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In-Transit Metastasis

MedGen UID:
457780
•Concept ID:
C2985554
•
Pathologic Function

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIn-Transit Metastasis

Professional guidelines

PubMed

Locoregional management of in-transit metastasis in melanoma: an Ontario Health (Cancer Care Ontario) clinical practice guideline.
Wright FC, Kellett S, Hong NJL, Sun AY, Hanna TP, Nessim C, Giacomantonio CA, Temple-Oberle CF, Song X, Petrella TM
Curr Oncol 2020 Jun;27(3):e318-e325. Epub 2020 Jun 1 doi: 10.3747/co.27.6523. PMID: 32669939Free PMC Article
Staging 18F-FDG PET/CT influences the treatment plan in melanoma patients with satellite or in-transit metastases.
Holtkamp LHJ, Chakera AH, Fung S, Stretch JR, Saw RPM, Lee K, Ch'ng S, Gonzalez M, Thompson JF, Emmett L, Nieweg OE
Melanoma Res 2020 Aug;30(4):358-363. doi: 10.1097/CMR.0000000000000666. PMID: 32628431Free PMC Article
Malignant Melanoma: Diagnostic and Management Update.
Knackstedt T, Knackstedt RW, Couto R, Gastman B
Plast Reconstr Surg 2018 Aug;142(2):202e-216e. doi: 10.1097/PRS.0000000000004571. PMID: 30045186

Recent clinical studies

Etiology

Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054): distant metastasis-free survival results from a double-blind, randomised, controlled, phase 3 trial.
Eggermont AMM, Blank CU, Mandalà M, Long GV, Atkinson VG, Dalle S, Haydon AM, Meshcheryakov A, Khattak A, Carlino MS, Sandhu S, Larkin J, Puig S, Ascierto PA, Rutkowski P, Schadendorf D, Koornstra R, Hernandez-Aya L, Di Giacomo AM, van den Eertwegh AJM, Grob JJ, Gutzmer R, Jamal R, Lorigan PC, van Akkooi ACJ, Krepler C, Ibrahim N, Marreaud S, Kicinski M, Suciu S, Robert C; EORTC Melanoma Group
Lancet Oncol 2021 May;22(5):643-654. Epub 2021 Apr 12 doi: 10.1016/S1470-2045(21)00065-6. PMID: 33857412
Longer Follow-Up Confirms Recurrence-Free Survival Benefit of Adjuvant Pembrolizumab in High-Risk Stage III Melanoma: Updated Results From the EORTC 1325-MG/KEYNOTE-054 Trial.
Eggermont AMM, Blank CU, Mandala M, Long GV, Atkinson VG, Dalle S, Haydon AM, Meshcheryakov A, Khattak A, Carlino MS, Sandhu S, Larkin J, Puig S, Ascierto PA, Rutkowski P, Schadendorf D, Koornstra R, Hernandez-Aya L, Di Giacomo AM, van den Eertwegh AJM, Grob JJ, Gutzmer R, Jamal R, Lorigan PC, van Akkooi ACJ, Krepler C, Ibrahim N, Marreaud S, Kicinski M, Suciu S, Robert C
J Clin Oncol 2020 Nov 20;38(33):3925-3936. Epub 2020 Sep 18 doi: 10.1200/JCO.20.02110. PMID: 32946353Free PMC Article
Managing in-transit melanoma metastases in the new era of effective systemic therapies for melanoma.
Read RL, Thompson JF
Expert Rev Clin Pharmacol 2019 Dec;12(12):1107-1119. Epub 2019 Nov 14 doi: 10.1080/17512433.2019.1689121. PMID: 31687857
Malignant Melanoma: Diagnostic and Management Update.
Knackstedt T, Knackstedt RW, Couto R, Gastman B
Plast Reconstr Surg 2018 Aug;142(2):202e-216e. doi: 10.1097/PRS.0000000000004571. PMID: 30045186
Adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): a randomised, double-blind, phase 3 trial.
Eggermont AM, Chiarion-Sileni V, Grob JJ, Dummer R, Wolchok JD, Schmidt H, Hamid O, Robert C, Ascierto PA, Richards JM, Lebbé C, Ferraresi V, Smylie M, Weber JS, Maio M, Konto C, Hoos A, de Pril V, Gurunath RK, de Schaetzen G, Suciu S, Testori A
Lancet Oncol 2015 May;16(5):522-30. Epub 2015 Mar 31 doi: 10.1016/S1470-2045(15)70122-1. PMID: 25840693

