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Anal Canal Neuroendocrine Carcinoma

MedGen UID:
473545
•Concept ID:
C2205189
•
Neoplastic Process
Synonyms: Anal Canal High Grade Neuroendocrine Carcinoma; Anal Canal NEC; Anal Canal NEC G3; Anal High Grade Neuroendocrine Carcinoma; Anal NEC; Anal NEC G3; Anal Neuroendocrine Carcinoma

Definition

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the anal canal. The mitotic count is more than 20 per 10 HPF. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnal Canal Neuroendocrine Carcinoma

Professional guidelines

PubMed

Treatment of poorly differentiated neuroendocrine carcinomas of rectum and anus with chemoradiotherapy: a single-centre evaluation.
Fløe LE, Aggerholm-Pedersen N, Tabaksblat EM
J Cancer Res Clin Oncol 2024 Mar 6;150(3):114. doi: 10.1007/s00432-024-05635-3. PMID: 38448660Free PMC Article
Neuroendocrine Carcinoma of the Anus and Rectum: Patient Characteristics and Treatment Options.
Ueberroth BE, Liu AJ, Starr JS, Hobday TJ, Ashman JB, Mishra N, Bekaii-Saab TS, Halfdanarson TR, Sonbol MB
Clin Colorectal Cancer 2021 Jun;20(2):e139-e149. Epub 2020 Dec 17 doi: 10.1016/j.clcc.2020.12.001. PMID: 33551318
Malignant tumors of the anal canal: the spectrum of disease, treatment, and outcomes.
Klas JV, Rothenberger DA, Wong WD, Madoff RD
Cancer 1999 Apr 15;85(8):1686-93. doi: 10.1002/(sici)1097-0142(19990415)85:8<1686::aid-cncr7>3.0.co;2-7. PMID: 10223561

Recent clinical studies

Prognosis

Anal canal neuroendocrine carcinoma associated with squamous intraepithelial neoplasia: a human papillomavirus 18-related lesion.
Ohtomo R, Sekine S, Taniguchi H, Tsuda H, Moriya Y, Kushima R
Pathol Int 2012 May;62(5):356-9. Epub 2012 Mar 28 doi: 10.1111/j.1440-1827.2012.02800.x. PMID: 22524667

Clinical prediction guides

Anal canal neuroendocrine carcinoma associated with squamous intraepithelial neoplasia: a human papillomavirus 18-related lesion.
Ohtomo R, Sekine S, Taniguchi H, Tsuda H, Moriya Y, Kushima R
Pathol Int 2012 May;62(5):356-9. Epub 2012 Mar 28 doi: 10.1111/j.1440-1827.2012.02800.x. PMID: 22524667
Anal canal neuroendocrine carcinoma with Pagetoid extension.
Guo L, Kuroda N, Miyazaki E, Jin Y, Toi M, Hamauzu T, Hiroi M, Inoue T, Inoue A, Enzan H
Pathol Int 2004 Aug;54(8):630-5. doi: 10.1111/j.1440-1827.2004.01673.x. PMID: 15260855

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