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Biliary cystadenocarcinoma

MedGen UID:
473526
•Concept ID:
C2064409
•
Neoplastic Process
Synonyms: biliary cystadenocarcinoma; Intrahepatic Bile Duct Cystadenocarcinoma; Intrahepatic bile duct cystadenocarcinoma; intrahepatic bile duct cystadenocarcinoma; Intrahepatic Bile Duct MCN with an Associated Invasive Carcinoma; Intrahepatic Bile Duct Mucinous Cystic Neoplasm with an Associated Invasive Carcinoma
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0018535
Orphanet: ORPHA424982

Definition

A mucinous cystic neoplasm that arises from the intrahepatic bile ducts and it is associated with an invasive carcinomatous component. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBiliary cystadenocarcinoma

Professional guidelines

PubMed

Preoperative differential diagnosis between intrahepatic biliary cystadenoma and cystadenocarcinoma: a single-center experience.
Zhang FB, Zhang AM, Zhang ZB, Huang X, Wang XT, Dong JH
World J Gastroenterol 2014 Sep 21;20(35):12595-601. doi: 10.3748/wjg.v20.i35.12595. PMID: 25253963Free PMC Article
Effective treatment of biliary cystadenoma.
Thomas KT, Welch D, Trueblood A, Sulur P, Wise P, Gorden DL, Chari RS, Wright JK Jr, Washington K, Pinson CW
Ann Surg 2005 May;241(5):769-73; discussion 773-5. doi: 10.1097/01.sla.0000161982.57360.1b. PMID: 15849512Free PMC Article
Radiologic spectrum of cholangiocarcinoma: emphasis on unusual manifestations and differential diagnoses.
Lee WJ, Lim HK, Jang KM, Kim SH, Lee SJ, Lim JH, Choo IW
Radiographics 2001 Oct;21 Spec No:S97-S116. doi: 10.1148/radiographics.21.suppl_1.g01oc12s97. PMID: 11598251

Recent clinical studies

Etiology

Rare biliary cystic tumors: a case series of biliary cystadenomas and cystadenocarcinoma.
Banerjee A, Shah SR, Singh A, Joshi A, Desai D
Ann Hepatol 2016 May-Jun;15(3):448-52. doi: 10.5604/16652681.1198825. PMID: 27049501
Preoperative differential diagnosis between intrahepatic biliary cystadenoma and cystadenocarcinoma: a single-center experience.
Zhang FB, Zhang AM, Zhang ZB, Huang X, Wang XT, Dong JH
World J Gastroenterol 2014 Sep 21;20(35):12595-601. doi: 10.3748/wjg.v20.i35.12595. PMID: 25253963Free PMC Article
Surgical management of biliary cystadenoma and cystadenocarcinoma of the liver.
Chen YW, Li CH, Liu Z, Dong JH, Zhang WZ, Jiang K
Genet Mol Res 2014 Aug 25;13(3):6383-90. doi: 10.4238/2014.August.25.1. PMID: 25158256
Intrahepatic biliary cystadenoma and cystadenocarcinoma: an experience of 30 cases.
Wang C, Miao R, Liu H, Du X, Liu L, Lu X, Zhao H
Dig Liver Dis 2012 May;44(5):426-31. Epub 2011 Dec 9 doi: 10.1016/j.dld.2011.11.007. PMID: 22169273
Computed tomography of biliary cystadenoma and biliary cystadenocarcinoma.
Pojchamarnwiputh S, Na Chiangmai W, Chotirosniramit A, Lertprasertsuke N
Singapore Med J 2008 May;49(5):392-6. PMID: 18465049

Diagnosis

Management of Mucinous Cystic Neoplasms of the Liver.
Aziz H, Hamad A, Afyouni S, Kamel IR, Pawlik TM
J Gastrointest Surg 2023 Sep;27(9):1963-1970. Epub 2023 May 23 doi: 10.1007/s11605-023-05709-6. PMID: 37221388
Preoperative differential diagnosis between intrahepatic biliary cystadenoma and cystadenocarcinoma: a single-center experience.
Zhang FB, Zhang AM, Zhang ZB, Huang X, Wang XT, Dong JH
World J Gastroenterol 2014 Sep 21;20(35):12595-601. doi: 10.3748/wjg.v20.i35.12595. PMID: 25253963Free PMC Article
Cystic neoplasms of the liver: biliary cystadenoma and cystadenocarcinoma.
Soares KC, Arnaoutakis DJ, Kamel I, Anders R, Adams RB, Bauer TW, Pawlik TM
J Am Coll Surg 2014 Jan;218(1):119-28. Epub 2013 Sep 14 doi: 10.1016/j.jamcollsurg.2013.08.014. PMID: 24045144Free PMC Article
Computed tomography of biliary cystadenoma and biliary cystadenocarcinoma.
Pojchamarnwiputh S, Na Chiangmai W, Chotirosniramit A, Lertprasertsuke N
Singapore Med J 2008 May;49(5):392-6. PMID: 18465049
Biliary cystadenocarcinoma.
Seo DW, Kang GH
Gastrointest Endosc 2000 Jan;51(1):66. doi: 10.1016/s0016-5107(00)70139-8. PMID: 10625799

