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Pancreatic Intraductal Papillary Mucinous Neoplasm, Intestinal-Type

MedGen UID:
459419
•Concept ID:
C2987193
•
Neoplastic Process

Definition

A pancreatic intraductal papillary mucinous neoplasm characterized by the presence of neoplastic epithelial cells that form tall papillae, similar to those that are present in colonic villous adenomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancreatic Intraductal Papillary Mucinous Neoplasm, Intestinal-Type

Professional guidelines

PubMed

Clinical implication of morphological subtypes in management of intraductal papillary mucinous neoplasm.
Yamada S, Fujii T, Shimoyama Y, Kanda M, Nakayama G, Sugimoto H, Koike M, Nomoto S, Fujiwara M, Nakao A, Kodera Y
Ann Surg Oncol 2014 Jul;21(7):2444-52. Epub 2014 Feb 22 doi: 10.1245/s10434-014-3565-1. PMID: 24562937

Recent clinical studies

Etiology

Are intratumoral microbiota involved in the progression of intraductal papillary mucinous neoplasms of the pancreas?
Hozaka Y, Oi H, Satake S, Uchino Y, Goto Y, Idichi T, Tanoue K, Yamasaki Y, Kawasaki Y, Mataki Y, Kurahara H, Nakajo A, Higashi M, Tanimoto A, Sugiura T, Ohtsuka T
Surgery 2023 Feb;173(2):503-510. Epub 2022 Nov 17 doi: 10.1016/j.surg.2022.10.003. PMID: 36404180
Pathways for the development of multiple epithelial types of intraductal papillary mucinous neoplasm of the pancreas.
Kobayashi T, Omori Y, Ono Y, Karasaki H, Mizukami Y, Makino N, Motoi F, Unno M, Ueno Y, Furukawa T
J Gastroenterol 2021 Jun;56(6):581-592. Epub 2021 Apr 1 doi: 10.1007/s00535-021-01783-2. PMID: 33796937
Diabetes mellitus in intraductal papillary mucinous neoplasm of the pancreas is associated with high-grade dysplasia and invasive carcinoma.
Morales-Oyarvide V, Mino-Kenudson M, Ferrone CR, Sahani DV, Pergolini I, Negreros-Osuna AA, Warshaw AL, Lillemoe KD, Fernández-Del Castillo C
Pancreatology 2017 Nov-Dec;17(6):920-926. Epub 2017 Sep 8 doi: 10.1016/j.pan.2017.08.073. PMID: 28890154
Intraductal papillary mucinous neoplasm.
Shi C, Hruban RH
Hum Pathol 2012 Jan;43(1):1-16. Epub 2011 Jul 20 doi: 10.1016/j.humpath.2011.04.003. PMID: 21777948
Current understanding of precursors to pancreatic cancer.
Takaori K
J Hepatobiliary Pancreat Surg 2007;14(3):217-23. Epub 2007 May 29 doi: 10.1007/s00534-006-1165-6. PMID: 17520195

Diagnosis

Tumoral Intraductal Neoplasms of the Bile Ducts Comprise Morphologically and Genetically Distinct Entities.
Wang T, Askan G, Ozcan K, Rana S, Zehir A, Bhanot UK, Yantiss RK, Rao DS, Wahl SJ, Bagci P, Balci S, Balachandran V, Jarnagin WR, Adsay NV, Klimstra DS, Basturk O
Arch Pathol Lab Med 2023 Dec 1;147(12):1390-1401. doi: 10.5858/arpa.2022-0343-OA. PMID: 36821179
Diabetes mellitus in intraductal papillary mucinous neoplasm of the pancreas is associated with high-grade dysplasia and invasive carcinoma.
Morales-Oyarvide V, Mino-Kenudson M, Ferrone CR, Sahani DV, Pergolini I, Negreros-Osuna AA, Warshaw AL, Lillemoe KD, Fernández-Del Castillo C
Pancreatology 2017 Nov-Dec;17(6):920-926. Epub 2017 Sep 8 doi: 10.1016/j.pan.2017.08.073. PMID: 28890154
Intraductal neoplasms of the bile duct. A new challenge to biliary tract tumor pathology.
Nakanuma Y, Uesaka K, Miyayama S, Yamaguchi H, Ohtsuka M
Histol Histopathol 2017 Oct;32(10):1001-1015. Epub 2017 Mar 24 doi: 10.14670/HH-11-892. PMID: 28337739
Interobserver variability in intraductal papillary mucinous neoplasm subtypes and application of their mucin immunoprofiles.
Kwak HA, Liu X, Allende DS, Pai RK, Hart J, Xiao SY
Mod Pathol 2016 Sep;29(9):977-84. Epub 2016 May 20 doi: 10.1038/modpathol.2016.93. PMID: 27198568
GNAS and KRAS Mutations Define Separate Progression Pathways in Intraductal Papillary Mucinous Neoplasm-Associated Carcinoma.
Tan MC, Basturk O, Brannon AR, Bhanot U, Scott SN, Bouvier N, LaFemina J, Jarnagin WR, Berger MF, Klimstra D, Allen PJ
J Am Coll Surg 2015 May;220(5):845-854.e1. Epub 2015 Feb 11 doi: 10.1016/j.jamcollsurg.2014.11.029. PMID: 25840541Free PMC Article

