U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Indefinite for Gastric Dysplasia

MedGen UID:
459628
•Concept ID:
C2987402
•
Finding
Synonym: Indefinite for Gastric Intraepithelial Neoplasia

Definition

A term used to describe an ambiguous morphologic pattern in the gastric mucosa, when there is doubt whether the findings represent a non-neoplastic or neoplastic pathologic process. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIndefinite for Gastric Dysplasia

Professional guidelines

PubMed

Refined Criteria for Separating Low-grade Dysplasia and Nondysplastic Barrett Esophagus Reduce Equivocal Diagnoses and Improve Prediction of Patient Outcome: A 10-Year Review.
Waters KM, Salimian KJ, Voltaggio L, Montgomery EA
Am J Surg Pathol 2018 Dec;42(12):1723-1729. doi: 10.1097/PAS.0000000000001162. PMID: 30234520
Detection of gastric carcinoma-associated MG7-Ag by serum immuno-PCR assay in a high-risk Chinese population, with implication for screening.
Zhang L, Ren J, Pan K, Ma J, Li J, Shen L, Zhang X, Li J, Fan D, Gail M, You W
Int J Cancer 2010 Jan 15;126(2):469-73. doi: 10.1002/ijc.24739. PMID: 19588495
Diagnostic criteria for gastrointestinal carcinomas in Japan and Western countries: proposal for a new classification system of gastrointestinal epithelial neoplasia.
Schlemper RJ, Kato Y, Stolte M
J Gastroenterol Hepatol 2000 Oct;15 Suppl:G49-57. doi: 10.1046/j.1440-1746.2000.02266.x. PMID: 11100994

Recent clinical studies

Etiology

Colorectal dysplasia in chronic inflammatory bowel disease: a contemporary consensus classification and interobserver study.
Harpaz N, Goldblum JR, Shepherd NA, Riddell RH, Rubio CA, Vieth M, Wang HH, Odze RD
Hum Pathol 2023 Aug;138:49-61. Epub 2023 May 27 doi: 10.1016/j.humpath.2023.05.008. PMID: 37247824
The Colombian Chemoprevention Trial: 20-Year Follow-Up of a Cohort of Patients With Gastric Precancerous Lesions.
Piazuelo MB, Bravo LE, Mera RM, Camargo MC, Bravo JC, Delgado AG, Washington MK, Rosero A, Garcia LS, Realpe JL, Cifuentes SP, Morgan DR, Peek RM Jr, Correa P, Wilson KT
Gastroenterology 2021 Mar;160(4):1106-1117.e3. Epub 2020 Nov 18 doi: 10.1053/j.gastro.2020.11.017. PMID: 33220252Free PMC Article
Risk stratification of patients with gastric lesions indefinite for dysplasia.
Cho YS, Chung IK, Jung Y, Han SJ, Yang JK, Lee TH, Park SH, Kim SJ
Korean J Intern Med 2021 Sep;36(5):1074-1082. Epub 2020 Sep 9 doi: 10.3904/kjim.2018.285. PMID: 32898394Free PMC Article
Treatment for gastric 'indefinite for neoplasm/dysplasia' lesions based on predictive factors.
Kwon MJ, Kang HS, Kim HT, Choo JW, Lee BH, Hong SE, Park KH, Jung DM, Lim H, Soh JS, Moon SH, Kim JH, Park HR, Min SK, Seo JW, Choe JY
World J Gastroenterol 2019 Jan 28;25(4):469-484. doi: 10.3748/wjg.v25.i4.469. PMID: 30700943Free PMC Article
Gastric epithelial dysplasia.
Misdraji J, Lauwers GY
Semin Diagn Pathol 2002 Feb;19(1):20-30. PMID: 11936263

