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Acute tonsillitis

MedGen UID:
472878
•Concept ID:
C0001361
•
Disease or Syndrome
Synonym: Acute adenoiditis
SNOMED CT: Acute tonsillitis (17741008); Infective tonsillitis (17741008)
 
Monarch Initiative: MONDO:0020686

Definition

An acute inflammation of the tonsils caused by viruses or bacteria. Signs and symptoms include fever, enlargement of the tonsils, difficulty swallowing, and enlargement of the regional lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute tonsillitis

Professional guidelines

PubMed

Complementary and alternative medicine in the (symptomatic) treatment of acute tonsillitis in children: A systematic review.
Büttner R, Schwermer M, Ostermann T, Längler A, Zuzak T
Complement Ther Med 2023 May;73:102940. Epub 2023 Mar 1 doi: 10.1016/j.ctim.2023.102940. PMID: 36868289
Corticosteroids for treatment of sore throat: systematic review and meta-analysis of randomised trials.
Sadeghirad B, Siemieniuk RAC, Brignardello-Petersen R, Papola D, Lytvyn L, Vandvik PO, Merglen A, Guyatt GH, Agoritsas T
BMJ 2017 Sep 20;358:j3887. doi: 10.1136/bmj.j3887. PMID: 28931508Free PMC Article
Clinical practice guideline: tonsillitis I. Diagnostics and nonsurgical management.
Windfuhr JP, Toepfner N, Steffen G, Waldfahrer F, Berner R
Eur Arch Otorhinolaryngol 2016 Apr;273(4):973-87. Epub 2016 Jan 11 doi: 10.1007/s00405-015-3872-6. PMID: 26755048Free PMC Article

Recent clinical studies

Etiology

Conservative management versus tonsillectomy in adults with recurrent acute tonsillitis in the UK (NATTINA): a multicentre, open-label, randomised controlled trial.
Wilson JA, O'Hara J, Fouweather T, Homer T, Stocken DD, Vale L, Haighton C, Rousseau N, Wilson R, McSweeney L, Wilkes S, Morrison J, MacKenzie K, Ah-See K, Carrie S, Hopkins C, Howe N, Hussain M, Mehanna H, Raine C, Sullivan F, von Wilamowitz-Moellendorff A, Teare MD
Lancet 2023 Jun 17;401(10393):2051-2059. Epub 2023 May 17 doi: 10.1016/S0140-6736(23)00519-6. PMID: 37209706
Healthcare aspects of peritonsillar infection before and during the COVID-19 pandemic.
García-Callejo FJ, Alba-García JR, Orozco-Núñez S, Martínez-Giménez L, Balaguer-García R, Ruescas-Gómez L
Acta Otorrinolaringol Esp (Engl Ed) 2023 Mar-Apr;74(2):108-115. Epub 2023 Mar 9 doi: 10.1016/j.otoeng.2022.04.003. PMID: 36906064Free PMC Article
Corticosteroids for treatment of sore throat: systematic review and meta-analysis of randomised trials.
Sadeghirad B, Siemieniuk RAC, Brignardello-Petersen R, Papola D, Lytvyn L, Vandvik PO, Merglen A, Guyatt GH, Agoritsas T
BMJ 2017 Sep 20;358:j3887. doi: 10.1136/bmj.j3887. PMID: 28931508Free PMC Article
Peritonsillar abscess: clinical aspects of microbiology, risk factors, and the association with parapharyngeal abscess.
Klug TE
Dan Med J 2017 Mar;64(3) PMID: 28260599
Deep neck space infections.
Beasley DJ, Amedee RG
J La State Med Soc 1995 May;147(5):181-4. PMID: 7782669

