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Increased body mass index

MedGen UID:
472957
•Concept ID:
C0231254
•
Finding
Synonym: Increased BMI
SNOMED CT: Body mass index above normal parameters (48499001); Increased body mass index (48499001)
 
HPO: HP:0031418

Definition

Abnormally increased weight-to-height squared ratio, calculated by dividing the individual's weight in kilograms by the square of the individual's height in meters and used as an indicator of overweight compared to averages. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased body mass index

Conditions with this feature

X-linked intellectual disability-short stature-overweight syndrome
MedGen UID:
901885
•Concept ID:
C0796218
•
Disease or Syndrome
X-linked intellectual developmental disorder-12 (XLID12) is characterized by borderline to severe intellectual disability with variable neurologic features, short stature, and elevated body mass index (BMI) (Kumar et al., 2015).
See: Condition Record
Congenital nongoitrous hypothryoidism 6
MedGen UID:
482447
•Concept ID:
C3280817
•
Disease or Syndrome
Any hypothyroidism, congenital, nongoitrous in which the cause of the disease is a mutation in the THRA gene.
See: Condition Record
Congenital nongoitrous hypothryoidism 6
X-linked intellectual disability-short stature-overweight syndrome

Professional guidelines

PubMed

Esophageal hiatal hernia: risk, diagnosis and management.
Yu HX, Han CS, Xue JR, Han ZF, Xin H
Expert Rev Gastroenterol Hepatol 2018 Apr;12(4):319-329. Epub 2018 Feb 22 doi: 10.1080/17474124.2018.1441711. PMID: 29451037
The Evaluation and Management of Suspicious Gastric Lesions Following Bariatric Surgery.
Gomez G
Surg Clin North Am 2017 Apr;97(2):467-474. doi: 10.1016/j.suc.2016.12.003. PMID: 28325198
ASPS clinical practice guideline summary on reduction mammaplasty.
Kalliainen LK; ASPS Health Policy Committee
Plast Reconstr Surg 2012 Oct;130(4):785-789. doi: 10.1097/PRS.0b013e318262f0c0. PMID: 23018692

Recent clinical studies

Etiology

Obesity, metabolic syndrome, and primary hypertension.
Litwin M, Kułaga Z
Pediatr Nephrol 2021 Apr;36(4):825-837. Epub 2020 May 9 doi: 10.1007/s00467-020-04579-3. PMID: 32388582Free PMC Article
Skin changes in the obese patient.
Hirt PA, Castillo DE, Yosipovitch G, Keri JE
J Am Acad Dermatol 2019 Nov;81(5):1037-1057. doi: 10.1016/j.jaad.2018.12.070. PMID: 31610857
Plantar Fasciitis.
Trojian T, Tucker AK
Am Fam Physician 2019 Jun 15;99(12):744-750. PMID: 31194492
The Impact of Childhood and Adolescent Obesity on Cardiovascular Risk in Adulthood: a Systematic Review.
Sommer A, Twig G
Curr Diab Rep 2018 Aug 30;18(10):91. doi: 10.1007/s11892-018-1062-9. PMID: 30167798
Esophageal hiatal hernia: risk, diagnosis and management.
Yu HX, Han CS, Xue JR, Han ZF, Xin H
Expert Rev Gastroenterol Hepatol 2018 Apr;12(4):319-329. Epub 2018 Feb 22 doi: 10.1080/17474124.2018.1441711. PMID: 29451037

Diagnosis

Exploring the Causality Between Body Mass Index and Sepsis: A Two-Sample Mendelian Randomization Study.
Wang J, Hu Y, Zeng J, Li Q, He L, Hao W, Song X, Yan S, Lv C
Int J Public Health 2023;68:1605548. Epub 2023 May 2 doi: 10.3389/ijph.2023.1605548. PMID: 37205044Free PMC Article
Overweight, obesity and assisted reproduction: A systematic review and meta-analysis.
Ribeiro LM, Sasaki LMP, Silva AA, Souza ES, Oliveira Lyrio A, C M G Figueiredo A, Gottems LBD
Eur J Obstet Gynecol Reprod Biol 2022 Apr;271:117-127. Epub 2022 Jan 31 doi: 10.1016/j.ejogrb.2022.01.019. PMID: 35183001
Skin changes in the obese patient.
Hirt PA, Castillo DE, Yosipovitch G, Keri JE
J Am Acad Dermatol 2019 Nov;81(5):1037-1057. doi: 10.1016/j.jaad.2018.12.070. PMID: 31610857
Plantar Fasciitis.
Trojian T, Tucker AK
Am Fam Physician 2019 Jun 15;99(12):744-750. PMID: 31194492
Esophageal hiatal hernia: risk, diagnosis and management.
Yu HX, Han CS, Xue JR, Han ZF, Xin H
Expert Rev Gastroenterol Hepatol 2018 Apr;12(4):319-329. Epub 2018 Feb 22 doi: 10.1080/17474124.2018.1441711. PMID: 29451037

