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Colorectal serrated adenocarcinoma

MedGen UID:
474442
•Concept ID:
C3272809
•
Neoplastic Process
Synonyms: Colorectal Serrated Adenocarcinoma; colorectal serrated adenocarcinoma
 
Monarch Initiative: MONDO:0006163

Definition

A rare, invasive colorectal adenocarcinoma characterized by the presence of a malignant infiltrate with serrated glandular architecture. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColorectal serrated adenocarcinoma

Professional guidelines

PubMed

Biology and Therapeutic Targets of Colorectal Serrated Adenocarcinoma; Clues for a Histologically Based Treatment against an Aggressive Tumor.
Alburquerque-González B, López-Calderón FF, López-Abellán MD, Esteban-Gil Á, García-Solano J, Conesa-Zamora P
Int J Mol Sci 2020 Mar 14;21(6) doi: 10.3390/ijms21061991. PMID: 32183342Free PMC Article
Expression profiling shows differential molecular pathways and provides potential new diagnostic biomarkers for colorectal serrated adenocarcinoma.
Conesa-Zamora P, García-Solano J, García-García F, Turpin Mdel C, Trujillo-Santos J, Torres-Moreno D, Oviedo-Ramírez I, Carbonell-Muñoz R, Muñoz-Delgado E, Rodriguez-Braun E, Conesa A, Pérez-Guillermo M
Int J Cancer 2013 Jan 15;132(2):297-307. Epub 2012 Jun 28 doi: 10.1002/ijc.27674. PMID: 22696308

Recent clinical studies

Etiology

Clinicopathologic and endoscopic features of early-stage colorectal serrated adenocarcinoma.
Hirano D, Oka S, Tanaka S, Sumimoto K, Ninomiya Y, Tamaru Y, Shigita K, Hayashi N, Urabe Y, Kitadai Y, Shimamoto F, Arihiro K, Chayama K
BMC Gastroenterol 2017 Dec 12;17(1):158. doi: 10.1186/s12876-017-0702-x. PMID: 29233113Free PMC Article
Protein-protein interaction networks and modules analysis for colorectal cancer and serrated adenocarcinoma.
Yu H, Ye L, Wang J, Jin L, Lv Y, Yu M
J Cancer Res Ther 2015 Oct-Dec;11(4):846-51. doi: 10.4103/0973-1482.140805. PMID: 26881529
Clinical significance of programmed death ligand-1 (PD-L1) in colorectal serrated adenocarcinoma.
Zhu H, Qin H, Huang Z, Li S, Zhu X, He J, Yang J, Yu X, Yi X
Int J Clin Exp Pathol 2015;8(8):9351-9. Epub 2015 Aug 1 PMID: 26464688Free PMC Article
Colorectal serrated adenocarcinoma shows a different profile of oncogene mutations, MSI status and DNA repair protein expression compared to conventional and sporadic MSI-H carcinomas.
García-Solano J, Conesa-Zamora P, Carbonell P, Trujillo-Santos J, Torres-Moreno D D, Pagán-Gómez I, Rodríguez-Braun E, Pérez-Guillermo M
Int J Cancer 2012 Oct 15;131(8):1790-9. Epub 2012 Mar 14 doi: 10.1002/ijc.27454. PMID: 22287190
Clinicopathologic study of 85 colorectal serrated adenocarcinomas: further insights into the full recognition of a new subset of colorectal carcinoma.
García-Solano J, Pérez-Guillermo M, Conesa-Zamora P, Acosta-Ortega J, Trujillo-Santos J, Cerezuela-Fuentes P, Mäkinen MJ
Hum Pathol 2010 Oct;41(10):1359-68. Epub 2010 Jul 1 doi: 10.1016/j.humpath.2010.04.002. PMID: 20594582

Diagnosis

VE1 immunohistochemistry accurately detects BRAF V600E mutations in colorectal carcinoma and can be utilized in the detection of poorly differentiated colorectal serrated adenocarcinoma.
Sajanti S, Sirniö P, Väyrynen JP, Tuomisto A, Klintrup K, Mäkelä J, Ristimäki A, Mäkinen MJ
Virchows Arch 2014 Jun;464(6):637-43. Epub 2014 Apr 11 doi: 10.1007/s00428-014-1555-0. PMID: 24722974
Microsatellite pathologic score does not efficiently identify high microsatellite instability in colorectal serrated adenocarcinoma.
García-Solano J, Conesa-Zamora P, Carbonell P, Trujillo-Santos J, Torres-Moreno D, Rodriguez-Braun E, Vicente-Ortega V, Pérez-Guillermo M
Hum Pathol 2013 May;44(5):759-65. Epub 2012 Oct 22 doi: 10.1016/j.humpath.2012.07.020. PMID: 23089493
Expression profiling shows differential molecular pathways and provides potential new diagnostic biomarkers for colorectal serrated adenocarcinoma.
Conesa-Zamora P, García-Solano J, García-García F, Turpin Mdel C, Trujillo-Santos J, Torres-Moreno D, Oviedo-Ramírez I, Carbonell-Muñoz R, Muñoz-Delgado E, Rodriguez-Braun E, Conesa A, Pérez-Guillermo M
Int J Cancer 2013 Jan 15;132(2):297-307. Epub 2012 Jun 28 doi: 10.1002/ijc.27674. PMID: 22696308
Clinicopathologic study of 85 colorectal serrated adenocarcinomas: further insights into the full recognition of a new subset of colorectal carcinoma.
García-Solano J, Pérez-Guillermo M, Conesa-Zamora P, Acosta-Ortega J, Trujillo-Santos J, Cerezuela-Fuentes P, Mäkinen MJ
Hum Pathol 2010 Oct;41(10):1359-68. Epub 2010 Jul 1 doi: 10.1016/j.humpath.2010.04.002. PMID: 20594582

