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Esophageal Spindle Cell Carcinoma

MedGen UID:
459478
•Concept ID:
C2987252
•
Neoplastic Process
Synonyms: Esophageal Carcinoma with Mesenchymal Stroma; Esophageal Carcinosarcoma; Esophageal Metaplastic Carcinoma; Esophageal Polypoid Carcinoma; Esophageal Pseudosarcomatous Squamous Cell Carcinoma; Esophageal Sarcomatoid Carcinoma; Esophageal Squamous Cell Carcinoma with a Spindle-Cell Component

Definition

An esophageal squamous cell carcinoma characterized by the presence of a spindle-cell carcinomatous component. Crossly it has a polypoid appearance and usually arises from the middle or lower third of the esophagus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEsophageal Spindle Cell Carcinoma

Professional guidelines

PubMed

Update on Management of Squamous Cell Esophageal Cancer.
Waters JK, Reznik SI
Curr Oncol Rep 2022 Mar;24(3):375-385. Epub 2022 Feb 10 doi: 10.1007/s11912-021-01153-4. PMID: 35142974
Endoscopic Management of Early Adenocarcinoma and Squamous Cell Carcinoma of the Esophagus: Screening, Diagnosis, and Therapy.
di Pietro M, Canto MI, Fitzgerald RC
Gastroenterology 2018 Jan;154(2):421-436. Epub 2017 Aug 2 doi: 10.1053/j.gastro.2017.07.041. PMID: 28778650Free PMC Article
Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria.
Pilarski R, Burt R, Kohlman W, Pho L, Shannon KM, Swisher E
J Natl Cancer Inst 2013 Nov 6;105(21):1607-16. Epub 2013 Oct 17 doi: 10.1093/jnci/djt277. PMID: 24136893

Recent clinical studies

Etiology

Prognosis and prognostic factors of esophageal spindle cell carcinoma treated by esophagectomy: a retrospective single-institution analysis.
Hashimoto M, Kitagami H, Niwa H, Kikkawa T, Ohuchi T, Takenouchi T, Hosokawa M
Esophagus 2019 Jul;16(3):292-299. Epub 2019 Apr 1 doi: 10.1007/s10388-019-00667-y. PMID: 30937574

Diagnosis

The alterations of cytokeratin and vimentin protein expressions in primary esophageal spindle cell carcinoma.
Li XM, Song X, Zhao XK, Hu SJ, Cheng R, Lv S, Du DF, Zhang XY, Lu JL, Ku JW, Zhang DY, Zhang Y, Fan ZM, Wang LD
BMC Cancer 2018 Apr 2;18(1):356. doi: 10.1186/s12885-018-4301-1. PMID: 29609569Free PMC Article

Prognosis

Prognosis and prognostic factors of esophageal spindle cell carcinoma treated by esophagectomy: a retrospective single-institution analysis.
Hashimoto M, Kitagami H, Niwa H, Kikkawa T, Ohuchi T, Takenouchi T, Hosokawa M
Esophagus 2019 Jul;16(3):292-299. Epub 2019 Apr 1 doi: 10.1007/s10388-019-00667-y. PMID: 30937574
The alterations of cytokeratin and vimentin protein expressions in primary esophageal spindle cell carcinoma.
Li XM, Song X, Zhao XK, Hu SJ, Cheng R, Lv S, Du DF, Zhang XY, Lu JL, Ku JW, Zhang DY, Zhang Y, Fan ZM, Wang LD
BMC Cancer 2018 Apr 2;18(1):356. doi: 10.1186/s12885-018-4301-1. PMID: 29609569Free PMC Article

Clinical prediction guides

The alterations of cytokeratin and vimentin protein expressions in primary esophageal spindle cell carcinoma.
Li XM, Song X, Zhao XK, Hu SJ, Cheng R, Lv S, Du DF, Zhang XY, Lu JL, Ku JW, Zhang DY, Zhang Y, Fan ZM, Wang LD
BMC Cancer 2018 Apr 2;18(1):356. doi: 10.1186/s12885-018-4301-1. PMID: 29609569Free PMC Article

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