Therapy

Contrast enhanced ultrasound features of hepatic cystadenoma and hepatic cystadenocarcinoma.
Dong Y, Wang WP, Mao F, Fan M, Ignee A, Serra C, Sparchez Z, Sporea I, Braden B, Dietrich CF
Scand J Gastroenterol 2017 Mar;52(3):365-372. Epub 2016 Nov 25 doi: 10.1080/00365521.2016.1259652. PMID: 27887203
Endoscopic ultrasonography-guided drainage of infected intracystic papillary adenocarcinoma of the liver.
Kodama R, Saegusa H, Ushimaru H, Ikeno T, Makino M, Kawaguchi K
Clin J Gastroenterol 2015 Oct;8(5):335-9. Epub 2015 Sep 28 doi: 10.1007/s12328-015-0607-6. PMID: 26412329
A case of biliary cystadenocarcinoma with malignant seeding of the tract after percutaneous catheter drainage.
Yuefeng M, Weili F, Jing L, Wenxiang T, Tianqing L, Liming W
Turk J Gastroenterol 2012;23(6):795-8. doi: 10.4318/tjg.2012.0644. PMID: 23864459
Biliary cystadenocarcinoma with mesenchymal stroma.
Gómez-Martín C, Rodríguez A, Malón D, Cortés-Funes H
Clin Transl Oncol 2010 Mar;12(3):234-7. doi: 10.1007/s12094-010-0495-7. PMID: 20231130
Hepatic arterial infusion chemotherapy of cisplatin for biliary cystadenocarcinoma.
Hanazaki K, Yoshizawa K, Mori H
Hepatogastroenterology 1999 Jan-Feb;46(25):462-4. PMID: 10228843

Prognosis

Management of Mucinous Cystic Neoplasms of the Liver.
Aziz H, Hamad A, Afyouni S, Kamel IR, Pawlik TM
J Gastrointest Surg 2023 Sep;27(9):1963-1970. Epub 2023 May 23 doi: 10.1007/s11605-023-05709-6. PMID: 37221388
Preoperative differential diagnosis between intrahepatic biliary cystadenoma and cystadenocarcinoma: a single-center experience.
Zhang FB, Zhang AM, Zhang ZB, Huang X, Wang XT, Dong JH
World J Gastroenterol 2014 Sep 21;20(35):12595-601. doi: 10.3748/wjg.v20.i35.12595. PMID: 25253963Free PMC Article
Cystic neoplasms of the liver: biliary cystadenoma and cystadenocarcinoma.
Soares KC, Arnaoutakis DJ, Kamel I, Anders R, Adams RB, Bauer TW, Pawlik TM
J Am Coll Surg 2014 Jan;218(1):119-28. Epub 2013 Sep 14 doi: 10.1016/j.jamcollsurg.2013.08.014. PMID: 24045144Free PMC Article
Biliary cystadenoma and cystadenocarcinoma of the liver: 10 cases of a single center experience.
Lee JH, Lee KG, Park HK, Lee KS
Hepatogastroenterology 2009 May-Jun;56(91-92):844-9. PMID: 19621714
Biliary cystadenoma and cystadenocarcinoma: report of 14 cases and review of the literature.
Ishak KG, Willis GW, Cummins SD, Bullock AA
Cancer 1977 Jan;39(1):322-38. doi: 10.1002/1097-0142(197701)39:1<322::aid-cncr2820390149>3.0.co;2-p. PMID: 318915

Clinical prediction guides

Clinicopathological features and management of biliary cystic tumors of the liver: a single-center experience.
El-Magd EA, El-Shobari M, Abdelsalam RA, Abbas A, Elmahdy Y, Hamed H
Langenbecks Arch Surg 2023 Jul 11;408(1):273. doi: 10.1007/s00423-023-02994-2. PMID: 37430153Free PMC Article
CT and MRI features differentiating mucinous cystic neoplasms of the liver from pathologically simple cysts.
Anderson MA, Dhami RS, Fadzen CM, Molina G, Taylor MS, Deshpande V, Qadan M, Catalano OA, Ferrone CR, Mojtahed A
Clin Imaging 2021 Aug;76:46-52. Epub 2021 Feb 3 doi: 10.1016/j.clinimag.2021.01.036. PMID: 33549919
Management of biliary cystic tumors: a multi-institutional analysis of a rare liver tumor.
Arnaoutakis DJ, Kim Y, Pulitano C, Zaydfudim V, Squires MH, Kooby D, Groeschl R, Alexandrescu S, Bauer TW, Bloomston M, Soares K, Marques H, Gamblin TC, Popescu I, Adams R, Nagorney D, Barroso E, Maithel SK, Crawford M, Sandroussi C, Marsh W, Pawlik TM
Ann Surg 2015 Feb;261(2):361-7. doi: 10.1097/SLA.0000000000000543. PMID: 24509187Free PMC Article
Preoperative differential diagnosis between intrahepatic biliary cystadenoma and cystadenocarcinoma: a single-center experience.
Zhang FB, Zhang AM, Zhang ZB, Huang X, Wang XT, Dong JH
World J Gastroenterol 2014 Sep 21;20(35):12595-601. doi: 10.3748/wjg.v20.i35.12595. PMID: 25253963Free PMC Article
Intrahepatic biliary cystadenoma and cystadenocarcinoma: an experience of 30 cases.
Wang C, Miao R, Liu H, Du X, Liu L, Lu X, Zhao H
Dig Liver Dis 2012 May;44(5):426-31. Epub 2011 Dec 9 doi: 10.1016/j.dld.2011.11.007. PMID: 22169273

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