Diagnosis

Peritonsillar abscess: clinical aspects of microbiology, risk factors, and the association with parapharyngeal abscess.
Klug TE
Dan Med J 2017 Mar;64(3) PMID: 28260599
Clinical practice guideline: tonsillitis I. Diagnostics and nonsurgical management.
Windfuhr JP, Toepfner N, Steffen G, Waldfahrer F, Berner R
Eur Arch Otorhinolaryngol 2016 Apr;273(4):973-87. Epub 2016 Jan 11 doi: 10.1007/s00405-015-3872-6. PMID: 26755048Free PMC Article
Tonsillitis.
Georgalas CC, Tolley NS, Narula PA
BMJ Clin Evid 2014 Jul 22;2014 PMID: 25051184Free PMC Article
Acute tonsillitis.
Sidell D, Shapiro NL
Infect Disord Drug Targets 2012 Aug;12(4):271-6. doi: 10.2174/187152612801319230. PMID: 22338587
Tonsillitis.
Georgalas CC, Tolley NS, Narula A
BMJ Clin Evid 2009 Oct 26;2009 PMID: 21718574Free PMC Article

Therapy

Conservative management versus tonsillectomy in adults with recurrent acute tonsillitis in the UK (NATTINA): a multicentre, open-label, randomised controlled trial.
Wilson JA, O'Hara J, Fouweather T, Homer T, Stocken DD, Vale L, Haighton C, Rousseau N, Wilson R, McSweeney L, Wilkes S, Morrison J, MacKenzie K, Ah-See K, Carrie S, Hopkins C, Howe N, Hussain M, Mehanna H, Raine C, Sullivan F, von Wilamowitz-Moellendorff A, Teare MD
Lancet 2023 Jun 17;401(10393):2051-2059. Epub 2023 May 17 doi: 10.1016/S0140-6736(23)00519-6. PMID: 37209706
Healthcare aspects of peritonsillar infection before and during the COVID-19 pandemic.
García-Callejo FJ, Alba-García JR, Orozco-Núñez S, Martínez-Giménez L, Balaguer-García R, Ruescas-Gómez L
Acta Otorrinolaringol Esp (Engl Ed) 2023 Mar-Apr;74(2):108-115. Epub 2023 Mar 9 doi: 10.1016/j.otoeng.2022.04.003. PMID: 36906064Free PMC Article
Corticosteroids for treatment of sore throat: systematic review and meta-analysis of randomised trials.
Sadeghirad B, Siemieniuk RAC, Brignardello-Petersen R, Papola D, Lytvyn L, Vandvik PO, Merglen A, Guyatt GH, Agoritsas T
BMJ 2017 Sep 20;358:j3887. doi: 10.1136/bmj.j3887. PMID: 28931508Free PMC Article
Peritonsillar abscess: clinical aspects of microbiology, risk factors, and the association with parapharyngeal abscess.
Klug TE
Dan Med J 2017 Mar;64(3) PMID: 28260599
Clinical practice guideline: tonsillitis I. Diagnostics and nonsurgical management.
Windfuhr JP, Toepfner N, Steffen G, Waldfahrer F, Berner R
Eur Arch Otorhinolaryngol 2016 Apr;273(4):973-87. Epub 2016 Jan 11 doi: 10.1007/s00405-015-3872-6. PMID: 26755048Free PMC Article

Prognosis

Changes in Otorhinolaryngologic Disease Incidences before and during the COVID-19 Pandemic in Korea.
Kim SY, Yoo DM, Kim JH, Kwon MJ, Kim JH, Chung J, Choi HG
Int J Environ Res Public Health 2022 Oct 12;19(20) doi: 10.3390/ijerph192013083. PMID: 36293687Free PMC Article
Ubi pus, ibi evacua: a review of 601 peritonsillar abscess adult cases.
Sideris G, Malamas V, Tyrellis G, Maragkoudakis P, Delides A, Nikolopoulos T
Ir J Med Sci 2022 Aug;191(4):1849-1853. Epub 2021 Oct 6 doi: 10.1007/s11845-021-02796-9. PMID: 34617243Free PMC Article
IL-8 and IFN-γ as Preoperative Predictors of the Outcome of Tonsillectomy.
Seethaler A, Stenner M, McNally A, Rudack C, Roth J, Vogl T, Spiekermann C
Ear Nose Throat J 2021 Sep;100(5_suppl):822S-827S. Epub 2020 Mar 17 doi: 10.1177/0145561320910682. PMID: 32182134
Peritonsillar abscess: clinical aspects of microbiology, risk factors, and the association with parapharyngeal abscess.
Klug TE
Dan Med J 2017 Mar;64(3) PMID: 28260599
Relation between peritonsillar infection and acute tonsillitis: myth or reality?
Kordeluk S, Novack L, Puterman M, Kraus M, Joshua BZ
Otolaryngol Head Neck Surg 2011 Dec;145(6):940-5. Epub 2011 Aug 2 doi: 10.1177/0194599811415802. PMID: 21810775

