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Liver diffuse large B-cell lymphoma

MedGen UID:
473542
•Concept ID:
C2184126
•
Neoplastic Process
Synonyms: diffuse large B-cell lymphoma of liver; Hepatic Diffuse Large B-Cell Lymphoma; hepatic diffuse large B-cell lymphoma; Liver Diffuse Large B-Cell Lymphoma; liver diffuse large B-cell lymphoma; Primary Hepatic Diffuse Large B-Cell Lymphoma; primary hepatic diffuse large B-cell lymphoma; Primary Liver Diffuse Large B-Cell Lymphoma; primary liver diffuse large B-cell lymphoma
 
Monarch Initiative: MONDO:0006268

Definition

A rare diffuse large B-cell lymphoma that arises from the liver and the bulk of the tumor is located in the liver. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLiver diffuse large B-cell lymphoma

Professional guidelines

PubMed

Reappraisal of primary hepatic lymphoma: Is surgical resection underestimated?
Cesaretti M, Loustau M, Robba C, Senescende L, Zarzavadjian Le Bian A
Crit Rev Oncol Hematol 2018 Mar;123:1-6. Epub 2018 Jan 30 doi: 10.1016/j.critrevonc.2018.01.004. PMID: 29482772
Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification.
Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E, Lister TA; Alliance, Australasian Leukaemia and Lymphoma Group; Eastern Cooperative Oncology Group; European Mantle Cell Lymphoma Consortium; Italian Lymphoma Foundation; European Organisation for Research; Treatment of Cancer/Dutch Hemato-Oncology Group; Grupo Español de Médula Ósea; German High-Grade Lymphoma Study Group; German Hodgkin's Study Group; Japanese Lymphorra Study Group; Lymphoma Study Association; NCIC Clinical Trials Group; Nordic Lymphoma Study Group; Southwest Oncology Group; United Kingdom National Cancer Research Institute
J Clin Oncol 2014 Sep 20;32(27):3059-68. doi: 10.1200/JCO.2013.54.8800. PMID: 25113753Free PMC Article
T-cell/histiocyte-rich B-cell lymphoma: biology, diagnosis, and management.
Abramson JS
Oncologist 2006 Apr;11(4):384-92. doi: 10.1634/theoncologist.11-4-384. PMID: 16614234

Recent clinical studies

Etiology

Clinical features and imaging manifestations for intravascular large B-cell lymphoma.
Jin H, Liao W, Yang S, Peng L, Xing W
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2023 Dec 28;48(12):1920-1928. doi: 10.11817/j.issn.1672-7347.2023.230305. PMID: 38448386Free PMC Article
Milk consumption and risk of twelve cancers: A large-scale observational and Mendelian randomisation study.
Lumsden AL, Mulugeta A, Hyppönen E
Clin Nutr 2023 Jan;42(1):1-8. Epub 2022 Nov 7 doi: 10.1016/j.clnu.2022.11.006. PMID: 36473423
The prognostic value of end-of-treatment FDG-PET/CT in diffuse large B cell lymphoma: comparison of visual Deauville criteria and a lesion-to-liver SUV(max) ratio-based evaluation system.
Li YH, Zhao YM, Jiang YL, Tang S, Chen MT, Xiao ZZ, Fan W, Hu YY, Zhang X
Eur J Nucl Med Mol Imaging 2022 Mar;49(4):1311-1321. Epub 2021 Oct 15 doi: 10.1007/s00259-021-05581-z. PMID: 34651231
Interim PET in Diffuse Large B-Cell Lymphoma.
Kurch L, Hüttmann A, Georgi TW, Rekowski J, Sabri O, Schmitz C, Kluge R, Dührsen U, Hasenclever D
J Nucl Med 2021 Aug 1;62(8):1068-1074. Epub 2020 Nov 27 doi: 10.2967/jnumed.120.255034. PMID: 33246974
Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification.
Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E, Lister TA; Alliance, Australasian Leukaemia and Lymphoma Group; Eastern Cooperative Oncology Group; European Mantle Cell Lymphoma Consortium; Italian Lymphoma Foundation; European Organisation for Research; Treatment of Cancer/Dutch Hemato-Oncology Group; Grupo Español de Médula Ósea; German High-Grade Lymphoma Study Group; German Hodgkin's Study Group; Japanese Lymphorra Study Group; Lymphoma Study Association; NCIC Clinical Trials Group; Nordic Lymphoma Study Group; Southwest Oncology Group; United Kingdom National Cancer Research Institute
J Clin Oncol 2014 Sep 20;32(27):3059-68. doi: 10.1200/JCO.2013.54.8800. PMID: 25113753Free PMC Article

