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Colorectal Sporadic Serrated Polyp

MedGen UID:
474429
•Concept ID:
C3272796
•
Disease or Syndrome

Definition

A term that refers to a group of polypoid lesions in the colon and rectum that are characterized by the presence of serrated architecture of the epithelial component. This group includes hyperplastic polyps, traditional serrated adenomas, and sessile serrated adenomas/polyps. [from NCI]

Professional guidelines

PubMed

Intramucosal fat is uncommon in large bowel polyps but raises three differential diagnoses.
Wong NACS, O'Mahony O
J Clin Pathol 2019 Aug;72(8):562-565. Epub 2019 May 16 doi: 10.1136/jclinpath-2019-205849. PMID: 31097491
An assessment of the diagnostic criteria for sessile serrated adenoma/polyps: SSA/Ps using image processing software analysis for Ki67 immunohistochemistry.
Fujimori Y, Fujimori T, Imura J, Sugai T, Yao T, Wada R, Ajioka Y, Ohkura Y
Diagn Pathol 2012 May 29;7:59. doi: 10.1186/1746-1596-7-59. PMID: 22642724Free PMC Article
Sporadic and syndromic hyperplastic polyps and serrated adenomas of the colon: classification, molecular genetics, natural history, and clinical management.
East JE, Saunders BP, Jass JR
Gastroenterol Clin North Am 2008 Mar;37(1):25-46, v. doi: 10.1016/j.gtc.2007.12.014. PMID: 18313538

Recent clinical studies

Etiology

RNF43 mutation analysis in serrated polyposis, sporadic serrated polyps and Lynch syndrome polyps.
van Herwaarden YJ, Koggel LM, Simmer F, Vink-Börger EM, Dura P, Meijer GA, Nagengast FM, Hoogerbrugge N, Bisseling TM, Nagtegaal ID
Histopathology 2021 Apr;78(5):749-758. Epub 2020 Dec 25 doi: 10.1111/his.14286. PMID: 33098683Free PMC Article
Sessile Serrated Polyps and Colon Cancer Prevention.
Rashtak S, Rego R, Sweetser SR, Sinicrope FA
Cancer Prev Res (Phila) 2017 May;10(5):270-278. Epub 2017 Mar 21 doi: 10.1158/1940-6207.CAPR-16-0264. PMID: 28325827
Serrated and non-serrated precursor lesions of colorectal cancer.
Langner C
Dig Dis 2015;33(1):28-37. Epub 2014 Dec 17 doi: 10.1159/000366032. PMID: 25531494
Sessile serrated adenoma: from identification to resection.
Bordaçahar B, Barret M, Terris B, Dhooge M, Dreanic J, Prat F, Coriat R, Chaussade S
Dig Liver Dis 2015 Feb;47(2):95-102. Epub 2014 Oct 25 doi: 10.1016/j.dld.2014.09.006. PMID: 25445408
Colorectal serrated pathway cancers and precursors.
O'Brien MJ, Zhao Q, Yang S
Histopathology 2015 Jan;66(1):49-65. Epub 2014 Dec 1 doi: 10.1111/his.12564. PMID: 25263173

Diagnosis

Sporadic Polyps of the Colorectum.
Brown I, Bettington M
Gastroenterol Clin North Am 2024 Mar;53(1):155-177. Epub 2023 Dec 9 doi: 10.1016/j.gtc.2023.10.002. PMID: 38280746
Current Approaches in Managing Colonic Serrated Polyps and Serrated Polyposis.
van Toledo DEFWM, IJspeert JEG, Dekker E
Annu Rev Med 2022 Jan 27;73:293-306. doi: 10.1146/annurev-med-042220-024703. PMID: 35084990
RNF43 mutation analysis in serrated polyposis, sporadic serrated polyps and Lynch syndrome polyps.
van Herwaarden YJ, Koggel LM, Simmer F, Vink-Börger EM, Dura P, Meijer GA, Nagengast FM, Hoogerbrugge N, Bisseling TM, Nagtegaal ID
Histopathology 2021 Apr;78(5):749-758. Epub 2020 Dec 25 doi: 10.1111/his.14286. PMID: 33098683Free PMC Article
Sessile serrated adenoma: from identification to resection.
Bordaçahar B, Barret M, Terris B, Dhooge M, Dreanic J, Prat F, Coriat R, Chaussade S
Dig Liver Dis 2015 Feb;47(2):95-102. Epub 2014 Oct 25 doi: 10.1016/j.dld.2014.09.006. PMID: 25445408
Sessile serrated adenomas: an evidence-based guide to management.
Crockett SD, Snover DC, Ahnen DJ, Baron JA
Clin Gastroenterol Hepatol 2015 Jan;13(1):11-26.e1. Epub 2013 Nov 9 doi: 10.1016/j.cgh.2013.10.035. PMID: 24216467

