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Peptic ulcer perforation

MedGen UID:
45385
•Concept ID:
C0030925
•
Disease or Syndrome
Synonyms: Peptic Ulcer Perforation; Peptic Ulcer Perforations; Perforation, Peptic Ulcer; Perforations, Peptic Ulcer; Ulcer Perforation, Peptic; Ulcer Perforations, Peptic
SNOMED CT: Peptic ulcer with perforation (88169003)
 
Monarch Initiative: MONDO:0004260

Definition

Penetration of a peptic ulcer through the wall of duodenum or stomach allowing the leakage of luminal contents into the peritoneal cavity. [from MONDO]

Professional guidelines

PubMed

Outcomes of Nonoperative Treatment for Gastroduodenal Ulcer Perforation: a Nationwide Study of 14,918 Inpatients in Japan.
Konishi T, Fujiogi M, Michihata N, Kumazawa R, Matsui H, Fushimi K, Tanabe M, Seto Y, Yasunaga H
J Gastrointest Surg 2021 Nov;25(11):2770-2777. Epub 2021 Apr 6 doi: 10.1007/s11605-021-05003-3. PMID: 33825122
Non-operative management of perforated peptic ulcer: A single-center experience.
Karabulut K, Dinçer M, Liman RK, Usta S
Ulus Travma Acil Cerrahi Derg 2019 Nov;25(6):585-588. doi: 10.14744/tjtes.2019.31967. PMID: 31701498
Medical versus surgical treatment for refractory or recurrent peptic ulcer.
Gurusamy KS, Pallari E
Cochrane Database Syst Rev 2016 Mar 29;3(3):CD011523. doi: 10.1002/14651858.CD011523.pub2. PMID: 27025289Free PMC Article

Recent clinical studies

Etiology

Duodenal ulcer perforation and its consequences.
Malik M, Magsi AM, Parveen S, Khan MI, Iqbal M
J Pak Med Assoc 2023 Jul;73(7):1506-1510. doi: 10.47391/JPMA.4768. PMID: 37469068
Duodenal ulcer perforation: A systematic literature review and narrative description of surgical techniques used to treat large duodenal defects.
Clinch D, Damaskos D, Di Marzo F, Di Saverio S
J Trauma Acute Care Surg 2021 Oct 1;91(4):748-758. doi: 10.1097/TA.0000000000003357. PMID: 34254960
TACTICS OF TREATMENT OF PERFORATIVE GASTRODUODENAL ULCER.
Dolimov KS, Аbdumazhidov AS, Тukhtamurod ZZ, Аshurmetov AM, Аkhmedov MJ, Zhafarov KM
Klin Khir 2016 Oct;(10):15-6. PMID: 30479106
Perforated peptic ulcer.
Søreide K, Thorsen K, Harrison EM, Bingener J, Møller MH, Ohene-Yeboah M, Søreide JA
Lancet 2015 Sep 26;386(10000):1288-1298. doi: 10.1016/S0140-6736(15)00276-7. PMID: 26460663Free PMC Article
Gastroduodenal perforation.
Nirula R
Surg Clin North Am 2014 Feb;94(1):31-4. Epub 2013 Nov 5 doi: 10.1016/j.suc.2013.10.002. PMID: 24267494

Diagnosis

Diagnosis and management of duodenal perforations: a narrative review.
Ansari D, Torén W, Lindberg S, Pyrhönen HS, Andersson R
Scand J Gastroenterol 2019 Aug;54(8):939-944. Epub 2019 Jul 27 doi: 10.1080/00365521.2019.1647456. PMID: 31353983
TACTICS OF TREATMENT OF PERFORATIVE GASTRODUODENAL ULCER.
Dolimov KS, Аbdumazhidov AS, Тukhtamurod ZZ, Аshurmetov AM, Аkhmedov MJ, Zhafarov KM
Klin Khir 2016 Oct;(10):15-6. PMID: 30479106
Perforated peptic ulcer.
Søreide K, Thorsen K, Harrison EM, Bingener J, Møller MH, Ohene-Yeboah M, Søreide JA
Lancet 2015 Sep 26;386(10000):1288-1298. doi: 10.1016/S0140-6736(15)00276-7. PMID: 26460663Free PMC Article
Gastroduodenal perforation.
Nirula R
Surg Clin North Am 2014 Feb;94(1):31-4. Epub 2013 Nov 5 doi: 10.1016/j.suc.2013.10.002. PMID: 24267494
Peptic ulcer disease.
Ramakrishnan K, Salinas RC
Am Fam Physician 2007 Oct 1;76(7):1005-12. PMID: 17956071

Therapy

Role of Radiology and Laparoscopy in Childhood Peptic Ulcer Perforation.
Demir M, Akın M, Yücel N, Unal A, Gürel D, Yaşa E
J Environ Public Health 2022;2022:1211499. Epub 2022 Jul 20 doi: 10.1155/2022/1211499. PMID: 35910757Free PMC Article
Duodenal ulcer perforation: A systematic literature review and narrative description of surgical techniques used to treat large duodenal defects.
Clinch D, Damaskos D, Di Marzo F, Di Saverio S
J Trauma Acute Care Surg 2021 Oct 1;91(4):748-758. doi: 10.1097/TA.0000000000003357. PMID: 34254960
Diagnosis and management of duodenal perforations: a narrative review.
Ansari D, Torén W, Lindberg S, Pyrhönen HS, Andersson R
Scand J Gastroenterol 2019 Aug;54(8):939-944. Epub 2019 Jul 27 doi: 10.1080/00365521.2019.1647456. PMID: 31353983
Perforated peptic ulcer.
Søreide K, Thorsen K, Harrison EM, Bingener J, Møller MH, Ohene-Yeboah M, Søreide JA
Lancet 2015 Sep 26;386(10000):1288-1298. doi: 10.1016/S0140-6736(15)00276-7. PMID: 26460663Free PMC Article
Peptic ulcer disease.
Ramakrishnan K, Salinas RC
Am Fam Physician 2007 Oct 1;76(7):1005-12. PMID: 17956071

