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Colorectal Adenomatous Polyp

MedGen UID:
474438
•Concept ID:
C3272805
•
Neoplastic Process
Synonyms: Adenomatous Polyp of Large Bowel; Adenomatous Polyp of the Large Bowel; Large Bowel Adenomatous Polyp

Definition

A polypoid adenoma that arises from and protrudes into the lumen of the colon or rectum. Epithelial dysplasia is always present. According to the architectural pattern it is classified as tubular, tubulovillous, or villous. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColorectal Adenomatous Polyp

Professional guidelines

PubMed

Screening for Colorectal Cancer: US Preventive Services Task Force Recommendation Statement.
US Preventive Services Task Force, Davidson KW, Barry MJ, Mangione CM, Cabana M, Caughey AB, Davis EM, Donahue KE, Doubeni CA, Krist AH, Kubik M, Li L, Ogedegbe G, Owens DK, Pbert L, Silverstein M, Stevermer J, Tseng CW, Wong JB
JAMA 2021 May 18;325(19):1965-1977. doi: 10.1001/jama.2021.6238. PMID: 34003218
Colorectal Cancer Screening Methods and Molecular Markers for Early Detection.
Wu Z, Li Y, Zhang Y, Hu H, Wu T, Liu S, Chen W, Xie S, Lu Z
Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820980426. doi: 10.1177/1533033820980426. PMID: 33353503Free PMC Article
ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes.
Syngal S, Brand RE, Church JM, Giardiello FM, Hampel HL, Burt RW; American College of Gastroenterology
Am J Gastroenterol 2015 Feb;110(2):223-62; quiz 263. Epub 2015 Feb 3 doi: 10.1038/ajg.2014.435. PMID: 25645574Free PMC Article

Recent clinical studies

Etiology

Polymorphisms in Cyclooxygenase, Lipoxygenase, and TP53 Genes Predict Colorectal Polyp Risk Reduction by Aspirin in the seAFOod Polyp Prevention Trial.
Davies JR, Mell T, Fuller H, Harland M, Saleh RNM, Race AD, Rees CJ, Brown LC, Loadman PM, Downing A, Minihane AM, Williams EA, Hull MA
Cancer Prev Res (Phila) 2023 Nov 1;16(11):621-629. doi: 10.1158/1940-6207.CAPR-23-0111. PMID: 37756582Free PMC Article
Diagnostic Value of Inflammation-Related Indicators in Distinguishing Early Colon Cancer and Adenomatous Polyps.
Feng Z, Lin H, Yang X, Cao S, Gu X, Zhang Z, Deng W
Cancer Control 2023 Jan-Dec;30:10732748231180745. doi: 10.1177/10732748231180745. PMID: 37421141Free PMC Article
Association between Colorectal Adenoma and Carotid Atherosclerosis in Korean Adults.
Kim H, Cho YJ, Kim YA, Gwak SG
Int J Environ Res Public Health 2018 Dec 6;15(12) doi: 10.3390/ijerph15122762. PMID: 30563254Free PMC Article
Adiposity and the risk of colorectal adenomatous polyps: a meta-analysis.
Lee YJ, Myung SK, Cho B, Park BJ, Park JH, Ju W, Park MS, Choi JH
Cancer Causes Control 2011 Jul;22(7):1021-35. Epub 2011 May 22 doi: 10.1007/s10552-011-9777-9. PMID: 21604177
The association between arterial stiffness and colorectal adenomatous polyp in women.
Kim HB, Lee HR, Shim JY, Na HY, Park BJ, Jung DH, Lee YJ
J Womens Health (Larchmt) 2011 May;20(5):765-9. Epub 2011 Mar 31 doi: 10.1089/jwh.2010.2538. PMID: 21453035