Therapy

Biology and Therapeutic Targets of Colorectal Serrated Adenocarcinoma; Clues for a Histologically Based Treatment against an Aggressive Tumor.
Alburquerque-González B, López-Calderón FF, López-Abellán MD, Esteban-Gil Á, García-Solano J, Conesa-Zamora P
Int J Mol Sci 2020 Mar 14;21(6) doi: 10.3390/ijms21061991. PMID: 32183342Free PMC Article

Prognosis

Biology and Therapeutic Targets of Colorectal Serrated Adenocarcinoma; Clues for a Histologically Based Treatment against an Aggressive Tumor.
Alburquerque-González B, López-Calderón FF, López-Abellán MD, Esteban-Gil Á, García-Solano J, Conesa-Zamora P
Int J Mol Sci 2020 Mar 14;21(6) doi: 10.3390/ijms21061991. PMID: 32183342Free PMC Article
Clinicopathologic and endoscopic features of early-stage colorectal serrated adenocarcinoma.
Hirano D, Oka S, Tanaka S, Sumimoto K, Ninomiya Y, Tamaru Y, Shigita K, Hayashi N, Urabe Y, Kitadai Y, Shimamoto F, Arihiro K, Chayama K
BMC Gastroenterol 2017 Dec 12;17(1):158. doi: 10.1186/s12876-017-0702-x. PMID: 29233113Free PMC Article
Microsatellite pathologic score does not efficiently identify high microsatellite instability in colorectal serrated adenocarcinoma.
García-Solano J, Conesa-Zamora P, Carbonell P, Trujillo-Santos J, Torres-Moreno D, Rodriguez-Braun E, Vicente-Ortega V, Pérez-Guillermo M
Hum Pathol 2013 May;44(5):759-65. Epub 2012 Oct 22 doi: 10.1016/j.humpath.2012.07.020. PMID: 23089493
Colorectal serrated adenocarcinoma shows a different profile of oncogene mutations, MSI status and DNA repair protein expression compared to conventional and sporadic MSI-H carcinomas.
García-Solano J, Conesa-Zamora P, Carbonell P, Trujillo-Santos J, Torres-Moreno D D, Pagán-Gómez I, Rodríguez-Braun E, Pérez-Guillermo M
Int J Cancer 2012 Oct 15;131(8):1790-9. Epub 2012 Mar 14 doi: 10.1002/ijc.27454. PMID: 22287190
Immunohistochemical expression profile of β-catenin, E-cadherin, P-cadherin, laminin-5γ2 chain, and SMAD4 in colorectal serrated adenocarcinoma.
García-Solano J, Conesa-Zamora P, Trujillo-Santos J, Torres-Moreno D, Mäkinen MJ, Pérez-Guillermo M
Hum Pathol 2012 Jul;43(7):1094-102. Epub 2011 Dec 29 doi: 10.1016/j.humpath.2011.08.020. PMID: 22209340

Clinical prediction guides

Microsatellite pathologic score does not efficiently identify high microsatellite instability in colorectal serrated adenocarcinoma.
García-Solano J, Conesa-Zamora P, Carbonell P, Trujillo-Santos J, Torres-Moreno D, Rodriguez-Braun E, Vicente-Ortega V, Pérez-Guillermo M
Hum Pathol 2013 May;44(5):759-65. Epub 2012 Oct 22 doi: 10.1016/j.humpath.2012.07.020. PMID: 23089493
Frequent mutations of KRAS in addition to BRAF in colorectal serrated adenocarcinoma.
Stefanius K, Ylitalo L, Tuomisto A, Kuivila R, Kantola T, Sirniö P, Karttunen TJ, Mäkinen MJ
Histopathology 2011 Apr;58(5):679-92. Epub 2011 Apr 4 doi: 10.1111/j.1365-2559.2011.03821.x. PMID: 21457162Free PMC Article
Downregulation of the hedgehog receptor PTCH1 in colorectal serrated adenocarcinomas is not caused by PTCH1 mutations.
Stefanius K, Kantola T, Tuomisto A, Vahteristo P, Karttunen TJ, Aaltonen LA, Mäkinen MJ, Karhu A
Virchows Arch 2011 Feb;458(2):213-9. Epub 2011 Jan 14 doi: 10.1007/s00428-010-1031-4. PMID: 21234763
Clinicopathologic study of 85 colorectal serrated adenocarcinomas: further insights into the full recognition of a new subset of colorectal carcinoma.
García-Solano J, Pérez-Guillermo M, Conesa-Zamora P, Acosta-Ortega J, Trujillo-Santos J, Cerezuela-Fuentes P, Mäkinen MJ
Hum Pathol 2010 Oct;41(10):1359-68. Epub 2010 Jul 1 doi: 10.1016/j.humpath.2010.04.002. PMID: 20594582
Morphology and microsatellite instability in sporadic serrated and non-serrated colorectal cancer.
Tuppurainen K, Mäkinen JM, Junttila O, Liakka A, Kyllönen AP, Tuominen H, Karttunen TJ, Mäkinen MJ
J Pathol 2005 Nov;207(3):285-94. doi: 10.1002/path.1850. PMID: 16177963

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