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Pancreatic Intraductal Papillary Mucinous Neoplasm, Oncocytic-Type

MedGen UID:
459423
•Concept ID:
C2987197
•
Neoplastic Process
Synonyms: Pancreatic Intraductal Oncocytic Papillary Neoplasm; Pancreatic IOPN

Definition

A pancreatic intraductal papillary mucinous neoplasm characterized by the presence of neoplastic epithelial cells with abundant eosinophilic granular cytoplasm. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancreatic Intraductal Papillary Mucinous Neoplasm, Oncocytic-Type

Professional guidelines

PubMed

Cytopathologic diagnosis of oncocytic type intraductal papillary mucinous neoplasm: Criteria and clinical implications of accurate diagnosis.
Reid MD, Stallworth CR, Lewis MM, Akkas G, Memis B, Basturk O, Adsay V
Cancer Cytopathol 2016 Feb;124(2):122-34. Epub 2015 Sep 28 doi: 10.1002/cncy.21627. PMID: 26415076Free PMC Article

Recent clinical studies

Etiology

Pathways for the development of multiple epithelial types of intraductal papillary mucinous neoplasm of the pancreas.
Kobayashi T, Omori Y, Ono Y, Karasaki H, Mizukami Y, Makino N, Motoi F, Unno M, Ueno Y, Furukawa T
J Gastroenterol 2021 Jun;56(6):581-592. Epub 2021 Apr 1 doi: 10.1007/s00535-021-01783-2. PMID: 33796937
Comparative clinicopathological study of biliary intraductal papillary neoplasms and papillary cholangiocarcinomas.
Fujikura K, Fukumoto T, Ajiki T, Otani K, Kanzawa M, Akita M, Kido M, Ku Y, Itoh T, Zen Y
Histopathology 2016 Dec;69(6):950-961. Epub 2016 Sep 23 doi: 10.1111/his.13037. PMID: 27410028
Cytopathologic diagnosis of oncocytic type intraductal papillary mucinous neoplasm: Criteria and clinical implications of accurate diagnosis.
Reid MD, Stallworth CR, Lewis MM, Akkas G, Memis B, Basturk O, Adsay V
Cancer Cytopathol 2016 Feb;124(2):122-34. Epub 2015 Sep 28 doi: 10.1002/cncy.21627. PMID: 26415076Free PMC Article
Oncocytic-type intraductal papillary mucinous neoplasms: a unique malignant pancreatic tumor with good long-term prognosis.
Marchegiani G, Mino-Kenudson M, Ferrone CR, Warshaw AL, Lillemoe KD, Fernández-del Castillo C
J Am Coll Surg 2015 May;220(5):839-44. Epub 2015 Feb 11 doi: 10.1016/j.jamcollsurg.2015.01.051. PMID: 25840549
Intraductal neoplasms of the pancreas.
Klöppel G, Basturk O, Schlitter AM, Konukiewitz B, Esposito I
Semin Diagn Pathol 2014 Nov;31(6):452-466. Epub 2014 Sep 2 doi: 10.1053/j.semdp.2014.08.005. PMID: 25282472

Diagnosis

The pathological features and prognoses of intraductal papillary mucinous neoplasm and mucinous cystic neoplasm after surgical resection: a single institution series.
Li Y, Zhu Z, Peng L, Jin Z, Sun L, Song B
World J Surg Oncol 2020 Nov 4;18(1):287. doi: 10.1186/s12957-020-02063-8. PMID: 33148260Free PMC Article
Comparative clinicopathological study of biliary intraductal papillary neoplasms and papillary cholangiocarcinomas.
Fujikura K, Fukumoto T, Ajiki T, Otani K, Kanzawa M, Akita M, Kido M, Ku Y, Itoh T, Zen Y
Histopathology 2016 Dec;69(6):950-961. Epub 2016 Sep 23 doi: 10.1111/his.13037. PMID: 27410028
Cytopathologic diagnosis of oncocytic type intraductal papillary mucinous neoplasm: Criteria and clinical implications of accurate diagnosis.
Reid MD, Stallworth CR, Lewis MM, Akkas G, Memis B, Basturk O, Adsay V
Cancer Cytopathol 2016 Feb;124(2):122-34. Epub 2015 Sep 28 doi: 10.1002/cncy.21627. PMID: 26415076Free PMC Article
Intraductal neoplasms of the pancreas.
Klöppel G, Basturk O, Schlitter AM, Konukiewitz B, Esposito I
Semin Diagn Pathol 2014 Nov;31(6):452-466. Epub 2014 Sep 2 doi: 10.1053/j.semdp.2014.08.005. PMID: 25282472
Prognosis of invasive intraductal papillary mucinous neoplasm depends on histological and precursor epithelial subtypes.
Mino-Kenudson M, Fernández-del Castillo C, Baba Y, Valsangkar NP, Liss AS, Hsu M, Correa-Gallego C, Ingkakul T, Perez Johnston R, Turner BG, Androutsopoulos V, Deshpande V, McGrath D, Sahani DV, Brugge WR, Ogino S, Pitman MB, Warshaw AL, Thayer SP
Gut 2011 Dec;60(12):1712-20. Epub 2011 Apr 20 doi: 10.1136/gut.2010.232272. PMID: 21508421Free PMC Article