Therapy

Malignant transformation and overall survival of morphological subtypes of intraductal papillary mucinous neoplasms of the pancreas: A network meta-analysis.
Qi X, Zhao X, Su J, Xu M, Zhang W, Sheng H, Li Z, Wang J
Eur J Intern Med 2015 Oct;26(8):652-7. Epub 2015 Aug 12 doi: 10.1016/j.ejim.2015.07.016. PMID: 26275457

Prognosis

Expression of PD-L1 and VISTA in Intraductal Papillary Mucinous Neoplasm With Associated Invasive Carcinoma of the Pancreas.
Mo S, Zou L, Hu Y, Chang X, Chen J
Mod Pathol 2023 Sep;36(9):100223. Epub 2023 May 25 doi: 10.1016/j.modpat.2023.100223. PMID: 37244388
Intraductal papillary mucinous neoplasms of the pancreas: Clinical association with KRAS.
Chang XY, Wu Y, Li Y, Wang J, Chen J
Mol Med Rep 2018 Jun;17(6):8061-8068. Epub 2018 Apr 12 doi: 10.3892/mmr.2018.8875. PMID: 29658583Free PMC Article
Interobserver variability in intraductal papillary mucinous neoplasm subtypes and application of their mucin immunoprofiles.
Kwak HA, Liu X, Allende DS, Pai RK, Hart J, Xiao SY
Mod Pathol 2016 Sep;29(9):977-84. Epub 2016 May 20 doi: 10.1038/modpathol.2016.93. PMID: 27198568
Intraductal papillary mucinous neoplasm.
Shi C, Hruban RH
Hum Pathol 2012 Jan;43(1):1-16. Epub 2011 Jul 20 doi: 10.1016/j.humpath.2011.04.003. PMID: 21777948
Invasive carcinoma derived from intestinal-type intraductal papillary mucinous neoplasm is associated with minimal invasion, colloid carcinoma, and less invasive behavior, leading to a better prognosis.
Nakata K, Ohuchida K, Aishima S, Sadakari Y, Kayashima T, Miyasaka Y, Nagai E, Mizumoto K, Tanaka M, Tsuneyoshi M, Oda Y
Pancreas 2011 May;40(4):581-7. doi: 10.1097/MPA.0b013e318214fa86. PMID: 21499213

Clinical prediction guides

Expression of PD-L1 and VISTA in Intraductal Papillary Mucinous Neoplasm With Associated Invasive Carcinoma of the Pancreas.
Mo S, Zou L, Hu Y, Chang X, Chen J
Mod Pathol 2023 Sep;36(9):100223. Epub 2023 May 25 doi: 10.1016/j.modpat.2023.100223. PMID: 37244388
Pathways for the development of multiple epithelial types of intraductal papillary mucinous neoplasm of the pancreas.
Kobayashi T, Omori Y, Ono Y, Karasaki H, Mizukami Y, Makino N, Motoi F, Unno M, Ueno Y, Furukawa T
J Gastroenterol 2021 Jun;56(6):581-592. Epub 2021 Apr 1 doi: 10.1007/s00535-021-01783-2. PMID: 33796937
Hyalinized stroma is a characteristic feature of pancreatic intraductal oncocytic papillary neoplasm: An immunohistochemical study.
Hirabayashi K, Kawanishi A, Morimachi M, Yamada M, Takanashi Y, Hori S, Serizawa A, Saika T, Nakagohri T, Nakamura N
Ann Diagn Pathol 2020 Dec;49:151639. Epub 2020 Oct 8 doi: 10.1016/j.anndiagpath.2020.151639. PMID: 33069084
Interobserver variability in intraductal papillary mucinous neoplasm subtypes and application of their mucin immunoprofiles.
Kwak HA, Liu X, Allende DS, Pai RK, Hart J, Xiao SY
Mod Pathol 2016 Sep;29(9):977-84. Epub 2016 May 20 doi: 10.1038/modpathol.2016.93. PMID: 27198568
Intraductal papillary mucinous neoplasm.
Shi C, Hruban RH
Hum Pathol 2012 Jan;43(1):1-16. Epub 2011 Jul 20 doi: 10.1016/j.humpath.2011.04.003. PMID: 21777948

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