728366
Paraphrenia: paranoid states of late life. I. European research.
Bridge TP, Wyatt RJ
J Am Geriatr Soc 1980 May;28(5):193-200. doi: 10.1111/j.1532-5415.1980.tb00518.x. PMID: 6102582
Late paraphrenia.
Herbert ME, Jacobson S
Br J Psychiatry 1967 May;113(498):461-9. doi: 10.1192/bjp.113.498.461. PMID: 6033487

Prognosis

Wilhelm Mayer's follow-up study of Kraepelin's cases of paraphrenia: diagnostic validity in 1921.
Kendler KS
Mol Psychiatry 2023 Jan;28(1):236-241. Epub 2022 Sep 18 doi: 10.1038/s41380-022-01763-9. PMID: 36117212
Wernicke-Kleist-Leonhard phenotypes 
of endogenous psychoses: a review of their validity
.
Foucher JR, Gawlik M, Roth JN, de Crespin de Billy C, Jeanjean LC, Obrecht A, Mainberger O, Clauss JME, Elowe J, Weibel S, Schorr B, Cetkovich M, Morra C, Rebok F, Ban TA, Bollmann B, Roser MM, Hanke MS, Jabs BE, Franzek EJ, Berna F, Pfuhlmann B
Dialogues Clin Neurosci 2020 Mar;22(1):37-49. doi: 10.31887/DCNS.2020.22.1/jfoucher. PMID: 32699504Free PMC Article
Antipsychotic drug treatment for elderly people with late-onset schizophrenia.
Arunpongpaisal S, Ahmed I, Aqeel N, Suchat P
Cochrane Database Syst Rev 2003;(2):CD004162. doi: 10.1002/14651858.CD004162. PMID: 12804499
Epidemiology of schizophrenia.
Häfner H, an der Heiden W
Can J Psychiatry 1997 Mar;42(2):139-51. doi: 10.1177/070674379704200204. PMID: 9067063
The diagnostic validity of paraphrenia.
Hassett AM, Keks NA, Jackson HJ, Copolov DL
Aust N Z J Psychiatry 1992 Mar;26(1):18-29. doi: 10.3109/00048679209068306. PMID: 1580882

Clinical prediction guides

Wernicke-Kleist-Leonhard phenotypes 
of endogenous psychoses: a review of their validity
.
Foucher JR, Gawlik M, Roth JN, de Crespin de Billy C, Jeanjean LC, Obrecht A, Mainberger O, Clauss JME, Elowe J, Weibel S, Schorr B, Cetkovich M, Morra C, Rebok F, Ban TA, Bollmann B, Roser MM, Hanke MS, Jabs BE, Franzek EJ, Berna F, Pfuhlmann B
Dialogues Clin Neurosci 2020 Mar;22(1):37-49. doi: 10.31887/DCNS.2020.22.1/jfoucher. PMID: 32699504Free PMC Article
The role of the entorhinal cortex in paraphrenia.
Casanova MF
Curr Psychiatry Rep 2010 Jun;12(3):202-7. doi: 10.1007/s11920-010-0109-7. PMID: 20425281
Hypoalgesia in schizophrenia is independent of antipsychotic drugs: a systematic quantitative review of experimental studies.
Potvin S, Marchand S
Pain 2008 Aug 15;138(1):70-78. Epub 2007 Dec 21 doi: 10.1016/j.pain.2007.11.007. PMID: 18160219
Clinical and cognitive diversity of psychotic states arising in late life (late paraphrenia).
Almeida OP, Howard RJ, Levy R, David AS, Morris RG, Sahakian BJ
Psychol Med 1995 Jul;25(4):699-714. doi: 10.1017/s0033291700034954. PMID: 7480448
The diagnostic validity of paraphrenia.
Hassett AM, Keks NA, Jackson HJ, Copolov DL
Aust N Z J Psychiatry 1992 Mar;26(1):18-29. doi: 10.3109/00048679209068306. PMID: 1580882

Recent systematic reviews

Hypoalgesia in schizophrenia is independent of antipsychotic drugs: a systematic quantitative review of experimental studies.
Potvin S, Marchand S
Pain 2008 Aug 15;138(1):70-78. Epub 2007 Dec 21 doi: 10.1016/j.pain.2007.11.007. PMID: 18160219
Antipsychotic drug treatment for elderly people with late-onset schizophrenia.
Arunpongpaisal S, Ahmed I, Aqeel N, Suchat P
Cochrane Database Syst Rev 2003;(2):CD004162. doi: 10.1002/14651858.CD004162. PMID: 12804499

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