U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cutaneous necrosis

MedGen UID:
472897
•Concept ID:
C0151799
•
Pathologic Function
Synonym: Skin necrosis
SNOMED CT: Cutaneous necrosis (95347000); Sloughing of skin (95347000); Skin necrosis (95347000)
 
HPO: HP:0033126

Definition

Skin and subcutaneous tissue necrosis (tissue death). Clinically, cutaneous necrosis may present as a painful and extremely tender black eschar (dead tissue found in a full-thickness wound) surrounded by dusky grey-red colored skin. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCutaneous necrosis

Professional guidelines

PubMed

Acute Cutaneous Necrosis: A Guide to Early Diagnosis and Treatment.
Karimi K, Odhav A, Kollipara R, Fike J, Stanford C, Hall JC
J Cutan Med Surg 2017 Sep/Oct;21(5):425-437. Epub 2017 May 4 doi: 10.1177/1203475417708164. PMID: 28470091
Adverse effects of levamisole in cocaine users: a review and risk assessment.
Brunt TM, van den Berg J, Pennings E, Venhuis B
Arch Toxicol 2017 Jun;91(6):2303-2313. Epub 2017 Mar 17 doi: 10.1007/s00204-017-1947-4. PMID: 28314885
Cutaneous necrosis, telangiectatic matting, and hyperpigmentation following sclerotherapy. Etiology, prevention, and treatment.
Goldman MP, Sadick NS, Weiss RA
Dermatol Surg 1995 Jan;21(1):19-29; quiz 31-2. doi: 10.1111/j.1524-4725.1995.tb00107.x. PMID: 7600016

Recent clinical studies

Etiology

Vasculopathies, cutaneous necrosis and emergency in dermatology.
Martinez-Mera C, Fraga J, Capusan TM, Herrero-Moyano M, Godoy-Trapero A, Gonzales Perez Y, Llamas-Velasco M
G Ital Dermatol Venereol 2017 Dec;152(6):615-637. Epub 2017 Jul 28 doi: 10.23736/S0392-0488.17.05727-3. PMID: 28845953
Cancer risk in dermatomyositis: a systematic review of the literature.
Di Rollo D, Abeni D, Tracanna M, Capo A, Amerio P
G Ital Dermatol Venereol 2014 Oct;149(5):525-37. Epub 2014 Jun 30 PMID: 24975953
Calciphylaxis--a topical overview.
Arseculeratne G, Evans AT, Morley SM
J Eur Acad Dermatol Venereol 2006 May;20(5):493-502. doi: 10.1111/j.1468-3083.2006.01506.x. PMID: 16684274
Penile calciphylaxis.
Wood JC, Monga M, Hellstrom WJ
Urology 1997 Oct;50(4):622-4. doi: 10.1016/S0090-4295(97)00311-7. PMID: 9338747
Cutaneous necrosis, telangiectatic matting, and hyperpigmentation following sclerotherapy. Etiology, prevention, and treatment.
Goldman MP, Sadick NS, Weiss RA
Dermatol Surg 1995 Jan;21(1):19-29; quiz 31-2. doi: 10.1111/j.1524-4725.1995.tb00107.x. PMID: 7600016