Diagnosis

Colorectal dysplasia in chronic inflammatory bowel disease: a contemporary consensus classification and interobserver study.
Harpaz N, Goldblum JR, Shepherd NA, Riddell RH, Rubio CA, Vieth M, Wang HH, Odze RD
Hum Pathol 2023 Aug;138:49-61. Epub 2023 May 27 doi: 10.1016/j.humpath.2023.05.008. PMID: 37247824
Combination of artificial intelligence-based endoscopy and miR148a methylation for gastric indefinite dysplasia diagnosis.
Watanabe Y, Oikawa R, Agawa S, Matsuo Y, Oda I, Futagami S, Yamamoto H, Tada T, Itoh F
J Clin Lab Anal 2022 Jan;36(1):e24122. Epub 2021 Nov 22 doi: 10.1002/jcla.24122. PMID: 34811809Free PMC Article
The Colombian Chemoprevention Trial: 20-Year Follow-Up of a Cohort of Patients With Gastric Precancerous Lesions.
Piazuelo MB, Bravo LE, Mera RM, Camargo MC, Bravo JC, Delgado AG, Washington MK, Rosero A, Garcia LS, Realpe JL, Cifuentes SP, Morgan DR, Peek RM Jr, Correa P, Wilson KT
Gastroenterology 2021 Mar;160(4):1106-1117.e3. Epub 2020 Nov 18 doi: 10.1053/j.gastro.2020.11.017. PMID: 33220252Free PMC Article
Gastric epithelial dysplasia.
Misdraji J, Lauwers GY
Semin Diagn Pathol 2002 Feb;19(1):20-30. PMID: 11936263
The Vienna classification of gastrointestinal epithelial neoplasia.
Schlemper RJ, Riddell RH, Kato Y, Borchard F, Cooper HS, Dawsey SM, Dixon MF, Fenoglio-Preiser CM, Fléjou JF, Geboes K, Hattori T, Hirota T, Itabashi M, Iwafuchi M, Iwashita A, Kim YI, Kirchner T, Klimpfinger M, Koike M, Lauwers GY, Lewin KJ, Oberhuber G, Offner F, Price AB, Rubio CA, Shimizu M, Shimoda T, Sipponen P, Solcia E, Stolte M, Watanabe H, Yamabe H
Gut 2000 Aug;47(2):251-5. doi: 10.1136/gut.47.2.251. PMID: 10896917Free PMC Article

Therapy

Gastric dysplasia in random biopsies: the influence of Helicobacter pylori infection and alcohol consumption in the presence of a lesion.
Ferreira AI, Lima Capela T, Macedo Silva V, Xavier S, Boal Carvalho P, Magalhães J, Cotter J
Scand J Gastroenterol 2024 Jan-Jun;59(2):125-132. Epub 2024 Jan 30 doi: 10.1080/00365521.2023.2272563. PMID: 37872792
Colorectal dysplasia in chronic inflammatory bowel disease: a contemporary consensus classification and interobserver study.
Harpaz N, Goldblum JR, Shepherd NA, Riddell RH, Rubio CA, Vieth M, Wang HH, Odze RD
Hum Pathol 2023 Aug;138:49-61. Epub 2023 May 27 doi: 10.1016/j.humpath.2023.05.008. PMID: 37247824
Improving clinical outcomes of Barrett's esophagus with high dose proton pump inhibitors and cryoablation.
Snady H
Ann Med 2023 Dec;55(1):1256-1264. doi: 10.1080/07853890.2023.2191002. PMID: 37232568Free PMC Article
The Colombian Chemoprevention Trial: 20-Year Follow-Up of a Cohort of Patients With Gastric Precancerous Lesions.
Piazuelo MB, Bravo LE, Mera RM, Camargo MC, Bravo JC, Delgado AG, Washington MK, Rosero A, Garcia LS, Realpe JL, Cifuentes SP, Morgan DR, Peek RM Jr, Correa P, Wilson KT
Gastroenterology 2021 Mar;160(4):1106-1117.e3. Epub 2020 Nov 18 doi: 10.1053/j.gastro.2020.11.017. PMID: 33220252Free PMC Article
Overdiagnosis of high-grade dysplasia in Barrett's esophagus: a multicenter, international study.
Sangle NA, Taylor SL, Emond MJ, Depot M, Overholt BF, Bronner MP
Mod Pathol 2015 Jun;28(6):758-65. Epub 2015 Feb 13 doi: 10.1038/modpathol.2015.2. PMID: 25676554