Clinical prediction guides

Conservative management versus tonsillectomy in adults with recurrent acute tonsillitis in the UK (NATTINA): a multicentre, open-label, randomised controlled trial.
Wilson JA, O'Hara J, Fouweather T, Homer T, Stocken DD, Vale L, Haighton C, Rousseau N, Wilson R, McSweeney L, Wilkes S, Morrison J, MacKenzie K, Ah-See K, Carrie S, Hopkins C, Howe N, Hussain M, Mehanna H, Raine C, Sullivan F, von Wilamowitz-Moellendorff A, Teare MD
Lancet 2023 Jun 17;401(10393):2051-2059. Epub 2023 May 17 doi: 10.1016/S0140-6736(23)00519-6. PMID: 37209706
Thermographic differential diagnosis of acute tonsillitis and exacerbation of chronic tonsillitis.
Andreychyn MA, Kopcha VS, Klymnyuk SI, Andreichyn IM, Kopcha YV, Halamba AA
Wiad Lek 2020;73(3):417-422. PMID: 32285805
Peritonsillar abscess: clinical aspects of microbiology, risk factors, and the association with parapharyngeal abscess.
Klug TE
Dan Med J 2017 Mar;64(3) PMID: 28260599
Clinical practice guideline: tonsillitis I. Diagnostics and nonsurgical management.
Windfuhr JP, Toepfner N, Steffen G, Waldfahrer F, Berner R
Eur Arch Otorhinolaryngol 2016 Apr;273(4):973-87. Epub 2016 Jan 11 doi: 10.1007/s00405-015-3872-6. PMID: 26755048Free PMC Article
Tonsillitis.
Georgalas CC, Tolley NS, Narula A
BMJ Clin Evid 2009 Oct 26;2009 PMID: 21718574Free PMC Article

Recent systematic reviews

Complementary and alternative medicine in the (symptomatic) treatment of acute tonsillitis in children: A systematic review.
Büttner R, Schwermer M, Ostermann T, Längler A, Zuzak T
Complement Ther Med 2023 May;73:102940. Epub 2023 Mar 1 doi: 10.1016/j.ctim.2023.102940. PMID: 36868289
Immediate or interval abscess tonsillectomy? A systematic review and meta-analysis.
Tsikopoulos A, Fountarlis A, Tsikopoulos K, Dilmperis F, Garefis K, Tsikopoulos I, Skoulakis C, Karkos P, Triaridis S
Eur Arch Otorhinolaryngol 2022 May;279(5):2245-2257. Epub 2022 Feb 15 doi: 10.1007/s00405-022-07294-x. PMID: 35169892
Corticosteroids for treatment of sore throat: systematic review and meta-analysis of randomised trials.
Sadeghirad B, Siemieniuk RAC, Brignardello-Petersen R, Papola D, Lytvyn L, Vandvik PO, Merglen A, Guyatt GH, Agoritsas T
BMJ 2017 Sep 20;358:j3887. doi: 10.1136/bmj.j3887. PMID: 28931508Free PMC Article
Tonsillitis.
Georgalas CC, Tolley NS, Narula PA
BMJ Clin Evid 2014 Jul 22;2014 PMID: 25051184Free PMC Article
Tonsillitis.
Georgalas CC, Tolley NS, Narula A
BMJ Clin Evid 2009 Oct 26;2009 PMID: 21718574Free PMC Article

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