Diagnosis

Vasculopathies, cutaneous necrosis and emergency in dermatology.
Martinez-Mera C, Fraga J, Capusan TM, Herrero-Moyano M, Godoy-Trapero A, Gonzales Perez Y, Llamas-Velasco M
G Ital Dermatol Venereol 2017 Dec;152(6):615-637. Epub 2017 Jul 28 doi: 10.23736/S0392-0488.17.05727-3. PMID: 28845953
Acute Cutaneous Necrosis: A Guide to Early Diagnosis and Treatment.
Karimi K, Odhav A, Kollipara R, Fike J, Stanford C, Hall JC
J Cutan Med Surg 2017 Sep/Oct;21(5):425-437. Epub 2017 May 4 doi: 10.1177/1203475417708164. PMID: 28470091
Distribution and medical aspects of Loxosceles rufescens, one of the most invasive spiders of the world (Araneae: Sicariidae).
Nentwig W, Pantini P, Vetter RS
Toxicon 2017 Jun 15;132:19-28. Epub 2017 Apr 10 doi: 10.1016/j.toxicon.2017.04.007. PMID: 28408204
Rheumatic manifestations of cocaine use.
Graf J
Curr Opin Rheumatol 2013 Jan;25(1):50-5. doi: 10.1097/BOR.0b013e32835b4449. PMID: 23196324
Calciphylaxis--a topical overview.
Arseculeratne G, Evans AT, Morley SM
J Eur Acad Dermatol Venereol 2006 May;20(5):493-502. doi: 10.1111/j.1468-3083.2006.01506.x. PMID: 16684274

Therapy

Acute Cutaneous Necrosis: A Guide to Early Diagnosis and Treatment.
Karimi K, Odhav A, Kollipara R, Fike J, Stanford C, Hall JC
J Cutan Med Surg 2017 Sep/Oct;21(5):425-437. Epub 2017 May 4 doi: 10.1177/1203475417708164. PMID: 28470091
Cutaneous adverse events associated with disease-modifying treatment in multiple sclerosis: a systematic review.
Balak DM, Hengstman GJ, Çakmak A, Thio HB
Mult Scler 2012 Dec;18(12):1705-17. Epub 2012 Feb 27 doi: 10.1177/1352458512438239. PMID: 22371220
Interferon-induced cutaneous necrosis.
Sasseville D, Ghamdi WA, Khenaizan SA
J Cutan Med Surg 1999 Oct;3(6):320-3. doi: 10.1177/120347549900300610. PMID: 10575164
Cutaneous necrosis.
Whitmore SE, Horn TD
Arch Dermatol 1996 Mar;132(3):341-2, 344-5. doi: 10.1001/archderm.1996.03890270119019. PMID: 8607642
Cutaneous necrosis, telangiectatic matting, and hyperpigmentation following sclerotherapy. Etiology, prevention, and treatment.
Goldman MP, Sadick NS, Weiss RA
Dermatol Surg 1995 Jan;21(1):19-29; quiz 31-2. doi: 10.1111/j.1524-4725.1995.tb00107.x. PMID: 7600016

Prognosis

Anatomical Variations in the Course of Labial Arteries: A Literature Review.
Samizadeh S, Pirayesh A, Bertossi D
Aesthet Surg J 2019 Oct 15;39(11):1225-1235. doi: 10.1093/asj/sjy235. PMID: 30204834
Vasculopathies, cutaneous necrosis and emergency in dermatology.
Martinez-Mera C, Fraga J, Capusan TM, Herrero-Moyano M, Godoy-Trapero A, Gonzales Perez Y, Llamas-Velasco M
G Ital Dermatol Venereol 2017 Dec;152(6):615-637. Epub 2017 Jul 28 doi: 10.23736/S0392-0488.17.05727-3. PMID: 28845953
Cancer risk in dermatomyositis: a systematic review of the literature.
Di Rollo D, Abeni D, Tracanna M, Capo A, Amerio P
G Ital Dermatol Venereol 2014 Oct;149(5):525-37. Epub 2014 Jun 30 PMID: 24975953
Calciphylaxis--a topical overview.
Arseculeratne G, Evans AT, Morley SM
J Eur Acad Dermatol Venereol 2006 May;20(5):493-502. doi: 10.1111/j.1468-3083.2006.01506.x. PMID: 16684274
Cutaneous necrosis, telangiectatic matting, and hyperpigmentation following sclerotherapy. Etiology, prevention, and treatment.
Goldman MP, Sadick NS, Weiss RA
Dermatol Surg 1995 Jan;21(1):19-29; quiz 31-2. doi: 10.1111/j.1524-4725.1995.tb00107.x. PMID: 7600016