Diagnosis

Gastrointestinal Tract Lymphomas.
Alvarez-Lesmes J, Chapman JR, Cassidy D, Zhou Y, Garcia-Buitrago M, Montgomery EA, Lossos IS, Sussman D, Poveda J
Arch Pathol Lab Med 2021 Dec 1;145(12):1585-1596. doi: 10.5858/arpa.2020-0661-RA. PMID: 33836528
TRPM4 in Cancer-A New Potential Drug Target.
Borgström A, Peinelt C, Stokłosa P
Biomolecules 2021 Feb 5;11(2) doi: 10.3390/biom11020229. PMID: 33562811Free PMC Article
Hepatic Lymphoma Diagnosis.
Choi WT, Gill RM
Surg Pathol Clin 2018 Jun;11(2):389-402. Epub 2018 Mar 21 doi: 10.1016/j.path.2018.02.003. PMID: 29751882
Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification.
Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E, Lister TA; Alliance, Australasian Leukaemia and Lymphoma Group; Eastern Cooperative Oncology Group; European Mantle Cell Lymphoma Consortium; Italian Lymphoma Foundation; European Organisation for Research; Treatment of Cancer/Dutch Hemato-Oncology Group; Grupo Español de Médula Ósea; German High-Grade Lymphoma Study Group; German Hodgkin's Study Group; Japanese Lymphorra Study Group; Lymphoma Study Association; NCIC Clinical Trials Group; Nordic Lymphoma Study Group; Southwest Oncology Group; United Kingdom National Cancer Research Institute
J Clin Oncol 2014 Sep 20;32(27):3059-68. doi: 10.1200/JCO.2013.54.8800. PMID: 25113753Free PMC Article
T cell/histiocyte-rich large B-cell lymphoma: an update on its biology and classification.
Tousseyn T, De Wolf-Peeters C
Virchows Arch 2011 Dec;459(6):557-63. Epub 2011 Nov 12 doi: 10.1007/s00428-011-1165-z. PMID: 22081105

Therapy

Milk consumption and risk of twelve cancers: A large-scale observational and Mendelian randomisation study.
Lumsden AL, Mulugeta A, Hyppönen E
Clin Nutr 2023 Jan;42(1):1-8. Epub 2022 Nov 7 doi: 10.1016/j.clnu.2022.11.006. PMID: 36473423
TRPM4 in Cancer-A New Potential Drug Target.
Borgström A, Peinelt C, Stokłosa P
Biomolecules 2021 Feb 5;11(2) doi: 10.3390/biom11020229. PMID: 33562811Free PMC Article
Carcinoma Camouflage.
Perry IE, Azam MU, Yap JE
Gastroenterology 2021 May;160(6):1940-1942. Epub 2021 Feb 3 doi: 10.1053/j.gastro.2021.01.226. PMID: 33545143
Final results of a phase 1 study of loncastuximab tesirine in relapsed/refractory B-cell non-Hodgkin lymphoma.
Hamadani M, Radford J, Carlo-Stella C, Caimi PF, Reid E, O'Connor OA, Feingold JM, Ardeshna KM, Townsend W, Solh M, Heffner LT, Ungar D, Wang L, Boni J, Havenith K, Qin Y, Kahl BS
Blood 2021 May 13;137(19):2634-2645. doi: 10.1182/blood.2020007512. PMID: 33211842Free PMC Article
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article

