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Therapy-Related Malignant Neoplasm

MedGen UID:
473326
•Concept ID:
C0877578
•
Neoplastic Process
Synonyms: Cancer, Therapy-Associated; Cancer, Therapy-Related; Cancer, Treatment-Associated; Cancer, Treatment-Related; Cancers, Therapy-Associated; Cancers, Therapy-Related; Cancers, Treatment-Associated; Cancers, Treatment-Related; Therapy Associated Cancer; Therapy Related Cancer; Therapy-Associated Cancer; Therapy-Associated Cancers; Therapy-Related Cancer; Therapy-Related Cancers; Treatment Associated Cancer; Treatment Related Cancer; Treatment-Associated Cancer; Treatment-Associated Cancers; Treatment-Related Cancer; Treatment-Related Cancers

Definition

The development of a malignant neoplasm in response to medical or surgical treatment, induced by the treatment itself. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTherapy-Related Malignant Neoplasm

Professional guidelines

PubMed

EASL-ILCA Clinical Practice Guidelines on the management of intrahepatic cholangiocarcinoma.
European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; European Association for the Study of the Liver
J Hepatol 2023 Jul;79(1):181-208. Epub 2023 Apr 20 doi: 10.1016/j.jhep.2023.03.010. PMID: 37084797
European consensus-based interdisciplinary guideline for melanoma. Part 2: Treatment - Update 2022.
Garbe C, Amaral T, Peris K, Hauschild A, Arenberger P, Basset-Seguin N, Bastholt L, Bataille V, Del Marmol V, Dréno B, Fargnoli MC, Forsea AM, Grob JJ, Hoeller C, Kaufmann R, Kelleners-Smeets N, Lallas A, Lebbé C, Lytvynenko B, Malvehy J, Moreno-Ramirez D, Nathan P, Pellacani G, Saiag P, Stratigos AJ, Van Akkooi ACJ, Vieira R, Zalaudek I, Lorigan P; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO), and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2022 Jul;170:256-284. Epub 2022 May 24 doi: 10.1016/j.ejca.2022.04.018. PMID: 35623961
Testicular Cancer: Diagnosis and Treatment.
Baird DC, Meyers GJ, Hu JS
Am Fam Physician 2018 Feb 15;97(4):261-268. PMID: 29671528

Recent clinical studies

Etiology

TP53 and therapy-related myeloid neoplasms.
Chung J, Sallman DA, Padron E
Best Pract Res Clin Haematol 2019 Mar;32(1):98-103. Epub 2019 Feb 19 doi: 10.1016/j.beha.2019.02.009. PMID: 30927980
Clonal Hematopoiesis and therapy related MDS/AML.
Desai P, Roboz GJ
Best Pract Res Clin Haematol 2019 Mar;32(1):13-23. Epub 2019 Feb 15 doi: 10.1016/j.beha.2019.02.006. PMID: 30927970
Radiation-Induced Gliomas.
Aherne NJ, Murphy BM
Crit Rev Oncog 2018;23(1-2):113-118. doi: 10.1615/CritRevOncog.2018025740. PMID: 29953370
Therapy-related myeloid neoplasms.
Ganser A, Heuser M
Curr Opin Hematol 2017 Mar;24(2):152-158. doi: 10.1097/MOH.0000000000000316. PMID: 27930389
Therapy-related myeloid neoplasms.
Leone G, Fianchi L, Voso MT
Curr Opin Oncol 2011 Nov;23(6):672-80. doi: 10.1097/CCO.0b013e32834bcc2a. PMID: 21918440

Diagnosis

Donor-Transmitted Melanoma: Is It Still Bothering Us?
Abdullayeva L
Curr Treat Options Oncol 2020 Apr 23;21(5):38. doi: 10.1007/s11864-020-00740-0. PMID: 32328846
Multiple Primary Tumors Over a Lifetime.
Copur MS, Manapuram S
Oncology (Williston Park) 2019 Jul 16;33(7) PMID: 31365752
Radiation-Induced Gliomas.
Aherne NJ, Murphy BM
Crit Rev Oncog 2018;23(1-2):113-118. doi: 10.1615/CritRevOncog.2018025740. PMID: 29953370
Therapy-related myeloid neoplasms.
Ganser A, Heuser M
Curr Opin Hematol 2017 Mar;24(2):152-158. doi: 10.1097/MOH.0000000000000316. PMID: 27930389
Therapy-Related Myeloid Neoplasms.
Bueso-Ramos CE, Kanagal-Shamanna R, Routbort MJ, Hanson CA
Am J Clin Pathol 2015 Aug;144(2):207-18. doi: 10.1309/AJCPU1JO2LYTWUAV. PMID: 26185306