Diagnosis

Association of tumor molecular factors with in-transit metastasis in primary cutaneous melanoma.
Jakub JW, Weaver AL, Meves A
Int J Dermatol 2022 Sep;61(9):1117-1123. Epub 2022 Mar 5 doi: 10.1111/ijd.16141. PMID: 35246838Free PMC Article
Preputial melanoma.
Tchernev G, Temelkova I
Wien Med Wochenschr 2021 Feb;171(1-2):41-42. Epub 2020 May 7 doi: 10.1007/s10354-020-00751-4. PMID: 32382854
Malignant Melanoma: Diagnostic and Management Update.
Knackstedt T, Knackstedt RW, Couto R, Gastman B
Plast Reconstr Surg 2018 Aug;142(2):202e-216e. doi: 10.1097/PRS.0000000000004571. PMID: 30045186
In-Transit Metastasis From Squamous Cell Carcinoma.
Ma JH, Wu A, Veness M, Estall V, Hong A, Borg M, James C, Ibbetson J, Ooi C, Weightman W, McColl I, Hamann I, Grieve N, Ozluer S, Salmon P, Nikitins M, Caplash Y, Marshall N, Edwards T, Patterson I, Selva D, Huilgol SC
Dermatol Surg 2016 Nov;42(11):1285-1292. doi: 10.1097/DSS.0000000000000864. PMID: 27598442
Cutaneous melanoma: role of ultrasound in the assessment of locoregional spread.
Catalano O, Siani A
Curr Probl Diagn Radiol 2010 Jan-Feb;39(1):30-6. doi: 10.1067/j.cpradiol.2009.04.001. PMID: 19931111

Therapy

Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054): distant metastasis-free survival results from a double-blind, randomised, controlled, phase 3 trial.
Eggermont AMM, Blank CU, Mandalà M, Long GV, Atkinson VG, Dalle S, Haydon AM, Meshcheryakov A, Khattak A, Carlino MS, Sandhu S, Larkin J, Puig S, Ascierto PA, Rutkowski P, Schadendorf D, Koornstra R, Hernandez-Aya L, Di Giacomo AM, van den Eertwegh AJM, Grob JJ, Gutzmer R, Jamal R, Lorigan PC, van Akkooi ACJ, Krepler C, Ibrahim N, Marreaud S, Kicinski M, Suciu S, Robert C; EORTC Melanoma Group
Lancet Oncol 2021 May;22(5):643-654. Epub 2021 Apr 12 doi: 10.1016/S1470-2045(21)00065-6. PMID: 33857412
Neoadjuvant ipilimumab plus nivolumab in synchronous clinical stage III melanoma.
Versluis JM, Reijers ILM, Rozeman EA, Menzies AM, van Akkooi ACJ, Wouters MW, Ch'ng S, Saw RPM, Scolyer RA, van de Wiel BA, Schilling B, Long GV, Blank CU
Eur J Cancer 2021 May;148:51-57. Epub 2021 Mar 15 doi: 10.1016/j.ejca.2021.02.012. PMID: 33735809
Longer Follow-Up Confirms Recurrence-Free Survival Benefit of Adjuvant Pembrolizumab in High-Risk Stage III Melanoma: Updated Results From the EORTC 1325-MG/KEYNOTE-054 Trial.
Eggermont AMM, Blank CU, Mandala M, Long GV, Atkinson VG, Dalle S, Haydon AM, Meshcheryakov A, Khattak A, Carlino MS, Sandhu S, Larkin J, Puig S, Ascierto PA, Rutkowski P, Schadendorf D, Koornstra R, Hernandez-Aya L, Di Giacomo AM, van den Eertwegh AJM, Grob JJ, Gutzmer R, Jamal R, Lorigan PC, van Akkooi ACJ, Krepler C, Ibrahim N, Marreaud S, Kicinski M, Suciu S, Robert C
J Clin Oncol 2020 Nov 20;38(33):3925-3936. Epub 2020 Sep 18 doi: 10.1200/JCO.20.02110. PMID: 32946353Free PMC Article
Isolated limb infusion: Institutional protocol and implementation.
Carr MJ, Sun J, Zager JS
J Surg Oncol 2020 Jul;122(1):99-105. Epub 2020 Mar 11 doi: 10.1002/jso.25886. PMID: 32162353
Adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): a randomised, double-blind, phase 3 trial.
Eggermont AM, Chiarion-Sileni V, Grob JJ, Dummer R, Wolchok JD, Schmidt H, Hamid O, Robert C, Ascierto PA, Richards JM, Lebbé C, Ferraresi V, Smylie M, Weber JS, Maio M, Konto C, Hoos A, de Pril V, Gurunath RK, de Schaetzen G, Suciu S, Testori A
Lancet Oncol 2015 May;16(5):522-30. Epub 2015 Mar 31 doi: 10.1016/S1470-2045(15)70122-1. PMID: 25840693

