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Esophageal Poorly Differentiated Squamous Cell Carcinoma

MedGen UID:
459482
•Concept ID:
C2987256
•
Neoplastic Process

Definition

An esophageal squamous cell carcinoma characterized by the presence of basal-like malignant squamous cells that form nests, often associated with central necrosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEsophageal Poorly Differentiated Squamous Cell Carcinoma

Professional guidelines

PubMed

American Society for Gastrointestinal Endoscopy guideline on endoscopic submucosal dissection for the management of early esophageal and gastric cancers: summary and recommendations.
ASGE standards of practice committee, Forbes N, Elhanafi SE, Al-Haddad MA, Thosani NC, Draganov PV, Othman MO, Ceppa EP, Kaul V, Feely MM, Sahin I, Buxbaum JL, Calderwood AH, Chalhoub JM, Coelho-Prabhu N, Desai M, Fujii-Lau LL, Kohli DR, Kwon RS, Machicado JD, Marya NB, Pawa S, Ruan W, Sheth SG, Storm AC, Thiruvengadam NR, Qumseya BJ; (ASGE Standards of Practice Committee Chair)
Gastrointest Endosc 2023 Sep;98(3):271-284. Epub 2023 Jul 25 doi: 10.1016/j.gie.2023.03.015. PMID: 37498266
American Society for Gastrointestinal Endoscopy guideline on endoscopic submucosal dissection for the management of early esophageal and gastric cancers: methodology and review of evidence.
Al-Haddad MA, Elhanafi SE, Forbes N, Thosani NC, Draganov PV, Othman MO, Ceppa EP, Kaul V, Feely MM, Sahin I, Ruan Y, Sadeghirad B, Morgan RL, Buxbaum JL, Calderwood AH, Chalhoub JM, Coelho-Prabhu N, Desai M, Fujii-Lau LL, Kohli DR, Kwon RS, Machicado JD, Marya NB, Pawa S, Ruan W, Sheth SG, Storm AC, Thiruvengadam NR, Qumseya BJ; (ASGE Standards of Practice Committee Chair)
Gastrointest Endosc 2023 Sep;98(3):285-305.e38. Epub 2023 Jul 25 doi: 10.1016/j.gie.2023.03.030. PMID: 37498265
Treatment of clinical T2N0M0 esophageal cancer.
Hardacker TJ, Ceppa D, Okereke I, Rieger KM, Jalal SI, LeBlanc JK, DeWitt JM, Kesler KA, Birdas TJ
Ann Surg Oncol 2014 Nov;21(12):3739-43. Epub 2014 Jul 22 doi: 10.1245/s10434-014-3929-6. PMID: 25047477

Recent clinical studies

Etiology

American Society for Gastrointestinal Endoscopy guideline on endoscopic submucosal dissection for the management of early esophageal and gastric cancers: summary and recommendations.
ASGE standards of practice committee, Forbes N, Elhanafi SE, Al-Haddad MA, Thosani NC, Draganov PV, Othman MO, Ceppa EP, Kaul V, Feely MM, Sahin I, Buxbaum JL, Calderwood AH, Chalhoub JM, Coelho-Prabhu N, Desai M, Fujii-Lau LL, Kohli DR, Kwon RS, Machicado JD, Marya NB, Pawa S, Ruan W, Sheth SG, Storm AC, Thiruvengadam NR, Qumseya BJ; (ASGE Standards of Practice Committee Chair)
Gastrointest Endosc 2023 Sep;98(3):271-284. Epub 2023 Jul 25 doi: 10.1016/j.gie.2023.03.015. PMID: 37498266
Bone metastasis in esophageal adenocarcinoma and squamous cell carcinoma: a SEER-based study.
Qin Y, Mao J, Liang X, Wang N, Yuan M, Zhu J, Wu D, Wang Q
Gen Thorac Cardiovasc Surg 2022 May;70(5):479-490. Epub 2022 Jan 19 doi: 10.1007/s11748-021-01765-4. PMID: 35044634
Clinical, epidemiological, and diagnostic characteristics of esophageal carcinoma in a Pakistani population.
Asghar MS, Khan NA, Kazmi SJH, Hassan M, Rasheed U, Jawed R, Yaseen R, Naqvi SAA
Ann Saudi Med 2021 Mar-Apr;41(2):91-100. Epub 2021 Apr 1 doi: 10.5144/0256-4947.2021.91. PMID: 33818145Free PMC Article
Neuroendocrine neoplasms of the esophagus and stomach.
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
AGA Institute Clinical Practice Update: Endoscopic Submucosal Dissection in the United States.
Draganov PV, Wang AY, Othman MO, Fukami N
Clin Gastroenterol Hepatol 2019 Jan;17(1):16-25.e1. Epub 2018 Aug 2 doi: 10.1016/j.cgh.2018.07.041. PMID: 30077787

Diagnosis

Clinical, epidemiological, and diagnostic characteristics of esophageal carcinoma in a Pakistani population.
Asghar MS, Khan NA, Kazmi SJH, Hassan M, Rasheed U, Jawed R, Yaseen R, Naqvi SAA
Ann Saudi Med 2021 Mar-Apr;41(2):91-100. Epub 2021 Apr 1 doi: 10.5144/0256-4947.2021.91. PMID: 33818145Free PMC Article
Neuroendocrine neoplasms of the esophagus and stomach.
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Esophageal Neuroendocrine Carcinoma With Focal Squamous Cell Carcinoma Component.
Kang MK, Kang DK
J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620918245. doi: 10.1177/2324709620918245. PMID: 32363938Free PMC Article
Immunohistochemistry for Protein Detection in Esophageal Squamous Cell Carcinoma.
Kasem K, Lam AK
Methods Mol Biol 2020;2129:279-294. doi: 10.1007/978-1-0716-0377-2_21. PMID: 32056185
Molecular pathology and potential therapeutic targets in esophageal basaloid squamous cell carcinoma.
Saito T, Mitomi H, Yao T
Int J Clin Exp Pathol 2015;8(3):2267-73. Epub 2015 Mar 1 PMID: 26045734Free PMC Article

