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Periapical periodontitis

MedGen UID:: 45396
•Concept ID:: C0031030
•: Disease or Syndrome

Synonyms:	Apical Periodontitides; Apical Periodontitis; Periapical Periodontitides; Periapical Periodontitis; Periodontitides, Apical; Periodontitides, Periapical; Periodontitis, Apical; Periodontitis, Periapical
SNOMED CT:	Apical periodontitis (39273001)

Monarch Initiative:	MONDO:0004508

Definition

Inflammation of the periapical tissue. It includes general, unspecified, or acute nonsuppurative inflammation. Chronic nonsuppurative inflammation is periapical granuloma. Suppurative inflammation is periapical abscess. [from MONDO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVPeriapical periodontitis

Disease
- Disorder by Site
  - Connective and Soft Tissue Disorder
    - Musculoskeletal system disorder
      - Disorder of jaw
        Disorder of periapical tissues of tooth
        Periapical periodontitis
        Periapical granuloma
        Suppurative periapical periodontitis
        Periapical abscess with sinus tract

Professional guidelines

PubMed

FACTORS INFLUENCING THE TREATMENT OUTCOME OF INTENTIONAL REPLANTATION ON TEETH WITH PERIAPICAL PERIODONTITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS.

Ong TK, Lim D, Singh M, Fial AV
J Evid Based Dent Pract 2022 Dec;22(4):101722. Epub 2022 Mar 21 doi: 10.1016/j.jebdp.2022.101722. PMID: 36494117

Evaluation of the evidence of effectiveness of ultrasonic activated irrigation for root canal treatment.

George R
Evid Based Dent 2019 Sep;20(3):83-84. doi: 10.1038/s41432-019-0037-2. PMID: 31562409

European Society of Endodontology position statement: the use of antibiotics in endodontics.

Segura-Egea JJ, Gould K, Şen BH, Jonasson P, Cotti E, Mazzoni A, Sunay H, Tjäderhane L, Dummer PMH
Int Endod J 2018 Jan;51(1):20-25. Epub 2017 Jun 14 doi: 10.1111/iej.12781. PMID: 28436043

See all (26)

Recent clinical studies

Etiology

Interaction between apical periodontitis and systemic disease (Review).

Ye L, Cao L, Song W, Yang C, Tang Q, Yuan Z
Int J Mol Med 2023 Jul;52(1) Epub 2023 Jun 2 doi: 10.3892/ijmm.2023.5263. PMID: 37264964 Free PMC Article

Present status and future directions: Microbiology of endodontic infections.

Siqueira JF Jr, Rôças IN
Int Endod J 2022 May;55 Suppl 3:512-530. Epub 2022 Jan 13 doi: 10.1111/iej.13677. PMID: 34958494

Endodontic medicine: connections between apical periodontitis and systemic diseases.

Segura-Egea JJ, Martín-González J, Castellanos-Cosano L
Int Endod J 2015 Oct;48(10):933-51. Epub 2015 Aug 3 doi: 10.1111/iej.12507. PMID: 26174809

Causes and management of post-treatment apical periodontitis.

Siqueira JF Jr, Rôças IN, Ricucci D, Hülsmann M
Br Dent J 2014 Mar;216(6):305-12. doi: 10.1038/sj.bdj.2014.200. PMID: 24651336

Clinical implications and microbiology of bacterial persistence after treatment procedures.

Siqueira JF Jr, Rôças IN
J Endod 2008 Nov;34(11):1291-1301.e3. Epub 2008 Sep 17 doi: 10.1016/j.joen.2008.07.028. PMID: 18928835

See all (1122)

Diagnosis

Artificial intelligence for caries and periapical periodontitis detection.

Li S, Liu J, Zhou Z, Zhou Z, Wu X, Li Y, Wang S, Liao W, Ying S, Zhao Z
J Dent 2022 Jul;122:104107. Epub 2022 Mar 24 doi: 10.1016/j.jdent.2022.104107. PMID: 35341892

Apical periodontitis after intense bruxism.

Gund MP, Wrbas KT, Hannig M, Rupf S
BMC Oral Health 2022 Mar 24;22(1):91. doi: 10.1186/s12903-022-02123-3. PMID: 35331220 Free PMC Article

Present status and future directions: Managing endodontic emergencies.

Abbott PV
Int Endod J 2022 May;55 Suppl 3:778-803. Epub 2022 Jan 13 doi: 10.1111/iej.13678. PMID: 34958512

The global prevalence of apical periodontitis: a systematic review and meta-analysis.

Tibúrcio-Machado CS, Michelon C, Zanatta FB, Gomes MS, Marin JA, Bier CA
Int Endod J 2021 May;54(5):712-735. Epub 2021 Jan 22 doi: 10.1111/iej.13467. PMID: 33378579

Endodontic Periapical Lesion: An Overview on the Etiology, Diagnosis and Current Treatment Modalities.

Karamifar K, Tondari A, Saghiri MA
Eur Endod J 2020;5(2):54-67. Epub 2020 Jul 14 doi: 10.14744/eej.2020.42714. PMID: 32766513 Free PMC Article

See all (703)

Therapy

Apical periodontitis after intense bruxism.

Gund MP, Wrbas KT, Hannig M, Rupf S
BMC Oral Health 2022 Mar 24;22(1):91. doi: 10.1186/s12903-022-02123-3. PMID: 35331220 Free PMC Article

Present status and future directions of intracanal medicaments.