Therapy

Effect of Electronic Symptom Monitoring on Patient-Reported Outcomes Among Patients With Metastatic Cancer: A Randomized Clinical Trial.
Basch E, Schrag D, Henson S, Jansen J, Ginos B, Stover AM, Carr P, Spears PA, Jonsson M, Deal AM, Bennett AV, Thanarajasingam G, Rogak LJ, Reeve BB, Snyder C, Bruner D, Cella D, Kottschade LA, Perlmutter J, Geoghegan C, Samuel-Ryals CA, Given B, Mazza GL, Miller R, Strasser JF, Zylla DM, Weiss A, Blinder VS, Dueck AC
JAMA 2022 Jun 28;327(24):2413-2422. doi: 10.1001/jama.2022.9265. PMID: 35661856Free PMC Article
Retreatment of Recurrent or Second Primary Head and Neck Cancer After Prior Radiation: Executive Summary of the American Radium Society Appropriate Use Criteria.
Ward MC, Koyfman SA, Bakst RL, Margalit DN, Beadle BM, Beitler JJ, Chang SS, Cooper JS, Galloway TJ, Ridge JA, Robbins JR, Sacco AG, Tsai CJ, Yom SS, Siddiqui F
Int J Radiat Oncol Biol Phys 2022 Jul 15;113(4):759-786. Epub 2022 Apr 8 doi: 10.1016/j.ijrobp.2022.03.034. PMID: 35398456
Tobacco Smoking and Risk of Second Primary Lung Cancer.
Aredo JV, Luo SJ, Gardner RM, Sanyal N, Choi E, Hickey TP, Riley TL, Huang WY, Kurian AW, Leung AN, Wilkens LR, Robbins HA, Riboli E, Kaaks R, Tjønneland A, Vermeulen RCH, Panico S, Le Marchand L, Amos CI, Hung RJ, Freedman ND, Johansson M, Cheng I, Wakelee HA, Han SS
J Thorac Oncol 2021 Jun;16(6):968-979. Epub 2021 Mar 17 doi: 10.1016/j.jtho.2021.02.024. PMID: 33722709Free PMC Article
CPX-351 (cytarabine and daunorubicin) Liposome for Injection Versus Conventional Cytarabine Plus Daunorubicin in Older Patients With Newly Diagnosed Secondary Acute Myeloid Leukemia.
Lancet JE, Uy GL, Cortes JE, Newell LF, Lin TL, Ritchie EK, Stuart RK, Strickland SA, Hogge D, Solomon SR, Stone RM, Bixby DL, Kolitz JE, Schiller GJ, Wieduwilt MJ, Ryan DH, Hoering A, Banerjee K, Chiarella M, Louie AC, Medeiros BC
J Clin Oncol 2018 Sep 10;36(26):2684-2692. Epub 2018 Jul 19 doi: 10.1200/JCO.2017.77.6112. PMID: 30024784Free PMC Article
Radiation-Induced Gliomas.
Aherne NJ, Murphy BM
Crit Rev Oncog 2018;23(1-2):113-118. doi: 10.1615/CritRevOncog.2018025740. PMID: 29953370

Prognosis

Association of Radiotherapy for Rectal Cancer and Second Gynecological Malignant Neoplasms.
Guan X, Wei R, Yang R, Lu Z, Liu E, Zhao Z, Chen H, Yang M, Liu Z, Jiang Z, Wang X
JAMA Netw Open 2021 Jan 4;4(1):e2031661. doi: 10.1001/jamanetworkopen.2020.31661. PMID: 33416884Free PMC Article
Therapy-related myelodysplastic syndromes deserve specific diagnostic sub-classification and risk-stratification-an approach to classification of patients with t-MDS.
Kuendgen A, Nomdedeu M, Tuechler H, Garcia-Manero G, Komrokji RS, Sekeres MA, Della Porta MG, Cazzola M, DeZern AE, Roboz GJ, Steensma DP, Van de Loosdrecht AA, Schlenk RF, Grau J, Calvo X, Blum S, Pereira A, Valent P, Costa D, Giagounidis A, Xicoy B, Döhner H, Platzbecker U, Pedro C, Lübbert M, Oiartzabal I, Díez-Campelo M, Cedena MT, Machherndl-Spandl S, López-Pavía M, Baldus CD, Martinez-de-Sola M, Stauder R, Merchan B, List A, Ganster C, Schroeder T, Voso MT, Pfeilstöcker M, Sill H, Hildebrandt B, Esteve J, Nomdedeu B, Cobo F, Haas R, Sole F, Germing U, Greenberg PL, Haase D, Sanz G
Leukemia 2021 Mar;35(3):835-849. Epub 2020 Jun 29 doi: 10.1038/s41375-020-0917-7. PMID: 32595214Free PMC Article
Subsequent neoplasms in childhood cancer survivors.
Zichová A, Eckschlager T, Ganevová M, Malinová B, Lukš A, Kruseová J
Cancer Epidemiol 2020 Oct;68:101779. Epub 2020 Jul 15 doi: 10.1016/j.canep.2020.101779. PMID: 32682319
Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer.
Fisher B, Anderson S, Bryant J, Margolese RG, Deutsch M, Fisher ER, Jeong JH, Wolmark N
N Engl J Med 2002 Oct 17;347(16):1233-41. doi: 10.1056/NEJMoa022152. PMID: 12393820
Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer.
Veronesi U, Cascinelli N, Mariani L, Greco M, Saccozzi R, Luini A, Aguilar M, Marubini E
N Engl J Med 2002 Oct 17;347(16):1227-32. doi: 10.1056/NEJMoa020989. PMID: 12393819