Prognosis

Milk consumption and risk of twelve cancers: A large-scale observational and Mendelian randomisation study.
Lumsden AL, Mulugeta A, Hyppönen E
Clin Nutr 2023 Jan;42(1):1-8. Epub 2022 Nov 7 doi: 10.1016/j.clnu.2022.11.006. PMID: 36473423
Interim PET in Diffuse Large B-Cell Lymphoma.
Kurch L, Hüttmann A, Georgi TW, Rekowski J, Sabri O, Schmitz C, Kluge R, Dührsen U, Hasenclever D
J Nucl Med 2021 Aug 1;62(8):1068-1074. Epub 2020 Nov 27 doi: 10.2967/jnumed.120.255034. PMID: 33246974
Final results of a phase 1 study of loncastuximab tesirine in relapsed/refractory B-cell non-Hodgkin lymphoma.
Hamadani M, Radford J, Carlo-Stella C, Caimi PF, Reid E, O'Connor OA, Feingold JM, Ardeshna KM, Townsend W, Solh M, Heffner LT, Ungar D, Wang L, Boni J, Havenith K, Qin Y, Kahl BS
Blood 2021 May 13;137(19):2634-2645. doi: 10.1182/blood.2020007512. PMID: 33211842Free PMC Article
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article
Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification.
Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E, Lister TA; Alliance, Australasian Leukaemia and Lymphoma Group; Eastern Cooperative Oncology Group; European Mantle Cell Lymphoma Consortium; Italian Lymphoma Foundation; European Organisation for Research; Treatment of Cancer/Dutch Hemato-Oncology Group; Grupo Español de Médula Ósea; German High-Grade Lymphoma Study Group; German Hodgkin's Study Group; Japanese Lymphorra Study Group; Lymphoma Study Association; NCIC Clinical Trials Group; Nordic Lymphoma Study Group; Southwest Oncology Group; United Kingdom National Cancer Research Institute
J Clin Oncol 2014 Sep 20;32(27):3059-68. doi: 10.1200/JCO.2013.54.8800. PMID: 25113753Free PMC Article

Clinical prediction guides

Milk consumption and risk of twelve cancers: A large-scale observational and Mendelian randomisation study.
Lumsden AL, Mulugeta A, Hyppönen E
Clin Nutr 2023 Jan;42(1):1-8. Epub 2022 Nov 7 doi: 10.1016/j.clnu.2022.11.006. PMID: 36473423
Interim PET in Diffuse Large B-Cell Lymphoma.
Kurch L, Hüttmann A, Georgi TW, Rekowski J, Sabri O, Schmitz C, Kluge R, Dührsen U, Hasenclever D
J Nucl Med 2021 Aug 1;62(8):1068-1074. Epub 2020 Nov 27 doi: 10.2967/jnumed.120.255034. PMID: 33246974
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article
Hepatitis C virus and diffuse large B-cell lymphoma: Pathogenesis, behavior and treatment.
Visco C, Finotto S
World J Gastroenterol 2014 Aug 28;20(32):11054-61. doi: 10.3748/wjg.v20.i32.11054. PMID: 25170194Free PMC Article
Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification.
Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E, Lister TA; Alliance, Australasian Leukaemia and Lymphoma Group; Eastern Cooperative Oncology Group; European Mantle Cell Lymphoma Consortium; Italian Lymphoma Foundation; European Organisation for Research; Treatment of Cancer/Dutch Hemato-Oncology Group; Grupo Español de Médula Ósea; German High-Grade Lymphoma Study Group; German Hodgkin's Study Group; Japanese Lymphorra Study Group; Lymphoma Study Association; NCIC Clinical Trials Group; Nordic Lymphoma Study Group; Southwest Oncology Group; United Kingdom National Cancer Research Institute
J Clin Oncol 2014 Sep 20;32(27):3059-68. doi: 10.1200/JCO.2013.54.8800. PMID: 25113753Free PMC Article

Recent systematic reviews

CD19 CAR-T therapy in solid organ transplant recipients: case report and systematic review.
Portuguese AJ, Gauthier J, Tykodi SS, Hall ET, Hirayama AV, Yeung CCS, Blosser CD
Bone Marrow Transplant 2023 Apr;58(4):353-359. Epub 2022 Dec 27 doi: 10.1038/s41409-022-01907-z. PMID: 36575360
Inferior survival and frequent hepatic dysfunction in non-Hodgkin's lymphoma patients with HBV infection: a systematic review and meta-analysis.
Zhang MY, Gao F, Zhao YW, Ni BW, Huang HH, Hou J
Hematology 2022 Dec;27(1):70-79. doi: 10.1080/16078454.2021.2011546. PMID: 34957924
Reappraisal of primary hepatic lymphoma: Is surgical resection underestimated?
Cesaretti M, Loustau M, Robba C, Senescende L, Zarzavadjian Le Bian A
Crit Rev Oncol Hematol 2018 Mar;123:1-6. Epub 2018 Jan 30 doi: 10.1016/j.critrevonc.2018.01.004. PMID: 29482772

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