Diagnosis

Diagnostic Value of Inflammation-Related Indicators in Distinguishing Early Colon Cancer and Adenomatous Polyps.
Feng Z, Lin H, Yang X, Cao S, Gu X, Zhang Z, Deng W
Cancer Control 2023 Jan-Dec;30:10732748231180745. doi: 10.1177/10732748231180745. PMID: 37421141Free PMC Article
Prevalence of colorectal adenomatous polyps in patients with chronic obstructive pulmonary disease.
Chun EM, Kim SW, Lim SY
Int J Chron Obstruct Pulmon Dis 2015;10:955-60. Epub 2015 May 18 doi: 10.2147/COPD.S83341. PMID: 26028968Free PMC Article
Systemic markers of oxidative status and colorectal adenomatous polyps.
Siamakpour-Reihani S, Scarbrough PM, Wang F, Spasojevic I, Base K, Sedjo R, D'Agostino RB Jr, Il'yasova D
Ann Epidemiol 2012 Aug;22(8):587-91. Epub 2012 Jun 12 doi: 10.1016/j.annepidem.2012.05.001. PMID: 22695388Free PMC Article
Role of high definition colonoscopy in colorectal adenomatous polyp detection.
Erim T, Rivas JM, Velis E, Castro F
World J Gastroenterol 2011 Sep 21;17(35):4001-6. doi: 10.3748/wjg.v17.i35.4001. PMID: 22046088Free PMC Article
Assessment of colorectal adenomatous polyp size measured during pathological examination highlights the importance of accuracy.
Hayes SJ
Gastrointest Endosc 2009 Sep;70(3):540-1. Epub 2009 Jun 24 doi: 10.1016/j.gie.2009.04.017. PMID: 19555943

Therapy

Polymorphisms in Cyclooxygenase, Lipoxygenase, and TP53 Genes Predict Colorectal Polyp Risk Reduction by Aspirin in the seAFOod Polyp Prevention Trial.
Davies JR, Mell T, Fuller H, Harland M, Saleh RNM, Race AD, Rees CJ, Brown LC, Loadman PM, Downing A, Minihane AM, Williams EA, Hull MA
Cancer Prev Res (Phila) 2023 Nov 1;16(11):621-629. doi: 10.1158/1940-6207.CAPR-23-0111. PMID: 37756582Free PMC Article
Traditional Chinese medicine (Xiaoai Jiedu Decoction) as an adjuvant treatment for prevention new colorectal adenomatous polyp occurrence in post-polypectomy: Study protocol for a randomized controlled trial.
Zhou Q, Chen YG, Xiao J, Chen TT, Liu JR, Zhou W, Li WZ, Wang Y, Zhang BP, Lin J, Meng FD, Gong B, Zheng GY, Han ST, Cheng HB
Medicine (Baltimore) 2019 Aug;98(31):e16680. doi: 10.1097/MD.0000000000016680. PMID: 31374049Free PMC Article
Prevalence of colorectal adenomatous polyps in patients with chronic obstructive pulmonary disease.
Chun EM, Kim SW, Lim SY
Int J Chron Obstruct Pulmon Dis 2015;10:955-60. Epub 2015 May 18 doi: 10.2147/COPD.S83341. PMID: 26028968Free PMC Article
Role of high definition colonoscopy in colorectal adenomatous polyp detection.
Erim T, Rivas JM, Velis E, Castro F
World J Gastroenterol 2011 Sep 21;17(35):4001-6. doi: 10.3748/wjg.v17.i35.4001. PMID: 22046088Free PMC Article
Fecal bile acid concentrations in a subpopulation of the wheat bran fiber colon polyp trial.
Alberts DS, Einspahr JG, Earnest DL, Krutzsch MF, Lin P, Hess LM, Heddens DK, Roe DJ, Martínez ME, Salen G, Batta AK
Cancer Epidemiol Biomarkers Prev 2003 Mar;12(3):197-200. PMID: 12646507

