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Esophageal spasms

MedGen UID:
4548
•Concept ID:
C0014863
•
Disease or Syndrome
Synonyms: Diffuse Esophageal Spasm; Diffuse Esophageal Spasms; Esophageal Spasm; Esophageal Spasm, Diffuse; Esophageal Spasms; Esophageal Spasms, Diffuse; Spasm, Diffuse Esophageal; Spasm, Esophageal; Spasms, Diffuse Esophageal; Spasms, Esophageal
SNOMED CT: DOS - Diffuse esophageal spasm (79962008); Esophageal spasm (79962008); Diffuse spasm of esophagus (79962008); ES - Esophageal spasm (79962008); Diffuse esophageal spasm (79962008); Esophagism (79962008); Esophagospasm (79962008); Spasm of esophagus (79962008)
 
HPO: HP:0025271

Definition

Involuntary contractions of the esophagus that are irregular, uncoordinated, and painful. [from HPO]

Professional guidelines

PubMed

Esophageal hypomotility and spastic motor disorders: current diagnosis and treatment.
Valdovinos MA, Zavala-Solares MR, Coss-Adame E
Curr Gastroenterol Rep 2014 Nov;16(11):421. doi: 10.1007/s11894-014-0421-1. PMID: 25376746
Management of spastic disorders of the esophagus.
Roman S, Kahrilas PJ
Gastroenterol Clin North Am 2013 Mar;42(1):27-43. Epub 2013 Jan 4 doi: 10.1016/j.gtc.2012.11.002. PMID: 23452629Free PMC Article
Esophageal pharmacology and treatment of primary motility disorders.
Storr M, Allescher HD
Dis Esophagus 1999;12(4):241-57. doi: 10.1046/j.1442-2050.1999.00059.x. PMID: 10770358

Recent clinical studies

Etiology

Efficacy of per-oral endoscopic myotomy for the treatment of non-achalasia esophageal motor disorders.
Bernardot L, Roman S, Barret M, Vitton V, Wallenhorst T, Pioche M, Chaussade S, Gonzalez JM, Ponchon T, Prat F, Barthet M, Vergniol J, Chabrun E, Zerbib F
Surg Endosc 2020 Dec;34(12):5508-5515. Epub 2020 Jan 13 doi: 10.1007/s00464-019-07348-y. PMID: 31932930
Patients with esophageal motility disorders show distinct patterns based on axial force measurements.
Lundager FH, Tack J, Blondeau K, Drewes AM, Gregersen H
Dig Dis Sci 2012 Nov;57(11):2929-35. Epub 2012 Jun 6 doi: 10.1007/s10620-012-2247-8. PMID: 22669209
Coronary spasm reflects inputs from adjacent esophageal system.
Manfrini O, Bazzocchi G, Luati A, Borghi A, Monari P, Bugiardini R
Am J Physiol Heart Circ Physiol 2006 May;290(5):H2085-91. Epub 2005 Dec 30 doi: 10.1152/ajpheart.00925.2005. PMID: 16387792
Calcium antagonists.
Grossman E, Messerli FH
Prog Cardiovasc Dis 2004 Jul-Aug;47(1):34-57. doi: 10.1016/j.pcad.2004.04.006. PMID: 15517514
High incidence of esophageal motor disorders in consecutive patients with globus sensation.
Moser G, Vacariu-Granser GV, Schneider C, Abatzi TA, Pokieser P, Stacher-Janotta G, Gaupmann G, Weber U, Wenzel T, Roden M
Gastroenterology 1991 Dec;101(6):1512-21. doi: 10.1016/0016-5085(91)90386-y. PMID: 1955117

Diagnosis

Discordance between high-resolution manometry, esophagoscopy and contrast esophagogram in determining landmarks for per-oral endoscopic myotomy in spastic esophageal disorders: a word of caution.
Serrano L, Saad AR, DuCoin C, Jacobs JW, Richter JE, Velanovich V
Surg Endosc 2021 Oct;35(10):5613-5619. Epub 2020 Oct 13 doi: 10.1007/s00464-020-08064-8. PMID: 33048228
Efficacy of per-oral endoscopic myotomy for the treatment of non-achalasia esophageal motor disorders.
Bernardot L, Roman S, Barret M, Vitton V, Wallenhorst T, Pioche M, Chaussade S, Gonzalez JM, Ponchon T, Prat F, Barthet M, Vergniol J, Chabrun E, Zerbib F
Surg Endosc 2020 Dec;34(12):5508-5515. Epub 2020 Jan 13 doi: 10.1007/s00464-019-07348-y. PMID: 31932930
Exploratory Research on Latent Esophageal Motility Disorders in Dysphagia Patients.
Kawaguchi S, Takeuchi T, Inoue Y, Takahashi Y, Ozaki H, Ota K, Harada S, Edogawa S, Kojima Y, Yamashita H, Fukuchi T, Ashida K, Higuchi K
Digestion 2017;95(4):269-274. Epub 2017 Apr 11 doi: 10.1159/000470901. PMID: 28395277
Esophageal motor disorders: achalasia and esophageal spasm.
Strader SL
J Am Acad Nurse Pract 2001 Nov;13(11):502-7; quiz 508-10. doi: 10.1111/j.1745-7599.2001.tb00015.x. PMID: 11930515
High incidence of esophageal motor disorders in consecutive patients with globus sensation.
Moser G, Vacariu-Granser GV, Schneider C, Abatzi TA, Pokieser P, Stacher-Janotta G, Gaupmann G, Weber U, Wenzel T, Roden M
Gastroenterology 1991 Dec;101(6):1512-21. doi: 10.1016/0016-5085(91)90386-y. PMID: 1955117