Ordinola-Zapata R, Noblett WC, Perez-Ron A, Ye Z, Vera J
Int Endod J 2022 May;55 Suppl 3(Suppl 3):613-636. Epub 2022 Apr 19 doi: 10.1111/iej.13731. PMID: 35322427 Free PMC Article

Regenerative Endodontic Procedures for the Treatment of Necrotic Mature Teeth with Apical Periodontitis: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Glynis A, Foschi F, Kefalou I, Koletsi D, Tzanetakis GN
J Endod 2021 Jun;47(6):873-882. Epub 2021 Mar 31 doi: 10.1016/j.joen.2021.03.015. PMID: 33811981

Endodontic procedures for retreatment of periapical lesions.

Del Fabbro M, Corbella S, Sequeira-Byron P, Tsesis I, Rosen E, Lolato A, Taschieri S
Cochrane Database Syst Rev 2016 Oct 19;10(10):CD005511. doi: 10.1002/14651858.CD005511.pub3. PMID: 27759881 Free PMC Article

Causes and management of post-treatment apical periodontitis.

Siqueira JF Jr, Rôças IN, Ricucci D, Hülsmann M
Br Dent J 2014 Mar;216(6):305-12. doi: 10.1038/sj.bdj.2014.200. PMID: 24651336

See all (894)

Prognosis

Interaction between apical periodontitis and systemic disease (Review).

Ye L, Cao L, Song W, Yang C, Tang Q, Yuan Z
Int J Mol Med 2023 Jul;52(1) Epub 2023 Jun 2 doi: 10.3892/ijmm.2023.5263. PMID: 37264964 Free PMC Article

Tooth survival after endodontic treatment.

Fransson H, Dawson V
Int Endod J 2023 Mar;56 Suppl 2:140-153. Epub 2022 Oct 2 doi: 10.1111/iej.13835. PMID: 36149887

Present status and future directions of intracanal medicaments.

Ordinola-Zapata R, Noblett WC, Perez-Ron A, Ye Z, Vera J
Int Endod J 2022 May;55 Suppl 3(Suppl 3):613-636. Epub 2022 Apr 19 doi: 10.1111/iej.13731. PMID: 35322427 Free PMC Article

Regenerative Endodontic Procedures for the Treatment of Necrotic Mature Teeth with Apical Periodontitis: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Glynis A, Foschi F, Kefalou I, Koletsi D, Tzanetakis GN
J Endod 2021 Jun;47(6):873-882. Epub 2021 Mar 31 doi: 10.1016/j.joen.2021.03.015. PMID: 33811981

Endodontic Periapical Lesion: An Overview on the Etiology, Diagnosis and Current Treatment Modalities.

Karamifar K, Tondari A, Saghiri MA
Eur Endod J 2020;5(2):54-67. Epub 2020 Jul 14 doi: 10.14744/eej.2020.42714. PMID: 32766513 Free PMC Article

See all (553)

Clinical prediction guides

Artificial intelligence for caries and periapical periodontitis detection.

Li S, Liu J, Zhou Z, Zhou Z, Wu X, Li Y, Wang S, Liao W, Ying S, Zhao Z
J Dent 2022 Jul;122:104107. Epub 2022 Mar 24 doi: 10.1016/j.jdent.2022.104107. PMID: 35341892

Present status and future directions of intracanal medicaments.

Ordinola-Zapata R, Noblett WC, Perez-Ron A, Ye Z, Vera J
Int Endod J 2022 May;55 Suppl 3(Suppl 3):613-636. Epub 2022 Apr 19 doi: 10.1111/iej.13731. PMID: 35322427 Free PMC Article

Present status and future directions: Microbiology of endodontic infections.

Siqueira JF Jr, Rôças IN
Int Endod J 2022 May;55 Suppl 3:512-530. Epub 2022 Jan 13 doi: 10.1111/iej.13677. PMID: 34958494

Endodontic Periapical Lesion: An Overview on the Etiology, Diagnosis and Current Treatment Modalities.

Karamifar K, Tondari A, Saghiri MA
Eur Endod J 2020;5(2):54-67. Epub 2020 Jul 14 doi: 10.14744/eej.2020.42714. PMID: 32766513 Free PMC Article

Assessment of treatment failure in endodontic therapy.

Bergenholtz G
J Oral Rehabil 2016 Oct;43(10):753-8. Epub 2016 Aug 13 doi: 10.1111/joor.12423. PMID: 27519460

See all (740)

Recent systematic reviews

Non-surgical root canal treatment and retreatment versus apical surgery in treating apical periodontitis: A systematic review.

Bucchi C, Rosen E, Taschieri S
Int Endod J 2023 Oct;56 Suppl 3:475-486. Epub 2022 Jul 9 doi: 10.1111/iej.13793. PMID: 35762859

Regenerative Endodontic Procedures for the Treatment of Necrotic Mature Teeth with Apical Periodontitis: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Glynis A, Foschi F, Kefalou I, Koletsi D, Tzanetakis GN
J Endod 2021 Jun;47(6):873-882. Epub 2021 Mar 31 doi: 10.1016/j.joen.2021.03.015. PMID: 33811981

The global prevalence of apical periodontitis: a systematic review and meta-analysis.

Tibúrcio-Machado CS, Michelon C, Zanatta FB, Gomes MS, Marin JA, Bier CA
Int Endod J 2021 May;54(5):712-735. Epub 2021 Jan 22 doi: 10.1111/iej.13467. PMID: 33378579

Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults.

Cope AL, Francis N, Wood F, Chestnutt IG
Cochrane Database Syst Rev 2018 Sep 27;9(9):CD010136. doi: 10.1002/14651858.CD010136.pub3. PMID: 30259968 Free PMC Article

Endodontic procedures for retreatment of periapical lesions.

See all (96)

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Periapical periodontitis

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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