Therapy

Elevated Risk for Sessile Serrated Polyps in African Americans with Endometrial Polyps.
Ashktorab H, Sherif Z, Tarjoman T, Azam S, Lee E, Shokrani B, Okereke I, Soleimani A, Carethers JM, Laiyemo AO, Aduli F, Nouraie M, Habtezion A, Brim H
Dig Dis Sci 2020 Sep;65(9):2686-2690. Epub 2019 Dec 12 doi: 10.1007/s10620-019-05991-y. PMID: 31832971Free PMC Article
Colorectal premalignancy is associated with consensus molecular subtypes 1 and 2.
Chang K, Willis JA, Reumers J, Taggart MW, San Lucas FA, Thirumurthi S, Kanth P, Delker DA, Hagedorn CH, Lynch PM, Ellis LM, Hawk ET, Scheet PA, Kopetz S, Arts J, Guinney J, Dienstmann R, Vilar E
Ann Oncol 2018 Oct 1;29(10):2061-2067. doi: 10.1093/annonc/mdy337. PMID: 30412224Free PMC Article
The "Studded" Rectum: Phenotypic Evidence of MYH-Associated Polyposis.
Church J, Kravochuck S
Dis Colon Rectum 2016 Jun;59(6):565-9. doi: 10.1097/DCR.0000000000000575. PMID: 27145315
Histological overlap between colorectal villous/tubulovillous and traditional serrated adenomas.
Hafezi-Bakhtiari S, Wang LM, Colling R, Serra S, Chetty R
Histopathology 2015 Jan;66(2):308-13. Epub 2014 Nov 13 doi: 10.1111/his.12555. PMID: 25257227
Sessile serrated adenomas: high-risk lesions?
Salaria SN, Streppel MM, Lee LA, Iacobuzio-Donahue CA, Montgomery EA
Hum Pathol 2012 Nov;43(11):1808-14. Epub 2012 Jul 9 doi: 10.1016/j.humpath.2012.04.001. PMID: 22784922Free PMC Article

Prognosis

Cancer Risk in Patients With and Relatives of Serrated Polyposis Syndrome and Sporadic Sessile Serrated Lesions.
Kanth P, Yu Z, Keener MB, Koptiuch C, Kohlmann WK, Neklason DW, Westover M, Curtin K
Am J Gastroenterol 2022 Feb 1;117(2):336-342. doi: 10.14309/ajg.0000000000001572. PMID: 34889311
Expression of Parkin, APC, APE1, and Bcl-xL in Colorectal Polyps.
Kühl Svoboda Baldin R, Austrália Paredes Marcondes Ribas C, de Noronha L, Veloso da Silva-Camargo CC, Santos Sotomaior V, Martins Sebastião AP, Vasconcelos de Castilho AP, Rodrigues Montemor Netto M
J Histochem Cytochem 2021 Jul;69(7):437-449. Epub 2021 Jun 15 doi: 10.1369/00221554211026296. PMID: 34126796Free PMC Article
Colorectal premalignancy is associated with consensus molecular subtypes 1 and 2.
Chang K, Willis JA, Reumers J, Taggart MW, San Lucas FA, Thirumurthi S, Kanth P, Delker DA, Hagedorn CH, Lynch PM, Ellis LM, Hawk ET, Scheet PA, Kopetz S, Arts J, Guinney J, Dienstmann R, Vilar E
Ann Oncol 2018 Oct 1;29(10):2061-2067. doi: 10.1093/annonc/mdy337. PMID: 30412224Free PMC Article
Serrated colorectal polyps in inflammatory bowel disease.
Ko HM, Harpaz N, McBride RB, Cui M, Ye F, Zhang D, Ullman TA, Polydorides AD
Mod Pathol 2015 Dec;28(12):1584-93. Epub 2015 Sep 25 doi: 10.1038/modpathol.2015.111. PMID: 26403785
Sporadic and syndromic hyperplastic polyps and serrated adenomas of the colon: classification, molecular genetics, natural history, and clinical management.
East JE, Saunders BP, Jass JR
Gastroenterol Clin North Am 2008 Mar;37(1):25-46, v. doi: 10.1016/j.gtc.2007.12.014. PMID: 18313538

Clinical prediction guides

c-MET immunohistochemical expression in sporadic and inflammatory bowel disease associated lesions.
Halliday G, Porter RJ, Black CJ, Arends MJ, Din S
World J Gastroenterol 2022 Apr 7;28(13):1338-1346. doi: 10.3748/wjg.v28.i13.1338. PMID: 35645542Free PMC Article
Cancer Risk in Patients With and Relatives of Serrated Polyposis Syndrome and Sporadic Sessile Serrated Lesions.
Kanth P, Yu Z, Keener MB, Koptiuch C, Kohlmann WK, Neklason DW, Westover M, Curtin K
Am J Gastroenterol 2022 Feb 1;117(2):336-342. doi: 10.14309/ajg.0000000000001572. PMID: 34889311
Expression of Parkin, APC, APE1, and Bcl-xL in Colorectal Polyps.
Kühl Svoboda Baldin R, Austrália Paredes Marcondes Ribas C, de Noronha L, Veloso da Silva-Camargo CC, Santos Sotomaior V, Martins Sebastião AP, Vasconcelos de Castilho AP, Rodrigues Montemor Netto M
J Histochem Cytochem 2021 Jul;69(7):437-449. Epub 2021 Jun 15 doi: 10.1369/00221554211026296. PMID: 34126796Free PMC Article
Elevated Risk for Sessile Serrated Polyps in African Americans with Endometrial Polyps.
Ashktorab H, Sherif Z, Tarjoman T, Azam S, Lee E, Shokrani B, Okereke I, Soleimani A, Carethers JM, Laiyemo AO, Aduli F, Nouraie M, Habtezion A, Brim H
Dig Dis Sci 2020 Sep;65(9):2686-2690. Epub 2019 Dec 12 doi: 10.1007/s10620-019-05991-y. PMID: 31832971Free PMC Article
Sessile Serrated Polyps and Colon Cancer Prevention.
Rashtak S, Rego R, Sweetser SR, Sinicrope FA
Cancer Prev Res (Phila) 2017 May;10(5):270-278. Epub 2017 Mar 21 doi: 10.1158/1940-6207.CAPR-16-0264. PMID: 28325827

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