Prognosis

Preputial melanoma.
Tchernev G, Temelkova I
Wien Med Wochenschr 2021 Feb;171(1-2):41-42. Epub 2020 May 7 doi: 10.1007/s10354-020-00751-4. PMID: 32382854
Longer Follow-Up Confirms Recurrence-Free Survival Benefit of Adjuvant Pembrolizumab in High-Risk Stage III Melanoma: Updated Results From the EORTC 1325-MG/KEYNOTE-054 Trial.
Eggermont AMM, Blank CU, Mandala M, Long GV, Atkinson VG, Dalle S, Haydon AM, Meshcheryakov A, Khattak A, Carlino MS, Sandhu S, Larkin J, Puig S, Ascierto PA, Rutkowski P, Schadendorf D, Koornstra R, Hernandez-Aya L, Di Giacomo AM, van den Eertwegh AJM, Grob JJ, Gutzmer R, Jamal R, Lorigan PC, van Akkooi ACJ, Krepler C, Ibrahim N, Marreaud S, Kicinski M, Suciu S, Robert C
J Clin Oncol 2020 Nov 20;38(33):3925-3936. Epub 2020 Sep 18 doi: 10.1200/JCO.20.02110. PMID: 32946353Free PMC Article
Managing in-transit melanoma metastases in the new era of effective systemic therapies for melanoma.
Read RL, Thompson JF
Expert Rev Clin Pharmacol 2019 Dec;12(12):1107-1119. Epub 2019 Nov 14 doi: 10.1080/17512433.2019.1689121. PMID: 31687857
Malignant Melanoma: Diagnostic and Management Update.
Knackstedt T, Knackstedt RW, Couto R, Gastman B
Plast Reconstr Surg 2018 Aug;142(2):202e-216e. doi: 10.1097/PRS.0000000000004571. PMID: 30045186
In-Transit Metastasis From Squamous Cell Carcinoma.
Ma JH, Wu A, Veness M, Estall V, Hong A, Borg M, James C, Ibbetson J, Ooi C, Weightman W, McColl I, Hamann I, Grieve N, Ozluer S, Salmon P, Nikitins M, Caplash Y, Marshall N, Edwards T, Patterson I, Selva D, Huilgol SC
Dermatol Surg 2016 Nov;42(11):1285-1292. doi: 10.1097/DSS.0000000000000864. PMID: 27598442

Clinical prediction guides

Association of tumor molecular factors with in-transit metastasis in primary cutaneous melanoma.
Jakub JW, Weaver AL, Meves A
Int J Dermatol 2022 Sep;61(9):1117-1123. Epub 2022 Mar 5 doi: 10.1111/ijd.16141. PMID: 35246838Free PMC Article
Implications of Satellitosis or In-transit Metastasis in Cutaneous Squamous Cell Carcinoma: A Prognostic Omission in Cancer Staging Systems.
Smile TD, Ruiz ES, Kus KJB, Murad F, Wei W, Xiong DD, Vidimos AT, Schmults CD, Koyfman SA
JAMA Dermatol 2022 Apr 1;158(4):390-394. doi: 10.1001/jamadermatol.2022.0001. PMID: 35195668Free PMC Article
Adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): a randomised, double-blind, phase 3 trial.
Eggermont AM, Chiarion-Sileni V, Grob JJ, Dummer R, Wolchok JD, Schmidt H, Hamid O, Robert C, Ascierto PA, Richards JM, Lebbé C, Ferraresi V, Smylie M, Weber JS, Maio M, Konto C, Hoos A, de Pril V, Gurunath RK, de Schaetzen G, Suciu S, Testori A
Lancet Oncol 2015 May;16(5):522-30. Epub 2015 Mar 31 doi: 10.1016/S1470-2045(15)70122-1. PMID: 25840693
A clinicopathological review of 33 patients with vulvar melanoma identifies c-KIT as a prognostic marker.
Heinzelmann-Schwarz VA, Nixdorf S, Valadan M, Diczbalis M, Olivier J, Otton G, Fedier A, Hacker NF, Scurry JP
Int J Mol Med 2014 Apr;33(4):784-94. Epub 2014 Feb 14 doi: 10.3892/ijmm.2014.1659. PMID: 24535703Free PMC Article
The natural course of cutaneous melanoma.
Leiter U, Meier F, Schittek B, Garbe C
J Surg Oncol 2004 Jul 1;86(4):172-8. doi: 10.1002/jso.20079. PMID: 15221923

Recent systematic reviews

Surgical excision margins in primary cutaneous melanoma: A systematic review and meta-analysis.
Hanna S, Lo SN, Saw RP
Eur J Surg Oncol 2021 Jul;47(7):1558-1574. Epub 2021 Mar 3 doi: 10.1016/j.ejso.2021.02.025. PMID: 33722422

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