Clinical prediction guides

Role of Germline Predisposition to Therapy-Related Myeloid Neoplasms.
Baranwal A, Hahn CN, Shah MV, Hiwase DK
Curr Hematol Malig Rep 2022 Dec;17(6):254-265. Epub 2022 Aug 20 doi: 10.1007/s11899-022-00676-2. PMID: 35986863
Therapy-related myelodysplastic syndromes deserve specific diagnostic sub-classification and risk-stratification-an approach to classification of patients with t-MDS.
Kuendgen A, Nomdedeu M, Tuechler H, Garcia-Manero G, Komrokji RS, Sekeres MA, Della Porta MG, Cazzola M, DeZern AE, Roboz GJ, Steensma DP, Van de Loosdrecht AA, Schlenk RF, Grau J, Calvo X, Blum S, Pereira A, Valent P, Costa D, Giagounidis A, Xicoy B, Döhner H, Platzbecker U, Pedro C, Lübbert M, Oiartzabal I, Díez-Campelo M, Cedena MT, Machherndl-Spandl S, López-Pavía M, Baldus CD, Martinez-de-Sola M, Stauder R, Merchan B, List A, Ganster C, Schroeder T, Voso MT, Pfeilstöcker M, Sill H, Hildebrandt B, Esteve J, Nomdedeu B, Cobo F, Haas R, Sole F, Germing U, Greenberg PL, Haase D, Sanz G
Leukemia 2021 Mar;35(3):835-849. Epub 2020 Jun 29 doi: 10.1038/s41375-020-0917-7. PMID: 32595214Free PMC Article
Whole-body MRI in paediatric oncology.
Nievelstein RA, Littooij AS
Radiol Med 2016 May;121(5):442-53. Epub 2015 Dec 2 doi: 10.1007/s11547-015-0600-7. PMID: 26631075Free PMC Article
Therapy-related myeloid neoplasms.
Leone G, Fianchi L, Voso MT
Curr Opin Oncol 2011 Nov;23(6):672-80. doi: 10.1097/CCO.0b013e32834bcc2a. PMID: 21918440
Therapy-related myeloid neoplasms: pathobiology and clinical characteristics.
Sill H, Olipitz W, Zebisch A, Schulz E, Wölfler A
Br J Pharmacol 2011 Feb;162(4):792-805. doi: 10.1111/j.1476-5381.2010.01100.x. PMID: 21039422Free PMC Article

Recent systematic reviews

2022 Update on Prostate Cancer Epidemiology and Risk Factors-A Systematic Review.
Bergengren O, Pekala KR, Matsoukas K, Fainberg J, Mungovan SF, Bratt O, Bray F, Brawley O, Luckenbaugh AN, Mucci L, Morgan TM, Carlsson SV
Eur Urol 2023 Aug;84(2):191-206. Epub 2023 May 16 doi: 10.1016/j.eururo.2023.04.021. PMID: 37202314Free PMC Article
MASCC multidisciplinary evidence-based recommendations for the management of malignant bowel obstruction in advanced cancer.
Madariaga A, Lau J, Ghoshal A, Dzierżanowski T, Larkin P, Sobocki J, Dickman A, Furness K, Fazelzad R, Crawford GB, Lheureux S
Support Care Cancer 2022 Jun;30(6):4711-4728. Epub 2022 Mar 10 doi: 10.1007/s00520-022-06889-8. PMID: 35274188Free PMC Article
The management of menopause in women with a history of endometriosis: a systematic review.
Gemmell LC, Webster KE, Kirtley S, Vincent K, Zondervan KT, Becker CM
Hum Reprod Update 2017 Jul 1;23(4):481-500. doi: 10.1093/humupd/dmx011. PMID: 28498913Free PMC Article
American Cancer Society/American Society of Clinical Oncology Breast Cancer Survivorship Care Guideline.
Runowicz CD, Leach CR, Henry NL, Henry KS, Mackey HT, Cowens-Alvarado RL, Cannady RS, Pratt-Chapman ML, Edge SB, Jacobs LA, Hurria A, Marks LB, LaMonte SJ, Warner E, Lyman GH, Ganz PA
J Clin Oncol 2016 Feb 20;34(6):611-35. Epub 2015 Dec 7 doi: 10.1200/JCO.2015.64.3809. PMID: 26644543
American Cancer Society/American Society of Clinical Oncology Breast Cancer Survivorship Care Guideline.
Runowicz CD, Leach CR, Henry NL, Henry KS, Mackey HT, Cowens-Alvarado RL, Cannady RS, Pratt-Chapman ML, Edge SB, Jacobs LA, Hurria A, Marks LB, LaMonte SJ, Warner E, Lyman GH, Ganz PA
CA Cancer J Clin 2016 Jan-Feb;66(1):43-73. Epub 2015 Dec 7 doi: 10.3322/caac.21319. PMID: 26641959

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