Therapy

Malignant transformation and overall survival of morphological subtypes of intraductal papillary mucinous neoplasms of the pancreas: A network meta-analysis.
Qi X, Zhao X, Su J, Xu M, Zhang W, Sheng H, Li Z, Wang J
Eur J Intern Med 2015 Oct;26(8):652-7. Epub 2015 Aug 12 doi: 10.1016/j.ejim.2015.07.016. PMID: 26275457

Prognosis

Intraductal papillary mucinous neoplasms of the pancreas: Clinical association with KRAS.
Chang XY, Wu Y, Li Y, Wang J, Chen J
Mol Med Rep 2018 Jun;17(6):8061-8068. Epub 2018 Apr 12 doi: 10.3892/mmr.2018.8875. PMID: 29658583Free PMC Article
Comparative clinicopathological study of biliary intraductal papillary neoplasms and papillary cholangiocarcinomas.
Fujikura K, Fukumoto T, Ajiki T, Otani K, Kanzawa M, Akita M, Kido M, Ku Y, Itoh T, Zen Y
Histopathology 2016 Dec;69(6):950-961. Epub 2016 Sep 23 doi: 10.1111/his.13037. PMID: 27410028
Oncocytic-type intraductal papillary mucinous neoplasms: a unique malignant pancreatic tumor with good long-term prognosis.
Marchegiani G, Mino-Kenudson M, Ferrone CR, Warshaw AL, Lillemoe KD, Fernández-del Castillo C
J Am Coll Surg 2015 May;220(5):839-44. Epub 2015 Feb 11 doi: 10.1016/j.jamcollsurg.2015.01.051. PMID: 25840549
Intraductal neoplasms of the pancreas.
Klöppel G, Basturk O, Schlitter AM, Konukiewitz B, Esposito I
Semin Diagn Pathol 2014 Nov;31(6):452-466. Epub 2014 Sep 2 doi: 10.1053/j.semdp.2014.08.005. PMID: 25282472
Prognosis of invasive intraductal papillary mucinous neoplasm depends on histological and precursor epithelial subtypes.
Mino-Kenudson M, Fernández-del Castillo C, Baba Y, Valsangkar NP, Liss AS, Hsu M, Correa-Gallego C, Ingkakul T, Perez Johnston R, Turner BG, Androutsopoulos V, Deshpande V, McGrath D, Sahani DV, Brugge WR, Ogino S, Pitman MB, Warshaw AL, Thayer SP
Gut 2011 Dec;60(12):1712-20. Epub 2011 Apr 20 doi: 10.1136/gut.2010.232272. PMID: 21508421Free PMC Article

Clinical prediction guides

Pathways for the development of multiple epithelial types of intraductal papillary mucinous neoplasm of the pancreas.
Kobayashi T, Omori Y, Ono Y, Karasaki H, Mizukami Y, Makino N, Motoi F, Unno M, Ueno Y, Furukawa T
J Gastroenterol 2021 Jun;56(6):581-592. Epub 2021 Apr 1 doi: 10.1007/s00535-021-01783-2. PMID: 33796937
Prognostic value of histological subtype in intraductal papillary mucinous neoplasm of the pancreas: A retrospective analysis of outcome from one single center.
Rong Y, Wang D, Xu C, Ji Y, Jin D, Wu W, Xu X, Kuang T, Lou W
Medicine (Baltimore) 2017 Apr;96(15):e6599. doi: 10.1097/MD.0000000000006599. PMID: 28403101Free PMC Article
Cytopathologic diagnosis of oncocytic type intraductal papillary mucinous neoplasm: Criteria and clinical implications of accurate diagnosis.
Reid MD, Stallworth CR, Lewis MM, Akkas G, Memis B, Basturk O, Adsay V
Cancer Cytopathol 2016 Feb;124(2):122-34. Epub 2015 Sep 28 doi: 10.1002/cncy.21627. PMID: 26415076Free PMC Article
Oncocytic-type intraductal papillary mucinous neoplasms: a unique malignant pancreatic tumor with good long-term prognosis.
Marchegiani G, Mino-Kenudson M, Ferrone CR, Warshaw AL, Lillemoe KD, Fernández-del Castillo C
J Am Coll Surg 2015 May;220(5):839-44. Epub 2015 Feb 11 doi: 10.1016/j.jamcollsurg.2015.01.051. PMID: 25840549
Intraductal papillary mucinous neoplasms of the pancreas with distinct pancreatic ductal adenocarcinomas are frequently of gastric subtype.
Ideno N, Ohtsuka T, Kono H, Fujiwara K, Oda Y, Aishima S, Ito T, Ishigami K, Tokunaga S, Ohuchida K, Takahata S, Nakamura M, Mizumoto K, Tanaka M
Ann Surg 2013 Jul;258(1):141-51. doi: 10.1097/SLA.0b013e31828cd008. PMID: 23532108

Recent systematic reviews

Systematic Review and Meta-analysis of Current Experience in Treating IPNB: Clinical and Pathological Correlates.
Gordon-Weeks AN, Jones K, Harriss E, Smith A, Silva M
Ann Surg 2016 Apr;263(4):656-63. doi: 10.1097/SLA.0000000000001426. PMID: 26501712

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