Prognosis

The Colombian Chemoprevention Trial: 20-Year Follow-Up of a Cohort of Patients With Gastric Precancerous Lesions.
Piazuelo MB, Bravo LE, Mera RM, Camargo MC, Bravo JC, Delgado AG, Washington MK, Rosero A, Garcia LS, Realpe JL, Cifuentes SP, Morgan DR, Peek RM Jr, Correa P, Wilson KT
Gastroenterology 2021 Mar;160(4):1106-1117.e3. Epub 2020 Nov 18 doi: 10.1053/j.gastro.2020.11.017. PMID: 33220252Free PMC Article
Risk stratification of patients with gastric lesions indefinite for dysplasia.
Cho YS, Chung IK, Jung Y, Han SJ, Yang JK, Lee TH, Park SH, Kim SJ
Korean J Intern Med 2021 Sep;36(5):1074-1082. Epub 2020 Sep 9 doi: 10.3904/kjim.2018.285. PMID: 32898394Free PMC Article
Prevalence and Incidence of Intestinal Metaplasia and Dysplasia of Gastric Cardia in Patients With Barrett's Esophagus After Endoscopic Therapy.
Eluri S, Earasi AG, Moist SE, Dellon ES, Shaheen NJ
Clin Gastroenterol Hepatol 2020 Jan;18(1):82-88.e1. Epub 2019 May 8 doi: 10.1016/j.cgh.2019.04.065. PMID: 31077822Free PMC Article
Treatment for gastric 'indefinite for neoplasm/dysplasia' lesions based on predictive factors.
Kwon MJ, Kang HS, Kim HT, Choo JW, Lee BH, Hong SE, Park KH, Jung DM, Lim H, Soh JS, Moon SH, Kim JH, Park HR, Min SK, Seo JW, Choe JY
World J Gastroenterol 2019 Jan 28;25(4):469-484. doi: 10.3748/wjg.v25.i4.469. PMID: 30700943Free PMC Article
Lesions indefinite for intraepithelial neoplasia and OLGA staging for gastric atrophy.
Fassan M, Pizzi M, Farinati F, Nitti D, Zagonel V, Genta RM, Rugge M
Am J Clin Pathol 2012 May;137(5):727-32. doi: 10.1309/AJCPEU41HTGXSJDQ. PMID: 22523210

Clinical prediction guides

Improving clinical outcomes of Barrett's esophagus with high dose proton pump inhibitors and cryoablation.
Snady H
Ann Med 2023 Dec;55(1):1256-1264. doi: 10.1080/07853890.2023.2191002. PMID: 37232568Free PMC Article
The Colombian Chemoprevention Trial: 20-Year Follow-Up of a Cohort of Patients With Gastric Precancerous Lesions.
Piazuelo MB, Bravo LE, Mera RM, Camargo MC, Bravo JC, Delgado AG, Washington MK, Rosero A, Garcia LS, Realpe JL, Cifuentes SP, Morgan DR, Peek RM Jr, Correa P, Wilson KT
Gastroenterology 2021 Mar;160(4):1106-1117.e3. Epub 2020 Nov 18 doi: 10.1053/j.gastro.2020.11.017. PMID: 33220252Free PMC Article
Risk stratification of patients with gastric lesions indefinite for dysplasia.
Cho YS, Chung IK, Jung Y, Han SJ, Yang JK, Lee TH, Park SH, Kim SJ
Korean J Intern Med 2021 Sep;36(5):1074-1082. Epub 2020 Sep 9 doi: 10.3904/kjim.2018.285. PMID: 32898394Free PMC Article
Treatment for gastric 'indefinite for neoplasm/dysplasia' lesions based on predictive factors.
Kwon MJ, Kang HS, Kim HT, Choo JW, Lee BH, Hong SE, Park KH, Jung DM, Lim H, Soh JS, Moon SH, Kim JH, Park HR, Min SK, Seo JW, Choe JY
World J Gastroenterol 2019 Jan 28;25(4):469-484. doi: 10.3748/wjg.v25.i4.469. PMID: 30700943Free PMC Article
Gastric dysplasia: the Padova international classification.
Rugge M, Correa P, Dixon MF, Hattori T, Leandro G, Lewin K, Riddell RH, Sipponen P, Watanabe H
Am J Surg Pathol 2000 Feb;24(2):167-76. doi: 10.1097/00000478-200002000-00001. PMID: 10680883

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...