Prognosis

Polymorphisms in Cyclooxygenase, Lipoxygenase, and TP53 Genes Predict Colorectal Polyp Risk Reduction by Aspirin in the seAFOod Polyp Prevention Trial.
Davies JR, Mell T, Fuller H, Harland M, Saleh RNM, Race AD, Rees CJ, Brown LC, Loadman PM, Downing A, Minihane AM, Williams EA, Hull MA
Cancer Prev Res (Phila) 2023 Nov 1;16(11):621-629. doi: 10.1158/1940-6207.CAPR-23-0111. PMID: 37756582Free PMC Article
Association between Colorectal Adenoma and Carotid Atherosclerosis in Korean Adults.
Kim H, Cho YJ, Kim YA, Gwak SG
Int J Environ Res Public Health 2018 Dec 6;15(12) doi: 10.3390/ijerph15122762. PMID: 30563254Free PMC Article
The potential role of the NEK6, AURKA, AURKB, and PAK1 genes in adenomatous colorectal polyps and colorectal adenocarcinoma.
Kasap E, Gerceker E, Boyacıoglu SÖ, Yuceyar H, Yıldırm H, Ayhan S, Korkmaz M
Tumour Biol 2016 Mar;37(3):3071-80. Epub 2015 Sep 30 doi: 10.1007/s13277-015-4131-6. PMID: 26423403
Prevalence of colorectal adenomatous polyps in patients with chronic obstructive pulmonary disease.
Chun EM, Kim SW, Lim SY
Int J Chron Obstruct Pulmon Dis 2015;10:955-60. Epub 2015 May 18 doi: 10.2147/COPD.S83341. PMID: 26028968Free PMC Article
MTSS1 overexpression correlates with poor prognosis in colorectal cancer.
Wang D, Xu MR, Wang T, Li T, Zhu Jw
J Gastrointest Surg 2011 Jul;15(7):1205-12. Epub 2011 May 12 doi: 10.1007/s11605-011-1546-2. PMID: 21562916

Clinical prediction guides

Polymorphisms in Cyclooxygenase, Lipoxygenase, and TP53 Genes Predict Colorectal Polyp Risk Reduction by Aspirin in the seAFOod Polyp Prevention Trial.
Davies JR, Mell T, Fuller H, Harland M, Saleh RNM, Race AD, Rees CJ, Brown LC, Loadman PM, Downing A, Minihane AM, Williams EA, Hull MA
Cancer Prev Res (Phila) 2023 Nov 1;16(11):621-629. doi: 10.1158/1940-6207.CAPR-23-0111. PMID: 37756582Free PMC Article
Association between Colorectal Adenoma and Carotid Atherosclerosis in Korean Adults.
Kim H, Cho YJ, Kim YA, Gwak SG
Int J Environ Res Public Health 2018 Dec 6;15(12) doi: 10.3390/ijerph15122762. PMID: 30563254Free PMC Article
The potential role of the NEK6, AURKA, AURKB, and PAK1 genes in adenomatous colorectal polyps and colorectal adenocarcinoma.
Kasap E, Gerceker E, Boyacıoglu SÖ, Yuceyar H, Yıldırm H, Ayhan S, Korkmaz M
Tumour Biol 2016 Mar;37(3):3071-80. Epub 2015 Sep 30 doi: 10.1007/s13277-015-4131-6. PMID: 26423403
Prevalence of colorectal adenomatous polyps in patients with chronic obstructive pulmonary disease.
Chun EM, Kim SW, Lim SY
Int J Chron Obstruct Pulmon Dis 2015;10:955-60. Epub 2015 May 18 doi: 10.2147/COPD.S83341. PMID: 26028968Free PMC Article
Adiposity and the risk of colorectal adenomatous polyps: a meta-analysis.
Lee YJ, Myung SK, Cho B, Park BJ, Park JH, Ju W, Park MS, Choi JH
Cancer Causes Control 2011 Jul;22(7):1021-35. Epub 2011 May 22 doi: 10.1007/s10552-011-9777-9. PMID: 21604177

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