Therapy

Botulinum toxin therapy: its use for neurological disorders of the autonomic nervous system.
Dressler D
J Neurol 2013 Mar;260(3):701-13. Epub 2012 Aug 10 doi: 10.1007/s00415-012-6615-2. PMID: 22878428
Coronary spasm reflects inputs from adjacent esophageal system.
Manfrini O, Bazzocchi G, Luati A, Borghi A, Monari P, Bugiardini R
Am J Physiol Heart Circ Physiol 2006 May;290(5):H2085-91. Epub 2005 Dec 30 doi: 10.1152/ajpheart.00925.2005. PMID: 16387792
Calcium antagonists.
Grossman E, Messerli FH
Prog Cardiovasc Dis 2004 Jul-Aug;47(1):34-57. doi: 10.1016/j.pcad.2004.04.006. PMID: 15517514
In situ light dosimetry during photodynamic therapy of Barrett's esophagus with 5-aminolevulinic acid.
van Veen RL, Aalders MC, Pasma KL, Siersema PD, Haringsma J, van de Vrie W, Gabeler EE, Robinson DJ, Sterenborg HJ
Lasers Surg Med 2002;31(5):299-304. doi: 10.1002/lsm.10129. PMID: 12430146
Preliminary results of thoracoscopic Belsey Mark IV antireflux procedure.
Nguyen NT, Schauer PR, Hutson W, Landreneau R, Weigel T, Ferson PF, Keenan RJ, Luketich JD
Surg Laparosc Endosc 1998 Jun;8(3):185-8. PMID: 9649040

Prognosis

Efficacy of per-oral endoscopic myotomy for the treatment of non-achalasia esophageal motor disorders.
Bernardot L, Roman S, Barret M, Vitton V, Wallenhorst T, Pioche M, Chaussade S, Gonzalez JM, Ponchon T, Prat F, Barthet M, Vergniol J, Chabrun E, Zerbib F
Surg Endosc 2020 Dec;34(12):5508-5515. Epub 2020 Jan 13 doi: 10.1007/s00464-019-07348-y. PMID: 31932930
Preliminary results of thoracoscopic Belsey Mark IV antireflux procedure.
Nguyen NT, Schauer PR, Hutson W, Landreneau R, Weigel T, Ferson PF, Keenan RJ, Luketich JD
Surg Laparosc Endosc 1998 Jun;8(3):185-8. PMID: 9649040
Globus sensation: pharyngoesophageal function, psychometric and psychiatric findings, and follow-up in 88 patients.
Moser G, Wenzel-Abatzi TA, Stelzeneder M, Wenzel T, Weber U, Wiesnagrotzki S, Schneider C, Schima W, Stacher-Janotta G, Vacariu-Granser GV, Pokieser P, Bergmann H, Stacher G
Arch Intern Med 1998 Jun 22;158(12):1365-73. doi: 10.1001/archinte.158.12.1365. PMID: 9645832
High incidence of esophageal motor disorders in consecutive patients with globus sensation.
Moser G, Vacariu-Granser GV, Schneider C, Abatzi TA, Pokieser P, Stacher-Janotta G, Gaupmann G, Weber U, Wenzel T, Roden M
Gastroenterology 1991 Dec;101(6):1512-21. doi: 10.1016/0016-5085(91)90386-y. PMID: 1955117

Clinical prediction guides

Efficacy of per-oral endoscopic myotomy for the treatment of non-achalasia esophageal motor disorders.
Bernardot L, Roman S, Barret M, Vitton V, Wallenhorst T, Pioche M, Chaussade S, Gonzalez JM, Ponchon T, Prat F, Barthet M, Vergniol J, Chabrun E, Zerbib F
Surg Endosc 2020 Dec;34(12):5508-5515. Epub 2020 Jan 13 doi: 10.1007/s00464-019-07348-y. PMID: 31932930
In situ light dosimetry during photodynamic therapy of Barrett's esophagus with 5-aminolevulinic acid.
van Veen RL, Aalders MC, Pasma KL, Siersema PD, Haringsma J, van de Vrie W, Gabeler EE, Robinson DJ, Sterenborg HJ
Lasers Surg Med 2002;31(5):299-304. doi: 10.1002/lsm.10129. PMID: 12430146
Globus sensation: pharyngoesophageal function, psychometric and psychiatric findings, and follow-up in 88 patients.
Moser G, Wenzel-Abatzi TA, Stelzeneder M, Wenzel T, Weber U, Wiesnagrotzki S, Schneider C, Schima W, Stacher-Janotta G, Vacariu-Granser GV, Pokieser P, Bergmann H, Stacher G
Arch Intern Med 1998 Jun 22;158(12):1365-73. doi: 10.1001/archinte.158.12.1365. PMID: 9645832
High incidence of esophageal motor disorders in consecutive patients with globus sensation.
Moser G, Vacariu-Granser GV, Schneider C, Abatzi TA, Pokieser P, Stacher-Janotta G, Gaupmann G, Weber U, Wenzel T, Roden M
Gastroenterology 1991 Dec;101(6):1512-21. doi: 10.1016/0016-5085(91)90386-y. PMID: 1955117
Manometric findings during spontaneous chest pain in patients with presumed esophageal "spasms".
Clouse RE, Staiano A, Landau DW, Schlachter JL
Gastroenterology 1983 Aug;85(2):395-402. PMID: 6862161

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