Therapy

Exploring the Causality Between Body Mass Index and Sepsis: A Two-Sample Mendelian Randomization Study.
Wang J, Hu Y, Zeng J, Li Q, He L, Hao W, Song X, Yan S, Lv C
Int J Public Health 2023;68:1605548. Epub 2023 May 2 doi: 10.3389/ijph.2023.1605548. PMID: 37205044Free PMC Article
Overweight, obesity and assisted reproduction: A systematic review and meta-analysis.
Ribeiro LM, Sasaki LMP, Silva AA, Souza ES, Oliveira Lyrio A, C M G Figueiredo A, Gottems LBD
Eur J Obstet Gynecol Reprod Biol 2022 Apr;271:117-127. Epub 2022 Jan 31 doi: 10.1016/j.ejogrb.2022.01.019. PMID: 35183001
Esophageal hiatal hernia: risk, diagnosis and management.
Yu HX, Han CS, Xue JR, Han ZF, Xin H
Expert Rev Gastroenterol Hepatol 2018 Apr;12(4):319-329. Epub 2018 Feb 22 doi: 10.1080/17474124.2018.1441711. PMID: 29451037
Chemistry behind Vegetarianism.
Li D
J Agric Food Chem 2011 Feb 9;59(3):777-84. Epub 2011 Jan 4 doi: 10.1021/jf103846u. PMID: 21204526
Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies.
Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M
Lancet 2008 Feb 16;371(9612):569-78. doi: 10.1016/S0140-6736(08)60269-X. PMID: 18280327

Prognosis

Body Mass Index, Interleukin-6 Signaling and Multiple Sclerosis: A Mendelian Randomization Study.
Vandebergh M, Becelaere S; CHARGE Inflammation Working Group, Dubois B, Goris A
Front Immunol 2022;13:834644. Epub 2022 Mar 21 doi: 10.3389/fimmu.2022.834644. PMID: 35386698Free PMC Article
Obesity, metabolic syndrome, and cancer: pathophysiological and therapeutic associations.
Mili N, Paschou SA, Goulis DG, Dimopoulos MA, Lambrinoudaki I, Psaltopoulou T
Endocrine 2021 Dec;74(3):478-497. Epub 2021 Oct 8 doi: 10.1007/s12020-021-02884-x. PMID: 34625915
Epidemiology of meningiomas.
Walsh KM
Handb Clin Neurol 2020;169:3-15. doi: 10.1016/B978-0-12-804280-9.00001-9. PMID: 32553297
Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index.
Taheri S, Lin L, Austin D, Young T, Mignot E
PLoS Med 2004 Dec;1(3):e62. Epub 2004 Dec 7 doi: 10.1371/journal.pmed.0010062. PMID: 15602591Free PMC Article
Obesity and the risk of heart failure.
Kenchaiah S, Evans JC, Levy D, Wilson PW, Benjamin EJ, Larson MG, Kannel WB, Vasan RS
N Engl J Med 2002 Aug 1;347(5):305-13. doi: 10.1056/NEJMoa020245. PMID: 12151467

Clinical prediction guides

Obesity, metabolic syndrome, and primary hypertension.
Litwin M, Kułaga Z
Pediatr Nephrol 2021 Apr;36(4):825-837. Epub 2020 May 9 doi: 10.1007/s00467-020-04579-3. PMID: 32388582Free PMC Article
The molecular mechanisms of obesity paradox.
Antonopoulos AS, Tousoulis D
Cardiovasc Res 2017 Jul 1;113(9):1074-1086. doi: 10.1093/cvr/cvx106. PMID: 28549096
Diabetes in HFE Hemochromatosis.
Barton JC, Acton RT
J Diabetes Res 2017;2017:9826930. Epub 2017 Feb 26 doi: 10.1155/2017/9826930. PMID: 28331855Free PMC Article
Age-related consequences of childhood obesity.
Kelsey MM, Zaepfel A, Bjornstad P, Nadeau KJ
Gerontology 2014;60(3):222-8. Epub 2014 Jan 9 doi: 10.1159/000356023. PMID: 24434909
Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index.
Taheri S, Lin L, Austin D, Young T, Mignot E
PLoS Med 2004 Dec;1(3):e62. Epub 2004 Dec 7 doi: 10.1371/journal.pmed.0010062. PMID: 15602591Free PMC Article

Recent systematic reviews

Overweight, obesity and assisted reproduction: A systematic review and meta-analysis.
Ribeiro LM, Sasaki LMP, Silva AA, Souza ES, Oliveira Lyrio A, C M G Figueiredo A, Gottems LBD
Eur J Obstet Gynecol Reprod Biol 2022 Apr;271:117-127. Epub 2022 Jan 31 doi: 10.1016/j.ejogrb.2022.01.019. PMID: 35183001
Obesity and anxiety symptoms: a systematic review and meta-analysis.
Amiri S, Behnezhad S
Neuropsychiatr 2019 Jun;33(2):72-89. Epub 2019 Feb 18 doi: 10.1007/s40211-019-0302-9. PMID: 30778841
The Impact of Childhood and Adolescent Obesity on Cardiovascular Risk in Adulthood: a Systematic Review.
Sommer A, Twig G
Curr Diab Rep 2018 Aug 30;18(10):91. doi: 10.1007/s11892-018-1062-9. PMID: 30167798
Body Mass Index and Risk of Gallbladder Cancer: Systematic Review and Meta-Analysis of Observational Studies.
Tan W, Gao M, Liu N, Zhang G, Xu T, Cui W
Nutrients 2015 Sep 25;7(10):8321-34. doi: 10.3390/nu7105387. PMID: 26426043Free PMC Article
Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies.
Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M
Lancet 2008 Feb 16;371(9612):569-78. doi: 10.1016/S0140-6736(08)60269-X. PMID: 18280327

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