Prognosis

Early post-operative morbidity and mortality predictors in peptic ulcer perforation.
Yalcin M, Oter S, Akınoğlu A
Ulus Travma Acil Cerrahi Derg 2022 Nov;28(11):1558-1562. doi: 10.14744/tjtes.2022.85686. PMID: 36282169Free PMC Article
Role of Radiology and Laparoscopy in Childhood Peptic Ulcer Perforation.
Demir M, Akın M, Yücel N, Unal A, Gürel D, Yaşa E
J Environ Public Health 2022;2022:1211499. Epub 2022 Jul 20 doi: 10.1155/2022/1211499. PMID: 35910757Free PMC Article
Surgical management of peptic ulcer disease.
Wang A, Yerxa J, Agarwal S, Turner MC, Schroder V, Youngwirth LM, Lagoo-Deenadayalan S, Pappas TN
Curr Probl Surg 2020 Feb;57(2):100728. Epub 2020 Jan 7 doi: 10.1016/j.cpsurg.2019.100728. PMID: 32138833
Perforated peptic ulcer.
Søreide K, Thorsen K, Harrison EM, Bingener J, Møller MH, Ohene-Yeboah M, Søreide JA
Lancet 2015 Sep 26;386(10000):1288-1298. doi: 10.1016/S0140-6736(15)00276-7. PMID: 26460663Free PMC Article
Gastroduodenal perforation.
Nirula R
Surg Clin North Am 2014 Feb;94(1):31-4. Epub 2013 Nov 5 doi: 10.1016/j.suc.2013.10.002. PMID: 24267494

Clinical prediction guides

Methamphetamine-related peptic ulcer perforation: a growing medical concern.
Turan B, Eroğlu H, Sultanoğlu B, Demirbakan K
Ulus Travma Acil Cerrahi Derg 2023 Dec;29(12):1357-1363. doi: 10.14744/tjtes.2023.53146. PMID: 38073456Free PMC Article
Duodenal ulcer perforation and its consequences.
Malik M, Magsi AM, Parveen S, Khan MI, Iqbal M
J Pak Med Assoc 2023 Jul;73(7):1506-1510. doi: 10.47391/JPMA.4768. PMID: 37469068
Early post-operative morbidity and mortality predictors in peptic ulcer perforation.
Yalcin M, Oter S, Akınoğlu A
Ulus Travma Acil Cerrahi Derg 2022 Nov;28(11):1558-1562. doi: 10.14744/tjtes.2022.85686. PMID: 36282169Free PMC Article
Omentopexy versus falciformopexy for peptic ulcer perforation.
Ölmez A, Çiçek E, Aydın C, Kaplan K, Kayaalp C
Ulus Travma Acil Cerrahi Derg 2019 Nov;25(6):580-584. doi: 10.14744/tjtes.2019.11387. PMID: 31701495
Perforated peptic ulcer.
Søreide K, Thorsen K, Harrison EM, Bingener J, Møller MH, Ohene-Yeboah M, Søreide JA
Lancet 2015 Sep 26;386(10000):1288-1298. doi: 10.1016/S0140-6736(15)00276-7. PMID: 26460663Free PMC Article

Recent systematic reviews

Primary closure versus Graham patch omentopexy in perforated peptic ulcer: A systematic review and meta-analysis.
Demetriou G, Chapman M
Surgeon 2022 Jun;20(3):e61-e67. Epub 2021 Jun 3 doi: 10.1016/j.surge.2021.04.006. PMID: 34090810
Duodenal ulcer perforation: A systematic literature review and narrative description of surgical techniques used to treat large duodenal defects.
Clinch D, Damaskos D, Di Marzo F, Di Saverio S
J Trauma Acute Care Surg 2021 Oct 1;91(4):748-758. doi: 10.1097/TA.0000000000003357. PMID: 34254960
Risk factors of perioperative mortality from complicated peptic ulcer disease in Africa: systematic review and meta-analysis.
Peiffer S, Pelton M, Keeney L, Kwon EG, Ofosu-Okromah R, Acharya Y, Chinchilli VM, Soybel DI, Oh JS, Ssentongo P
BMJ Open Gastroenterol 2020;7(1):e000350. Epub 2020 Feb 17 doi: 10.1136/bmjgast-2019-000350. PMID: 32128227Free PMC Article
Surgery for Peptic Ulcer Disease in sub-Saharan Africa: Systematic Review of Published Data.
Rickard J
J Gastrointest Surg 2016 Apr;20(4):840-50. Epub 2015 Nov 16 doi: 10.1007/s11605-015-3025-7. PMID: 26573850
Systematic review of the epidemiology of complicated peptic ulcer disease: incidence, recurrence, risk factors and mortality.
Lau JY, Sung J, Hill C, Henderson C, Howden CW, Metz DC
Digestion 2011;84(2):102-13. Epub 2011 Apr 14 doi: 10.1159/000323958. PMID: 21494041

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