Clinical prediction guides

Clinical features and long-term outcomes of patients with systemic polyarteritis nodosa diagnosed since 2005: Data from 196 patients.
Rohmer J, Nguyen Y, Trefond L, Agard C, Allain JS, Berezne A, Charles P, Cohen P, Gondran G, Groh M, Huscenot T, Lacout C, Lazaro E, London J, Maurier F, Mekinian A, Mesbah R, Nubourgh I, Perard L, Puéchal X, Pugnet G, Puyade M, Queyrel V, Roux A, Rouzaud D, Durel CA, Guillevin L, Terrier B; French Vasculitis Study Group (FVSG)
J Autoimmun 2023 Sep;139:103093. Epub 2023 Aug 1 doi: 10.1016/j.jaut.2023.103093. PMID: 37536165
Cancer risk in dermatomyositis: a systematic review of the literature.
Di Rollo D, Abeni D, Tracanna M, Capo A, Amerio P
G Ital Dermatol Venereol 2014 Oct;149(5):525-37. Epub 2014 Jun 30 PMID: 24975953
Rhinocerebral mucormycosis: five cases and a literature review.
Mbarek C, Zribi S, Khamassi K, Hariga I, Ouni H, Ben Amor M, Ben Gamra O, El Khedim A
B-ENT 2011;7(3):189-93. PMID: 22026140
Calciphylaxis--a topical overview.
Arseculeratne G, Evans AT, Morley SM
J Eur Acad Dermatol Venereol 2006 May;20(5):493-502. doi: 10.1111/j.1468-3083.2006.01506.x. PMID: 16684274
Cutaneous necrosis, telangiectatic matting, and hyperpigmentation following sclerotherapy. Etiology, prevention, and treatment.
Goldman MP, Sadick NS, Weiss RA
Dermatol Surg 1995 Jan;21(1):19-29; quiz 31-2. doi: 10.1111/j.1524-4725.1995.tb00107.x. PMID: 7600016

Recent systematic reviews

Vipera snakebite in Europe: a systematic review of a neglected disease.
Paolino G, Di Nicola MR, Pontara A, Didona D, Moliterni E, Mercuri SR, Grano M, Borgianni N, Kumar R, Pampena R
J Eur Acad Dermatol Venereol 2020 Oct;34(10):2247-2260. Epub 2020 Jul 20 doi: 10.1111/jdv.16722. PMID: 32530549
Smoking and plastic surgery, part II. Clinical implications: a systematic review with meta-analysis.
Pluvy I, Panouillères M, Garrido I, Pauchot J, Saboye J, Chavoin JP, Tropet Y, Grolleau JL, Chaput B
Ann Chir Plast Esthet 2015 Feb;60(1):e15-49. Epub 2014 Oct 25 doi: 10.1016/j.anplas.2014.09.011. PMID: 25447218
Cancer risk in dermatomyositis: a systematic review of the literature.
Di Rollo D, Abeni D, Tracanna M, Capo A, Amerio P
G Ital Dermatol Venereol 2014 Oct;149(5):525-37. Epub 2014 Jun 30 PMID: 24975953
Factors predicting malignancy in patients with polymyositis and dermatomyostis: a systematic review and meta-analysis.
Lu X, Yang H, Shu X, Chen F, Zhang Y, Zhang S, Peng Q, Tian X, Wang G
PLoS One 2014;9(4):e94128. Epub 2014 Apr 8 doi: 10.1371/journal.pone.0094128. PMID: 24713868Free PMC Article
Cutaneous adverse events associated with disease-modifying treatment in multiple sclerosis: a systematic review.
Balak DM, Hengstman GJ, Çakmak A, Thio HB
Mult Scler 2012 Dec;18(12):1705-17. Epub 2012 Feb 27 doi: 10.1177/1352458512438239. PMID: 22371220

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...