Therapy

Predicting response to CCRT for esophageal squamous carcinoma by a radiomics-clinical SHAP model.
Cheng X, Zhang Y, Zhu M, Sun R, Liu L, Li X
BMC Med Imaging 2023 Oct 2;23(1):145. doi: 10.1186/s12880-023-01089-0. PMID: 37779188Free PMC Article
NRF2/ACSS2 axis mediates the metabolic effect of alcohol drinking on esophageal squamous cell carcinoma.
Odera JO, Xiong Z, Huang C, Gu N, Yang W, Githang'a J, Odera E, Paiboonrungruang C, Chen X
Biochem J 2020 Aug 28;477(16):3075-3089. doi: 10.1042/BCJ20200452. PMID: 32776152Free PMC Article
Risk of tumor implantation in percutaneous endoscopic gastrostomy in the upper aerodigestive tumors.
Vincenzi F, De Caro G, Gaiani F, Fornaroli F, Minelli R, Leandro G, Di Mario F, De' Angelis GL
Acta Biomed 2018 Dec 17;89(8-S):117-121. doi: 10.23750/abm.v89i8-S.7894. PMID: 30561429Free PMC Article
Molecular pathology and potential therapeutic targets in esophageal basaloid squamous cell carcinoma.
Saito T, Mitomi H, Yao T
Int J Clin Exp Pathol 2015;8(3):2267-73. Epub 2015 Mar 1 PMID: 26045734Free PMC Article
Loss of TACSTD2 contributed to squamous cell carcinoma progression through attenuating TAp63-dependent apoptosis.
Wang F, Liu X, Yang P, Guo L, Liu C, Li H, Long S, Shen Y, Wan H
Cell Death Dis 2014 Mar 20;5(3):e1133. doi: 10.1038/cddis.2014.96. PMID: 24651436Free PMC Article

Prognosis

Clinicopathological and mutational analysis of esophageal basaloid squamous cell carcinoma.
Yanai Y, Hayashi T, Tsuyama S, Nasu M, Hashimoto T, Kajiyama Y, Tsurumaru M, Mine S, Orita H, Fukunaga T, Yao T, Saito T
Virchows Arch 2022 Sep;481(3):477-487. Epub 2022 May 31 doi: 10.1007/s00428-022-03350-3. PMID: 35641667
Bone metastasis in esophageal adenocarcinoma and squamous cell carcinoma: a SEER-based study.
Qin Y, Mao J, Liang X, Wang N, Yuan M, Zhu J, Wu D, Wang Q
Gen Thorac Cardiovasc Surg 2022 May;70(5):479-490. Epub 2022 Jan 19 doi: 10.1007/s11748-021-01765-4. PMID: 35044634
Neuroendocrine neoplasms of the esophagus and stomach.
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
AGA Institute Clinical Practice Update: Endoscopic Submucosal Dissection in the United States.
Draganov PV, Wang AY, Othman MO, Fukami N
Clin Gastroenterol Hepatol 2019 Jan;17(1):16-25.e1. Epub 2018 Aug 2 doi: 10.1016/j.cgh.2018.07.041. PMID: 30077787
Molecular pathology and potential therapeutic targets in esophageal basaloid squamous cell carcinoma.
Saito T, Mitomi H, Yao T
Int J Clin Exp Pathol 2015;8(3):2267-73. Epub 2015 Mar 1 PMID: 26045734Free PMC Article

Clinical prediction guides

Bone metastasis in esophageal adenocarcinoma and squamous cell carcinoma: a SEER-based study.
Qin Y, Mao J, Liang X, Wang N, Yuan M, Zhu J, Wu D, Wang Q
Gen Thorac Cardiovasc Surg 2022 May;70(5):479-490. Epub 2022 Jan 19 doi: 10.1007/s11748-021-01765-4. PMID: 35044634
Neuroendocrine neoplasms of the esophagus and stomach.
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Immunohistochemistry for Protein Detection in Esophageal Squamous Cell Carcinoma.
Kasem K, Lam AK
Methods Mol Biol 2020;2129:279-294. doi: 10.1007/978-1-0716-0377-2_21. PMID: 32056185
AGA Institute Clinical Practice Update: Endoscopic Submucosal Dissection in the United States.
Draganov PV, Wang AY, Othman MO, Fukami N
Clin Gastroenterol Hepatol 2019 Jan;17(1):16-25.e1. Epub 2018 Aug 2 doi: 10.1016/j.cgh.2018.07.041. PMID: 30077787
Molecular pathology and potential therapeutic targets in esophageal basaloid squamous cell carcinoma.
Saito T, Mitomi H, Yao T
Int J Clin Exp Pathol 2015;8(3):2267-73. Epub 2015 Mar 1 PMID: 26045734Free PMC Article

Recent systematic reviews

Helicobacter pylori eradication for the prevention of gastric neoplasia.
Ford AC, Yuan Y, Forman D, Hunt R, Moayyedi P
Cochrane Database Syst Rev 2020 Jul 6;7(7):CD005583. doi: 10.1002/14651858.CD005583.pub3. PMID: 32628791Free PMC Article

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